Functions of circular RNAs and their potential applications in gastric cancer

References

• Jeck WR, Sharpless NE. Detecting and characterizing circular RNAs. Nat Biotechnol. 2014;32(5):453–461.
   PubMed Web of Science ®Google Scholar
• Vea A, Llorente-Cortes V, de Gonzalo-calvo D. Circular RNAs in blood. Adv Exp Med Biol. 2018;1087:119–130.
   PubMed Web of Science ®Google Scholar
• Han YN, Xia SQ, Zhang YY, et al. Circular RNAs: A novel type of biomarker and genetic tools in cancer. Oncotarget. 2017;8(38):64551–64563.
   PubMedGoogle Scholar
• Chen L, Huang C, Wang X, et al. Circular RNAs in eukaryotic cells. Curr Genomics. 2015;16(5):312–318.
   PubMed Web of Science ®Google Scholar
• Panda AC, De S, Grammatikakis I, et al. High-purity circular RNA isolation method (RPAD) reveals vast collection of intronic circRNAs. Nucleic Acids Res. 2017;45(12):e116.
   PubMed Web of Science ®Google Scholar
• Ragan C, Goodall GJ, Shirokikh NE, et al. Insights into the biogenesis and potential functions of exonic circular RNA. Sci Rep. 2019;9(1):2048.
   PubMedGoogle Scholar
• Aufiero S, Reckman YJ, Pinto YM, et al. Circular RNAs open a new chapter in cardiovascular biology. Nat Rev Cardiol. 2019;16:503–514.
   PubMed Web of Science ®Google Scholar
• Fu L, Jiang Z, Li T, et al. Circular RNAs in hepatocellular carcinoma: functions and implications. Cancer Med. 2018;7:3101–3109.
   PubMed Web of Science ®Google Scholar
• Li Z, Huang C, Bao C, et al. Exon-intron circular RNAs regulate transcription in the nucleus. Nat Struct Mol Biol. 2015;22(3):256–264.
   PubMed Web of Science ®Google Scholar
• Tian M, Chen R, Li T, et al. Reduced expression of circRNA hsa_circ_0003159 in gastric cancer and its clinical significance. J Clin Lab Anal. 2018;32(3):e 22281.
   Web of Science ®Google Scholar
• Xie Y, Shao Y, Sun W, et al. Downregulated expression of hsa_circ_0074362 in gastric cancer and its potential diagnostic values. Biomark Med. 2018;12(1):11–20.
   PubMed Web of Science ®Google Scholar
• Han B, Chao J, Yao H. Circular RNA and its mechanisms in disease: from the bench to the clinic. Pharmacol Ther. 2018;187:31–44.
   PubMed Web of Science ®Google Scholar
• Rybak-Wolf A, Stottmeister C, Glazar P, et al. Circular RNAs in the mammalian brain are highly abundant, conserved, and dynamically expressed. Mol Cell. 2015;58(5):870–885.
   PubMed Web of Science ®Google Scholar
• Salzman J, Gawad C, Wang PL, et al. Circular RNAs are the predominant transcript isoform from hundreds of human genes in diverse cell types. PLoS One. 2012;7(2):e30733.
   PubMed Web of Science ®Google Scholar
• Keshavarzi M, Sorayayi S, Jafar Rezaei M, et al. MicroRNAs-based imaging techniques in cancer diagnosis and therapy. J Cell Biochem. 2017;118(12):4121–4128.
   PubMed Web of Science ®Google Scholar
• Feng S, Wang L, Liu W, et al. MiR-126 correlates with increased disease severity and promotes keratinocytes proliferation and inflammation while suppresses cells’ apoptosis in psoriasis. J Clin Lab Anal. 2018;32(9):e22588.
   PubMed Web of Science ®Google Scholar
• Tavakolizadeh J, Roshanaei K, Salmaninejad A, et al. MicroRNAs and exosomes in depression: potential diagnostic biomarkers. J Cell Biochem. 2018;119(5):3783–3797.
   PubMed Web of Science ®Google Scholar
• Saeedi Borujeni MJ, Esfandiary E, Taheripak G, et al. Molecular aspects of diabetes mellitus: resistin, microRNA, and exosome. J Cell Biochem. 2018;119(2):1257–1272.
   PubMed Web of Science ®Google Scholar
• Mirzaei H, Ferns GA, Avan A, et al. Cytokines and microRNA in coronary artery disease. Adv Clin Chem. 2017;82:47–70.
