Risks associated with lung transplantation in cystic fibrosis patients

References

• Cystic Fibrosis Foundation. Cystic Fibrosis Foundation Patient Registry annual data report, 2016. 2017. Available from: https://www.cff.org/Research/Researcher-Resources/Patient-Registry/2016-Patient-Registry-Annual-Data-Report.pdf.
   Google Scholar
• Thabut G, Christie JD, Mal H, et al. Survival benefit of lung transplant for cystic fibrosis since lung allocation score implementation. Am J Respir Crit Care Med. 2013;187(12):1335–1340.
   PubMed Web of Science ®Google Scholar
• The International Society for Heart and Lung Transplantation. Thirty-second annual report 2017. JHLT, Oct,2017; 36(10):1037–1079 Available from: http://www.ishlt.org/registries/slides.asp?slides=heartLungRegistry,
   Google Scholar
• Snell G, Reed A, Stern M, et al. The evolution of lung transplantation for cystic fibrosis: a 2017 update. J Cyst Fibros. 2017;16(5):553–564.
   PubMed Web of Science ®Google Scholar
• Vock DM, Durheim MT, Tsuang WM, et al. Survival benefit of lung transplantation in the modern era of lung allocation. Ann Am Thorac Soc. 2017;14(2):172–181.
   PubMed Web of Science ®Google Scholar
• Blatter J, Sweet S. Lung transplantation in cystic fibrosis: trends and controversies. Pediatr Allergy Immunol Pulmonol. 2015;28(4):237–243.
   PubMed Web of Science ®Google Scholar
• Hayes D Jr., Tumin D, Daniels CJ, et al. Pulmonary artery pressure and benefit of lung transplantation in adult cystic fibrosis patients. Ann Thorac Surg. 2016;101(3):1104–1109.
   PubMed Web of Science ®Google Scholar
• Lobo LJ, Aris RM, Schmitz J, et al. Donor-specific antibodies are associated with antibody-mediated rejection, acute cellular rejection, bronchiolitis obliterans syndrome, and cystic fibrosis after lung transplantation. J Heart Lung Transplant. 2013;32(1):70–77.
   PubMed Web of Science ®Google Scholar
• Hayes D Jr., Black SM, Tobias JD, et al. Influence of human leukocyte antigen mismatching on bronchiolitis obliterans syndrome in lung transplantation. J Heart Lung Transplant. 2016;35(2):186–194.
   PubMed Web of Science ®Google Scholar
• Hayes D Jr., Auletta JJ, Whitson BA, et al. Human leukocyte antigen mismatching and survival after lung transplantation in adult and pediatric patients with cystic fibrosis. J Thorac Cardiovasc Surg. 2016;151(2):549–557.e541.
   PubMed Web of Science ®Google Scholar
• Mueller C, Braag SA, Keeler A, et al. Lack of cystic fibrosis transmembrane conductance regulator in CD3+ lymphocytes leads to aberrant cytokine secretion and hyperinflammatory adaptive immune responses. Am J Respir Cell Mol Biol. 2011;44(6):922–929.
   PubMed Web of Science ®Google Scholar
• Johansson J, Vezzalini M, Verze G, et al. Detection of CFTR protein in human leukocytes by flow cytometry. Cytometry A. 2014;85(7):611–620.
   PubMedGoogle Scholar
• Bubien JK. CFTR may play a role in regulated secretion by lymphocytes: a new hypothesis for the pathophysiology of cystic fibrosis. Pflugers Arch. 2001;443(Suppl 1):S36–39.
   PubMedGoogle Scholar
• Galar A, Engelson BA, Kubiak DW, et al. Serologic response to hepatitis B vaccination among lung transplantation candidates. Transplantation. 2014;98(6):676–679.
   PubMed Web of Science ®Google Scholar
• Mj B, Mt L, Kenia P, et al. Pneumococcal polysaccharide vaccine responses are impaired in a subgroup of children with cystic fibrosis. J Cyst Fibros. 2014;13(6):632–638.
