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Review

Small bowel imaging in inflammatory bowel disease: updates for 2023

&
Pages 1117-1134 | Received 12 May 2023, Accepted 20 Oct 2023, Published online: 30 Oct 2023

References

  • Kucharzik T, Tielbeek J, Carter D, et al. ECCO-ESGAR topical review on optimizing reporting for cross-sectional imaging in inflammatory bowel disease. J Crohns Colitis. 2022;16:523–543. doi: 10.1093/ecco-jcc/jjab180
  • Turner D, Ricciuto A, Lewis A, et al. STRIDE-II: an update on the Selecting therapeutic targets in inflammatory bowel disease [STRIDE] initiative of the international organization for the study of IBD [IOIBD]: determining therapeutic goals for treat-to-target strategies in IBD. Gastroenterology. 2021;160(5):1570–1583. doi: 10.1053/j.gastro.2020.12.031
  • Wilkens R, Novak KL, Maaser C, et al. Relevance of monitoring transmural disease activity in patients with Crohn’s disease: current status and future perspectives. Ther Adv Gastroenterol. 2021;14:17562848211006672. doi: 10.1177/17562848211006672
  • Grand DJ, Deepak P, Rimola J. MRE evaluation of intestinal inflammation: qualitative and quantitative assessment. Top Magn Reson Imaging. 2021;30(1):13–22. doi: 10.1097/RMR.0000000000000270
  • Rimola J, Torres J, Kumar S, et al. Recent advances in clinical practice: advances in cross-sectional imaging in inflammatory bowel disease. Gut. 2022;71:2587–2597. doi: 10.1136/gutjnl-2021-326562
  • Geyl S, Guillo L, Laurent V, et al. Transmural healing as a therapeutic goal in Crohn’s disease: a systematic review. Lancet Gastroenterol Hepatol. Lancet Gastroenterol Hepatol. 2021;6(8):659–667. doi: 10.1016/S2468-1253[21]00096-0
  • Kucharzik T, Wilkens R, D’Agostino M-A, et al. Early ultrasound response and progressive transmural remission after treatment with ustekinumab in Crohn’s disease. Clin Gastroenterol Hepatol. 2023;21(1):153–163.e12. doi: 10.1016/j.cgh.2022.05.055
  • Messadeg L, Hordonneau C, Bouguen G, et al. Early transmural response assessed using Magnetic resonance imaging could predict sustained clinical remission and prevent bowel damage in patients with Crohn’s disease treated with anti-tumour necrosis factor therapy. J Crohns Colitis. 2020;14:1524–1534. doi: 10.1093/ecco-jcc/jjaa098
  • Weinstein-Nakar I, Focht G, Church P, et al. Associations among mucosal and transmural healing and fecal level of calprotectin in children with Crohn’s disease. Clin Gastroenterol Hepatol. 2018;16(7):1089–1097.e4. doi: 10.1016/j.cgh.2018.01.024
  • Ma L, Li W, Zhuang N, et al. Comparison of transmural healing and mucosal healing as predictors of positive long-term outcomes in Crohn’s disease. Ther Adv Gastroenterol. 2021;14:175628482110162. doi: 10.1177/17562848211016259
  • Goodsall TM, Noy R, Nguyen TM, et al. Systematic review: patient perceptions of monitoring tools in inflammatory bowel disease. J Can Assoc Gastroenterol. 2021;4:e31–e41. doi: 10.1093/jcag/gwaa001
  • Buisson A, Gonzalez F, Poullenot F, et al. Comparative acceptability and perceived clinical utility of monitoring tools: a nationwide survey of patients with inflammatory bowel disease. Inflamm Bowel Dis. 2017;23:1425–1433. doi: 10.1097/MIB.0000000000001140
  • METRIC investigators, Miles A, Bhatnagar G, et al. Magnetic resonance enterography, small bowel ultrasound and colonoscopy to diagnose and stage Crohn’s disease: patient acceptability and perceived burden. Eur Radiol. 2019;29(3):1083–1093.
