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Review

An update on pediatric bronchiectasis

&
Pages 517-532 | Received 06 Dec 2016, Accepted 23 May 2017, Published online: 05 Jun 2017

References

  • Goeminne PC, de Soyza A. Bronchiectasis: how to be an orphan with many parents? Eur Respir J. 2016;47(1):10–13.
  • Quint JK, Millett ER, Joshi M, et al. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study. Eur Respir J. 2016;47(1):186–193.
  • Pasteur MC, Bilton D, Hill AT. British Thoracic Society non CFBGG. British Thoracic Society guideline for non-CF bronchiectasis. Thorax. 2010;65(7):577.
  • Goyal V, Grimwood K, Marchant J, et al. Pediatric bronchiectasis: no longer an orphan disease. Pediatr Pulmonol. 2016;51(5):450–469.
  • Chang AB, Upham JW, Masters IB, et al. Protracted bacterial bronchitis: the last decade and the road ahead. Pediatr Pulmonol. 2016;51(3):225–242.
  • Gibson GJ, Loddenkemper R, Sibille Y, et al., al. e. In: European Respiratory Society: the European Lung White Book. Chapter 15: Bronchiectasis. wwwerswhitebookorg accessed 17/11/2016
  • Valery PC, Torzillo PJ, Mulholland K, et al. Hospital-based case-control study of bronchiectasis in indigenous children in central Australia. Pediatr Infect Dis J. 2004;23(10):902–908.
  • Field CE. Bronchiectasis in childhood; clinical survey of 160 cases. Pediatrics. 1949;4(1):21–46.
  • Glauser EM, Cook CD, Harris GB. Bronchiectasis: a review of 187 cases in children with follow-up pulmonary function studies in 58. Acta Paediatr Scand. 1966;Suppl 165:1+.
  • Wynn-Williams N. Bronchiectasis: a study centred on Bedford and its environs. Br Med J. 1953;1(4821):1194–1199.
  • Chang AB, Bell SC, Torzillo PJ, et al. Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand Thoracic Society of Australia and New Zealand guidelines. Med J Aust. 2015;202(1):21–23.
  • Chang AB, Redding GJ, Everard ML. Chronic wet cough: protracted bronchitis, chronic suppurative lung disease and bronchiectasis. Pediatr Pulmonol. 2008;43(6):519–531.
  • Cole P. The damaging role of bacteria in chronic lung infection. J Antimicrob Chemother. 1997;40(Suppl A):5–10.
  • Chang AB, Bell SC, Byrnes CA, et al. Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand. Med J Aust. 2010;193(6):356–365.
  • Goyal V, Grimwood K, Chang AB. Bronchiectasis: the arrival of better evidence. Lancet Respir Med. 2014;2(1):12–13.
  • Chang AB, Grimwood K, Wilson AC, et al. Bronchiectasis exacerbation study on azithromycin and amoxycillin-clavulanate for respiratory exacerbations in children (BEST-2): study protocol for a randomized controlled trial. Trials. 2013;14:53.
  • Chang AB, Grimwood K, Robertson CF, et al. Antibiotics for bronchiectasis exacerbations in children: rationale and study protocol for a randomised placebo-controlled trial. Trials. 2012;13:156.
  • Sunny S, Davison J, De Soyza A. Management of non-cystic fibrosis bronchiectasis. Clinical Practice. 2013;10(5):629–640.
  • Kang EY, Miller RR, Muller NL. Bronchiectasis: comparison of preoperative thin-section CT and pathologic findings in resected specimens. Radiology. 1995;195(3):649–654.
  • McGuinness G, Naidich DP. CT of airways disease and bronchiectasis. Radiol Clin North Am. 2002;40(1):1–19.
  • Chang AB, Grimwood K, Maguire G, et al. Management of bronchiectasis and chronic suppurative lung disease in indigenous children and adults from rural and remote Australian communities. Med J Aust. 2008;189(7):386–393.