   PubMed Web of Science ®Google Scholar
• Barclay NG, Spurrell JC, Bruno TF, et al. Pseudomonas aeruginosa exoenzyme S stimulates murine lymphocyte proliferation in vitro. Infect Immun. 1999;67(9):4613–4619.
   PubMed Web of Science ®Google Scholar
• Bacigalupo A. A closer look at permissive HLA mismatch. Blood. 2013;122(22):3555–3556.
   PubMed Web of Science ®Google Scholar
• Moreno P, Alvarez A, Carrasco G, et al. Lung transplantation for cystic fibrosis: differential characteristics and outcomes between children and adults. Eur J Cardiothorac Surg. 2016;49(5):1334–1343.
   PubMed Web of Science ®Google Scholar
• Hayes D Jr., McCoy KS, Whitson BA, et al. High-risk age window for mortality in children with cystic fibrosis after lung transplantation. Pediatr Transplant. 2015;19(2):206–210.
   PubMed Web of Science ®Google Scholar
• Liou TG, Adler FR, Cox DR, et al. Lung transplantation and survival in children with cystic fibrosis. N Engl J Med. 2008;359(5):2143–2152.
   PubMed Web of Science ®Google Scholar
• Paraskeva MA, Edwards LB, Levvey B, et al. Outcomes of adolescent recipients after lung transplantation: an analysis of the International Society for Heart and Lung Transplantation Registry. J Heart Lung Transplant. 2018;37(3):323–331.
   PubMed Web of Science ®Google Scholar
• Hayes D Jr., Glanville AR, McGiffin D, et al. Age-related survival disparity associated with lung transplantation in cystic fibrosis: an analysis of the Registry of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2016;35(9):1108–1115.
   PubMed Web of Science ®Google Scholar
• Plant BJ, Gallagher CG, Bucala R, et al. Cystic fibrosis, disease severity, and a macrophage migration inhibitory factor polymorphism. Am J Respir Crit Care Med. 2005;172(11):1412–1415.
   PubMed Web of Science ®Google Scholar
• Quon BS, Psoter K, Mayer-Hamblett N, et al. Disparities in access to lung transplantation for patients with cystic fibrosis by socioeconomic status. Am J Respir Crit Care Med. 2012;186(10):1008–1013.
   PubMed Web of Science ®Google Scholar
• Allen JG, Arnaoutakis GJ, Orens JB, et al. Insurance status is an independent predictor of long-term survival after lung transplantation in the United States. J Heart Lung Transplant. 2011;30(1):45–53.
   PubMed Web of Science ®Google Scholar
• Stephenson AL, Sykes J, Stanojevic S, et al. Survival comparison of patients with cystic fibrosis in Canada and the United States: a population-based cohort study. Ann Intern Med. 2017;166(8):537–546.
   PubMed Web of Science ®Google Scholar
• Hayes D Jr., Sweet SC, Benden C, et al. Transplant center volume and outcomes in lung transplantation for cystic fibrosis. Transpl Int. 2017;30(4):371–377.
   PubMed Web of Science ®Google Scholar
• Tumin D, Foraker RE, Tobias JD, et al. No survival benefit to gaining private health insurance coverage for post-lung transplant care in adults with cystic fibrosis. Clin Transplant. 2016;30(3):320–327.
   PubMed Web of Science ®Google Scholar
• Diamond JM, Arcasoy S, Kennedy CC, et al. Report of the International Society for Heart and Lung Transplantation Working Group on Primary Lung Graft Dysfunction, part ii: epidemiology, risk factors, and outcomes-a 2016 Consensus Group statement of the International Society for Heart and Lung Transplantation. J Heart Lung Transplant. 2017;36(10):1104–1113.
   PubMed Web of Science ®Google Scholar
• Thabut G, Vinatier I, Stern JB, et al. Primary graft failure following lung transplantation: predictive factors of mortality. Chest. 2002;121(6):1876–1882.
   PubMed Web of Science ®Google Scholar
• Felten ML, Sinaceur M, Treilhaud M, et al. Factors associated with early graft dysfunction in cystic fibrosis patients receiving primary bilateral lung transplantation. Eur J Cardiothorac Surg. 2012;41(3):686–690.
