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Chemotherapy-free approaches to newly-diagnosed acute promyelocytic leukemia: is oral-arsenic trioxide/all-trans retinoic acid/ascorbic acid the answer?

Received 27 Apr 2024, Accepted 07 Aug 2024, Accepted author version posted online: 09 Aug 2024
Accepted author version

References

  • Tallman MS, Altman JK. How I treat acute promyelocytic leukemia. Blood. 2009;114(25):5126–5135. doi:10.1182/blood-2009-07-216457
  • Tallman MS, Andersen JW, Schiffer CA et al. All-trans retinoic acid in acute promyelocytic leukemia: long-term outcome and prognostic factor analysis from the North American Intergroup protocol. Blood, 100(13), 4298–4302 (2002).
  • Lengfelder E, Haferlach C, Saussele S, et al. High dose ara-C in the treatment of newly diagnosed acute promyelocytic leukemia: long-term results of the German AMLCG. Leukemia. 2009;23(12):2248–2258. doi: 10.1038/leu.2009.183
  • Lo-Coco F, Avvisati G, Vignetti M, et al. Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group. Blood. 2010;116(17):3171–3179. doi: 10.1182/blood-2010-03-276196
  • Kelaidi C, Chevret S, De Botton S, et al. Improved outcome of acute promyelocytic leukemia with high WBC counts over the last 15 years: the European APL group experience. J Clin Oncol. 2009;27(16):2668–2676. doi: 10.1200/JCO.2008.18.4119
  • Hu J, Liu YF, Wu CF, et al. Long-term efficacy and safety of all-trans retinoic acid/arsenic trioxide-based therapy in newly diagnosed acute promyelocytic leukemia. Proc Natl Acad Sci U S A. 2009;106(9):3342–3347. doi: 10.1073/pnas.0813280106
  • Iland HJ, Bradstock K, Supple SG, et al. All-trans-retinoic acid, idarubicin, and IV arsenic trioxide as initial therapy in acute promyelocytic leukemia (APML4). Blood. 2012;120(8):1570–1580; quiz 1752. doi: 10.1182/blood-2012-02-410746
  • Lo-Coco F, Avvisati G, Vignetti M, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013;369(2):111–121. doi: 10.1056/NEJMoa1300874
  • Abaza Y, Kantarjian H, Garcia-Manero G, et al. Long-term outcome of acute promyelocytic leukemia treated with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab. Blood. 2017;129(10):1275–1283. doi: 10.1182/blood-2016-09-736686
  • Burnett AK, Russell NH, Hills RK, et al. Arsenic trioxide and all-trans retinoic acid treatment for acute promyelocytic leukaemia in all risk groups (AML17): results of a randomised, controlled, phase 3 trial. Lancet Oncol. 2015;16(13):1295–1305. doi: 10.1016/S1470-2045(15)00193-X
  • Kumana CR, Mak R, Kwong YL, et al. Resurrection of oral arsenic trioxide for treating acute promyelocytic leukaemia: a historical account from bedside to bench to bedside. Front Oncol. 2020;10:1294. doi:10.3389/fonc.2020.01294
  • Au WY, Kumana CR, Kou M, et al. Oral arsenic trioxide in the treatment of relapsed acute promyelocytic leukemia. Blood. 2003;102(1):407–408. doi: 10.1182/blood-2003-01-0298
  • Au WY, Li CK, Lee V, et al. Oral arsenic trioxide for relapsed acute promyelocytic leukemia in pediatric patients. Pediatr Blood Cancer. 2012;58(4):630–632. doi: 10.1002/pbc.23306
  • Au WY, Kumana CR, Lee HK et al. Oral arsenic trioxide-based maintenance regimens for first complete remission of acute promyelocytic leukemia: a 10-year follow-up study. Blood, 118(25), 6535–6543 (2011).
  • Gill H, Kumana CR, Yim R, et al. Oral arsenic trioxide incorporation into frontline treatment with all-trans retinoic acid and chemotherapy in newly diagnosed acute promyelocytic leukemia: a 5-year prospective study. Cancer. 2019;125(17):3001–3012. doi: 10.1002/cncr.32180
  • Gill HS, Yim R, Kumana CR, et al. Oral arsenic trioxide, all-trans retinoic acid, and ascorbic acid maintenance after first complete remission in acute promyelocytic leukemia: Long-term results and unique prognostic indicators. Cancer, 126(14), 3244–3254 10.1002/cncr.32937(2020).. 2020
  • Kwong YL, Todd D. Delicious poison: arsenic trioxide for the treatment of leukemia. Blood, 89(9), 3487–3488 (1997).