  • Kapur N, Masel JP, Watson D, et al. Bronchoarterial ratio on high-resolution CT scan of the chest in children without pulmonary pathology: need to redefine bronchial dilatation. Chest. 2011;139(6):1445–1450.
  • Dournes G, Laurent F. Airway remodelling in asthma and COPD: findings, similarities, and differences using quantitative CT. Pulm Med. 2012;2012:670414.
  • Kuo W, Andrinopoulou ER, Perez-Rovira A, et al. Objective airway artery dimensions compared to CT scoring methods assessing structural cystic fibrosis lung disease. J Cyst Fibros. 2017;16(1):116–123.
  • Chang AB, Byrnes CA, Everard ML. Diagnosing and preventing chronic suppurative lung disease (CSLD) and bronchiectasis. Paediatr Respir Rev. 2011;12(2):97–103.
  • Kapur N, Masters IB, Morris PS, et al. Defining pulmonary exacerbation in children with non-cystic fibrosis bronchiectasis. Pediatr Pulmonol. 2012;47(1):68–75.
  • Kapur N, Masters IB, Chang AB. Exacerbations in noncystic fibrosis bronchiectasis: clinical features and investigations. Respir Med. 2009;103(11):1681–1687.
  • King PT, Holdsworth SR, Freezer NJ, et al. Outcome in adult bronchiectasis. Copd. 2005;2(1):27–34.
  • Chang AB, Redding GJ, Everard ML. Chronic wet cough: protracted bronchitis, chronic suppurative lung disease and bronchiectasis. Pediatr Pulmonol. 2008;43(6):519–531.
  • Wurzel DF, Marchant JM, Yerkovich ST, et al. Protracted bacterial bronchitis in children: natural history and risk factors for bronchiectasis. Chest. 2016;150(5):1101-1108.
  • Singleton RJ, Valery PC, Morris P, et al. Indigenous children from three countries with non-cystic fibrosis chronic suppurative lung disease/bronchiectasis. Pediatr Pulmonol. 2014;49(2):189–200.
  • Chang AB, Masel JP, Boyce NC, et al. Non-CF bronchiectasis: clinical and HRCT evaluation. Pediatr Pulmonol. 2003;35(6):477–483.
  • Fleshman JK, Wilson JF, Cohen JJ. Bronchiectasis in Alaska native children. Arch Environ Health. 1968;17(4):517–523.
  • Edwards EA, Asher MI, Byrnes CA. Paediatric bronchiectasis in the twenty-first century: experience of a tertiary children’s hospital in New Zealand. J Paediatr Child Health. 2003;39(2):111–117.
  • Singleton R, Morris A, Redding G, et al. Bronchiectasis in Alaska native children: causes and clinical courses. Pediatr Pulmonol. 2000;29(3):182–187.
  • Munro KA, Reed PW, Joyce H, et al. Do New Zealand children with non-cystic fibrosis bronchiectasis show disease progression? Pediatr Pulmonol. 2011;46(2):131–138.
  • Roberts HJ, Hubbard R. Trends in bronchiectasis mortality in England and Wales. Respir Med. 2010;104(7):981–985.
  • Craig E, Reddington A, Adams J, et al. The health of children and young people with chronic conditions and disabilities in New Zealand.Dunedin: New Zealand Child and Youth Epidemiology Service, University of Otago; 2013: 193.
  • Craig E, Adams J, Oben G, et al. South Island bronchiectasis. In: The health status of children and young people in New Zealand.Dunedin: New Zealand Child and Youth Epidemiology Service, University of Otago; 2013. p. 193.
  • Steinfort DP, Brady S, Weisinger HS, et al. Bronchiectasis in central Australia: a young face to an old disease. Respir Med. 2008;102(4):574–578.
  • Onen ZP, Gulbay BE, Sen E, et al. Analysis of the factors related to mortality in patients with bronchiectasis. Respir Med. 2007;101(7):1390–1397.
  • Perry K, King D. Bronchiectasis: a study of prognosis based on a follow-up of 400 patients. Am Rev Tuberc. 1940;41:531–548.