   PubMed Web of Science ®Google Scholar
• Gholamin S, Mirzaei H, Razavi SM, et al. GD2-targeted immunotherapy and potential value of circulating microRNAs in neuroblastoma. J Cell Physiol. 2018;233(2):866–879.
   PubMed Web of Science ®Google Scholar
• Jamali L, Tofigh R, Tutunchi S, et al. Circulating microRNAs as diagnostic and therapeutic biomarkers in gastric and esophageal cancers. J Cell Physiol. 2018;233(11):8538–8550.
   PubMed Web of Science ®Google Scholar
• Mirzaei H, Khataminfar S, Mohammadparast S, et al. Circulating microRNAs as potential diagnostic biomarkers and therapeutic targets in gastric cancer: current status and future perspectives. Curr Med Chem. 2016;23(36):4135–4150.
   PubMed Web of Science ®Google Scholar
• Simonian M, Mosallayi M, Mirzaei H. Circulating miR-21 as novel biomarker in gastric cancer: diagnostic and prognostic biomarker. J Cancer Res Ther. 2018;14(2):475.
   PubMed Web of Science ®Google Scholar
• Li P, Chen H, Chen S, et al. Circular RNA 0000096 affects cell growth and migration in gastric cancer. Br J Cancer. 2017;116(5):626–633.
   PubMed Web of Science ®Google Scholar
• Hansen TB, Jensen TI, Clausen BH, et al. Natural RNA circles function as efficient microRNA sponges. Nature. 2013;495(7441):384–388.
   PubMed Web of Science ®Google Scholar
• Su C, Han Y, Zhang H, et al. CiRS-7 targeting miR-7 modulates the progression of non-small cell lung cancer in a manner dependent on NF-kappaB signalling. J Cell Mol Med. 2018;22(6):3097–3107.
   PubMed Web of Science ®Google Scholar
• Huang H, Wei L, Qin T, et al. Circular RNA ciRS-7 triggers the migration and invasion of esophageal squamous cell carcinoma via miR-7/KLF4 and NF-kappaB signals. Cancer Biol Ther. 2019;20(1):73–80.
   PubMed Web of Science ®Google Scholar
• Xie F, Li Y, Wang M, et al. Circular RNA BCRC-3 suppresses bladder cancer proliferation through miR-182-5p/p27 axis. Mol Cancer. 2018;17(1):144.
   PubMed Web of Science ®Google Scholar
• Wang R, Zhang S, Chen X, et al. EIF4A3-induced circular RNA MMP9 (circMMP9) acts as a sponge of miR-124 and promotes glioblastoma multiforme cell tumorigenesis. Mol Cancer. 2018;17(1):166.
   PubMed Web of Science ®Google Scholar
• Barbagallo D, Caponnetto A, Cirnigliaro M, et al. CircSMARCA5 inhibits migration of glioblastoma multiforme cells by regulating a molecular axis involving splicing factors SRSF1/SRSF3/PTB. Int J Mol Sci. 2018;19(2):pii: E480.
   Web of Science ®Google Scholar
• Barbagallo D, Caponnetto A, Brex D, et al. CircSMARCA5 regulates VEGFA mRNA splicing and angiogenesis in glioblastoma multiforme through the binding of SRSF1. Cancers (Basel). 2019;11(2):pii: E194.
   Web of Science ®Google Scholar
• Xia P, Wang S, Ye B, et al. A circular RNA protects dormant hematopoietic stem cells from DNA sensor cGAS-mediated exhaustion. Immunity. 2018;48(4):688–701.e687.
   PubMed Web of Science ®Google Scholar
• Du WW, Yang W, Chen Y, et al. Foxo3 circular RNA promotes cardiac senescence by modulating multiple factors associated with stress and senescence responses. Eur Heart J. 2017;38(18):1402–1412.
   PubMed Web of Science ®Google Scholar
• Zhang M, Huang N, Yang X, et al. A novel protein encoded by the circular form of the SHPRH gene suppresses glioma tumorigenesis. Oncogene. 2018;37(13):1805–1814.
   PubMed Web of Science ®Google Scholar
• Legnini I, Di Timoteo G, Rossi F, et al. Circ-ZNF609 is a circular RNA that can be translated and functions in myogenesis. Mol Cell. 2017;66(1):22–37.e29.
   PubMed Web of Science ®Google Scholar
• Pamudurti NR, Bartok O, Jens M, et al. Translation of circRNAs. Mol Cell. 2017;66(1):9–21.e27.
   PubMed Web of Science ®Google Scholar
• Yang Y, Fan X, Mao M, et al. Extensive translation of circular RNAs driven by N(6)-methyladenosine. Cell Res. 2017;27(5):626–641.
