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Review

Bronchial thermoplasty as a treatment for severe asthma: controversies, progress and uncertainties

Pages 269-282 | Received 04 Jan 2018, Accepted 21 Feb 2018, Published online: 27 Feb 2018

References

  • GINA Report, Global strategy for asthma management and prevention. [cited 2018 Jan 4]. Available from: http://www.ginasthma.com
  • Demoly P, Annunziata K, Gubba E, et al. Repeated cross-sectional survey of patient-reported asthma control in Europe in the past 5 years. Eur Respir Review. 2012;21(123):66–74.
  • Price D, Fletcher M, Van Der Molen T. Asthma control and management in 8,000 European patients: the recognise asthma and link to symptoms and experience (REALISE) survey. NPJ Prim Care Respir Med. 2014;24:14009.
  • Bel EH, Sousa A, Fleming L, et al. Diagnosis and definition of severe refractory asthma: an international consensus statement from the innovative medicine initiative (IMI). Thorax. 2011;66(10):910–917.
  • Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373.
  • Heaney LG, Brightling CE, Menzies-Gow A, et al., On behalf of the British Thoracic Society Difficult Asthma N. Refractory asthma in the UK: cross-sectional findings from a UK multicentre registry. Thorax. 2010;65:787–794.
  • Wark PAB, Hew M, Maltby S, et al. Diagnosis and investigation in the severe asthma clinic. Exp Rev Respir Med. 2016;10(5):491–503.
  • Hekking P-PW, Wener RR, Amelink M, et al. The prevalence of severe refractory asthma. J Allergy Clin Immunol. 2015;135(4):896–902.
  • Sweeney J, Patterson CC, Menzies-Gow A, et al. Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the optimum patient care research database and the British Thoracic Difficult Asthma Registry. Thorax. 2016;71(4):339–346.
  • O’Neill S, Sweeney J, Patterson CC, et al. The cost of treating severe refractory asthma in the UK: an economic analysis from the British Thoracic Society Difficult Asthma Registry. Thorax. 2015;70(4):376–378.
  • Chen W, Marra CA, Lynd LD, et al. The natural history of severe asthma and influences of early risk factors: a population-based cohort study. Thorax. 2016;71(3):267–275.
  • Fahy JV. Type 2 inflammation in asthma - present in most, absent in many. Nat Rev Immunol. 2015;15(1):57–65.
  • Ray A, Raundhal M, Oriss TB, et al. Current concepts of severe asthma. J Clin Invest. 2016;126(7):2394–2403.
  • Barnes PJ, Bonini S, Seeger W, et al. Barriers to new drug development in respiratory disease. Eur Respir J. 2015;45(5):1197–1207.
  • Cox PG, Miller J, Mitzner W, et al. Radiofrequency ablation of airway smooth muscle for sustained treatment of asthma: preliminary investigations. Eur Respir J. 2004;24(4):659–663.
  • U.S. Food and Drug Administration. 2010. Alair Bronchial Thermoplasty System: Alair Catheter and Alair RF controller (Ed.^(Eds). [Cited 2018 Jan 4]. Available from: https://www.accessdata.fda.gov/cdrh_docs/pdf8/p080032a.pdf
  • Torrego A, Solà I, Munoz A, et al. Bronchial thermoplasty for moderate or severe persistent asthma in adults. Cochrane Database Syst Rev. 2014;3:Art. No.: CD009910. DOI:10.1002/14651858.CD009910.pub2.
  • Thomson NC, Bicknell S, Chaudhuri R. Bronchial thermoplasty for severe asthma. Curr Opin Allergy Clin Immunol. 2012;12(3):241–248.
  • Dombret M-C, Alagha K, Philippe Boulet L, et al. Bronchial thermoplasty: a new therapeutic option for the treatment of severe, uncontrolled asthma in adults. Eur Respir Rev. 2014;23(134):510–518.
  • Sheshadri A, McKenzie M, Castro M. Critical review of bronchial thermoplasty: where should it fit into asthma therapy? Curr Allergy Asthma Rep. 2014;14(11):470.
  • Laxmanan B, Egressy K, Murgu SD, et al. Advances in bronchial thermoplasty. Chest. 2016;150(3):694–704.
  • Danek CJ, Lombard CM, Dungworth DL, et al. Reduction in airway hyperresponsiveness to methacholine by the application of RF energy in dogs. J Appl Physiol. 2004;97(5):1946–1953.
  • Brown RH, Wizeman W, Danek C, et al. In vivo evaluation of the effectiveness of bronchial thermoplasty with computed tomography. J Appl Physiol. 2005;98(5):1603–1606.
  • Brown RH, Wizeman W, Danek C, et al. Effect of bronchial thermoplasty on airway distensibility. Eur Respir J. 2005;26(2):277–282.