  • Au WY. A biography of arsenic and medicine in Hong Kong and China. Hong Kong Med J, 17(6), 507–513 (2011).
  • Kumana CR, Au WY, Lee NS et al. Systemic availability of arsenic from oral arsenic-trioxide used to treat patients with hematological malignancies. Eur J Clin Pharmacol, 58(8), 521–526 (2002).
  • Siu CW, Au WY, Yung C, et al. Effects of oral arsenic trioxide therapy on QT intervals in patients with acute promyelocytic leukemia: implications for long-term cardiac safety. Blood. 2006;108(1):103–106. doi: 10.1182/blood-2006-01-0054
  • Hai JJ, Gill H, Tse HF, et al. Torsade de pointes during oral arsenic trioxide therapy for acute promyelocytic leukemia in a patient with heart failure. Ann Hematol. 2015;94(3):501–503. doi:10.1007/s00277-014-2174-1
  • Au WY, Kwong YL. Arsenic trioxide: safety issues and their management. Acta Pharmacol Sin. 2008;29(3):296–304. doi:10.1111/j.1745-7254.2008.00771.x
  • Au WY, Cheung GT, Yuen TW, Kumana CR, Kwong YL. Successful treatment of relapsed acute promyelocytic leukemia in a patient receiving continuous ambulatory peritoneal dialysis with oral arsenic trioxide. Arch Intern Med, 165(9), 1067–1068 (2005).
  • Au WY, Fong BM, Tam S, et al. Feasibility of oral arsenic trioxide treatment for acute promyelocytic leukemia during hemodialysis. Ann Hematol. 2013;92(3):417–418. doi:10.1007/s00277-012-1576-1
  • Au WY, Tam S, Fong BM, et al. Determinants of cerebrospinal fluid arsenic concentration in patients with acute promyelocytic leukemia on oral arsenic trioxide therapy. Blood. 2008;112(9):3587–3590. doi:10.1182/blood-2008-06-161000
  • Au WY, Tam S, Kwong YL. Entry of elemental arsenic into the central nervous system in patients with acute promyelocytic leukemia during arsenic trioxide treatment. Leuk Res. 2008;32(2):357–358. doi:10.1016/j.leukres.2007.06.005
  • Gill H, Yim R, Lee HKK, et al. Long-term outcome of relapsed acute promyelocytic leukemia treated with oral arsenic trioxide-based reinduction and maintenance regimens: a 15-year prospective study. Cancer. 2018;124(11):2316–2326. doi: 10.1002/cncr.31327
  • Dai J, Weinberg RS, Waxman S, et al. Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system. Blood. 1999;93(1):268–277. doi:10.1182/blood.V93.1.268
  • Grad JM, Bahlis NJ, Reis I, Oshiro MM, Dalton WS, Boise LH. Ascorbic acid enhances arsenic trioxide-induced cytotoxicity in multiple myeloma cells. Blood, 98(3), 805–813 (2001).
  • Au WY, Kwong YL. Frequent varicella zoster reactivation associated with therapeutic use of arsenic trioxide: portents of an old scourge. J Am Acad Dermatol. 2005;53(5):890–892. doi:10.1016/j.jaad.2005.07.030
  • Gill H, Raghupathy R, Ni M, et al.. Epidemiology and outcomes of acute promyelocytic leukaemia in the era of all-trans retinoic acid (ATRA) chemotherapy and arsenic trioxide plus ATRA: a retrospective analysis. The Lancet Oncology. 2022;23:S11. doi: 10.1016/S1470-2045(22)00410-7
  • Gill H, Raghupathy R, Lee CY et al. Acute promyelocytic leukaemia: population-based study of epidemiology and outcome with ATRA and oral-ATO from 1991 to 2021. BMC Cancer, 23(1), 141 (2023).
  • Gill H, Yung Y, Chu HT, et al. Characteristics and predictors of early hospital deaths in newly diagnosed APL: a 13-year population-wide study. Blood Adv. 2021;5(14):2829–2838. doi: 10.1182/bloodadvances.2021004789
  • Norsworthy KJ, Avagyan A, Bird ST, et al. Second cancers in adults with acute promyelocytic leukemia treated with or without arsenic trioxide: a SEER-medicare analysis. Leukemia. 2020;34(11):3082–3084. doi: 10.1038/s41375-020-0905-y
  • Singh AP, Goel RK, Kaur T. Mechanisms pertaining to arsenic toxicity. Toxicol Int, 18(2), 87–93 (2011).