   PubMed Web of Science ®Google Scholar
• Strueber M, Fischer S, Gottlieb J, et al. Long-term outcome after pulmonary retransplantation. J Thorac Cardiovasc Surg. 2006;132(2):407–412.
   PubMed Web of Science ®Google Scholar
• Whitson BA, Nath DS, Johnson AC, et al. Risk factors for primary graft dysfunction after lung transplantation. J Thorac Cardiovasc Surg. 2006;131(1):73–80.
   PubMed Web of Science ®Google Scholar
• Diamond JM, Lee JC, Kawut SM, et al. Clinical risk factors for primary graft dysfunction after lung transplantation. Am J Respir Crit Care Med. 2013;187(5):527–534.
   PubMed Web of Science ®Google Scholar
• Li JW, Xu L, Han ZJ, et al. [Logistic regression analysis of risk factors for primary graft dysfunction after lung transplantation]. Zhonghua Yi Xue Za Zhi. 2018;98(19):1503–1506.
   PubMedGoogle Scholar
• Hayes D Jr., Tumin D, Kopp BT, et al. Influence of graft ischemic time on survival in children with cystic fibrosis after lung transplantation. Pediatr Pulmonol. 2016;51(9):908–913.
   PubMed Web of Science ®Google Scholar
• Grimm JC, Valero V 3rd, Kilic A, et al. Association between prolonged graft ischemia and primary graft failure or survival following lung transplantation. JAMA Surg. 2015;150(6):547–553.
   PubMed Web of Science ®Google Scholar
• Warnecke G, Sommer SP, Gohrbandt B, et al. Warm or cold ischemia in animal models of lung ischemia-reperfusion injury: is there a difference? Thorac Cardiovasc Surg. 2004;52(3):174–179.
   PubMed Web of Science ®Google Scholar
• Martinu T, Chen DF, Palmer SM. Acute rejection and humoral sensitization in lung transplant recipients. Proc Am Thorac Soc. 2009;6(1):54–65.
   PubMedGoogle Scholar
• Yusen RD, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: thirty-second official adult lung and heart-lung transplantation report–2015; Focus theme: early graft failure. J Heart Lung Transplant. 2015;34(10):1264–1277.
   PubMedGoogle Scholar
• Goldfarb SB, Benden C, Edwards LB, et al. The Registry of the International Society for Heart and Lung Transplantation: eighteenth official pediatric lung and heart-lung transplantation report–2015; Focus theme: early graft failure. J Heart Lung Transplant. 2015;34(10):1255–1263.
   PubMedGoogle Scholar
• Hirche TO, Knoop C, Hebestreit H, et al. Practical guidelines: lung transplantation in patients with cystic fibrosis. Pulm Med. 2014;2014:621342.
   PubMedGoogle Scholar
• Kugler C, Fischer S, Gottlieb J, et al. Health-related quality of life in two hundred-eighty lung transplant recipients. J Heart Lung Transplant. 2005;24(12):2262–2268.
   PubMed Web of Science ®Google Scholar
• Calabrese F, Lunardi F, Nannini N, et al. Higher risk of acute cellular rejection in lung transplant recipients with cystic fibrosis. Ann Transplant. 2015;20:769–776.
   PubMed Web of Science ®Google Scholar
• Chambers DC, Yusen RD, Cherikh WS, et al. The Registry of the International Society for Heart and Lung Transplantation: thirty-fourth adult lung and heart-lung transplantation report-2017; Focus theme: allograft ischemic time. J Heart Lung Transplant. 2017;36(10):1047–1059.
   PubMed Web of Science ®Google Scholar
• Christie JD, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: twenty-seventh official adult lung and heart-lung transplant report–2010. J Heart Lung Transplant. 2010;29(10):1104–1118.
   PubMed Web of Science ®Google Scholar
• Hadjiliadis D. Special considerations for patients with cystic fibrosis undergoing lung transplantation. Chest. 2007;131(4):1224–1231.