  • Available from: http://www.cff/aboutCF.com asN.
  • Seitz AE, Olivier KN, Steiner CA, et al. Trends and burden of bronchiectasis-associated hospitalizations in the United States, 1993-2006. Chest. 2010;138(4):944–949.
  • Chang AB, Marsh RL, Upham JW, et al. Toward making inroads in reducing the disparity of lung health in Australian indigenous and New Zealand Maori children. Front Pediatr. 2015;3:9.
  • Cole PJ. Inflammation: a two-edged sword–the model of bronchiectasis. Eur J Respir Dis Suppl. 1986;147:6–15.
  • Gaillard EA, Carty H, Heaf D, et al. Reversible bronchial dilatation in children: comparison of serial high-resolution computer tomography scans of the lungs. Eur J Radiol. 2003;47(3):215–220.
  • Crowley S, Matthews I. Resolution of extensive severe bronchiectasis in an infant. Pediatr Pulmonol. 2010;45(7):717–720.
  • Field CE. Bronchiectasis in childhood; aetiology and pathogenesis, including a survey of 272 cases of doubtful irreversible bronchiectasis. Pediatrics. 1949;4(2):231–248.
  • Erdem E, Ersu R, Karadag B, et al. Effect of night symptoms and disease severity on subjective sleep quality in children with non-cystic-fibrosis bronchiectasis. Pediatr Pulmonol. 2011;46(9):919–926.
  • Kapur N, Masters IB, Newcombe P, et al. The burden of disease in pediatric non-cystic fibrosis bronchiectasis. Chest. 2012;141(4):1018–1024.
  • Newcombe PA, Sheffield JK, Juniper EF, et al. Development of a parent-proxy quality-of-life chronic cough-specific questionnaire: clinical impact vs. psychometric evaluations. Chest. 2008;133(2):386–395.
  • Gokdemir Y, Hamzah A, Erdem E, et al. Quality of life in children with non-cystic-fibrosis bronchiectasis. Respiration. 2014;88(1):46–51.
  • Bahali K, Gedik AH, Bilgic A, et al. The relationship between psychological symptoms, lung function and quality of life in children and adolescents with non-cystic fibrosis bronchiectasis. Gen Hosp Psychiatry. 2014;36(5):528–532.
  • Cochrane GM. Chronic bronchial sepsis and progressive lung damage. Br Med J (Clin Res Ed). 1985;290(6474):1026–1027.
  • Brower KS, Del Vecchio MT, Aronoff SC. The etiologies of non-CF bronchiectasis in childhood: a systematic review of 989 subjects. BMC Pediatr. 2014;14:4.
  • Grimwood K, Bell SC, Chang AB. Antimicrobial treatment of non-cystic fibrosis bronchiectasis. Expert Rev Anti Infect Ther. 2014;12(10):1277–1296.
  • Sidhu MK, Mandal P, Hill AT. Bronchiectasis: an update on current pharmacotherapy and future perspectives. Expert Opin Pharmacother. 2014;15(4):505–525.
  • Chang AB, Marsh RL, Smith-Vaughan HC, et al. Emerging drugs for bronchiectasis: an update. Expert Opin Emerg Drugs. 2015;20(2):277–297.
  • Haidopoulou K, Calder A, Jones A, et al. Bronchiectasis secondary to primary immunodeficiency in children: longitudinal changes in structure and function. Pediatr Pulmonol. 2009;44(7):669–675.
  • Kapur N, Karadag B. Differences and similarities in non-cystic fibrosis bronchiectasis between developing and affluent countries. Paediatr Respir Rev. 2011;12(2):91–96.
  • King PT, Holdsworth SR, Farmer M, et al. Phenotypes of adult bronchiectasis: onset of productive cough in childhood and adulthood. Copd. 2009;6(2):130–136.
  • Douros K, Alexopoulou E, Nicopoulou A, et al. Bronchoscopic and high-resolution CT scan findings in children with chronic wet cough. Chest. 2011;140(2):317–323.