   PubMed Web of Science ®Google Scholar
• Johnson AG, Grosely R, Petrov AN, et al. Dynamics of IRES-mediated translation. Philos Trans R Soc Lond B Biol Sci. 2017;372(1716):pii: 20160177.
   Web of Science ®Google Scholar
• Yang Y, Gao X, Zhang M, et al. Novel role of FBXW7 circular RNA in repressing glioma tumorigenesis. J Natl Cancer Inst. 2018;110(3):304–315.
   PubMedGoogle Scholar
• Zhang M, Zhao K, Xu X, et al. A peptide encoded by circular form of LINC-PINT suppresses oncogenic transcriptional elongation in glioblastoma. Nat Commun. 2018;9(1):4475.
   PubMed Web of Science ®Google Scholar
• Park OH, Ha H, Lee Y, et al. Endoribonucleolytic cleavage of m(6)A-containing RNAs by RNase P/MRP complex. Mol Cell. 2019;74(3):494–507.e8.
   PubMed Web of Science ®Google Scholar
• Zhang Y, Zhang XO, Chen T, et al. Circular intronic long noncoding RNAs. Mol Cell. 2013;51(6):792–806.
   PubMed Web of Science ®Google Scholar
• Liang D, Tatomer DC, Luo Z, et al. The output of protein-coding genes shifts to circular RNAs when the pre-mRNA processing machinery is limiting. Mol Cell. 2017;68(5):940–954.e943.
   PubMed Web of Science ®Google Scholar
• Ashwal-Fluss R, Meyer M, Pamudurti NR, et al. CircRNA biogenesis competes with pre-mRNA splicing. Mol Cell. 2014;56(1):55–66.
   PubMed Web of Science ®Google Scholar
• Conn VM, Hugouvieux V, Nayak A, et al. A circRNA from SEPALLATA3 regulates splicing of its cognate mRNA through R-loop formation. Nat Plants. 2017;3:17053.
   PubMed Web of Science ®Google Scholar
• Dong R, Zhang XO, Zhang Y, et al. CircRNA-derived pseudogenes. Cell Res. 2016;26(6):747–750.
   PubMed Web of Science ®Google Scholar
• Faghihloo E, Araei Y, Mohammadi M, et al. The effect of oxamflatin on the E-cadherin expression in gastric cancer cell line. Cancer Gene Ther. 2016;23(11):396–399.
   PubMed Web of Science ®Google Scholar
• Mo X, Wu Y, Chen L, et al. Global expression profiling of metabolic pathway-related lncRNAs in human gastric cancer and the identification of RP11-555H23.1 as a new diagnostic biomarker. J Clin Lab Anal. 2019;33(2):e22692.
   PubMed Web of Science ®Google Scholar
• Tan WL, Lim BT, Anene-Nzelu CG, et al. A landscape of circular RNA expression in the human heart. Cardiovasc Res. 2017;113(3):298–309.
   PubMed Web of Science ®Google Scholar
• Hanan M, Soreq H, Kadener S. CircRNAs in the brain. RNA Biol. 2017;14(8):1028–1034.
   PubMed Web of Science ®Google Scholar
• Song M, Xia L, Sun M, et al. Circular RNA in liver: health and diseases. Adv Exp Med Biol. 2018;1087:(245–257.
   Web of Science ®Google Scholar
• Shao Y, Ye M, Jiang X, et al. Gastric juice long noncoding RNA used as a tumor marker for screening gastric cancer. Cancer. 2014;120(21):3320–3328.
   PubMed Web of Science ®Google Scholar
• Shao Y, Li J, Lu R, et al. Global circular RNA expression profile of human gastric cancer and its clinical significance. Cancer Med. 2017;6(6):1173–1180.
   PubMed Web of Science ®Google Scholar
• Matsuoka T, Yashiro M. Biomarkers of gastric cancer: current topics and future perspective. World J Gastroenterol. 2018;24(26):2818–2832.
   PubMed Web of Science ®Google Scholar
• Wang W, Xu X, Tian B, et al. The diagnostic value of serum tumor markers CEA, CA19-9, CA125, CA15-3, and TPS in metastatic breast cancer. Clin Chim Acta. 2017;470:(51–55.
   Web of Science ®Google Scholar
• Wang X, Zhang Y, Sun L, et al. Evaluation of the clinical application of multiple tumor marker protein chip in the diagnostic of lung cancer. J Clin Lab Anal. 2018;32(8):e22565.
