Epidemiology and risk factors for eosinophilic esophagitis: lessons for clinicians

References

• Lucendo AJ, Molina-Infante J, Arias A, et al., Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United Eur Gastroenterol J. 2017;5(3): 335–358.
   PubMed Web of Science ®Google Scholar
• Straumann A, Spichtin HP, Bernoulli R, et al. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings. Schweiz Med Wochenschr. 1994;124(33):1419–1429.
   PubMedGoogle Scholar
• Attwood SE, Smyrk TC, Demeester TR, et al. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome. Dig Dis Sci. 1993;38(1):109–116.
   PubMed Web of Science ®Google Scholar
• Arias A, Pérez-Martínez I, Tenías JM, et al. Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther. 2016;43(1):3–15.
   PubMed Web of Science ®Google Scholar
• Navarro P, Arias Á, Arias-González L, et al., Systematic review with meta-analysis: the growing incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther. 2019;49(9): 1116–1125.
   PubMed Web of Science ®Google Scholar
• Hommeida S, Grothe RM, Hafed Y, et al. Assessing the incidence trend and characteristics of eosinophilic esophagitis in children in Olmsted County, Minnesota. Dis Esophagus. 2018;31(12):1–8.
   Web of Science ®Google Scholar
• Robson J, O’Gorman M, McClain A, et al., Incidence and prevalence of pediatric eosinophilic esophagitis in Utah based on a 5-year population-based study. Clin Gastroenterol Hepatol. 2019;17(1): 107–114.
   PubMed Web of Science ®Google Scholar
• Arias Á, Lucendo AJ. Incidence and prevalence of eosinophilic oesophagitis increase continiously in adults and children in Central Spain: a 12-year population-based study. Dig Liver Dis. 2019;51(1):55–62.
   PubMedGoogle Scholar
• Dellon ES. Epidemiology of eosinophilic esophagitis. Gastroenterol Clin North Am. 2014;43(2):201–218.
   PubMed Web of Science ®Google Scholar
• Prasad GA, Talley NJ, Romero Y, et al. Prevalence and predictive factors of eosinophilic esophagitis in patients presenting with dysphagia: a prospective study. Am J Gastroenterol. 2007;102(12):2627–2632.
   PubMed Web of Science ®Google Scholar
• La Orden Izquierdo E, Gutiérrez Junquera C, Mahillo-Fernández I, et al. Increasing incidence of pediatric eosinophilic esophagitis in the southwest of Madrid, Spain. J Investig Allergol Clin Immunol. 2019;29(1):24–29.
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Gonzalez-Cordero PL, Ferreira-Nossa HC, et al. Rising incidence and prevalence of adult eosinophilic esophagitis in midwestern Spain (2007-2016). United Eur Gastroenterol J. 2018;6(1):29–37.
   PubMed Web of Science ®Google Scholar
• Ally MR, Maydonovitch CL, Betteridge JD, et al. Prevalence of eosinophilic esophagitis in a United States military health-care population. Dis Esophagus. 2015;28(6):505–511.
   PubMed Web of Science ®Google Scholar
• Stewart MJ, Shaffer E, Urbanski SJ, et al. The association between celiac disease and eosinophilic esophagitis in children and adults. BMC Gastroenterol. 2013;13(1):96.
   PubMedGoogle Scholar
• Dellon ES, Jensen ET, Martin CF, et al. Prevalence of eosinophilic esophagitis in the United States. Clin Gastroenterol Hepatol. 2014;12(4):589–596.
   PubMed Web of Science ®Google Scholar
• Noel RJ, Putnam PE, Rothenberg ME. Eosinophilic esophagitis. N Engl J Med. 2004;351(9):940–941.
   PubMed Web of Science ®Google Scholar
• Arias A, Lucendo AJ. Prevalence of eosinophilic oesophagitis in adult patients in a central region of Spain. Eur J Gastroenterol Hepatol. 2013;25(2):208–212.
   PubMed Web of Science ®Google Scholar
• Hruz P, Straumann A, Bussmann C, et al. Escalating incidence of eosinophilic esophagitis: a 20-year prospective, population-based study in Olten County, Switzerland. J Allergy Clin Immunol. 2011;128(6):1349–1350.
   PubMed Web of Science ®Google Scholar
• Prakash R, Maradey C, Fass R. Eosinophilic esophagitis is much less common than previously thought: a large nationwide database study. Am J Gastroenterol. 2013;108(Suppl. 1):S33.
   Google Scholar
• Prasad GA, Alexander JA, Schleck CD, et al. Epidemiology of eosinophilic esophagitis over three decades in Olmsted County, Minnesota. Clin Gastroenterol Hepatol. 2009;7(10):1055–1061.
   PubMed Web of Science ®Google Scholar
• Kim S, Kim S, Sheikh J. Prevalence of eosinophilic esophagitis in a population-based cohort from Southern California. J Allergy Clin Immunol Pract. 2015;3(6):978–979.
   PubMed Web of Science ®Google Scholar
• Maradey-Romero C, Prakash R, Lewis S, et al. The 2011-2014 prevalence of eosinophilic oesophagitis in the elderly amongst 10 million patients in the United States. Aliment Pharmacol Ther. 2015;41(10):1016–1022.
   PubMed Web of Science ®Google Scholar
• Gokhale M, Bell C, Law M. Implications on patient identification using claims data. Pharmacoepidemiol Drug Saf. 2017;26(Suppl 2):67.