  • Bruining DH, Zimmermann EM, Loftus EV, et al. Consensus recommendations for evaluation, interpretation, and utilization of computed tomography and Magnetic resonance enterography in patients with small bowel Crohn’s disease. Radiology. 2018;286:776–799. doi: 10.1148/radiol.2018171737
  • Bettenworth D, Bokemeyer A, Baker M, et al. Assessment of Crohn’s disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review. Gut. 2019;68:1115–1126. doi: 10.1136/gutjnl-2018-318081
  • Semelka RC, Ramalho M. Gadolinium deposition disease: Current state of knowledge and expert opinion. 2023. [cited 2023 Apr 16]. InternetPublish Ahead of Print Invest Radiol. 58(8):523–529. doi: 10.1097/RLI.0000000000000977
  • Puylaert CAJ, Nolthenius CJT, Tielbeek JAW, et al. Comparison of MRI activity scoring systems and features for the terminal ileum in patients with Crohn disease. Am J Roentgenol. 2019;212:W25–W31. doi: 10.2214/AJR.18.19876
  • Seo N, Park SH, Kim K-J, et al. MR Enterography for the evaluation of small-bowel inflammation in Crohn disease by using diffusion-weighted imaging without intravenous contrast material: a prospective noninferiority study. Radiology. 2016;278:762–772. doi: 10.1148/radiol.2015150809
  • Taylor SA, Mallett S, Bhatnagar G, et al. Magnetic resonance enterography compared with ultrasonography in newly diagnosed and relapsing Crohn’s disease patients: the METRIC diagnostic accuracy study. Health Technol Assess. 2019;23(66):1–270. doi: 10.3310/hta23420
  • Jesuratnam-Nielsen K, Løgager VB, Munkholm P, et al. Diagnostic accuracy of three different MRI protocols in patients with inflammatory bowel disease. Acta Radiol Open. 2015;4(6):205846011558809. doi: 10.1177/2058460115588099
  • Bhatnagar G, Mallett S, Quinn L, et al. Influence of oral contrast type and volume on patient experience and quality of luminal distension at MR Enterography in Crohn’s disease: an observational study of patients recruited to the METRIC trial. Eur Radiol. 2022;32:5075–5085. doi: 10.1007/s00330-022-08614-9
  • Parente F. Oral contrast enhanced bowel ultrasonography in the assessment of small intestine Crohn’s disease. A prospective comparison with conventional ultrasound, x ray studies, and ileocolonoscopy. Gut. 2004;53:1652–1657. doi: 10.1136/gut.2004.041038
  • Pallotta N, Vincoli G, Montesani C, et al. Small intestine contrast ultrasonography (SICUS) for the detection of small bowel complications in crohnʼs disease: a prospective comparative study versus intraoperative findings. Inflamm Bowel Dis. 2012;18(1):74–84. doi: 10.1002/ibd.21678
  • Taylor SA, Mallett S, Bhatnagar G, et al. Diagnostic accuracy of magnetic resonance enterography and small bowel ultrasound for the extent and activity of newly diagnosed and relapsed Crohn’s disease [METRIC]: a multicentre trial. Lancet Gastroenterol Hepatol. 2018;3(8):548–558. doi: 10.1016/S2468-1253[18]30161-4
  • Goodsall TM, Nguyen TM, Parker CE, et al. Systematic review: gastrointestinal ultrasound scoring indices for inflammatory bowel disease. J Crohns Colitis. 2021;15:125–142. doi: 10.1093/ecco-jcc/jjaa129
  • Rao N, Kumar S, Taylor S, et al. Diagnostic pathways in Crohn’s disease. Clin Radiol. 2019;74:578–591. doi: 10.1016/j.crad.2019.03.013
  • Goodsall TM, Jairath V, Feagan BG, et al. Standardisation of intestinal ultrasound scoring in clinical trials for luminal Crohn’s disease. Aliment Pharmacol Ther. 2021;53:873–886. doi: 10.1111/apt.16288
  • Ilvemark JFKF, Hansen T, Goodsall TM, et al. Defining Transabdominal intestinal ultrasound treatment response and remission in inflammatory bowel disease: systematic review and expert consensus statement. J Crohns Colitis. 2022;16(4):554–580. doi: 10.1093/ecco-jcc/jjab173
  • Bots S, Nylund K, Löwenberg M, et al. Ultrasound for assessing disease activity in IBD patients: a systematic review of activity scores. J Crohns Colitis. 2018;12:920–929. doi: 10.1093/ecco-jcc/jjy048