   PubMed Web of Science ®Google Scholar
• Tan KK, Trull AK, Hue KL, et al. Pharmacokinetics of cyclosporine in heart and lung transplant candidates and recipients with cystic fibrosis and Eisenmenger’s syndrome. Clin Pharmacol Ther. 1993;53(5):544–554.
   PubMed Web of Science ®Google Scholar
• Kumar D, Husain S, Chen MH, et al. A prospective molecular surveillance study evaluating the clinical impact of community-acquired respiratory viruses in lung transplant recipients. Transplantation. 2010;89(8):1028–1033.
   PubMed Web of Science ®Google Scholar
• Verleden GM, Raghu G, Meyer KC, et al. A new classification system for chronic lung allograft dysfunction. J Heart Lung Transplant. 2014;33(2):127–133.
   PubMed Web of Science ®Google Scholar
• Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: an update of the diagnostic criteria. J Heart Lung Transplant. 2002;21(3):297–310.
   PubMed Web of Science ®Google Scholar
• Christie JD, Edwards LB, Kucheryavaya AY, et al. The Registry of the International Society for Heart and Lung Transplantation: 29th adult lung and heart-lung transplant report-2012. J Heart Lung Transplant. 2012;31(10):1073–1086.
   PubMed Web of Science ®Google Scholar
• Bando K, Paradis IL, Similo S, et al. Obliterative bronchiolitis after lung and heart-lung transplantation. An analysis of risk factors and management. J Thorac Cardiovasc Surg. 1995;110(1):4–13; discussion 13–14.
   PubMed Web of Science ®Google Scholar
• Burton CM, Carlsen J, Mortensen J, et al. Long-term survival after lung transplantation depends on development and severity of bronchiolitis obliterans syndrome. J Heart Lung Transplant. 2007;26(7):681–686.
   PubMed Web of Science ®Google Scholar
• Husain AN, Siddiqui MT, Holmes EW, et al. Analysis of risk factors for the development of bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 1999;159(3):829–833.
   PubMed Web of Science ®Google Scholar
• Hachem RR. Humoral responses after lung transplantation. Curr Opin Organ Transplant. 2016;21(3):267–271.
   PubMed Web of Science ®Google Scholar
• Daud SA, Yusen RD, Meyers BF, et al. Impact of immediate primary lung allograft dysfunction on bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2007;175(5):507–513.
   PubMed Web of Science ®Google Scholar
• Gregson AL, Wang X, Weigt SS, et al. Interaction between Pseudomonas and CXC chemokines increases risk of bronchiolitis obliterans syndrome and death in lung transplantation. Am J Respir Crit Care Med. 2013;187(5):518–526.
   PubMed Web of Science ®Google Scholar
• Weigt SS, Elashoff RM, Huang C, et al. Aspergillus colonization of the lung allograft is a risk factor for bronchiolitis obliterans syndrome. Am J Transplant. 2009;9(8):1903–1911.
   PubMed Web of Science ®Google Scholar
• Snyder LD, Finlen-Copeland CA, Turbyfill WJ, et al. Cytomegalovirus pneumonitis is a risk for bronchiolitis obliterans syndrome in lung transplantation. Am J Respir Crit Care Med. 2010;181(12):1391–1396.
   PubMed Web of Science ®Google Scholar
• Dickson RP, Erb-Downward JR, Freeman CM, et al. Changes in the lung microbiome following lung transplantation include the emergence of two distinct Pseudomonas species with distinct clinical associations. PLoS One. 2014;9(5):e97214.
   PubMed Web of Science ®Google Scholar
• Yates B, Murphy DM, Forrest IA, et al. Azithromycin reverses airflow obstruction in established bronchiolitis obliterans syndrome. Am J Respir Crit Care Med. 2005;172(6):772–775.
   PubMed Web of Science ®Google Scholar
• Vos R, Vanaudenaerde BM, Verleden SE, et al. A randomised controlled trial of azithromycin to prevent chronic rejection after lung transplantation. Eur Respir J. 2011;37(1):164–172.