   Google Scholar
• Straumann A, Simon H-U. Eosinophilic esophagitis: escalating epidemiology? J Allergy Clin Immunol. 2005;115(2):418–419.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ. Meta-analysis-based guidance for dietary management in eosinophilic esophagitis. Curr Gastroenterol Rep. 2015;17(10):464.
   PubMedGoogle Scholar
• Madison JM, Bhardwaj V, Braskett M. Strategy for food reintroduction following empiric elimination and elemental dietary therapy in the treatment of eosinophilic gastrointestinal disorders. Curr Gastroenterol Rep. 2020;22(5):25.
   PubMedGoogle Scholar
• Syed AAN, Andrews CN, Shaffer E, et al. The rising incidence of eosinophilic oesophagitis is associated with increasing biopsy rates: a population-based study. Aliment Pharmacol Ther. 2012;36(10):950–958.
   PubMed Web of Science ®Google Scholar
• Vanderheyden AD, Petras RE, DeYoung BR, et al. Emerging eosinophilic (allergic) esophagitis: increased incidence or increased recognition? Arch Pathol Lab Med. 2007;131(5):777–779.
   PubMed Web of Science ®Google Scholar
• Patel NP, Bussler JF, Geisinger KR, et al. Are pathologists accurately diagnosing eosinophilic esophagitis in children? A 9-year single academic institutional experience with interobserver observations. Int J Surg Pathol. 2011;19(3):290–296.
   PubMed Web of Science ®Google Scholar
• Kanakala V, Lamb CA, Haigh C, et al. The diagnosis of primary eosinophilic oesophagitis in adults: missed or misinterpreted? Eur J Gastroenterol Hepatol. 2010;22(7):848–855.
   PubMed Web of Science ®Google Scholar
• Dellon ES, Erichsen R, Baron JA, et al. The increasing incidence and prevalence of eosinophilic oesophagitis outpaces changes in endoscopic and biopsy practice: national population-based estimates from Denmark. Aliment Pharmacol Ther. 2015;41(7):662–670.
   PubMed Web of Science ®Google Scholar
• Kidambi T, Toto E, Ho N, et al. Temporal trends in the relative prevalence of dysphagia etiologies from 1999-2009. World J Gastroenterol. 2012;18(32):4335–4341.
   PubMed Web of Science ®Google Scholar
• Dellon ES, Liacouras CA, Molina-Infante J, et al. Updated international consensus diagnostic criteria for eosinophilic esophagitis: proceedings of the AGREE conference. Gastroenterology. 2018;155(4):1022–1033.
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Rivas MD, Hernandez-Alonso M, et al. Proton pump inhibitor-responsive oesophageal eosinophilia correlates with downregulation of eotaxin-3 and Th2 cytokines overexpression. Aliment Pharmacol Ther. 2014;40(8):955–965.
   PubMed Web of Science ®Google Scholar
• Wen T, Dellon ES, Moawad FJ, et al. Transcriptome analysis of proton pump inhibitor-responsive esophageal eosinophilia reveals proton pump inhibitor-reversible allergic inflammation. J Allergy Clin Immunol. 2015;135(1):187–197.
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Schoepfer AM, Lucendo AJ, et al. Eosinophilic esophagitis: what can we learn from Crohn’s disease? United Eur Gastroenterol J. 2017;5(6):762–772.
   PubMed Web of Science ®Google Scholar
• Dellon ES, Gonsalves N, Hirano I, et al. ACG clinical guideline: evidenced based approach to the diagnosis and management of esophageal eosinophilia and eosinophilic esophagitis (EoE). Am J Gastroenterol. 2013;108(5):679–692.
   PubMed Web of Science ®Google Scholar
• Furuta GT, Liacouras CA, Collins MH, et al. Eosinophilic esophagitis in children and adults: a systematic review and consensus recommendations for diagnosis and treatment. Gastroenterology. 2007;133(4):1342–1363.
   PubMed Web of Science ®Google Scholar
• Liacouras CA, Furuta GT, Hirano I, et al. Eosinophilic esophagitis: updated consensus recommendations for children and adults. J Allergy Clin Immunol. 2011;128(1):3–20.
   PubMed Web of Science ®Google Scholar
• Papadopoulou A, Koletzko S, Heuschkel R, et al. Management guidelines of eosinophilic esophagitis in childhood. J Pediatr Gastroenterol Nutr. 2014;58(1):107–118.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias A, Molina-Infante J, et al. Diagnostic and therapeutic management of eosinophilic oesophagitis in children and adults: results from a Spanish registry of clinical practice. Dig Liver Dis. 2013;45(7):562–568.
   PubMedGoogle Scholar
• Schoepfer AM, Safroneeva E, Bussmann C, et al. Delay in diagnosis of eosinophilic esophagitis increases risk for stricture formation in a time-dependent manner. Gastroenterology. 2013;145(6):1230–1236.
   PubMed Web of Science ®Google Scholar
• Reed CC, Koutlas NT, Robey BS, et al. Prolonged time to diagnosis of eosinophilic esophagitis despite increasing knowledge of the disease. Clin Gastroenterol Hepatol. 2018;16(10):1667–1669.
   PubMed Web of Science ®Google Scholar
• Minshall EM, Leung DY, Martin RJ, et al. Eosinophil-associated TGF-beta1 mRNA expression and airways fibrosis in bronchial asthma. Am J Respir Cell Mol Biol. 1997;17(3):326–333.
   PubMed Web of Science ®Google Scholar
• Alizadeh-Sani Z, Vakili-Zarch A, Kiavar M, et al. Eosinophilic endomyocardial fibrosis and strongyloides stercoralis: a case report. Res Cardiovasc Med. 2013;2(2):104–105.