  • Sagami S, Kobayashi T, Miyatani Y, et al. Accuracy of ultrasound for evaluation of colorectal segments in patients with inflammatory bowel diseases: a systematic review and meta-analysis. Clin Gastroenterol Hepatol. 2021;19(5):908–921.e6. doi: 10.1016/j.cgh.2020.07.067
  • Hanžel J, Jairath V, Ma C, et al. Responsiveness of Magnetic resonance enterography indices for evaluation of luminal disease activity in Crohn’s disease. Clin Gastroenterol Hepatol. 2022;20(11):2598–2606. doi: 10.1016/j.cgh.2022.01.055
  • Schulberg JD, Wright EK, Holt BA, et al. Intensive drug therapy versus standard drug therapy for symptomatic intestinal Crohn’s disease strictures [STRIDENT]: an open-label, single-centre, randomised controlled trial. Lancet Gastroenterol Hepatol. 2022;7(4):318–331. doi: 10.1016/S2468-1253[21]00393-9
  • Gower-Rousseau C, Sarter H, Savoye G, et al. Validation of the inflammatory bowel disease Disability index in a population-based cohort. Gut. 2017;66:588–596. doi: 10.1136/gutjnl-2015-310151
  • Rimola J, Alvarez-Cofiño A, Pérez-Jeldres T, et al. Comparison of three magnetic resonance enterography indices for grading activity in Crohn’s disease. J Gastroenterol. 2017;52:585–593. doi: 10.1007/s00535-016-1253-6
  • Ordás I, Rimola J, Alfaro I, et al. Development and validation of a simplified Magnetic resonance index of activity for Crohn’s disease. Gastroenterology. 2019;157(2):432–439.e1. doi: 10.1053/j.gastro.2019.03.051
  • Roseira J, Ventosa AR, Sousa HT, et al. The new simplified MARIA score applies beyond clinical trials: a suitable clinical practice tool for Crohn’s disease that parallels a simple endoscopic index and fecal calprotectin. United Eur Gastroenterol J. 2020;8:1208–1216. doi: 10.1177/2050640620943089
  • Capozzi N, Ordás I, Fernandez-Clotet A, et al. Validation of the simplified Magnetic resonance index of activity [sMARIA] without gadolinium-enhanced sequences for Crohn’s disease. J Crohns Colitis. 2020;14:1074–1081. doi: 10.1093/ecco-jcc/jjaa030
  • Tao Y, Li H, Xu H, et al. Can the simplified magnetic resonance index of activity be used to evaluate the degree of activity in Crohn’s disease? BMC Gastroenterol. 2021;21:409. doi: 10.1186/s12876-021-01987-z
  • Bae H, Seo N, Kang EA, et al. Validation of the simplified magnetic resonance index of activity by using DWI without gadolinium enhancement to evaluate bowel inflammation in Crohn’s disease. Eur Radiol. Internet. [cited 2023 Apr 16] 2023;33(5):3266–3275. doi: 10.1007/s00330-023-09501-7
  • Steward MJ, Punwani S, Proctor I, et al. Non-perforating small bowel Crohn’s disease assessed by MRI enterography: derivation and histopathological validation of an MR-based activity index. Eur J Radiol. 2012;81:2080–2088. doi: 10.1016/j.ejrad.2011.07.013
  • Novak KL, Kaplan GG, Panaccione R, et al. A simple ultrasound score for the accurate detection of inflammatory activity in Crohnʼs disease: Inflamm Bowel Dis. Inflamm Bowel Dis. 2017;23(11):2001–2010. doi: 10.1097/MIB.0000000000001174
  • Sævik F, Eriksen R, Eide GE, et al. Development and validation of a simple ultrasound activity score for Crohn’s disease. J Crohns Colitis. 2021;15:115–124. doi: 10.1093/ecco-jcc/jjaa112
  • Allocca M, Craviotto V, Dell’avalle C, et al. Bowel ultrasound score is accurate in assessing response to therapy in patients with Crohn’s disease. Aliment Pharmacol Ther. 2022;55:446–454. doi: 10.1111/apt.16700
  • Novak KL, Nylund K, Maaser C, et al. Expert consensus on optimal acquisition and Development of the International bowel ultrasound segmental activity score [IBUS-SAS]: a reliability and inter-rater variability study on intestinal ultrasonography in Crohn’s disease. J Crohns Colitis. 2021;15:609–616. doi: 10.1093/ecco-jcc/jjaa216
  • Wang L, Xu C, Zhang Y, et al. External validation and comparison of simple ultrasound activity score and international bowel ultrasound segmental activity score for Crohn’s disease. Scand J Gastroenterol. 2023;8:883–889.