   PubMed Web of Science ®Google Scholar
• Kunsebeck HW, Kugler C, Fischer S, et al. Quality of life and bronchiolitis obliterans syndrome in patients after lung transplantation. Prog Transplant. 2007;17(2):136–141.
   PubMedGoogle Scholar
• Baskaran G, Tiriveedhi V, Ramachandran S, et al. Efficacy of extracorporeal photopheresis in clearance of antibodies to donor-specific and lung-specific antigens in lung transplant recipients. J Heart Lung Transplant. 2014;33(9):950–956.
   PubMed Web of Science ®Google Scholar
• Del Fante C, Scudeller L, Oggionni T, et al. Long-term off-line extracorporeal photochemotherapy in patients with chronic lung allograft rejection not responsive to conventional treatment: a 10-year single-centre analysis. Respiration. 2015;90(2):118–128.
   PubMed Web of Science ®Google Scholar
• Isenring B, Robinson C, Buergi U, et al. Lung transplant recipients on long-term extracorporeal photopheresis. Clin Transplant. 2017;31(10):e13041.
   Web of Science ®Google Scholar
• van Den BJ, Geertsma A, van Der BW, et al. Bronchiolitis obliterans syndrome after lung transplantation and health-related quality of life. Am J Respir Crit Care Med. 2000;161(6):1937–1941.
   PubMed Web of Science ®Google Scholar
• Kanj SS, Tapson V, Davis RD, et al. Infections in patients with cystic fibrosis following lung transplantation. Chest. 1997;112(4):924–930.
   PubMed Web of Science ®Google Scholar
• Nash EF, Coonar A, Kremer R, et al. Survival of Burkholderia cepacia sepsis following lung transplantation in recipients with cystic fibrosis. Transpl Infect Dis. 2010;12(6):551–554.
   PubMed Web of Science ®Google Scholar
• Stephenson AL, Sykes J, Berthiaume Y, et al. Clinical and demographic factors associated with post-lung transplantation survival in individuals with cystic fibrosis. J Heart Lung Transplant. 2015;34(9):1139–1145.
   PubMed Web of Science ®Google Scholar
• Boussaud V, Guillemain R, Grenet D, et al. Clinical outcome following lung transplantation in patients with cystic fibrosis colonised with Burkholderia cepacia complex: results from two French centres. Thorax. 2008;63(8):732–737.
   PubMed Web of Science ®Google Scholar
• Ramos KJ, Quon BS, Heltshe SL, et al. Heterogeneity in survival in adult patients with cystic fibrosis with FEV1 < 30% of predicted in the United States. Chest. 2017;151(6):1320–1328.
   PubMed Web of Science ®Google Scholar
• Zamora MR. Cytomegalovirus and lung transplantation. Am J Transplant. 2004;4(8):1219–1226.
   PubMed Web of Science ®Google Scholar
• Pereyra F, Rubin RH. Prevention and treatment of cytomegalovirus infection in solid organ transplant recipients. Curr Opin Infect Dis. 2004;17(4):357–361.
   PubMed Web of Science ®Google Scholar
• Kotton CN, Kumar D, Caliendo AM, et al. Updated international consensus guidelines on the management of cytomegalovirus in solid-organ transplantation. Transplantation. 2013;96(4):333–360.
   PubMed Web of Science ®Google Scholar
• Hopkins P, McNeil K, Kermeen F, et al. Human metapneumovirus in lung transplant recipients and comparison to respiratory syncytial virus. Am J Respir Crit Care Med. 2008;178(8):876–881.
   PubMed Web of Science ®Google Scholar
• Gottlieb J, Zamora MR, Hodges T, et al. ALN-RSV01 for prevention of bronchiolitis obliterans syndrome after respiratory syncytial virus infection in lung transplant recipients. J Heart Lung Transplant. 2016;35(2):213–221.
   PubMed Web of Science ®Google Scholar
• Burke DG, Harrison MJ, Fleming C, et al. Clostridium difficile carriage in adult cystic fibrosis (CF); implications for patients with CF and the potential for transmission of nosocomial infection. J Cyst Fibros. 2017;16(2):291–298.