   PubMedGoogle Scholar
• Bramuzzo M, Martelossi S, Villanacci V, et al. Ileoileal intussusceptions caused by eosinophilic enteropathy. J Pediatr Gastroenterol Nutr. 2016;62(6):e60.
   PubMed Web of Science ®Google Scholar
• Colizzo JM, Clayton SB, Richter JE. Intrabolus pressure on high-resolution manometry distinguishes fibrostenotic and inflammatory phenotypes of eosinophilic esophagitis. Dis Esophagus. 2016;29(6):551–557.
   PubMed Web of Science ®Google Scholar
• Dellon ES, Kim HP, Sperry SLW, et al. A phenotypic analysis shows that eosinophilic esophagitis is a progressive fibrostenotic disease. Gastrointest Endosc. 2014;79(4):577–585.
   PubMed Web of Science ®Google Scholar
• Lipka S, Kumar A, Richter JE. Impact of diagnostic delay and other risk factors on eosinophilic esophagitis phenotype and esophageal diameter. J Clin Gastroenterol. 2016;50(2):134–140.
   PubMed Web of Science ®Google Scholar
• Jensen ET, Hoffman K, Shaheen NJ, et al. Esophageal eosinophilia is increased in rural areas with low population density: results from a national pathology database. Am J Gastroenterol. 2014;109(5):668–675.
   PubMed Web of Science ®Google Scholar
• Hurrell JM, Genta RM, Dellon ES. Prevalence of esophageal eosinophilia varies by climate zone in the United States. Am J Gastroenterol. 2012;107(5):698–706.
   PubMed Web of Science ®Google Scholar
• Sherrill JD, Gao P-S, Stucke EM, et al. Variants of thymic stromal lymphopoietin and its receptor associate with eosinophilic esophagitis. J Allergy Clin Immunol. 2010;126(1):160–165.
   PubMed Web of Science ®Google Scholar
• Allen-Brady K, Firszt R, Fang JC, et al. Population-based familial aggregation of eosinophilic esophagitis suggests a genetic contribution. J Allergy Clin Immunol. 2017;140(4):1138–1143.
   PubMed Web of Science ®Google Scholar
• Mansoor E, Cooper GS. The 2010-2015 prevalence of eosinophilic esophagitis in the USA: a population-based study. Dig Dis Sci. 2016;61(10):2928–2934.
   PubMed Web of Science ®Google Scholar
• Yu C, Sterling D, Albayati I, et al. The prevalence of biopsy-proven eosinophilic esophagitis in hispanics undergoing endoscopy is infrequent compared to caucasians: a cross-sectional study. Dig Dis Sci. 2017;62(12):3511–3516.
   PubMed Web of Science ®Google Scholar
• Tan LN, Srivastava S, Teh M, et al. Eosinophilic oesophagitis in children: an uncommon occurrence in a predominantly Chinese population in Singapore. Singapore Med J. 2017;58(4):218–222.
   PubMed Web of Science ®Google Scholar
• Simon D, Marti H, Heer P, et al. Eosinophilic esophagitis is frequently associated with IgE-mediated allergic airway diseases. J Allergy Clin Immunol. 2005;115(5):1090–1092.
   PubMed Web of Science ®Google Scholar
• Pelz BJ, Wechsler JB, Amsden K, et al. IgE-associated food allergy alters the presentation of paediatric eosinophilic esophagitis. Clin Exp Allergy. 2016;46(11):1431–1440.
   PubMed Web of Science ®Google Scholar
• González-Cervera J, Arias Á, Redondo-González O, et al. Association between atopic manifestations and eosinophilic esophagitis: a systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2017;118(5):582–590.
   PubMed Web of Science ®Google Scholar
• Hill DA, Grundmeier RW, Ramos M, et al., Eosinophilic esophagitis is a late manifestation of the allergic march. J Allergy Clin Immunol Pract. 2018;6(5): 1528–1533.
   PubMed Web of Science ®Google Scholar
• Kelly KJ, Lazenby AJ, Rowe PC, et al. Eosinophilic esophagitis attributed to gastroesophageal reflux: improvement with an amino acid-based formula. Gastroenterology. 1995;109(5):1503–1512.
   PubMed Web of Science ®Google Scholar
• Gómez Torrijos E, Sánchez Miranda P, Donado Palencia P, et al. Eosinophilic esophagitis: demographic, clinical, endoscopic, histologic, and atopic characteristics of children and teenagers in a region in central Spain. J Investig Allergol Clin Immunol. 2017;27(2):104–110.
   PubMed Web of Science ®Google Scholar
• He YT, Christos PJ, Reisacher WR. Airborne and food sensitization patterns in children and adults with eosinophilic esophagitis. Int Forum Allergy Rhinol. 2018;8(5):571–576.
   PubMed Web of Science ®Google Scholar
• Moawad FJ, Veerappan GR, Lake JM, et al. Correlation between eosinophilic oesophagitis and aeroallergens. Aliment Pharmacol Ther. 2010;31(4):509–515.
   PubMed Web of Science ®Google Scholar
• Fogg MI, Spergel JM. Management of food allergies. Expert Opin Pharmacother. 2003;4(7):1025–1037.
   PubMed Web of Science ®Google Scholar
• Wolf WA, Jerath MR, Dellon ES. De-novo onset of eosinophilic esophagitis after large volume allergen exposures. J Gastrointest Liver Dis. 2013;22(2):205–208.
   PubMed Web of Science ®Google Scholar
• Miehlke S, Alpan O, Schröder S, et al. Induction of eosinophilic esophagitis by sublingual pollen immunotherapy. Case Rep Gastroenterol. 2013;7(3):268–363.