  • Miller JD, Cox G, Vincic L, et al. A prospective feasibility study of bronchial thermoplasty in the human airway. Chest. 2005;127(6):1999–2006.
  • Cox G, Miller JD, McWilliams A, et al. Bronchial thermoplasty for asthma. Am J Respir Crit Care Med. 2006;173(9):965–969.
  • Bicknell S, Chaudhuri R, Thomson NC. How to: bronchial thermoplasty in asthma. Breathe. 2014;10(1):48–59.
  • Castro M, Rubin AS, Laviolette M, et al. Effectiveness and safety of bronchial thermoplasty in the treatment of severe asthma: a multicenter, randomized, double-blind, sham-controlled clinical trial. Am J Respir Crit Care Med. 2010;181(2):116–124.
  • d’Hooghe JNS, Eberl S, Annema JT, et al. Propofol and remifentanil sedation for bronchial thermoplasty: a prospective cohort trial. Respiration. 2017;93(1):58–64.
  • U.S. National Institutes of Health. 2018. [Cited 2018 Jan 4]. Available from: https://clinicaltrials.gov/
  • Cox G, Thomson NC, Rubin AS, et al. Asthma control during the year after bronchial thermoplasty. N Eng J Med. 2007;356(13):1327–1337.
  • Pavord ID, Cox G, Thomson NC, et al. Safety and efficacy of bronchial thermoplasty in symptomatic, severe asthma. Am J Respir Crit Care Med. 2007;176(12):1185–1191.
  • Wechsler ME, Laviolette M, Rubin AS, et al. Bronchial thermoplasty: long-term safety and effectiveness in patients with severe persistent asthma. J Allergy Clin Immunol. 2013;132:1295–1302.
  • Inhaber N, Goodrich R, Bolt J,MR. AQLQ response is correlated with a decrease in asthma exacerbations in the bronchial thermoplasty AIR2 population. Am J Resir Crit Care Med. 2015;191:A4189.
  • Iyer VN, Lim KG. Bronchial thermoplasty: reappraising the evidence (or lack thereof). Chest. 2014;146(1):17–21.
  • Castro M, Cox G, Wechsler ME, et al. Bronchial thermoplasty: ready for prime time - the evidence is there! Chest. 2015;147(2):e73–e74.
  • Wu Q, Xing Y, Zhou X, et al. Meta-analysis of the efficacy and safety of bronchial thermoplasty in patients with moderate-to-severe persistent asthma. J Int Med Res. 2011;39(1):10–22.
  • Thomson NC, Rubin A, Niven R, et al. Long term (5 year) safety of bronchial thermoplasty: asthma intervention research (AIR) trial. BMC Pulm Med. 2011;11(1):8.
  • Pavord ID, Thomson NC, Niven RM, et al. Safety of bronchial thermoplasty in patients with severe refractory asthma. Ann Allergy Asthma Immunol. 2013;111(5):402–407.
  • Doeing DC, Mahajan AK, White SR, et al. Safety and feasibility of bronchial thermoplasty in asthma patients with very severe fixed airflow obstruction: a case series. J Asthma. 2013;50:215–218.
  • Bicknell S, Chaudhuri R, Lee N, et al. Effectiveness of bronchial thermoplasty in severe asthma in ‘real life’ patients compared with those recruited to clinical trials in the same centre. Therap Adv Respir Dis. 2015;9(6):267–271.
  • Chakir J, Haj-Salem I, Gras D, et al. Effects of bronchial thermoplasty on airway smooth muscle and collagen deposition in asthma. Annals ATS. 2015;12(11):1612–1618.
  • Salem IH, Boulet L-P, Biardel S, et al. Long-term effects of bronchial thermoplasty on airway smooth muscle and reticular basement membrane thickness in severe asthma. Annals ATS. 2016;13(8):1426–1428.
  • Pretolani M, Bergqvist A, Thabut G, et al. Effectiveness of bronchial thermoplasty in patients with severe refractory asthma: clinical and histopathological correlations. J Allergy Clin Immunol. 2017;139(4):1176–1185.
  • Langton D, Sha J, Ing A, et al. Bronchial thermoplasty in severe asthma in Australia. Intern Med J. 2017;47(5):536–541.
  • Iikura M, Hojo M, Nagano N, et al. Bronchial thermoplasty for severe uncontrolled asthma in Japan. Allergol Internat. 2017 Jul 29. pii: S1323-8730(17)30107-7.
  • Zanon M, Strieder DL, Rubin AS, et al. Use of MDCT to assess the results of bronchial thermoplasty. AJR Am J Roentgenol. 2017;209(4):752–756.
  • Kanaan R, Strange C, Hogarth K, et al. Bronchial thermoplasty is effective and relatively safe in high risk asthma patients. Am J Respir Crit Care Med. 2017;195:A4690.
