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Systematic Review

Burden of comorbid anxiety and depression in patients with inflammatory bowel disease: a systematic literature review

ORCID Icon, , ORCID Icon, , , , , & ORCID Icon show all
Pages 985-997 | Received 21 Dec 2020, Accepted 30 Mar 2021, Published online: 15 Jun 2021

References

  • Dahlhamer JM, Zammitti EP, Ward BW, et al. Prevalence of inflammatory bowel disease among adults aged ≥18 years - United States, 2015. MMWR Morb Mortal Wkly Rep. 2016;65(42):1166–1169.
  • Burisch J, Jess T, Martinato M, et al. The burden of inflammatory bowel disease in Europe. J Crohns Colitis. 2013;7(4):322–337.
  • Mak WY, Zhao M, Ng SC, et al. The epidemiology of inflammatory bowel disease: east meets west. J Gastroenterol Hepatol. 2020;35(3):380–389.
  • Kaplan GG. The global burden of IBD: from 2015 to 2025. Nat Rev Gastroenterol Hepatol. 2015;12(12):720–727.
  • Zhang CK, Hewett J, Hemming J, et al. The influence of depression on quality of life in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2013;19(8):1732–1739.
  • Mikocka-Walus A, Knowles SR, Keefer L, et al. Controversies revisited: a systematic review of the comorbidity of depression and anxiety with inflammatory bowel diseases. Inflamm Bowel Dis. 2016;22(3):752–762.
  • Walker JR, Ediger JP, Graff LA, et al. The Manitoba IBD cohort study: a population-based study of the prevalence of lifetime and 12-month anxiety and mood disorders. Am J Gastroenterol. 2008;103(8):1989–1997.
  • Fuller-Thomson E, Sulman J. Depression and inflammatory bowel disease: findings from two nationally representative Canadian surveys. Inflamm Bowel Dis. 2006;12(8):697–707.
  • Byrne G, Rosenfeld G, Leung Y, et al. Prevalence of anxiety and depression in patients with inflammatory bowel disease. Can J Gastroenterol Hepatol. 2017;2017:6496727.
  • Graff LA, Walker JR, Bernstein CN. Depression and anxiety in inflammatory bowel disease: a review of comorbidity and management. Inflamm Bowel Dis. 2009;15(7):1105–1118.
  • Jedel S, Sable KA, Berger D, et al. The psychosocial impact of IBD on spouses. Am J Gastroenterol. 2015;110:S770–771.
  • Barnes EL, Kochar B, Long MD, et al. Modifiable risk factors for hospital readmission among patients with inflammatory bowel disease in a nationwide database. Inflamm Bowel Dis. 2017;23(6):875–881.
  • Szigethy E, Murphy SM, Ehrlich OG, et al. Mental health costs of inflammatory bowel diseases. Inflamm Bowel Dis. 2021;27(1):40–48 .
  • Szigethy EM, Allen JI, Reiss M, et al. White Paper AGA: the impact of mental and psychosocial factors on the care of patients with inflammatory bowel disease. Clin Gastroenterol Hepatol. 2017;15(7):986–997.
  • Park KT, Ehrlich OG, Allen JI, et al. The cost of inflammatory bowel disease: an initiative from the Crohn’s & Colitis Foundation. Inflamm Bowel Dis. 2020;26(1):1–10.
  • Parian AM, Chen P-H, Lazarev M, et al. Tu2002 Comorbid psychiatric diagnoses are common among IBD hospitalizations and increase health care utilization: a nationwide analysis. Gastroenterology. 2016;150(4):S1002.
  • Czuber-Dochan W, Ream E, Norton C. Review article: description and management of fatigue in inflammatory bowel disease. Aliment Pharmacol Ther. 2013;37(5):505–516.
  • Borren NZ, van der Woude CJ, Ananthakrishnan AN. Fatigue in IBD: epidemiology, pathophysiology and management. Nat Rev Gastroenterol Hepatol. 2019;16(4):247–259.
  • Fiest KM, Bernstein CN, Walker JR, et al. Systematic review of interventions for depression and anxiety in persons with inflammatory bowel disease. BMC Res Notes. 2016;9(1):404.