  • Estey E, Garcia-Manero G, Ferrajoli A, et al. Use of all-trans retinoic acid plus arsenic trioxide as an alternative to chemotherapy in untreated acute promyelocytic leukemia. Blood. 2006;107(9):3469–3473. doi: 10.1182/blood-2005-10-4006
  • Ravandi F, Estey E, Jones D, et al. Effective treatment of acute promyelocytic leukemia with all-trans-retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin. J Clin Oncol. 2009;27(4):504–510. doi: 10.1200/JCO.2008.18.6130
  • Powell BL, Moser B, Stock W, et al. Arsenic trioxide improves event-free and overall survival for adults with acute promyelocytic leukemia: north american leukemia intergroup study C9710. Blood. 2010;116(19):3751–3757. doi: 10.1182/blood-2010-02-269621
  • Sanz MA, Martin G, Gonzalez M et al. Risk-adapted treatment of acute promyelocytic leukemia with all-trans-retinoic acid and anthracycline monochemotherapy: a multicenter study by the PETHEMA group. Blood, 103(4), 1237–1243 (2004).
  • Platzbecker U, Avvisati G, Cicconi L et al. Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial. J Clin Oncol, 35(6), 605–612 (2017).
  • Wang L, Zhou GB, Liu P, et al. Dissection of mechanisms of Chinese medicinal formula Realgar-indigo naturalis as an effective treatment for promyelocytic leukemia. Proc Natl Acad Sci U S A. 2008;105(12):4826–4831. doi: 10.1073/pnas.0712365105
  • Wu J, Shao Y, Liu J, Chen G, Ho PC. The medicinal use of realgar (As(4)S(4)) and its recent development as an anticancer agent. J Ethnopharmacol, 135(3), 595–602 (2011).
  • Zhu HH, Wu DP, Jin J, et al. Oral tetra-arsenic tetra-sulfide formula versus intravenous arsenic trioxide as first-line treatment of acute promyelocytic leukemia: a multicenter randomized controlled trial. J Clin Oncol. 2013;31(33):4215–4221. doi: 10.1200/JCO.2013.48.8312
  • Gill H, Yim R, Chin L, et al. An entirely oral regimen of oral-arsenic Trioxide/All-Trans Retinoic Acid/Ascorbic Acid in newly-diagnosed acute promyelocytic leukaemia (APL): updated results of an ongoing multicentre trial. Blood. 2023;142(Supplement 1):157. doi: 10.1182/blood-2023-179644
  • Gill H, Raghupathy R, Hou H-A, et al.. P493: ORAL-ATO/ATRA/ASCORBIC ACID (AAA)-BASED INDUCTION OR MAINTENANCE OF FIRST COMPLETE REMISSION IMPROVED OUTCOMES IN NEWLY DIAGNOSED APL: A MULTICENTRE ANALYSIS OF THE APL ASIAN CONSORTIUM (APLAC). HemaSphere. 2023;7(S3):e6159196. doi: 10.1097/01.HS9.0000968880.61591.96
  • Sanz MA, Montesinos P, Rayon C, et al. Risk-adapted treatment of acute promyelocytic leukemia based on all-trans retinoic acid and anthracycline with addition of cytarabine in consolidation therapy for high-risk patients: further improvements in treatment outcome. Blood. 2010;115(25):5137–5146. doi: 10.1182/blood-2010-01-266007
  • Jacomo RH, Melo RA, Souto FR, et al. Clinical features and outcomes of 134 Brazilians with acute promyelocytic leukemia who received ATRA and anthracyclines. Haematologica. 2007;92(10):1431–1432. doi: 10.3324/haematol.10874
  • Serefhanoglu S, Buyukasik Y, Goker H et al. Clinical features and outcomes of 49 Turkish patients with acute promyelocytic leukemia who received ATRA and anthracyclines (PETHEMA protocol) therapy. Leuk Res, 34(12), e317–319 (2010).