  • Chang AB, Robertson CF, van Asperen PP, et al. A multicenter study on chronic cough in children: burden and etiologies based on a standardized management pathway. Chest. 2012;142(4):943–950.
  • Bastardo CM, Sonnappa S, Stanojevic S, et al. Non-cystic fibrosis bronchiectasis in childhood: longitudinal growth and lung function. Thorax. 2009;64(3):246–251.
  • Indinnimeo L, Tancredi G, Barreto M, et al. Effects of a program of hospital-supervised chest physical therapy on lung function tests in children with chronic respiratory disease: 1-year follow-up. Int J Immunopathol Pharmacol. 2007;20(4):841–845.
  • Main E, Grillo L, Rand S. Airway clearance strategies in cystic fibrosis and non-cystic fibrosis bronchiectasis. Semin Respir Crit Care Med. 2015;36(2):251–266.
  • Lee AL, Burge AT, Holland AE. Airway clearance techniques for bronchiectasis. Cochrane Database Syst Rev. 2015;11:CD008351.
  • Schneiderman-Walker J, Pollock SL, Corey M, et al. A randomized controlled trial of a 3-year home exercise program in cystic fibrosis. J Pediatr. 2000;136(3):304–310.
  • Phillips GE, Thomas S, Heather S, et al. Airway response of children with primary ciliary dyskinesia to exercise and beta2-agonist challenge. Eur Respir J. 1998;11(6):1389–1391.
  • Kapur N, Grimwood K, Masters IB, et al. Lower airway microbiology and cellularity in children with newly diagnosed non-CF bronchiectasis. Pediatr Pulmonol. 2012;47(3):300–307.
  • Murray MP, Turnbull K, Macquarrie S, et al. Assessing response to treatment of exacerbations of bronchiectasis in adults. Eur Respir J. 2009;33(2):312–318.
  • Goddard AF, Staudinger BJ, Dowd SE, et al. Direct sampling of cystic fibrosis lungs indicates that DNA-based analyses of upper-airway specimens can misrepresent lung microbiota. Proc Natl Acad Sci U S A. 2012;109(34):13769–13774.
  • Rosenfeld M, Emerson J, Accurso F, et al. Diagnostic accuracy of oropharyngeal cultures in infants and young children with cystic fibrosis. Pediatr Pulmonol. 1999;28(5):321–328.
  • Pizzutto SJ, Grimwood K, Bauert P, et al. Bronchoscopy contributes to the clinical management of indigenous children newly diagnosed with bronchiectasis. Pediatr Pulmonol. 2013;48(1):67–73.
  • Brent J, Guzman D, Bangs C, et al. Clinical and laboratory correlates of lung disease and cancer in adults with idiopathic hypogammaglobulinaemia. Clin Exp Immunol. 2016;184(1):73–82.
  • Calligaro GL, Esmail A, Gray DM. Severe airflow obstruction in vertically acquired HIV infection. Respirol Case Rep. 2014;2(4):135–137.
  • Hu X, Lee JS, Pianosi PT, et al. Aspiration-related pulmonary syndromes. Chest. 2015;147(3):815–823.
  • Mansour Y, Beck R, Danino J, et al. Resolution of severe bronchiectasis after removal of long-standing retained foreign body. Pediatr Pulmonol. 1998;25(2):130–132.
  • Patterson R, Greenberger PA, Halwig JM, et al. Allergic bronchopulmonary aspergillosis. Natural history and classification of early disease by serologic and roentgenographic studies. Arch Intern Med. 1986;146(5):916–918.
  • Agarwal R, Gupta D, Aggarwal AN, et al. Allergic bronchopulmonary aspergillosis: lessons from 126 patients attending a chest clinic in north India. Chest. 2006;130(2):442–448.
  • Patterson TF, Thompson GR 3rd, Denning DW, et al. Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the Infectious Diseases Society of America. Clin Infect Dis. 2016;63(4):e1–e60.