  • Bennebroek Evertsz F, Thijssens NAM, Stokkers PCF, et al. Do inflammatory bowel disease patients with anxiety and depressive symptoms receive the care they need? J Crohns Colitis. 2012;6(1):68–76.
  • Knowles SR, Graff LA, Wilding H, et al. Quality of life in inflammatory bowel disease: a systematic review and meta-analyses - Part I. Inflamm Bowel Dis. 2018;24(4):742–751.
  • Knowles SR, Keefer L, Wilding H, et al. Quality of life in inflammatory bowel disease: a systematic review and meta-analyses - Part II. Inflamm Bowel Dis. 2018;24(5):966–976.
  • Alexakis C, Kumar S, Saxena S, et al. Systematic review with meta-analysis: the impact of a depressive state on disease course in adult inflammatory bowel disease. Aliment Pharmacol Ther. 2017;46(3):225–235.
  • Brooks AJ, Rowse G, Ryder A, et al. Systematic review: psychological morbidity in young people with inflammatory bowel disease - risk factors and impacts. Aliment Pharmacol Ther. 2016;44(1):3–15.
  • Tarricone I, Regazzi MG, Bonucci G, et al. Prevalence and effectiveness of psychiatric treatments for patients with IBD: a systematic literature review. J Psychosom Res. 2017;101:68–95.
  • Langhorst J, Hofstetter A, Wolfe F, et al. Short-term stress, but not mucosal healing nor depression was predictive for the risk of relapse in patients with ulcerative colitis: a prospective 12-month follow-up study. Inflamm Bowel Dis. 2013;19(11):2380–2386.
  • Mikocka-Walus A, Pittet V, Rossel JB, et al. Symptoms of depression and anxiety are independently associated with clinical recurrence of inflammatory bowel disease. Clin Gastroenterol Hepatol. 2016;14(6):829–835 e1.
  • Castillo A, Fasihuddin F, Saliaj M, et al. Tu2015 The impact of depression on disease activity in inflammatory bowel disease (IBD) patients. Gastroenterology. 2016;150(4):S1006[abstract].
  • Persoons P, Vermeire S, Demyttenaere K, et al. The impact of major depressive disorder on the short- and long-term outcome of Crohn’s disease treatment with infliximab. Aliment Pharmacol Ther. 2005;22(2):101–110.
  • Marrie RA, Walld R, Bolton JM, et al. Physical comorbidities increase the risk of psychiatric comorbidity in immune-mediated inflammatory disease. Gen Hosp Psychiatry. 2018;51:71–78.
  • Brooks A, Rowse G, Ryder A, et al. PTU-059 “i can cope right now, because i know where i have come from”; a qualitative exploration of the lived experience of young adults with inflammatory bowel disease. Gut. 2015;64(suppl_1):A85–A86.
  • Sirois FM, Hirsch JK. A longitudinal study of the profiles of psychological thriving, resilience, and loss in people with inflammatory bowel disease. Br J Health Psychol. 2017;22(4):920–939.
  • Keefer L, Washington JP, Manning L, et al. Mo1815 Validation of the gaining resilience through transitions [GRITTTM-IBD] Score: a tool for clinicians to stratify patients based on need for team-based multidisciplinary care. Gastroenterology. 2018;154(6):S–812–S–813[abstract].
  • Kunzendorf S, Jantschek G, Straubinger K, et al. The Luebeck interview for psychosocial screening in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2007;13(1):33–41.
  • Reigada L, Martin C, Kappelman M, et al. P-109 Pediatric IBD-Specific Anxiety Scale: a novel measure for identifying disease distress. Inflamm Bowel Dis. 2016;22(suppl_1):S44 [poster].
  • Vigano C, Calzolari R, Marinaccio PM, et al. Unrevealed depression involves dysfunctional coping strategies in Crohn’s disease patients in clinical remission. Gastroenterol Res Pract. 2016;2016:7803262.
  • Lores T, Goess C, Grafton R, et al. P627 What is the need for, and acceptability of, routine, integrated psychological care in an established inflammatory bowel disease (IBD) service? Early data from a new initiative in clinical IBD care. J Crohns Colitis. 2016;10(suppl_1):S418–S419.