  • Zorzi F, Ghosh S, Chiaramonte C, et al. Response assessed by Ultrasonography as target of biological treatment for Crohn’s disease. Clin Gastroenterol Hepatol. 2020;18:2030–2037. doi: 10.1016/j.cgh.2019.10.042
  • Lafeuille P, Hordonneau C, Vignette J, et al. Transmural healing and MRI healing are associated with lower risk of bowel damage progression than endoscopic mucosal healing in Crohn’s disease. Aliment Pharmacol Ther Cited: in: PMID: 33368525. 2021;53:577–586. doi: 10.1111/apt.16232
  • Fernandes SR, Serrazina J, Botto IA, et al. Transmural remission improves clinical outcomes up to 5 years in Crohn’s disease. United Eur Gastroenterol J. 2023;11(1):51–59. doi: 10.1002/ueg2.12356
  • Calabrese E, Rispo A, Zorzi F, et al. Ultrasonography tight control and monitoring in Crohn’s disease during different biological therapies: a multicenter study. Clin Gastroenterol Hepatol. 2022;20:e711–e722. doi: 10.1016/j.cgh.2021.03.030
  • Danese S, Sandborn WJ, Colombel J-F, et al. Endoscopic, radiologic, and histologic healing with vedolizumab in patients with active Crohn’s disease. Gastroenterology. 2019;157(4):1007–1018.e7. doi: 10.1053/j.gastro.2019.06.038
  • Castiglione F, Mainenti P, Testa A, et al. Cross-sectional evaluation of transmural healing in patients with Crohn’s disease on maintenance treatment with anti-TNF alpha agents. Dig Liver Dis. 2017;49:484–489. doi: 10.1016/j.dld.2017.02.014
  • Serban ED. Treat-to-target in Crohn’s disease: will transmural healing become a therapeutic endpoint? World J Clin Cases. 2018;6:501–513. doi: 10.12998/wjcc.v6.i12.501
  • Fernandes SR, Rodrigues RV, Bernardo S, et al. Transmural healing is associated with improved long-term outcomes of patients with Crohnʼs disease: Inflamm Bowel Dis. Inflamm Bowel Dis. 2017;23(8):1403–1409. doi: 10.1097/MIB.0000000000001143
  • Zorzi F, Rubin DT, Cleveland NK, et al. Ultrasonographic transmural healing in Crohn’s disease. Am J Gastroenterol. InternetPublish Ahead of Print. [cited 2023 Apr 11] 2023;118(6):961–969. doi: 10.14309/ajg.0000000000002265
  • de Voogd F, Bots S, Gecse K, et al. Intestinal ultrasound early on in treatment follow-up Predicts endoscopic response to anti-TNFα treatment in Crohn’s disease. J Crohns Colitis. 2022;16(10):1598–1608. doi: 10.1093/ecco-jcc/jjac072
  • Pariente B, Mary J-Y, Danese S, et al. Development of the Lémann index to assess digestive tract damage in patients with Crohn’s disease. Gastroenterology. 2015;148:52–63.e3. doi: 10.1053/j.gastro.2014.09.015
  • Pariente B, Torres J, Burisch J, et al. Validation and update of the Lémann index to measure cumulative structural bowel damage in Crohn’s disease. Gastroenterology. 2021;161(3):853–864.e13. doi: 10.1053/j.gastro.2021.05.049
  • Kumar S, Plumb A, Mallett S, et al. METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease—protocol for a multicentre, non-randomised, single-arm, prospective study. BMJ Open. 2022;12:e067265. doi: 10.1136/bmjopen-2022-067265
  • Radford SJ, Taylor S, Moran G. Ultrasound use to assess Crohn’s disease in the UK: a survey of British Society of Gastroenterology Inflammatory Bowel Disease Group members. Frontline Gastroenterol. 2022;13:471–476. doi: 10.1136/flgastro-2021-102065
  • Allocca M, Fiorino G, Bonifacio C, et al. Comparative accuracy of bowel ultrasound versus Magnetic resonance enterography in combination with colonoscopy in assessing Crohn’s disease and guiding clinical decision-making. J Crohns Colitis. 2018;12:1280–1287. doi: 10.1093/ecco-jcc/jjy093