  • Paramothayan NS, Lasserson TJ, Jones PW. Corticosteroids for pulmonary sarcoidosis. Cochrane Database Syst Rev. 2005;2:CD001114.
  • Khosroshahi A, Wallace ZS, Crowe JL, et al. International consensus guidance statement on the management and treatment of IgG4-related disease. Arthritis Rheumatol. 2015;67(7):1688–1699.
  • Hare KM, Grimwood K, Leach AJ, et al. Respiratory bacterial pathogens in the nasopharynx and lower airways of Australian indigenous children with bronchiectasis. J Pediatr. 2010;157(6):1001–1005.
  • Kapur N, Mackay IM, Sloots TP, et al. Respiratory viruses in exacerbations of non-cystic fibrosis bronchiectasis in children. Arch Dis Child. 2014;99(8):749–753.
  • Jansen RR, Wieringa J, Koekkoek SM, et al. Frequent detection of respiratory viruses without symptoms: toward defining clinically relevant cutoff values. J Clin Microbiol. 2011;49(7):2631–2636.
  • Advani S, Sengupta A, Forman M, et al. Detecting respiratory viruses in asymptomatic children. Pediatr Infect Dis J. 2012;31(12):1221–1226.
  • Wurzel DF, Mackay IM, Marchant JM, et al. Adenovirus species C is associated with chronic suppurative lung diseases in children. Clin Infect Dis. 2014;59(1):34–40.
  • Chang AB, Bell SC, Torzillo PJ, et al. Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand Thoracic Society of Australia and New Zealand guidelines. Med J Aust. 2015;202(3):130.
  • Kapur N, Masters IB, Chang AB. Longitudinal growth and lung function in pediatric non-cystic fibrosis bronchiectasis: what influences lung function stability? Chest. 2010;138(1):158–164.
  • Martinez-Garcia MA, Soler-Cataluna JJ, Perpina-Tordera M, et al. Factors associated with lung function decline in adult patients with stable non-cystic fibrosis bronchiectasis. Chest. 2007;132(5):1565–1572.
  • Ellerman A, Bisgaard H. Longitudinal study of lung function in a cohort of primary ciliary dyskinesia. Eur Respir J. 1997;10(10):2376–2379.
  • Chalmers JD, Moffitt KL, Suarez-Cuartin G, et al. Neutrophil elastase activity is associated with exacerbations and lung function decline in bronchiectasis. Am J Respir Crit Care Med. 2017;195(10):1384-1393.
  • Marsh RL, Thornton RB, Smith-Vaughan HC, et al. Detection of biofilm in bronchoalveolar lavage from children with non-cystic fibrosis bronchiectasis. Pediatr Pulmonol. 2015;50(3):284-292.
  • Macia MD, Blanquer D, Togores B, et al. Hypermutation is a key factor in development of multiple-antimicrobial resistance in Pseudomonas aeruginosa strains causing chronic lung infections. Antimicrob Agents Chemother. 2005;49(8):3382–3386.
  • Chalmers JD, Smith MP, McHugh BJ, et al. Short- and long-term antibiotic treatment reduces airway and systemic inflammation in non-cystic fibrosis bronchiectasis. Am J Respir Crit Care Med. 2012;186(7):657–665.
  • Chang AB, Bell SC, Byrnes CA, et al. Chronic suppurative lung disease and bronchiectasis in children and adults in Australia and New Zealand. Med J Aust. 2010;193(6):356–365.
  • Hnin K, Nguyen C, Carson KV, et al. Prolonged antibiotics for non-cystic fibrosis bronchiectasis in children and adults. Cochrane Database Syst Rev. 2015;8:CD001392.
  • Kanoh S, Rubin BK. Mechanisms of action and clinical application of macrolides as immunomodulatory medications. Clin Microbiol Rev. 2010;23(3):590–615.
  • Valery PC, Morris PS, Byrnes CA, et al. Long-term azithromycin for indigenous children with non-cystic-fibrosis bronchiectasis or chronic suppurative lung disease (bronchiectasis intervention study): a multicentre, double-blind, randomised controlled trial. Lancet Respir Med. 2013;1(8):610–620.