  • Zhang M, Hong L, Zhang T, et al. Illness perceptions and stress: mediators between disease severity and psychological well-being and quality of life among patients with Crohn’s disease. Patient Prefer Adherence. 2016;10:2387–2396.
  • Furfaro F, Bezzio C, Carmagnola S, et al. Cryptogenetic and Crohn’s perianal fistula: what change in psychology of patients. United European Gastroenterol J. 2015;3(5):A233.
  • McCombie A, Swaminathan A, Mulder R, et al. The IBD-Cope: a new instrument for measuring coping in inflammatory bowel disease patients. J Crohns Colitis. 2016;10(6):678–686.
  • Liberati A, Altman DG, Tetzlaff J, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. PLoS Med. 2009;6(7):e1000100.
  • Cozaru GC, Papari AC, Sava N. P-1363 Assessment of anxiety and depression in patients with Crohn disease. Eur Psychiatry. 2012;27:1.
  • Tribbick D, Salzberg M, Ftanou M, et al. Prevalence of mental health disorders in inflammatory bowel disease: an Australian outpatient cohort. Clin Exp Gastroenterol. 2015;8:197–204.
  • Selinger CP, Lal S, Eaden J, et al. Better disease specific patient knowledge is associated with greater anxiety in inflammatory bowel disease. J Crohns Colitis. 2013;7(6):e214–e218.
  • Brandi MT, Ribeiro MS, Chebli LA, et al. Psychological distress in Brazilian Crohn’s disease patients: screening, prevalence, and risk factors. Med Sci Monit. 2009;15(8):PH101–108.
  • Bernstein CN, Walker J, Bolton J, et al. Prevalence of psychiatric disorders is increased five years before the diagnosis in IBD. Gastroenterology. 2017;152(5):S973.
  • Chao C-Y, Lemieux C, Afif W, et al. P342 Maladaptive coping, self-efficacy and patient reported outcomes in inflammatory bowel disease. J Crohns Colitis. 2017;11(suppl_1):S250–S251.
  • Kaplan G, Hart A, Brown C, et al. Factors that influence ulcerative colitis patients‘ anxiety and depression following the colectomy surgery. Value Health. 2013;16(3):A215–A216.
  • Luo XP, Mao R, Chen BL, et al. Over-reaching beyond disease activity: the influence of anxiety and medical economic burden on health-related quality of life in patients with inflammatory bowel disease. Patient Prefer Adherence. 2016;11:23–31.
  • Nahon S, Lahmek P, Nahon S, et al. Factors associated with anxiety and depression in IBD patients: results of the ISSEO survey. Gastroenterology. 2011;140(5):S–284.
  • Tabatabaeian M, Afshar H, Roohafza HR, et al. Psychological status in Iranian patients with ulcerative colitis and its relation to disease activity and quality of life. J Res Med Sci. 2015;20(6):577–584.
  • Viganò C, Truzoli R, Beltrami M, et al. Prevalence of anxious and depressive symptoms, and coping strategies as risk factors in Crohn’s disease outpatients in clinical remission. Act Nerv Super Rediviva. 2016;58(4):118–122.
  • Choi G, Han K, Chun J, et al. P824 Increased risk of anxiety and depression in patients with inflammatory bowel disease: a nationwide population-based study in Korea. J Crohns Colitis. 2018;12(suppl_1):S532.
  • McCombie AM, Mulder RT, Gearry RB. Coping strategies and psychological outcomes of patients with inflammatory bowel disease in the first 6 months after diagnosis. Inflamm Bowel Dis. 2015;21(10):2272–2280.
  • Chan W, Shim HH, Lim MS, et al. Symptoms of anxiety and depression are independently associated with inflammatory bowel disease-related disability. Dig Liver Dis. 2017;49(12):1314–1319.
  • Iglesias-Rey M, Barreiro-de Acosta M, Caamano-Isorna F, et al. Psychological factors are associated with changes in the health-related quality of life in inflammatory bowel disease. Inflamm Bowel Dis. 2014;20(1):92–102.