  • Sierra M, Fernandez-Bussy S, Mehta H, et al. Bronchial thermoplasty in severe uncontrolled asthma with different phenotypes. Chest. 2017;152(4, Supplement):A29.
  • d’Hooghe JNS, Weersink EJM, Ten Hacken NHT, et al. Clinical response of severe asthma patients following bronchial thermoplasty. Eur Respir J. 2017;50(suppl61):PA3029.
  • Burn J, Sims AJ, Keltie K, et al. Procedural and short-term safety of bronchial thermoplasty in clinical practice: evidence from a national registry and hospital episode statistics. J Asthma. 2017;54(8):872–879.
  • Chupp G, Laviolette M, Cohn L, et al. Long-term outcomes of bronchial thermoplasty in subjects with severe asthma: a comparison of 3-year follow-up results from two prospective multicentre studies. Eur Respir J. 2017; 50(2):pii: 1700017.
  • Debray M-P, Dombret M-C, Pretolani M, et al. Early computed tomography modifications following bronchial thermoplasty in patients with severe asthma. Eur Respir J. 2017;49:3.
  • d’Hooghe JNS, Van Den Berk IAH, Annema JT, et al. Acute radiological abnormalities after bronchial thermoplasty: a prospective cohort trial. Respiration. 2017;94(3):258–262.
  • Thomson NC, Chanez P. How effective is bronchial thermoplasty for severe asthma in clinical practice?. Eur Respir J. 2017;50:2.
  • Hanania NA, Wenzel S, Rosen K, et al. Exploring the effects of omalizumab in allergic asthma. Am J Respir Crit Care Med. 2013;187(8):804–811.
  • Ortega HG, Liu MC, Pavord ID, et al. Mepolizumab treatment in patients with severe eosinophilic asthma. N Eng J Med. 2014;371(13):1198–1207.
  • Castro M, Zangrilli J, Wechsler ME, et al. Reslizumab for inadequately controlled asthma with elevated blood eosinophil counts: results from two multicentre, parallel, double-blind, randomised, placebo-controlled, phase 3 trials. Lancet Respir Med. 2015;3(5):355–366.
  • Bleecker ER, FitzGerald JM, Chanez P, et al. Efficacy and safety of benralizumab for patients with severe asthma uncontrolled with high-dosage inhaled corticosteroids and long-acting β2-agonists (SIROCCO): a randomised, multicentre, placebo-controlled phase 3 trial. Lancet. 2016;388(10056):2115–2212.
  • British Guideline on the Management of Asthma. A national clinical guideline. 2016. [Cited 2018 Jan 4]. Available from: www.sign.ac.uk
  • Blaiss MS, Castro M, Chipps BE, et al. Guiding principles for use of newer biologics and bronchial thermoplasty for patients with severe asthma. Ann Allergy Asthma Immunol. 2017;119(6):533–540.
  • Oberle AJ, Mathur P. Precision medicine in asthma: the role of bronchial thermoplasty. Curr Opin Pulm Med. 2017;23(3):254–260.
  • Zein JG, Menegay MC, Singer ME, et al. Cost effectiveness of bronchial thermoplasty in patients with severe uncontrolled asthma. J Asthma. 2015;53(2):194–200.
  • Zafari Z, Sadatsafavi M, Marra CA, et al. Cost-effectiveness of bronchial thermoplasty, omalizumab, and standard therapy for moderate-to-severe allergic asthma. PLoS ONE. 2016;11(1):e0146003.
  • Nguyen HV, Bose S, Mital S, et al. Is bronchial thermoplasty cost-effective as treatment for problematic asthma patients? Singapore’s perspective on a global model. Respirology. 2017;22(6):1102–1109.
  • Niven RM, Simmonds MR, Cangelosi MJ, et al. Indirect comparison of bronchial thermoplasty versus omalizumab for uncontrolled severe asthma. J Asthma. 2017;1–9.
  • Humbert M, Beasley R, Ayres J, et al. Benefits of omalizumab as add-on therapy in patients with severe persistent asthma who are inadequately controlled despite best available therapy (GINA 2002 step 4 treatment): INNOVATE. Allergy. 2005;60(3):309–316.
  • Hanania NA, Alpan O, Hamilos DL, et al. Omalizumab in severe allergic asthma inadequately controlled with standard therapy. Ann Intern Med. 2011;154(9):573–582.
  • Sarikonda K, Sheshadri A, Koch T, et al. Predictors of bronchial thermoplasty response in patients with severe refractory asthma. Am J Respir Crit Care Med. 2014;189:A2429.
  • Langton D, Sha J, Ing A, et al. Bronchial thermoplasty: activations predict response. Respir Res. 2017;18(1):134.
  • Iikura M, Ishii S, Izumi S, et al. Clinical characteristics of responders treated with bronchial thermoplasty in severe asthmatic patients. Am J Respir Crit Care Med. 2017;195:A3208.