  • Hare KM, Grimwood K, Chang AB, et al. Nasopharyngeal carriage and macrolide resistance in indigenous children with bronchiectasis randomized to long-term azithromycin or placebo. Eur J Clin Microbiol Infect Dis. 2015;34(11):2275–2285.
  • Wong C, Jayaram L, Karalus N, et al. Azithromycin for prevention of exacerbations in non-cystic fibrosis bronchiectasis (EMBRACE): a randomised, double-blind, placebo-controlled trial. Lancet. 2012;380(9842):660–667.
  • Serisier DJ, Martin ML, McGuckin MA, et al. Effect of long-term, low-dose erythromycin on pulmonary exacerbations among patients with non-cystic fibrosis bronchiectasis: the BLESS randomized controlled trial. JAMA. 2013;309(12):1260–1267.
  • Altenburg J, De Graaff CS, Stienstra Y, et al. Effect of azithromycin maintenance treatment on infectious exacerbations among patients with non-cystic fibrosis bronchiectasis: the BAT randomized controlled trial. JAMA. 2013;309(12):1251–1259.
  • Shteinberg M, Elborn JS. Use of inhaled tobramycin in cystic fibrosis. Adv Ther. 2015;32(1):1–9.
  • Vendrell M, Munoz G, De Gracia J. Evidence of inhaled tobramycin in non-cystic fibrosis bronchiectasis. Open Respir Med J. 2015;9:30–36.
  • Barker AF, O’Donnell AE, Flume P, et al. Aztreonam for inhalation solution in patients with non-cystic fibrosis bronchiectasis (AIR-BX1 and AIR-BX2): two randomised double-blind, placebo-controlled phase 3 trials. Lancet Respir Med. 2014;2(9):738–749.
  • Brodt AM, Stovold E, Zhang L. Inhaled antibiotics for stable non-cystic fibrosis bronchiectasis: a systematic review. Eur Respir J. 2014;44(2):382–393.
  • Ip M, Lam WK, So SY, et al. Analysis of factors associated with bronchial hyperreactivity to methacholine in bronchiectasis. Lung. 1991;169(1):43–51.
  • Kapur N, Bell S, Kolbe J, et al. Inhaled steroids for bronchiectasis. Cochrane Database Syst Rev. 2009;1:CD000996.
  • Hernando R, Drobnic ME, Cruz MJ, et al. Budesonide efficacy and safety in patients with bronchiectasis not due to cystic fibrosis. Int J Clin Pharm. 2012;34(4):644–650.
  • Balsamo R, Lanata L, Egan CG. Mucoactive drugs. Eur Respir Rev. 2010;19(116):127–133.
  • Daviskas E, Robinson M, Anderson SD, et al. Osmotic stimuli increase clearance of mucus in patients with mucociliary dysfunction. J Aerosol Med. 2002;15(3):331–341.
  • Shibuya Y, Wills PJ, Cole PJ. Effect of osmolality on mucociliary transportability and rheology of cystic fibrosis and bronchiectasis sputum. Respirology. 2003;8(2):181–185.
  • Nicolson CH, Stirling RG, Borg BM, et al. The long term effect of inhaled hypertonic saline 6% in non-cystic fibrosis bronchiectasis. Respir Med. 2012;106(5):661–667.
  • Bilton D, Robinson P, Cooper P, et al. Inhaled dry powder mannitol in cystic fibrosis: an efficacy and safety study. Eur Respir J. 2011;38(5):1071–1080.
  • Aitken ML, Bellon G, De Boeck K, et al. Long-term inhaled dry powder mannitol in cystic fibrosis: an international randomized study. Am J Respir Crit Care Med. 2012;185(6):645–652.
  • Bilton D, Daviskas E, Anderson SD, et al. Phase 3 randomized study of the efficacy and safety of inhaled dry powder mannitol for the symptomatic treatment of non-cystic fibrosis bronchiectasis. Chest. 2013;144(1):215–225.