  • Alexakis C, Saxena S, Chhaya V, et al. P138 Does depression at IBD diagnosis impact on disease outcomes in Crohn’s? J Crohns Colitis. 2017;11(suppl_1):S146–S147 [poster].
  • Swart N, Wellsted D, Friedli K, et al. PWE-083 Distinguishing between possible mental health disorders and psychological distress by screening for acceptance and adjustment issues. Gut. 2014;63(suppl_1):A160.
  • Long MD, Kappelman MD, Martin CF, et al. Risk factors for depression in the elderly inflammatory bowel disease population. J Crohns Colitis. 2014;8(2):113–119.
  • Bhandari S, Larson ME, Dahal P, et al. Impact of inflammatory bowel disease on depression in U.S. population and independent predictors of depression in IBD Population: an NHANES study: 604. Am J Gastroenterol. 2016;111:S277–S278.
  • Herzer M, Denson LA, Baldassano RN, et al. Patient and parent psychosocial factors associated with health-related quality of life in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2011;52(3):295–299.
  • Thakur ER, Waljee AK, Gaidos J, et al. Su1842 The incidence and prevalence of anxiety, depression, and PTSD among a national cohort of U.S. veterans with inflammatory bowel disease. Gastroenterology. 2016;150(4):S567[abstract].
  • Han C, Zhao N, Blank M, et al. 43 Impact of psychiatric disorders on patients with Crohn’s disease: an analysis based on a healthcare claims database. Gastroenterology. 2010;138(5):S9[abstract].
  • Victor C, Jana H, Gregory T, et al. O-006 YI Clinical predictors of moderate depression and suicidality in adults with IBD. Inflamm Bowel Dis. 2014;20(suppl_1):S5[abstract].
  • Cohen I, Benyamini Y, Tulchinsky H, et al. P300 Illness perceptions and coping with health-related quality of life in patients with inflammatory bowel disease. J Crohns Colitis. 2017;11(suppl_1):S229–S230 [poster].
  • Lee EJ, Rami A, Sebastian L, et al. Young investigator: psychiatric conditions are associated with medical noncompliance and worsening disease course in IBD patient population: p-085. Am J Gastroenterol. 2018;113:S20.
  • Syed B, Langberg K, Proctor D. The prevalence of depression and its association with opioid exposure in IBD patients: abstract 715. Am J Gastroenterol. 2016;111:S322.
  • Kochar B, Barnes EL, Cushing KC, et al. Self-report is not a sensitive method of assessing depression in patients with inflammatory bowel disease. Gastroenterology. 2017;152(5):S797.
  • Sharma M, Choudhary M, Panwar R. Depression in ulcerative colitis: gender difference. Dig Endosc. 2017;29(29):179.
  • Bhamre R, Sawrav S, Adarkar S, et al. Psychiatric morbidity in patients with inflammatory bowel disease. J Gastroenterol Hepatol. 2017;32(S3):152.
  • Baig BJ. Biological predictors of depression in IBD: preliminary results of the ISA study. J Crohns Colitis. 2011;5(1):S133–S134.
  • Yanatas O, Kani H, Banzragch M, et al. P112 Effectiveness of “Hospital Anxiety and Depression Scale” for the screening of the psychiatric treatment need in outpatients with inflammatory bowel diseases. J Crohns Colitis. 2015;9(suppl_1):S132 [poster].
  • Coates M, Stuart A, Bobb A, et al. Affective spectrum disorders significantly influence total symptom burden in inflammatory bowel disease. Gastroenterology. 2017;152(5):S794.
  • Bertomoro P, Vettorato MG, Simonetti F, et al. Inflammatory bowel disease and psychological status: determinants and social consequences. Dig Liver Dis. 2015;47(2):e138–e139.
  • van der Valk ME, Mangen MJ, Leenders M, et al. Risk factors of work disability in patients with inflammatory bowel disease — a Dutch nationwide web-based survey. J Crohns Colitis. 2014;8(7):590–597.