   PubMed Web of Science ®Google Scholar
• Shimada H, Noie T, Ohashi M, et al. Clinical significance of serum tumor markers for gastric cancer: a systematic review of literature by the Task Force of the Japanese Gastric Cancer Association. Gastric Cancer. 2014;17(1):26–33.
   PubMed Web of Science ®Google Scholar
• Wei J, W W, Xu H, et al. Circular RNA hsa_circRNA_102958 may serve as a diagnostic marker for gastric cancer. Cancer Biomark. 2019;1–7. DOI:10.3233/CBM-182029.
   Web of Science ®Google Scholar
• Sun H, Tang W, Rong D, et al. Hsa_circ_0000520, a potential new circular RNA biomarker, is involved in gastric carcinoma. Cancer Biomark. 2018;21(2):299–306.
   PubMed Web of Science ®Google Scholar
• Li T, Shao Y, Fu L, et al. Plasma circular RNA profiling of patients with gastric cancer and their droplet digital RT-PCR detection. J Mol Med (Berl). 2018;96(1):85–96.
   PubMed Web of Science ®Google Scholar
• Zhao Q, Chen S, Li T, et al. Clinical values of circular RNA 0000181 in the screening of gastric cancer. J Clin Lab Anal. 2018;32(4):e22333.
   PubMed Web of Science ®Google Scholar
• Chen S, Li T, Zhao Q, et al. Using circular RNA hsa_circ_0000190 as a new biomarker in the diagnosis of gastric cancer. Clin Chim Acta. 2017;466:167–171.
   PubMed Web of Science ®Google Scholar
• Li P, Chen S, Chen H, et al. Using circular RNA as a novel type of biomarker in the screening of gastric cancer. Clin Chim Acta. 2015;444:132–136.
   PubMed Web of Science ®Google Scholar
• Huang M, He YR, Liang LC, et al. Circular RNA hsa_circ_0000745 may serve as a diagnostic marker for gastric cancer. World J Gastroenterol. 2017;23(34):6330–6338.
   PubMed Web of Science ®Google Scholar
• Li WH, Song YC, Zhang H, et al. Decreased expression of hsa_circ_00001649 in gastric cancer and its clinical significance. Dis Markers. 2017;2017:4587698.
   PubMed Web of Science ®Google Scholar
• Ding L, Zhao Y, Dang S, et al. Circular RNA circ-DONSON facilitates gastric cancer growth and invasion via NURF complex dependent activation of transcription factor SOX4. Mol Cancer. 2019;18(1):45.
   PubMed Web of Science ®Google Scholar
• Zhang J, Hou L, Liang R, et al. CircDLST promotes the tumorigenesis and metastasis of gastric cancer by sponging miR-502-5p and activating the NRAS/MEK1/ERK1/2 signaling. Mol Cancer. 2019;18(1):80.
   PubMed Web of Science ®Google Scholar
• Ghasemi S, Emadi-Baygi M, Nikpour P. Down-regulation of circular RNA ITCH and circHIPK3 in gastric cancer tissues. Turk J Med Sci. 2019;49(2):687–695.
   PubMed Web of Science ®Google Scholar
• He J, Chen J, Ma B, et al. CircLMTK2 acts as a novel tumor suppressor in gastric cancer. Biosci Rep. 2019;39(5):pii: BSR20190363.
   Google Scholar
• Rong D, Lu C, Zhang B, et al. CircPSMC3 suppresses the proliferation and metastasis of gastric cancer by acting as a competitive endogenous RNA through sponging miR-296-5p. Mol Cancer. 2019;18(1):25.
   PubMed Web of Science ®Google Scholar
• Rong D, Dong C, Fu K, et al. Upregulation of circ_0066444 promotes the proliferation, invasion, and migration of gastric cancer cells. Onco Targets Ther. 2018;11:2753–2761.
   PubMed Web of Science ®Google Scholar
• Lu J, Zhang PY, Li P, et al. Circular RNA hsa_circ_0001368 suppresses the progression of gastric cancer by regulating miR-6506-5p/FOXO3 axis. Biochem Biophys Res Commun. 2019;512(1):29–33.
   PubMed Web of Science ®Google Scholar
• Liu T, Liu S, Xu Y, et al. Circular RNA-ZFR inhibited cell proliferation and promoted apoptosis in gastric cancer by sponging miR-130a/miR-107 and modulating PTEN. Cancer Res Treat. 2018;50(4):1396–1417.