  • Bilton D, Tino G, Barker AF, et al. Inhaled mannitol for non-cystic fibrosis bronchiectasis: a randomised, controlled trial. Thorax. 2014;69(12):1073–1079.
  • Bilton D, Bellon G, Charlton B, et al. Pooled analysis of two large randomised phase III inhaled mannitol studies in cystic fibrosis. J Cyst Fibros. 2013;12(4):367–376.
  • O’Donnell AE, Barker AF, Ilowite JS, et al. Treatment of idiopathic bronchiectasis with aerosolized recombinant human DNase I. Rhdnase Study Group. Chest. 1998;113(5):1329–1334.
  • Llewellyn-Jones CG, Johnson MM, Mitchell JL, et al. In vivo study of indomethacin in bronchiectasis: effect on neutrophil function and lung secretion. Eur Respir J. 1995;8(9):1479–1487.
  • Pizzutto SJ, Upham JW, Yerkovich ST, et al. Inhaled non-steroid anti-inflammatories for children and adults with bronchiectasis. Cochrane Database Syst Rev. 2016;1:CD007525.
  • Kapur N, Chang AB. Oral non steroid anti-inflammatories for children and adults with bronchiectasis. Cochrane Database Syst Rev. 2007;4:CD006427.
  • Fabbri LM, Beghe B, Yasothan U, et al. Roflumilast. Nat Rev Drug Discov. 2010;9(10):761–762.
  • Chapman RW, Phillips JE, Hipkin RW, et al. CXCR2 antagonists for the treatment of pulmonary disease. Pharmacol Ther. 2009;121(1):55–68.
  • De Soyza A, Pavord I, Elborn JS, et al. A randomised, placebo-controlled study of the CXCR2 antagonist AZD5069 in bronchiectasis. Eur Respir J. 2015;46(4):1021–1032.
  • Otgun I, Karnak I, Tanyel FC, et al. Surgical treatment of bronchiectasis in children. J Pediatr Surg. 2004;39(10):1532–1536.
  • Weber A, Stammberger U, Inci I, et al. Thoracoscopic lobectomy for benign disease–a single centre study on 64 cases. Eur J Cardiothorac Surg. 2001;20(3):443–448.
  • Zhang P, Zhang F, Jiang S, et al. Video-assisted thoracic surgery for bronchiectasis. Ann Thorac Surg. 2011;91(1):239–243.
  • Mitchell JD, Yu JA, Bishop A, et al., Thoracoscopic lobectomy and segmentectomy for infectious lung disease. Ann Thorac Surg. 2012;934:1033–1039. discussion 9-40
  • Mandal P, Sidhu MK, Kope L, et al. A pilot study of pulmonary rehabilitation and chest physiotherapy versus chest physiotherapy alone in bronchiectasis. Respir Med. 2012;106(12):1647–1654.
  • Lee AL, Hill CJ, Cecins N, et al. The short and long term effects of exercise training in non-cystic fibrosis bronchiectasis–a randomised controlled trial. Respir Res. 2014;15:44.
  • O’Grady KA, Chang AB, Grimwood K. Vaccines for children and adults with chronic lung disease: efficacy against acute exacerbations. Expert Rev Respir Med. 2014;8(1):43–55.
  • Higgins D, Trujillo C, Keech C. Advances in RSV vaccine research and development - a global agenda. Vaccine. 2016;34(26):2870–2875.
  • Pizzutto SJ, Yerkovich ST, Upham JW, et al. Improving immunity to haemophilus influenzae in children with chronic suppurative lung disease. Vaccine. 2015;33(2):321–326.
  • Hare KM, Binks MJ, Grimwood K, et al. PCR detection of haemophilus influenzae and haemophilus haemolyticus in Australian indigenous children with bronchiectasis. J Clin Microbiol. 2012;50(7):2444–2445.