  • Kirby M, Ohtani K, Lopez Lisbona RM, et al. Bronchial thermoplasty in asthma: 2-year follow-up using optical coherence tomography. Eur Respir J. 2015;46(3):859–862.
  • d’Hooghe JNS, Ten Hacken NH, Weersink EJM, et al. Emerging understanding of the mechanism of action of bronchial thermoplasty in asthma. Pharmacol Therapeut. 2018;181:101–107.
  • James AL, Elliot JG, Jones RL, et al. Airway smooth muscle hypertrophy and hyperplasia in asthma. Am J Respir Crit Care Med. 2012;185(10):1058–1064.
  • Pepe C, Foley S, Shannon J, et al. Differences in airway remodeling between subjects with severe and moderate asthma. J Allergy Clin Immunol. 2005;116(3):544–549.
  • Solway J, Irvin CG. Airway smooth muscle as a target for asthma therapy. N Engl J Med. 2007;356(13):1367–1369.
  • Zuyderduyn S, Sukkar MB, Fust A, et al. Treating asthma means treating airway smooth muscle cells. Eur Resp J. 2008;32(2):265–274.
  • Gordon I, Husain A, Charbeneau J, et al. Endobronchial biopsy: a guide for asthma therapy selection in the era of bronchial thermoplasty. J Asthma. 2013;50(6):634–641.
  • Denner DR, Doeing DC, Hogarth DK, et al. Airway inflammation after bronchial thermoplasty for severe asthma. Annals Am Thor Soc. 2015;12(9):1302–1309.
  • d’Hooghe JNS, Ten Hacken NHT, Roelofs JJTH, et al. Airway smooth muscle mass reduction after bronchial thermoplasty; the TASMA randomized controlled trial. Eur Respir J. 2017;50(suppl61):PA3027.
  • Ishii S, Iikura M, Hojo M, et al. Use of 3D-CT airway analysis software to assess a patient with severe persistent bronchial asthma treated with bronchial thermoplasty. Allergol Int. 2017;66(3):501–503.
  • Dyrda P, Tazzeo T, DoHarris L, et al. Acute response of airway muscle to extreme temperature includes disruption of actin-myosin interaction. Am J Respir Cell Mol Biol. 2011;44(2):213–221.
  • Chakir J, Haj Salem I, Gras D, et al. MUC5AC expression decrease correlates with the decline in rates of severe asthma exacerbations post bronchial thermoplasty. Eur Respir J. 2017;50(suppl61):OA279.
  • Russell R, Singapuri A, Berair R, et al. Clinical and histological effects of bronchial thermoplasty in severe asthma. Eur Respir J. 2017;50(suppl61):PA3031.
  • Ryan DM, Fowler SJ, Niven RM. Reduction in peripheral blood eosinophil counts after bronchial thermoplasty. J Allergy Clin Immunol. 2016;138(1):308–310.e302.
  • Chupp G, Michaud G, Puchalski J, et al. Longitudinal effects of bronchial thermoplasty on blood gene expression: modulation of inflammatory and neuron function. Am J Resir Crit Care Med. 2015;191:A6431.
  • Contoli M, Santus P, Papi A. Small airway disease in asthma: pathophysiological and diagnostic considerations. Curr Opin Pulm Med. 2015;21(1):68–73.
  • Farah C, Langton D, Pierucci P, et al. Changes in lung function and forced oscillatory technique (FOT) parameters following bronchial thermoplasty (BT) in patients with refractory asthma. Am J Respir Crit Care Med. 2017;195:A6497.
  • Baydur A, Virdi R, Barbers R. Lung compliance and resistance in patients with severe persistent asthma before and after undergoing bronchial thermoplasty: a pilot study. Am J Respir Crit Care Med. 2017;195:A6496.
  • Boulet L-P, Laviolette M. Acute effects of bronchial thermoplasty: a matter of concern or an indicator of possible benefit to small airways? Eur Respir J. 2017;49(3):1700029.
  • Redberg RF. Sham controls in medical device trials. N Eng J Med. 2014;371(10):892–893.
  • Thomson NC. Novel approaches to the management of noneosinophilic asthma. Therap Adv Respir Dis. 2016;10(3):211–234.
  • Thomson NC. New and developing non-adrenoreceptor small molecule drugs for the treatment of asthma. Expert Opin Pharmacother. 2017;18(3):283–293.
  • Pahus L, Alagha K, Sofalvi T, et al. External validity of randomized controlled trials in severe asthma. Am J Resp Crit Care Med. 2015;192(2):259–261.
  • Tri JA, DeSimone CV, Daniels C, et al. Electroporation ablation of bronchial smooth muscle cells: a novel non-thermal asthma therapy. Pulm Crit Care Med. 2016;1(4). DOI:10.15761/PCCM.1000120

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