   PubMed Web of Science ®Google Scholar
• Theunissen C, Knoop C, Nonhoff C, et al. Clostridium difficile colitis in cystic fibrosis patients with and without lung transplantation. Transpl Infect Dis. 2008;10(4):240–244.
   PubMed Web of Science ®Google Scholar
• Rosen JB, Schecter MG, Heinle JS, et al. Clostridium difficile colitis in children following lung transplantation. Pediatr Transplant. 2010;14(5):651–656.
   PubMed Web of Science ®Google Scholar
• Lee JT, Hertz MI, Dunitz JM, et al. The rise of Clostridium difficile infection in lung transplant recipients in the modern era. Clin Transplant. 2013;27(2):303–310.
   PubMed Web of Science ®Google Scholar
• Yates B, Murphy DM, Fisher AJ, et al. Pseudomembranous colitis in four patients with cystic fibrosis following lung transplantation. Thorax. 2007;62(6):554–556.
   PubMed Web of Science ®Google Scholar
• Fink AK, Yanik EL, Marshall BC, et al. Cancer risk among lung transplant recipients with cystic fibrosis. J Cyst Fibros. 2017;16(1):91–97.
   PubMed Web of Science ®Google Scholar
• Maisonneuve P, FitzSimmons SC, Neglia JP, et al. Cancer risk in nontransplanted and transplanted cystic fibrosis patients: a 10-year study. J Natl Cancer Inst. 2003;95(5):381–387.
   PubMedGoogle Scholar
• Neoh CF, Snell GI, Levvey B, et al. Lung transplant recipients receiving voriconazole and skin squamous cell carcinoma risk in Australia. Med J Aust. 2014;201(9):543–544.
   PubMed Web of Science ®Google Scholar
• Lindelof B, Jarnvik J, Ternesten-Bratel A, et al. Mortality and clinicopathological features of cutaneous squamous cell carcinoma in organ transplant recipients: a study of the Swedish cohort. Acta Derm Venereol. 2006;86(3):219–222.
   PubMed Web of Science ®Google Scholar
• Than BLN, Linnekamp JF, Starr TK, et al. CFTR is a tumor suppressor gene in murine and human intestinal cancer. Oncogene. 2017;36:3504, England
   PubMed Web of Science ®Google Scholar
• Ahn J, Sinha R, Pei Z, et al. Human gut microbiome and risk for colorectal cancer. J Natl Cancer Inst. 2013;105(24):1907–1911.
   PubMedGoogle Scholar
• Frey NV, Tsai DE. The management of posttransplant lymphoproliferative disorder. Med Oncol. 2007;24(2):125–136.
   PubMed Web of Science ®Google Scholar
• Lowery EM, Adams W, Grim SA, et al. Increased risk of PTLD in lung transplant recipients with cystic fibrosis. J Cyst Fibros. 2017;16(6):727–734.
   PubMed Web of Science ®Google Scholar
• Mendez BM, Davis CS, Weber C, et al. Gastroesophageal reflux disease in lung transplant patients with cystic fibrosis. Am J Surg. 2012;204(5):e21–26.
   PubMed Web of Science ®Google Scholar
• Blondeau K, Dupont LJ, Mertens V, et al. Gastro-oesophageal reflux and aspiration of gastric contents in adult patients with cystic fibrosis. Gut. 2008;57(8):1049–1055.
   PubMed Web of Science ®Google Scholar
• Hartwig MG, Anderson DJ, Onaitis MW, et al. Fundoplication after lung transplantation prevents the allograft dysfunction associated with reflux. Ann Thorac Surg. 2011;92(2):462–468; discussion; 468–469.
   PubMed Web of Science ®Google Scholar
• Hoppo T, Jarido V, Pennathur A, et al. Antireflux surgery preserves lung function in patients with gastroesophageal reflux disease and end-stage lung disease before and after lung transplantation. Arch Surg. 2011;146(9):1041–1047.
   PubMedGoogle Scholar
• Fisichella PM, Davis CS, Gagermeier J, et al. Laparoscopic antireflux surgery for gastroesophageal reflux disease after lung transplantation. J Surg Res. 2011;170(2):e279–286.