   Google Scholar
• van Rhijn BD, van Ree R, Versteeg SA, et al. Birch pollen sensitization with cross-reactivity to food allergens predominates in adults with eosinophilic esophagitis. Allergy. 2013;68(11):1475–1481.
   PubMed Web of Science ®Google Scholar
• Mishra A, Hogan SP, Brandt EB, et al. An etiological role for aeroallergens and eosinophils in experimental esophagitis. J Clin Invest. 2001;107(1):83–90.
   PubMed Web of Science ®Google Scholar
• Mishra A, Wang M, Pemmaraju VR, et al. Esophageal remodeling develops as a consequence of tissue specific IL-5-induced eosinophilia. Gastroenterology. 2008;134(1):204–214.
   PubMed Web of Science ®Google Scholar
• Almansa C, Krishna M, Buchner AM, et al. Seasonal distribution in newly diagnosed cases of eosinophilic esophagitis in adults. Am J Gastroenterol. 2009;104(4):828–833.
   PubMed Web of Science ®Google Scholar
• Suryawala K, Palle S. Altaf MA. Epidemiology, clinical presentation, and seasonal variation in the diagnosis of children with eosinophilic esophagitis in Oklahoma. South Med J. 2020;113(1):37–41.
   PubMed Web of Science ®Google Scholar
• Wang FY, Gupta SK, Fitzgerald JF. Is there a seasonal variation in the incidence or intensity of allergic eosinophilic esophagitis in newly diagnosed children? J Clin Gastroenterol. 2007;41(5):451–453.
   PubMed Web of Science ®Google Scholar
• Larsson H, Bergquist H, Bove M. The incidence of esophageal bolus impaction: is there a seasonal variation? Otolaryngol Neck Surg. 2011;144(2):186–190.
   PubMed Web of Science ®Google Scholar
• Simon D, Cianferoni A, Spergel JM, et al., Eosinophilic esophagitis is characterized by a non-IgE-mediated food hypersensitivity. Allergy. 2016;71(5): 611–620.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias A, Redondo-Gonzalez O, et al., Seasonal distribution of initial diagnosis and clinical recrudescence of eosinophilic esophagitis: a systematic review and meta-analysis. Allergy. 2015;70(12): 1640–1650.
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Arias A, Barrio J, et al. Four-food group elimination diet for adult eosinophilic esophagitis: a prospective multicenter study. J Allergy Clin Immunol. 2014;134(5):1093–1099.
   PubMed Web of Science ®Google Scholar
• Kagalwalla AF, Wechsler JB, Amsden K, et al. Efficacy of a 4-food elimination diet for children with eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2017;15(11):1698–1707.
   PubMed Web of Science ®Google Scholar
• Molina-Infante J, Arias Á, Alcedo J, et al. Step-up empiric elimination diet for pediatric and adult eosinophilic esophagitis: the 2-4-6 study. J Allergy Clin Immunol. 2018;141(4):1365–1372.
   PubMed Web of Science ®Google Scholar
• Ekre M, Tytor J, Bove M, et al. Retrospective chart review: seasonal variation in incidence of bolus impaction is maintained and statistically significant in subgroups with atopy and eosinophilic esophagitis. Dis Esophagus. 2020;33(6). DOI:10.1093/dote/doaa013
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Molina-Infante J, Arias A, et al. Seasonal variation in the diagnosis of eosinophilic esophagitis: there and back again. J Pediatr Gastroenterol Nutr. 2017;64(1):e25.
   PubMed Web of Science ®Google Scholar
• Hooi JKY, Lai WY, Ng WK, et al. Global prevalence of helicobacter pylori infection: systematic review and meta-analysis. Gastroenterology. 2017;153(2):420–429.
   PubMed Web of Science ®Google Scholar
• Ronkainen J, Talley NJ, Aro P, et al. Prevalence of oesophageal eosinophils and eosinophilic oesophagitis in adults: the population-based Kalixanda study. Gut. 2007;56(5):615–620.
   PubMed Web of Science ®Google Scholar
• Dellon ES, Peery AF, Shaheen NJ, et al. Inverse association of esophageal eosinophilia with Helicobacter pylori based on analysis of a US pathology database. Gastroenterology. 2011;141(5):1586–1592.
   PubMed Web of Science ®Google Scholar
• Elitsur Y, Alrazzak BA, Preston D, et al. Does Helicobacter pylori protect against eosinophilic esophagitis in children? Helicobacter. 2014;19(5):367–371.
   PubMed Web of Science ®Google Scholar
• Von Arnim U, Wex T, Link A, et al. Helicobacter pylori infection is associated with a reduced risk of developing eosinophilic oesophagitis. Aliment Pharmacol Ther. 2016;43(7):825–830.
   PubMed Web of Science ®Google Scholar
• Sonnenberg A, Dellon ES, Turner KO, et al. The influence of Helicobacter pylori on the ethnic distribution of esophageal eosinophilia. Helicobacter. 2017;22(3):3.
   Web of Science ®Google Scholar
• Nguyen T, Ramsey D, Graham D, et al. The prevalence of Helicobacter pylori remains high in African American and Hispanic veterans. Helicobacter. 2015;20(4):305–315.
   PubMed Web of Science ®Google Scholar
• Agréus L, Hellström PM, Talley NJ, et al. Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community. United Eur Gastroenterol J. 2016;4(5):686–696.