   PubMed Web of Science ®Google Scholar
• Li X, He M, Guo J, et al. Upregulation of circular RNA circ-ERBB2 predicts unfavorable prognosis and facilitates the progression of gastric cancer via miR-503/CACUL1 and miR-637/MMP-19 signaling. Biochem Biophys Res Commun. 2019;511(4):926–930.
   PubMed Web of Science ®Google Scholar
• Sun H, Xi P, Sun Z, et al. Circ-SFMBT2 promotes the proliferation of gastric cancer cells through sponging miR-182-5p to enhance CREB1 expression. Cancer Manag Res. 2018;10:5725–5734.
   PubMed Web of Science ®Google Scholar
• Zhang X, Wang S, Wang H, et al. Circular RNA circNRIP1 acts as a microRNA-149-5p sponge to promote gastric cancer progression via the AKT1/mTOR pathway. Mol Cancer. 2019;18(1):20.
   PubMed Web of Science ®Google Scholar
• Piwecka M, Glazar P, Hernandez-Miranda LR, et al. Loss of a mammalian circular RNA locus causes miRNA deregulation and affects brain function. Science. 2017;357(6357):pii: eaam8526.
   PubMed Web of Science ®Google Scholar
• Huang X, Li Z, Zhang Q, et al. Circular RNA AKT3 upregulates PIK3R1 to enhance cisplatin resistance in gastric cancer via miR-198 suppression. Mol Cancer. 2019;18(1):71.
   PubMed Web of Science ®Google Scholar
• Fang J, Hong H, Xue X, et al. A novel circular RNA, circFAT1(e2), inhibits gastric cancer progression by targeting miR-548g in the cytoplasm and interacting with YBX1 in the nucleus. Cancer Lett. 2019;442:222–232.
   PubMed Web of Science ®Google Scholar
• Wang Z, Ma K, Pitts S, et al. Novel circular RNA NF1 acts as a molecular sponge, promoting gastric cancer by absorbing miR-16. Endocr Relat Cancer. 2019;26(3):265–277.
   Web of Science ®Google Scholar
• Zhong S, Wang J, Hou J, et al. Circular RNA hsa_circ_0000993 inhibits metastasis of gastric cancer cells. Epigenomics. 2018;10(10):1301–1313.
   PubMed Web of Science ®Google Scholar
• Cheng J, Zhuo H, Xu M, et al. Regulatory network of circRNA-miRNA-mRNA contributes to the histological classification and disease progression in gastric cancer. J Transl Med. 2018;16(1):216.
   PubMed Web of Science ®Google Scholar
• Sun HD, Xu ZP, Sun ZQ, et al. Down-regulation of circPVRL3 promotes the proliferation and migration of gastric cancer cells. Sci Rep. 2018;8(1):10111.
   PubMed Web of Science ®Google Scholar
• Pegtel DM, Gould SJ. Exosomes. Annu Rev Biochem. 2019;88:487–514.
   PubMed Web of Science ®Google Scholar
• Braicu C, Tomuleasa C, Monroig P, et al. Exosomes as divine messengers: are they the Hermes of modern molecular oncology?. Cell Death Differ. 2015;22(1):34–45.
   PubMed Web of Science ®Google Scholar
• Yan Y, Fu G, Ye Y, et al. Exosomes participate in the carcinogenesis and the malignant behavior of gastric cancer. Scand J Gastroenterol. 2017;52(5):499–504.
   PubMed Web of Science ®Google Scholar
• Li Y, Zheng Q, Bao C, et al. Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis. Cell Res. 2015;25(8):981–984.
   PubMed Web of Science ®Google Scholar
• Shabaninejad Z, Vafadar A, Movahedpour A, et al. Circular RNAs in cancer: new insights into functions and implications in ovarian cancer. J Ovarian Res. 2019;12(1):84.
   PubMed Web of Science ®Google Scholar
• Zhang H, Zhu L, Bai M, et al. Exosomal circRNA derived from gastric tumor promotes white adipose browning by targeting the miR-133/PRDM16 pathway. Int J Cancer. 2019;144(10):2501–2515.
   PubMed Web of Science ®Google Scholar
• Shao Y, Tao X, Lu R, et al. Hsa_circ_0065149 is an indicator for early gastric cancer screening and prognosis prediction. Pathol Oncol Res. 2019. DOI:10.1016/j.prp.2019.152763.
   Google Scholar
• Lu J, Wang YH, Yoon C, et al. Circular RNA circ-RanGAP1 regulates VEGFA expression by targeting miR-877-3p to facilitate gastric cancer invasion and metastasis. Cancer Lett. 2019;471:38–48.
   PubMed Web of Science ®Google Scholar