  • Smith-Vaughan HC, Chang AB, Sarovich DS, et al. Absence of an important vaccine and diagnostic target in carriage- and disease-related nontypeable haemophilus influenzae. Clin Vaccine Immunol. 2014;21(2):250–252.
  • Zar HJ, Ferkol TW. The global burden of respiratory disease-impact on child health. Pediatr Pulmonol. 2014;49(5):430–434.
  • Chalmers JD, McHugh BJ, Docherty C, et al. Vitamin-D deficiency is associated with chronic bacterial colonisation and disease severity in bronchiectasis. Thorax. 2013;68(1):39–47.
  • Theodoratou E, Tzoulaki I, Zgaga L, et al. Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials. Bmj. 2014;348:g2035.
  • Gama R, Waldron JL, Ashby HL, et al. Hypovitaminosis D and disease: consequence rather than cause? Bmj. 2012;345:e5706.
  • Redding GJ, Byrnes CA. Chronic respiratory symptoms and diseases among indigenous children. Pediatr Clin North Am. 2009;56(6):1323–1342.
  • Goeminne PC, Bijnens E, Nemery B, et al. Impact of traffic related air pollution indicators on non-cystic fibrosis bronchiectasis mortality: a cohort analysis. Respir Res. 2014;15:108.
  • Li JS, Peat JK, Xuan W, et al. Meta-analysis on the association between environmental tobacco smoke (ETS) exposure and the prevalence of lower respiratory tract infection in early childhood. Pediatr Pulmonol. 1999;27(1):5–13.
  • http://www.crelungs.org.au/.
  • Marchant JM, Masel JP, Dickinson FL, et al. Application of chest high-resolution computer tomography in young children with cystic fibrosis. Pediatr Pulmonol. 2001;31(1):24–29.
  • Santamaria F, Montella S, Camera L, et al. Lung structure abnormalities, but normal lung function in pediatric bronchiectasis. Chest. 2006;130(2):480–486.
  • Guran T, Ersu R, Karadag B, et al. Association between inflammatory markers in induced sputum and clinical characteristics in children with non-cystic fibrosis bronchiectasis. Pediatr Pulmonol. 2007;42(4):362–369.
  • Brody AS, Guillerman RP. Don’t let radiation scare trump patient care: 10 ways you can harm your patients by fear of radiation-induced cancer from diagnostic imaging. Thorax. 2014;69(8):782–784.
  • Martinez-Garcia MA, De Gracia J, Vendrell Relat M, et al. Multidimensional approach to non-cystic fibrosis bronchiectasis: the FACED score. Eur Respir J. 2014;43(5):1357–1367.
  • Chalmers JD, Goeminne P, Aliberti S, et al. The bronchiectasis severity index. An International Derivation and Validation Study. Am J Respir Crit Care Med. 2014;189(5):576–585.
  • Minov J, Karadzinska-Bislimovska J, Vasilevska K, et al. Assessment of the non-cystic fibrosis bronchiectasis severity: the FACED score vs. the bronchiectasis severity index. Open Respir Med J. 2015;9:46–51.
  • Loebinger MR, Wells AU, Hansell DM, et al. Mortality in bronchiectasis: a long-term study assessing the factors influencing survival. Eur Respir J. 2009;34(4):843–849.
  • Matsuoka S, Uchiyama K, Shima H, et al. Bronchoarterial ratio and bronchial wall thickness on high-resolution CT in asymptomatic subjects: correlation with age and smoking. AJR Am J Roentgenol. 2003;180(2):513–518.
  • Pasteur MC, Helliwell SM, Houghton SJ, et al. An investigation into causative factors in patients with bronchiectasis. Am J Respir Crit Care Med. 2000;162(4 Pt 1):1277–1284.
  • Campbell F, Conti G, Heckman JJ, et al. Early childhood investments substantially boost adult health. Science. 2014;343(6178):1478–1485.
  • Martin MJ, Harrison TW. Causes of chronic productive cough: an approach to management. Respir Med. 2015;109(9):1105–1113.

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