   PubMed Web of Science ®Google Scholar
• Arnold IC, Dehzad N, Reuter S, et al. Helicobacter pylori infection prevents allergic asthma in mouse models through the induction of regulatory T cells. J Clin Invest. 2011;121(8):3088–3093.
   PubMed Web of Science ®Google Scholar
• Oertli M, Müller A. Helicobacter pylori targets dendritic cells to induce immune tolerance, promote persistence and confer protection against allergic asthma. Gut Microbes. 2012;3(6):566–571.
   PubMed Web of Science ®Google Scholar
• Lankarani KB, Honarvar B, Athari SS. The mechanisms underlying helicobacter pylori-mediated protection against allergic asthma. Tanaffos. 2017;16(4):251–259.
   PubMedGoogle Scholar
• Molina-Infante J, Gutierrez-Junquera C, Savarino E, et al. Helicobacter pylori infection does not protect against eosinophilic esophagitis: results from a large multicenter case-control study. Am J Gastroenterol. 2018;113(7):972–979.
   PubMed Web of Science ®Google Scholar
• Shah SC, Tepler A, Peek RM, et al. Association between Helicobacter pylori exposure and decreased odds of eosinophilic esophagitis-a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2019;17(11):2185–2198.
   PubMed Web of Science ®Google Scholar
• Collins MH, Blanchard C, Abonia JP, et al. Clinical, pathologic, and molecular characterization of familial eosinophilic esophagitis compared with sporadic cases. Clin Gastroenterol Hepatol. 2008;6(6):621–629.
   PubMed Web of Science ®Google Scholar
• Alexander ES, Martin LJ, Collins MH, et al., Twin and family studies reveal strong environmental and weaker genetic cues explaining heritability of eosinophilic esophagitis. J Allergy Clin Immunol. 2014;134(5): 1084–1092.
   PubMed Web of Science ®Google Scholar
• Kottyan LC, Parameswaran S, Weirauch MT, et al. The genetic etiology of eosinophilic esophagitis. J Allergy Clin Immunol. 2020;145(1):9–15.
   PubMed Web of Science ®Google Scholar
• Sherrill JD, Kc K, Wang X, et al. Whole-exome sequencing uncovers oxidoreductases DHTKD1 and OGDHL as linkers between mitochondrial dysfunction and eosinophilic esophagitis. JCI Insight. 2018 ;3(8):e99922.
   PubMed Web of Science ®Google Scholar
• Jensen ET, Kappelman MD, Kim HP, et al. Early life exposures as risk factors for pediatric eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2013;57(1):67–71.
   PubMed Web of Science ®Google Scholar
• Jensen ET, Kuhl JT, Martin LJ, et al., Early-life environmental exposures interact with genetic susceptibility variants in pediatric patients with eosinophilic esophagitis. J Allergy Clin Immunol. 2018;141(2): 632–637.
   PubMed Web of Science ®Google Scholar
• Jensen ET, Kuhl JT, Martin LJ, et al., Prenatal, intrapartum, and postnatal factors are associated with pediatric eosinophilic esophagitis. J Allergy Clin Immunol. 2018;141(1): 214–222.
   PubMed Web of Science ®Google Scholar
• Slae M, Persad R, Leung AJ-T, et al. Role of environmental factors in the development of pediatric eosinophilic esophagitis. Dig Dis Sci. 2015;60(11):3364–3372.
   PubMed Web of Science ®Google Scholar
• Radano MC, Yuan Q, Katz A, et al. Cesarean section and antibiotic use found to be associated with eosinophilic esophagitis. J Allergy Clin Immunol Pract. 2014;2(4):475–477.
   PubMed Web of Science ®Google Scholar
• Castro-Rodriguez JA, Forno E, Rodriguez-Martinez CE, et al. Risk and protective factors for childhood asthma: what is the evidence? J Allergy Clin Immunol Pract. 2016;4(6):1111–1122.
   PubMed Web of Science ®Google Scholar
• Kashyap PC, Johnson S, Geno DM, et al. A decreased abundance of clostridia characterizes the gut microbiota in eosinophilic esophagitis. Physiol Rep. 2019;7(20):e14261.
   PubMed Web of Science ®Google Scholar
• Benitez AJ, Hoffmann C, Muir AB, et al. Inflammation-associated microbiota in pediatric eosinophilic esophagitis. Microbiome. 2015;3(1):23.
   PubMedGoogle Scholar
• Harris JK, Fang R, Wagner BD, et al. Esophageal microbiome in eosinophilic esophagitis. PloS One. 2015;10(5):e0128346.
   PubMed Web of Science ®Google Scholar
• Arias A, Vicario M, Bernardo D, et al. Toll-like receptors-mediated pathways activate inflammatory responses in the esophageal mucosa of adult eosinophilic esophagitis. Clin Transl Gastroenterol. 2018;9(4):147.
   PubMedGoogle Scholar
• Casas L, Tischer C, Tiesler C, et al. Association of gas cooking with children’s respiratory health: results from GINIplus and LISAplus birth cohort studies: gas cooking and children’s respiratory health. Indoor Air. 2012;22(6):476–482.
   PubMed Web of Science ®Google Scholar
• Ostro BD, Lipsett MJ, Mann JK, et al. Indoor air pollution and asthma. Results from a panel study. Am J Respir Crit Care Med. 1994;149(6):1400–1406.
   PubMed Web of Science ®Google Scholar
• Belanger K, Triche EW. Indoor combustion and asthma. Immunol Allergy Clin North Am. 2008;28(3):507–519.