  • Calabrese E, Maaser C, Zorzi F, et al. Bowel ultrasonography in the management of Crohnʼs disease. A review with recommendations of an International panel of experts: Inflamm bowel Dis. Inflamm Bowel Dis. 2016;22(5):1168–1183. doi: 10.1097/MIB.0000000000000706
  • Servais L, Boschetti G, Meunier C, et al. Intestinal conventional ultrasonography, Contrast-Enhanced ultrasonography and Magnetic resonance enterography in assessment of Crohn’s disease activity: a comparison with surgical histopathology analysis. Dig Dis Sci. 2022;67:2492–2502. doi: 10.1007/s10620-021-07074-3
  • Kopylov U, Yung DE, Engel T, et al. Diagnostic yield of capsule endoscopy versus magnetic resonance enterography and small bowel contrast ultrasound in the evaluation of small bowel Crohn’s disease: systematic review and meta-analysis. Dig Liver Dis. 2017;49:854–863. doi: 10.1016/j.dld.2017.04.013
  • Xu C, Li L, Zhang Y, et al. Diagnostic accuracy of different cross-sectional imaging techniques for disease location and activity in Crohn’s disease and external validation and comparison of MARIAs and IBUS-SAS. Abdom Radiol. Internet. [cited 2023 Apr 17]. 2022. doi: 10.1007/s00261-022-03751-7
  • García-Bosch O, Ordás I, Aceituno M, et al. Comparison of diagnostic accuracy and impact of Magnetic resonance imaging and colonoscopy for the management of Crohn’s disease. J Crohns Colitis. 2016;10:663–669. doi: 10.1093/ecco-jcc/jjw015
  • Rieder F, Latella G, Magro F, et al. European Crohn’s and Colitis Organisation Topical review on prediction, diagnosis and management of fibrostenosing Crohn’s disease. J Crohns Colitis. 2016;10:873–885. doi: 10.1093/ecco-jcc/jjw055
  • Rieder F, Bettenworth D, Ma C, et al. An expert consensus to standardise definitions, diagnosis and treatment targets for anti-fibrotic stricture therapies in Crohn’s disease. Aliment Pharmacol Ther. 2018;48(3):347–357. doi: 10.1111/apt.14853
  • Li X, Mao R, Huang S, et al. Characterization of degree of intestinal fibrosis in patients with Crohn disease by using magnetization transfer MR Imaging. Radiology. 2018;287:494–503. doi: 10.1148/radiol.2017171221
  • Coimbra A, Rimola J, Cuatrecasas M, et al. Magnetic resonance enterography and histology in patients with fibrostenotic Crohn’s disease: a multicenter study. Clin Transl Gastroenterol. 2022;13:e00505. doi: 10.14309/ctg.0000000000000505
  • Caron B, Laurent V, Odille F, et al. New magnetic resonance imaging sequences for fibrosis assessment in Crohn’s disease: a pilot study. Scand J Gastroenterol. 2022;57:1450–1453. doi: 10.1080/00365521.2022.2094727
  • Dal Buono A, Faita F, Peyrin-Biroulet L, et al. Ultrasound elastography in inflammatory bowel diseases: a systematic review of accuracy compared with histopathological assessment. J Crohns Colitis. 2022;16:1637–1646. doi: 10.1093/ecco-jcc/jjac082
  • Orlando S, Fraquelli M, Coletta M, et al. Ultrasound elasticity imaging predicts therapeutic outcomes of patients with Crohn’s disease treated with anti-tumour necrosis factor antibodies. J Crohns Colitis. 2018;12:63–70. doi: 10.1093/ecco-jcc/jjx116
  • Avila F, Caron B, Hossu G, et al. Magnetic resonance elastography for assessing fibrosis in patients with Crohn’s disease: a Pilot study. Dig Dis Sci. 2022;67:4518–4524. doi: 10.1007/s10620-021-07311-9
  • Scharitzer M, Macher-Beer A, Mang T, et al. Evaluation of intestinal fibrosis with 68 Ga-FAPI PET/MR enterography in Crohn disease. Radiology. 2023;307(3):222389. doi: 10.1148/radiol.222389
  • QK-T N, Triumbari EKA, Omidvari N, et al. Total-body PET/CT – first clinical experiences and future perspectives. Semin Nucl Med. Cited: in: PMID: 35272853. 2022;52(3):330–339. doi: 10.1053/j.semnuclmed.2022.01.002