  • Lehmann S, Ravn A, Carlsson L, et al. Continuing high early death rate in acute promyelocytic leukemia: a population-based report from the swedish adult acute leukemia registry. Leukemia. 2011;25(7):1128–1134. doi: 10.1038/leu.2011.78
  • Park JH, Qiao B, Panageas KS, et al. Early death rate in acute promyelocytic leukemia remains high despite all-trans retinoic acid. Blood. 2011;118(5):1248–1254. doi: 10.1182/blood-2011-04-346437
  • Chen Y, Kantarjian H, Wang H, et al. Acute promyelocytic leukemia: a population-based study on incidence and survival in the United States, 1975-2008. Cancer. 2012;118(23):5811–5818. doi:10.1002/cncr.27623
  • Jeddi R, Ghedira H, Ben Amor R, et al. Treatment of acute promyelocytic leukemia with AIDA based regimen. Update of a Tunisian single center study. Mediterr J Hematol Infect Dis. 2011;3(1):e2011033. doi: 10.4084/mjhid.2011.033
  • McClellan JS, Kohrt HE, Coutre S, et al. Treatment advances have not improved the early death rate in acute promyelocytic leukemia. Haematologica. 2012;97(1):133–136. doi: 10.3324/haematol.2011.046490
  • Pagoni M, Garofalaki M, Panitsas F, et al. Acute promyelocytic leukemia: an experience on 95 greek patients treated in the all-trans-retinoic acid era. Mediterr J Hematol Infect Dis. 2011;3(1):e2011053. doi: 10.4084/mjhid.2011.053
  • Imagawa J, Harada Y, Shimomura T, et al. High early death rate in elderly patients with acute promyelocytic leukemia treated with all-trans retinoic acid combined chemotherapy. Int J Hematol. 2013;98(2):264–266. doi:10.1007/s12185-013-1390-0
  • Paulson K, Serebrin A, Lambert P, et al. Acute promyelocytic leukaemia is characterized by stable incidence and improved survival that is restricted to patients managed in leukaemia referral centres: a pan-Canadian epidemiological study. Br J Haematol. 2014;166(5):660–666. doi: 10.1111/bjh.12931
  • Karim F, Shaikh U, Adil SN, et al. Clinical characteristics, outcome and early induction deaths in patients with acute promyelocytic leukaemia: a five-year experience at a tertiary care centre. Singapore Med J. 2014;55(8):443–447. doi:10.11622/smedj.2014105
  • Bajpai J, Sharma A, Kumar L, et al. Acute promyelocytic leukemia: an experience from a tertiary care centre in north India. Indian J Cancer. 2011;48(3):316–322. doi: 10.4103/0019-509X.84938
  • Rahme R, Thomas X, Recher C, et al. Early death in acute promyelocytic leukemia (APL) in French centers: a multicenter study in 399 patients. Leukemia. 2014;28(12):2422–2424. doi: 10.1038/leu.2014.240
  • Guru Murthy GS, Szabo A, Michaelis L, et al. Improving outcomes of acute promyelocytic leukemia in the Current era: analysis of the SEER database. J Natl Compr Canc Netw. 2020;18(2):169–175. doi: 10.6004/jnccn.2019.7351
  • Sanz MA, Fenaux P, Tallman MS, et al. Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet. Blood. 2019;133(15):1630–1643. doi: 10.1182/blood-2019-01-894980
  • Kayser S, Rahme R, Martinez-Cuadron D et al. Outcome of older (>/=70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study. Leukemia, 34(9), 2333–2341 (2020).
  • Gurnari C, Breccia M, Di Giuliano F, et al. Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico-biological parameters. Br J Haematol. 2021;193(1):129–132. doi: 10.1111/bjh.17018
  • Altman JK, Rademaker A, Cull E, et al. Administration of ATRA to newly diagnosed patients with acute promyelocytic leukemia is delayed contributing to early hemorrhagic death. Leuk Res. 2013;37(9):1004–1009. doi: 10.1016/j.leukres.2013.05.007
  • Kwaan HC, Weiss I, Tallman MS. The role of abnormal hemostasis and fibrinolysis in morbidity and mortality of acute promyelocytic leukemia. Semin Thromb Hemost. 2019;45(6):612–621. doi:10.1055/s-0039-1693478
  • Kwaan HC, Cull EH. The coagulopathy in acute promyelocytic leukaemia–what have we learned in the past twenty years. Best Pract Res Clin Haematol. 2014;27(1):11–18. doi:10.1016/j.beha.2014.04.005

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