   PubMed Web of Science ®Google Scholar
• Norbäck D, Lu C, Zhang Y, et al. Sources of indoor particulate matter (PM) and outdoor air pollution in China in relation to asthma, wheeze, rhinitis and eczema among pre-school children: synergistic effects between antibiotics use and PM10 and second hand smoke. Environ Int. 2019;125:252–260.
   PubMed Web of Science ®Google Scholar
• Dodson RE, Udesky JO, Colton MD, et al. Chemical exposures in recently renovated low-income housing: influence of building materials and occupant activities. Environ Int. 2017;109:114–127.
   PubMed Web of Science ®Google Scholar
• Volchek K, Thouin G, Kuang W, et al. The release of lindane from contaminated building materials. Environ Sci Pollut Res Int. 2014;21(20):11844–11855.
   PubMed Web of Science ®Google Scholar
• Corder SR, Tappata M, Shaheen O, et al. Relationship between housing components and development of eosinophilic esophagitis. Dig Dis Sci. 2020. DOI:10.1007/s10620-020-06063-2
   PubMed Web of Science ®Google Scholar
• Lucendo AJ. Disease associations in eosinophilic oesophagitis and oesophageal eosinophilia. Best Pract Res Clin Gastroenterol. 2015;29(5):759–769.
   PubMed Web of Science ®Google Scholar
• Quaglietta L, Coccorullo P, Miele E, et al. Eosinophilic oesophagitis and coeliac disease: is there an association? Aliment Pharmacol Ther. 2007;26(3):487–493.
   PubMed Web of Science ®Google Scholar
• Verzegnassi F, Bua J, De Angelis P, et al. Eosinophilic oesophagitis and coeliac disease: is it just a casual association? Gut. 2007;56(7):1029–1030.
   PubMed Web of Science ®Google Scholar
• Thompson JS, Lebwohl B, Reilly NR, et al. Increased incidence of eosinophilic esophagitis in children and adults with celiac disease. J Clin Gastroenterol. 2012;46(1):e6–11.
   PubMed Web of Science ®Google Scholar
• Dharmaraj R, Hagglund K, Lyons H. Eosinophilic esophagitis associated with celiac disease in children. BMC Res Notes. 2015;8(1):263.
   PubMedGoogle Scholar
• Ludvigsson JF, Aro P, Walker MM, et al., Celiac disease, eosinophilic esophagitis and gastroesophageal reflux disease, an adult population-based study. Scand J Gastroenterol. 2013;48(7): 808–814.
   PubMed Web of Science ®Google Scholar
• Jensen ET, Eluri S, Lebwohl B, et al. Increased risk of esophageal eosinophilia and eosinophilic esophagitis in patients with active celiac disease on Biopsy. Clin Gastroenterol Hepatol. 2015;13(8):1426–1431.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias Á, Tenias JM. Systematic review: the association between eosinophilic oesophagitis and coeliac disease. Aliment Pharmacol Ther. 2014;40(5):422–434.
   PubMed Web of Science ®Google Scholar
• Hommeida S, Alsawas M, Murad MH, et al. The Association between celiac disease and eosinophilic esophagitis: mayo experience and meta-analysis of the literature. J Pediatr Gastroenterol Nutr. 2017;65(1):58–63.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias A, Perez-Martinez I, et al. Adult patients with eosinophilic esophagitis do not show an increased frequency of the HLA-DQ2/DQ8 genotypes predisposing to celiac disease. Dig Dis Sci. 2011;56(4):1107–1111.
   PubMed Web of Science ®Google Scholar
• Walsh RE, Gaginella TS. The eosinophil in inflammatory bowel disease. Scand J Gastroenterol. 1991;26(12):1217–1224.
   PubMed Web of Science ®Google Scholar
• Bischoff SC, Mayer J, Nguyen Q-T, et al. Immunohistological assessment of intestinal eosinophil activation in patients with eosinophilic gastroenteritis and inflammatory bowel disease. Am J Gastroenterol. 1999;94(12):3521–3529.
   PubMed Web of Science ®Google Scholar
• Mulder DJ, Hookey LC, Hurlbut DJ, et al. Impact of Crohn disease on eosinophilic esophagitis: evidence for an altered TH1-TH2 immune response. J Pediatr Gastroenterol Nutr. 2011;53(2):213–215.
   PubMed Web of Science ®Google Scholar
• Suttor VP, Chow C, Turner I. Eosinophilic esophagitis with Crohn’s disease: a new association or overlapping immune-mediated enteropathy? Am J Gastroenterol. 2009;104(3):794–795.
   PubMed Web of Science ®Google Scholar
• Fan YC, Steele D, Kochar B, et al. Increased prevalence of esophageal eosinophilia in patients with inflammatory bowel disease. Inflamm Intest Dis. 2018;3(4):180–186.
   Google Scholar
• Limketkai BN, Shah SC, Hirano I, et al. Epidemiology and implications of concurrent diagnosis of eosinophilic oesophagitis and IBD based on a prospective population-based analysis. Gut. 2019;68(12):2152–2160.
   PubMed Web of Science ®Google Scholar
• Sonnenberg A, Turner KO, Genta RM. Comorbid occurrence of eosinophilic esophagitis and inflammatory bowel disease. Clin Gastroenterol Hepatol. 2020. DOI:10.1016/j.cgh.2020.02.015
   Google Scholar
• Burisch J, Pedersen N, Čuković-Čavka S, et al. East–West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort. Gut. 2014;63(4):588–597.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Hervias D, Roncero O, et al. Epidemiology and temporal trends (2000-2012) of inflammatory bowel disease in adult patients in a central region of Spain. Eur J Gastroenterol Hepatol. 2014;26(12):1399–1407.