  • Huh JY, Park YJ, Ham M, et al. Crosstalk between adipocytes and immune cells in adipose tissue inflammation and metabolic dysregulation in obesity. Mol Cells. 2014;37:365–371. doi: 10.14348/molcells.2014.0074
  • Peyrin-Biroulet L, Chamaillard M, Gonzalez F, et al. Mesenteric fat in Crohn’s disease: a pathogenetic hallmark or an innocent bystander? Gut. 2007;56:577–583. doi: 10.1136/gut.2005.082925
  • Kredel LI, Siegmund B. Adipose-tissue and intestinal inflammation – Visceral obesity and creeping fat. Front Immunol. Internet. 2014. [cited 2023 Apr 14];5 . doi: 10.3389/fimmu.2014.00462
  • Coffey CJ, Kiernan MG, Sahebally SM, et al. Inclusion of the mesentery in ileocolic resection for Crohn’s disease is associated with reduced surgical recurrence. J Crohns Colitis. 2018;12:1139–1150. doi: 10.1093/ecco-jcc/jjx187
  • CWY H, Martin A, Sepich-Poore GD, et al. Translocation of viable Gut microbiota to mesenteric adipose drives formation of creeping fat in humans. Cell. 2020;183(3):666–683.e17. doi: 10.1016/j.cell.2020.09.009
  • Boronat-Toscano A, Monfort-Ferré D, Menacho M, et al. Anti-TNF therapies suppress adipose tissue inflammation in Crohn’s disease. Int J Mol Sci Cited: in: PMID: 36232469. 2022;23:11170. doi: 10.3390/ijms231911170
  • Li X-H, Feng S-T, Cao Q-H, et al. Degree of creeping fat assessed by computed tomography enterography is associated with intestinal fibrotic stricture in patients with Crohn’s disease: a potentially novel mesenteric creeping fat index. J Crohns Colitis. 2021;15:1161–1173. doi: 10.1093/ecco-jcc/jjab005
  • Zhou Z, Xiong Z, Shen Y, et al. Magnetic resonance imaging-based body composition is associated with nutritional and inflammatory status: a longitudinal study in patients with Crohn’s disease. Insights Imaging. 2021;12:178. doi: 10.1186/s13244-021-01121-3
  • Ando K, Uehara K, Sugiyama Y, et al. Correlation among body composition parameters and long-term outcomes in Crohn’s disease after anti-TNF therapy. Front Nutr Cited: in: PMID: 35433773. 2022;9:765209. doi: 10.3389/fnut.2022.765209
  • Odille F, Menys A, Ahmed A, et al. Quantitative assessment of small bowel motility by nonrigid registration of dynamic MR images. Magn Reson Med. 2012;68:783–793. doi: 10.1002/mrm.23298
  • Menys A, Puylaert C, Tutein Nolthenius CE, et al. Quantified terminal ileal motility during MR Enterography as a biomarker of Crohn disease activity: prospective multi-institution study. Radiology. 2018;289:428–435. doi: 10.1148/radiol.2018180100
  • de Jonge CS, Smout AJPM, Nederveen AJ, et al. Evaluation of gastrointestinal motility with MRI: advances, challenges and opportunities. Neurogastroenterol Motil. 2018;30(1):e13257. doi: 10.1111/nmo.13257
  • Plumb AA, Menys A, Russo E, et al. Magnetic resonance imaging-quantified small bowel motility is a sensitive marker of response to medical therapy in Crohn’s disease. Aliment Pharmacol Ther. 2015;42:343–355. doi: 10.1111/apt.13275
  • Gollifer RM, Menys A, Plumb A, et al. Automated versus subjective assessment of spatial and temporal MRI small bowel motility in Crohn’s disease. Clin Radiol. 2019;74:.e814.9–.e814.19. doi: 10.1016/j.crad.2019.06.016
  • Dohan A, Taylor S, Hoeffel C, et al. Diffusion-weighted MRI in Crohn’s disease: Current status and recommendations. J Magn Reson Imaging. 2016;44:1381–1396. doi: 10.1002/jmri.25325
  • Thormann M, Melekh B, Bär C, et al. Apparent diffusion coefficient for assessing Crohn’s disease activity: a meta-analysis. Eur Radiol. 2023;33(3):1677–1686. doi: 10.1007/s00330-022-09149-9