  • Loomes DE, Dittrich AE, Madsen K, et al. Tu1189 Effect of Anti-TNFα therapy on prevalence of depression in patients with inflammatory bowel disease. Gastroenterology. 2014;146(5):S779[abstract].
  • Mittermaier C, Dejaco C, Waldhoer T, et al. Impact of depressive mood on relapse in patients with inflammatory bowel disease: a prospective 18-month follow-up study. Psychosom Med. 2004;66(1):79–84.
  • Bertomoro P, Vettorato MG, Simonetti F, et al. Tu2007 Inflammatory bowel disease and psychological status: determinants and social consequences. Gastroenterology. 2016;150(4):S1004[abstract].
  • Jowett SL, Seal CJ, Barton JR, et al. The short inflammatory bowel disease questionnaire is reliable and responsive to clinically important change in ulcerative colitis. Am J Gastroenterol. 2001;96(10):2921–2928.
  • Allegretti JR, Borges L, Lucci M, et al. Risk factors for rehospitalization within 90 days in patients with inflammatory bowel disease. Inflamm Bowel Dis. 2015;21(11):2583–2589.
  • Jinjuvadia R, Hart BR, Parekh R, et al. 148 Rates of mental disorders are high among individuals with inflammatory bowel disease in United States. Gastroenterology. 2015;148(4):S40[abstract].
  • Ananthakrishnan AN, Gainer VS, Perez RG, et al. Psychiatric co-morbidity is associated with increased risk of surgery in Crohn’s disease. Aliment Pharmacol Ther. 2013;37(4):445–454.
  • Barreiro-de Acosta M, Iglesias M, Ferreiro R, et al. P209 Influence of anxiety and depression in the clinical course of inflammatory bowel disease patients. J Crohns Colitis. 2014;8:S149[abstract].
  • Lores T, Goess C, Hrycek C, et al. P0396 Integrating psychological support into routine care for people with inflammatory bowel disease. United European Gastroenterol J. 2017;5(suppl_1):A300 [poster].
  • Barnes EL, Nadkarni A, Levine JS, et al. 796 Unrecognized psychiatric disease in patients with inflammatory bowel disease (IBD): patients with worse IBD specific patient reported outcome measures demonstrate increased anxiety and depression scores even without a psychiatric history. Gastroenterology. 2016;150(4):S166–S167[abstract].
  • Falaiye T, Schaefer M, Zeiger T. P-221 Integration of clinical psychology into a multidisciplinary pediatric IBD clinic. Inflamm Bowel Dis. 2016;22(suppl_1):S76
  • Sirin G, Celebi A, Senturk O, et al. P201 Is depression associated with more emergency visits in inflammatory bowel disease? J Crohns Colitis. 2014;8:S146 [poster].
  • Barocas J, Dougherty T, Adham K, et al. P-0086 Physicians inconsistently screen for depression in inflammatory bowel disease patients. Inflamm Bowel Dis. 2009;15(suppl_2):S32 [poster].
  • Halverson MM, Jedel S, Bayoumi MM, et al. Mo1139 Addressing the psychosocial needs of IBD patients. Gastroenterology. 2016;150(4):S647[abstract].
  • Reigada LC, Benkov KJ, Bruzzese JM, et al. Integrating illness concerns into cognitive behavioral therapy for children and adolescents with inflammatory bowel disease and co-occurring anxiety. J Spec Pediatr Nurs. 2013;18(2):133–143.
  • Szigethy E, Whitton SW, Levy-Warren A, et al. Cognitive-behavioral therapy for depression in adolescents with inflammatory bowel disease: a pilot study. J Am Acad Child Adolesc Psychiatry. 2004;43(12):1469–1477.
  • Szigethy E, Carpenter J, Baum E, et al. Case study: longitudinal treatment of adolescents with depression and inflammatory bowel disease. J Am Acad Child Adolesc Psychiatry. 2006;45(4):396–400.
  • Bennebroek Evertsz F, Sprangers MAG, Sitnikova K, et al. Effectiveness of cognitive–behavioral therapy on quality of life, anxiety, and depressive symptoms among patients with inflammatory bowel disease: a multicenter randomized controlled trial. J Consult Clin Psychol. 2017;85(9):918–925.