   PubMed Web of Science ®Google Scholar
• Burisch J, Munkholm P. The epidemiology of inflammatory bowel disease. Scand J Gastroenterol. 2015;50(8):942–951.
   PubMed Web of Science ®Google Scholar
• Mintz MJ, Ananthakrishnan AN. Phenotype and natural history of inflammatory bowel disease in patients with concomitant eosinophilic esophagitis. Inflamm Bowel Dis. 2020. DOI:10.1093/ibd/izaa094
   PubMedGoogle Scholar
• Abonia JP, Wen T, Stucke EM, et al. High prevalence of eosinophilic esophagitis in patients with inherited connective tissue disorders. J Allergy Clin Immunol. 2013;132(2):378–386.
   PubMed Web of Science ®Google Scholar
• Capucilli P, Cianferoni A, Grundmeier RW, et al. Comparison of comorbid diagnoses in children with and without eosinophilic esophagitis in a large population. Ann Allergy Asthma Immunol. 2018;121(6):711–716.
   PubMed Web of Science ®Google Scholar
• Rothenberg ME. Molecular, genetic, and cellular bases for treating eosinophilic esophagitis. Gastroenterology. 2015;148(6):1143–1157.
   PubMed Web of Science ®Google Scholar
• Lardenois E, Michaud L, Schneider A, et al. Prevalence of eosinophilic esophagitis in adolescents with esophageal atresia. J Pediatr Gastroenterol Nutr. 2019;69(1):52–56.
   PubMed Web of Science ®Google Scholar
• Gorter RR, Heij HA, van der Voorn JP, et al. Eosinophilic esophagitis after esophageal atresia: is there an association? Case presentation and literature review. J Pediatr Surg. 2012;47(6):e9–13.
   PubMed Web of Science ®Google Scholar
• Oliveira C, Zamakhshary M, Marcon P, et al. Eosinophilic esophagitis and intermediate esophagitis after tracheoesophageal fistula repair: a case series. J Pediatr Surg. 2008;43(5):810–814.
   PubMed Web of Science ®Google Scholar
• Sfeir R, Bonnard A, Khen-Dunlop N, et al. Esophageal atresia: data from a national cohort. J Pediatr Surg. agosto de. 2013;48(8):1664–1669.
   PubMed Web of Science ®Google Scholar
• Krishnan U. Eosinophilic esophagitis in esophageal atresia. Front Pediatr. 2019;7:497.
   PubMed Web of Science ®Google Scholar
• Spechler SJ, Genta RM, Souza RF. Thoughts on the complex relationship between gastroesophageal reflux disease and eosinophilic esophagitis. Am J Gastroenterol. 2007;102(6):1301–1306.
   PubMed Web of Science ®Google Scholar
• Deurloo JA, Klinkenberg EC, Ekkelkamp S, et al. Adults with corrected oesophageal atresia: is oesophageal function associated with complaints and/or quality of life? Pediatr Surg Int. 2008;24(5):537–541.
   PubMed Web of Science ®Google Scholar
• Stankiewicz P, Sen P, Bhatt SS, et al. Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations. Am J Hum Genet. 2009;84(6):780–791.
   PubMed Web of Science ®Google Scholar
• Wen T, Aronow BJ, Rochman Y, et al. Single-cell RNA sequencing identifies inflammatory tissue T cells in eosinophilic esophagitis. J Clin Invest. 2019;129(5):2014–2028.
   PubMed Web of Science ®Google Scholar
• Costa RH, Kalinichenko VV, Lim L. Transcription factors in mouse lung development and function. Am J Physiol-Lung Cell Mol Physiol. 2001;280(5):L823–838.
   PubMed Web of Science ®Google Scholar
• Arias Á, Lucendo AJ. Molecular basis and cellular mechanisms of eosinophilic esophagitis for the clinical practice. Expert Rev Gastroenterol Hepatol. 2019;13(2):99–117.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ. Cellular and molecular immunological mechanisms in eosinophilic esophagitis: an updated overview of their clinical implications. Expert Rev Gastroenterol Hepatol. 2014;8(6):669–685.
   PubMed Web of Science ®Google Scholar
• Blanchard C, Wang N, Stringer KF, et al. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. J Clin Invest. 2006;116(2):536–547.
   PubMed Web of Science ®Google Scholar
• Blanchard C, Mingler MK, Vicario M, et al. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J Allergy Clin Immunol. 2007;120(6):1292–1300.
   PubMed Web of Science ®Google Scholar
• Mukkada V, Falk GW, Eichinger CS, et al. Health-related quality of life and costs associated with eosinophilic esophagitis: a systematic review. Clin Gastroenterol Hepatol. 2018;16(4):495–503.
   PubMed Web of Science ®Google Scholar
• Friedlander JA, DeBoer EM, Soden JS, et al. Unsedated transnasal esophagoscopy for monitoring therapy in pediatric eosinophilic esophagitis. Gastrointest Endosc. 2016;83(2):299–306.
   PubMed Web of Science ®Google Scholar
• Kavitt RT, Penson DF, Vaezi MF. Eosinophilic esophagitis: dilate or medicate? A cost analysis model of the choice of initial therapy. Dis Esophagus. 2014;27(5):418–423.
   PubMed Web of Science ®Google Scholar
• Dellon ES. Cost-effective care in eosinophilic esophagitis. Ann Allergy Asthma Immunol. 2019;123(2):166–172.
   PubMed Web of Science ®Google Scholar
• Anderson J, Moonie S, Hogan MB, et al. Cost of chronic inflammatory disease: the impact of eosinophilic esophagitis in Nevada. J Dig Dis. 2020;21(1):12–19.