  • Tielbeek JAW, Ziech MLW, Li Z, et al. Evaluation of conventional, dynamic contrast enhanced and diffusion weighted MRI for quantitative Crohn’s disease assessment with histopathology of surgical specimens. Eur Radiol. 2014;24:619–629. doi: 10.1007/s00330-013-3015-7
  • Ripollés T, Martínez-Pérez MJ, Paredes JM, et al. The role of intravenous contrast agent in the sonographic assessment of Crohn’s disease activity: is contrast agent injection necessary? J Crohns Colitis. 2019;13:585–592. doi: 10.1093/ecco-jcc/jjy204
  • Fulwadhva UP, Wortman JR, Sodickson AD. Use of Dual-energy CT and iodine maps in evaluation of bowel disease. Radiographics. 2016;36:393–406. doi: 10.1148/rg.2016150151
  • Dua A, Sharma V, Gupta P. Dual energy computed tomography in Crohn’s disease: a targeted review. Expert Rev Gastroenterol Hepatol. 2022;16:699–705. doi: 10.1080/17474124.2022.2105203
  • Zhu C, Hu J, Rong C, et al. Mucosal healing assessment in Crohn’s disease with normalized iodine concentration from dual-energy CT enterography: comparison with endoscopy. Insights Imaging. 2023;14:63. doi: 10.1186/s13244-023-01397-7
  • Stidham RW, Enchakalody B, Waljee AK, et al. Assessing small bowel stricturing and morphology in Crohn’s disease using semi-automated image analysis. Inflamm Bowel Dis. 2020;26:734–742. doi: 10.1093/ibd/izz196
  • Puylaert CAJ, Schüffler PJ, Naziroglu RE, et al. Semiautomatic assessment of the terminal ileum and colon in patients with Crohn disease using MRI [the VIGOR++ project]. Acad Radiol. 2018;25(8):1038–1045. doi: 10.1016/j.acra.2017.12.024
  • De Kock I, Bos S, Delrue L, et al. MRI texture analysis of T2-weighted images is preferred over magnetization transfer imaging for readily longitudinal quantification of gut fibrosis. Eur Radiol. Internet. [cited 2023 Apr 23] 2023;33(9):5943–5952. doi: 10.1007/s00330-023-09624-x
  • Meng J, Luo Z, Chen Z, et al. Intestinal fibrosis classification in patients with Crohn’s disease using CT enterography–based deep learning: comparisons with radiomics and radiologists. Eur Radiol. 2022;32:8692–8705. doi: 10.1007/s00330-022-08842-z
  • Jauregui-Amezaga A, Rimola J, Ordás I, et al. Value of endoscopy and MRI for predicting intestinal surgery in patients with Crohn’s disease in the era of biologics. Gut. 2015;64:1397–1402. doi: 10.1136/gutjnl-2014-308101
  • Castiglione F, Imperatore N, Testa A, et al. One-year clinical outcomes with biologics in Crohn’s disease: transmural healing compared with mucosal or no healing. Aliment Pharmacol Ther. 2019;49:1026–1039. doi: 10.1111/apt.15190
  • Fernández-Clotet A, Panés J, Ricart E, et al. Predictors of bowel damage in the long-term progression of Crohn’s disease. World J Clin Cases. 2022;10:12208–12220. doi: 10.12998/wjcc.v10.i33.12208
  • Fiorino G, Morin M, Bonovas S, et al. Prevalence of bowel damage assessed by cross-sectional imaging in early Crohn’s disease and its impact on disease outcome. J Crohns Colitis. 2016;jjwR̥185. doi: 10.1093/ecco-jcc/jjw185
  • Dane B, Qian K, Krieger R, et al. Correlation between imaging findings on outpatient MR enterography (MRE) in adult patients with Crohn disease and progression to surgery within 5 years. Abdom Radiol. 2022;47(10):3424–3435. doi: 10.1007/s00261-022-03624-z
  • Bachour SP, Shah RS, Lyu R, et al. Test characteristics of cross-sectional imaging and concordance with endoscopy in postoperative Crohn’s disease. Clin Gastroenterol Hepatol. 2022;20(10):2327–2336.e4. doi: 10.1016/j.cgh.2021.12.033
  • Le Berre C, Peyrin-Biroulet L, Sandborn WJ, et al. Selecting end points for disease-modification trials in inflammatory bowel disease: the SPIRIT consensus from the IOIBD. Gastroenterology. 2021;160(5):1452–1460.e21. doi: 10.1053/j.gastro.2020.10.065