  • Diaz Sibaja MA, Comeche Moreno MI, Mas Hesse B. [Protocolized cognitive-behavioural group therapy for inflammatory bowel disease]. Rev Esp Enferm Dig. 2007;99(10):593–598.
  • Tripp DA, Verreault P, Gates J, et al. Development and piloting of a cognitive-behavioral self-management program for patients with inflammatory bowel disease: an early stage update. Gastroenterology. 2017;152(5):S799.
  • Larsson K, Sundberg Hjelm M, Karlbom U, et al. A group-based patient education programme for high-anxiety patients with Crohn disease or ulcerative colitis. Scand J Gastroenterol. 2003;38(7):763–769.
  • Korzenik JR, Hosmer Kirby C, Kagan L, et al. Tu2010 A study of a novel pilot program to address the psychosocial needs of IBD patients: possible impact on disease outcome and reduction of health care utilization. Gastroenterology. 2016;150(4):S1005[abstract].
  • Vanga RR, Thakur E, Gonzalez I, et al. One-day behavioral intervention for patients with inflammatory bowel disease and co-morbid psychological distress and a pilot study. Gastroenterology. 2017;152(5):S124.
  • Stapersma L, van den Brink G, Szigethy EM, et al. Systematic review with meta-analysis: anxiety and depression in children and adolescents with inflammatory bowel disease. Aliment Pharmacol Ther. 2018;48(5):496–506.
  • Gracie DJ, Irvine AJ, Sood R, et al. Effect of psychological therapy on disease activity, psychological comorbidity, and quality of life in inflammatory bowel disease: a systematic review and meta-analysis. Lancet Gastroenterol Hepatol. 2017;2(3):189–199.
  • Timmer A, Preiss JC, Motschall E, et al. Psychological interventions for treatment of inflammatory bowel disease. Cochrane Database Syst Rev. 2011;(2):CD006913.
  • Stapersma L, van den Brink G, van der Ende J, et al. Effectiveness of disease-specific cognitive behavioral therapy on anxiety, depression, and quality of life in youth with inflammatory bowel disease: a randomized controlled trial. J Pediatr Psychol. 2018;43(9):967–980.
  • Stapersma L, van den Brink G, van der Ende J, et al. Psychological outcomes of a cognitive behavioral therapy for youth with inflammatory bowel disease: results of the HAPPY-IBD randomized controlled trial at 6- and 12-month follow-up. J Clin Psychol Med Settings. 2020;27(3):490–506.
  • Brooks AJ, Norman P, Peach EJ, et al. Prospective study of psychological morbidity and illness perceptions in young people with inflammatory bowel disease. J Crohns Colitis. 2019;13(8):1003–1011.
  • Stapersma L, van den Brink G, van der Ende J, et al. Illness perceptions and depression are associated with health-related quality of life in youth with inflammatory bowel disease. Int J Behav Med. 2019;26(4):415–426.
  • Davis SP, Bolin LP, Crane PB, et al. Non-pharmacological Interventions for anxiety and depression in adults with inflammatory bowel disease: a systematic review and meta-analysis. Front Psychol. 2020;11:538741.
  • Sehgal P, Ungaro RC, Foltz C, et al. High levels of psychological resilience associated with less disease activity, better quality of life, and fewer surgeries in inflammatory bowel disease. Inflamm Bowel Dis. 2020. Epub ahead of print. doi: https://doi.org/10.1093/ibd/izaa196.
  • Lores T, Goess C, Mikocka-Walus A, et al. Integrated psychological care is needed, welcomed and effective in ambulatory inflammatory bowel disease management: evaluation of a new initiative. J Crohns Colitis. 2019;13(7):819–827.
  • Keefer L. Editorial: depression in the setting of inflammatory bowel disease means we have failed to provide early, effective, psychosocial care. Aliment Pharmacol Ther. 2017;46(5):553–554.
  • Feingold J, Murray HB, Keefer L. Recent advances in cognitive behavioral therapy for digestive disorders and the role of applied positive psychology across the spectrum of GI care. J Clin Gastroenterol. 2019;53(7):477–485.