   PubMed Web of Science ®Google Scholar
• Jensen ET, Kappelman MD, Martin CF, et al., Health-care utilization, costs, and the burden of disease related to eosinophilic esophagitis in the United States. Am J Gastroenterol. 2015;110(5): 626–632.
   PubMed Web of Science ®Google Scholar
• Peery AF, Dellon ES, Lund J, et al. Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology. 2012;143(5):1179–1187.
   PubMed Web of Science ®Google Scholar
• Arias-González L, Rey-Iborra E, Ruiz-Ponce M, et al. Esophageal perforation in eosinophilic esophagitis: A systematic review on clinical presentation, management and outcomes. Dig Liver Dis. 2020;52(3):245–252.
   PubMedGoogle Scholar
• Zhan T, Ali A, Choi JG, et al. Model to determine the optimal dietary elimination strategy for treatment of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2018;16(11):1730–1737.
   PubMed Web of Science ®Google Scholar
• Cotton CC, Erim D, Eluri S, et al. Cost utility analysis of topical steroids compared with dietary elimination for treatment of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2017;15(6):841–849.
   PubMed Web of Science ®Google Scholar
• Global Status of Commercialized Biotech/GM Crops, 2014. ISAAA; 2014.
   Google Scholar
• Fernánez-Cornejo J, Wechler S, Livingston M, et al. Adoption of genetically engineered crops in the U.S. 1996-2015. USDA ERS; Department of Agriculture, Economic Research Service. 2015.
   Google Scholar
• Lucendo AJ, Molina-Infante J. Treatment of eosinophilic esophagitis with diets. Minerva Gastroenterol Dietol. 2020;66(2):124–135.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Molina-Infante J. Dietary therapy for eosinophilic esophagitis: chances and limitations in the clinical practice. Expert Rev Gastroenterol Hepatol. 2020;1–12. DOI:10.1080/17474124.2020.1791084
   PubMed Web of Science ®Google Scholar
• Moawad FJ, Molina-Infante J, Lucendo AJ, et al. Systematic review with meta-analysis: endoscopic dilation is highly effective and safe in children and adults with eosinophilic oesophagitis. Aliment Pharmacol Ther. 2017;46(2):96–105.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias A, Molina-Infante J, et al. The role of endoscopy in eosinophilic esophagitis: from diagnosis to therapy. Expert Rev Gastroenterol Hepatol. 2017;11(12):1135–1149.
   PubMed Web of Science ®Google Scholar
• Murali AR, Gupta A, Attar BM, et al. Topical steroids in eosinophilic esophagitis: systematic review and meta-analysis of placebo-controlled randomized clinical trials. J Gastroenterol Hepatol. 2016;31(6):1111–1119.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, Arias A, Molina-Infante J. Efficacy of proton pump inhibitor drugs for inducing clinical and histologic remission in patients with symptomatic esophageal eosinophilia: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2016;14(1):13–22.
   PubMed Web of Science ®Google Scholar
• Straumann A, Hoesli S, Bussmann C, et al. Anti-eosinophil activity and clinical efficacy of the CRTH2 antagonist OC000459 in eosinophilic esophagitis. Allergy. 2013;68(3):375–385.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ, De Rezende LC, Jimenez-Contreras S, et al. Montelukast was inefficient in maintaining steroid-induced remission in adult eosinophilic esophagitis. Dig Dis Sci. 2011;56(12):3551–3558.
   PubMed Web of Science ®Google Scholar
• Lucendo AJ. Pharmacological treatments for eosinophilic esophagitis: current options and emerging therapies. Expert Rev Clin Immunol. 2020;16(1):63–77.
   PubMed Web of Science ®Google Scholar
• Lucendo A, López-Sánchez P. Targeted therapies for eosinophilic gastrointestinal disorders. BioDrugs. 2020;34(4):477–493.
   PubMed Web of Science ®Google Scholar
• Hirano I, Chan ES, Rank MA, et al. AGA Institute and the joint task force on allergy-immunology practice parameters clinical guidelines for the management of eosinophilic esophagitis. Gastroenterology. 2020;158(6):1776–1786.
   PubMed Web of Science ®Google Scholar
• Eluri S, Iglesia EGA, Massaro M, et al. Practice patterns and adherence to clinical guidelines for diagnosis and management of eosinophilic esophagitis among gastroenterologists. Dis Esophagus. 2020;33(7). DOI:10.1093/dote/doaa025
   PubMed Web of Science ®Google Scholar
• Hannan N, Steel A, McMillan SS, et al. Health service use and treatment choices for pediatric eosinophilic esophagitis: findings from a cross-sectional survey of Australian carers. Front Pediatr. 2020;8:147.
   PubMed Web of Science ®Google Scholar
• Green DJ, Cotton CC, Dellon ES. The role of environmental exposures in the etiology of eosinophilic esophagitis: a systematic review. Mayo Clin Proc. 2015;90(10):1400–1410.
   PubMed Web of Science ®Google Scholar
• Moawad FJ, Dellon ES, Achem SR, et al. Effects of race and sex on features of eosinophilic esophagitis. Clin Gastroenterol Hepatol. 2016;14(1):23–30.
   PubMed Web of Science ®Google Scholar
• Laserna-Mendieta EJ, Casabona S, Savarino E, et al. Efficacy of therapy for eosinophilic esophagitis in real-world practice. Clin Gastroenterol Hepatol. 2020. DOI:10.1016/j.cgh.2020.01.024.
   PubMedGoogle Scholar