   PubMed Web of Science ®Google Scholar
• Mertens V, Dupont L, Sifrim D. Relevance of GERD in lung transplant patients. Curr Gastroenterol Rep. 2010;12(3):160–166.
   PubMedGoogle Scholar
• Hadjiliadis D, Steele MP, Chaparro C, et al. Survival of lung transplant patients with cystic fibrosis harboring panresistant bacteria other than Burkholderia cepacia, compared with patients harboring sensitive bacteria. J Heart Lung Transplant. 2007;26(8):834–838.
   PubMed Web of Science ®Google Scholar
• Hofer M, Schmid C, Benden C, et al. Diabetes mellitus and survival in cystic fibrosis patients after lung transplantation. J Cyst Fibros. 2012;11(2):131–136.
   PubMed Web of Science ®Google Scholar
• Hackman KL, Bailey MJ, Snell GI, et al. Diabetes is a major risk factor for mortality after lung transplantation. Am J Transplant. 2014;14(2):438–445.
   PubMed Web of Science ®Google Scholar
• Milla CE, Warwick WJ, Moran A. Trends in pulmonary function in patients with cystic fibrosis correlate with the degree of glucose intolerance at baseline. Am J Respir Crit Care Med. 2000;162(3 Pt 1):891–895.
   PubMed Web of Science ®Google Scholar
• Quon BS, Mayer-Hamblett N, Aitken ML, et al. Risk of post-lung transplant renal dysfunction in adults with cystic fibrosis. Chest. 2012;142(1):185–191.
   PubMed Web of Science ®Google Scholar
• Hmiel SP, Beck AM, de la Morena MT, et al. Progressive chronic kidney disease after pediatric lung transplantation. Am J Transplant. 2005;5(7):1739–1747.
   PubMed Web of Science ®Google Scholar
• Banga A, Mohanka M, Mullins J, et al. Characteristics and outcomes among patients with need for early dialysis after lung transplantation surgery. Clin Transplant. 2017;31(11):e13106.
   Web of Science ®Google Scholar
• Broekroelofs J, Navis GJ, Stegeman CA, et al. Long-term renal outcome after lung transplantation is predicted by the 1-month postoperative renal function loss. Transplantation. 2000;69(8):1624–1628.
   PubMed Web of Science ®Google Scholar
• Aris RM, Neuringer IP, Weiner MA, et al. Severe osteoporosis before and after lung transplantation. Chest. 1996;109(5):1176–1183.
   PubMed Web of Science ®Google Scholar
• Aris RM, Lester GE, Renner JB, et al. Efficacy of pamidronate for osteoporosis in patients with cystic fibrosis following lung transplantation. Am J Respir Crit Care Med. 2000;162(3 Pt 1):941–946.
   PubMed Web of Science ®Google Scholar
• Gore AP, Kwon SH, Stenbit AE. A roadmap to the brittle bones of cystic fibrosis. J Osteoporos. 2010;2011:926045.
   PubMedGoogle Scholar
• Aris RM, Renner JB, Winders AD, et al. Increased rate of fractures and severe kyphosis: sequelae of living into adulthood with cystic fibrosis. Ann Intern Med. 1998;128(3):186–193.
   PubMed Web of Science ®Google Scholar
• Nunley DR, Grgurich W, Iacono AT, et al. Allograft colonization and infections with pseudomonas in cystic fibrosis lung transplant recipients. Chest. 1998;113(5):1235–1243.
   PubMed Web of Science ®Google Scholar
• Leung MK, Rachakonda L, Weill D, et al. Effects of sinus surgery on lung transplantation outcomes in cystic fibrosis. Am J Rhinol. 2008;22(2):192–196.
   PubMedGoogle Scholar
• Holzmann D, Speich R, Kaufmann T, et al. Effects of sinus surgery in patients with cystic fibrosis after lung transplantation: a 10-year experience. Transplantation. 2004;77(1):134–136.
   PubMed Web of Science ®Google Scholar
• Vital D, Hofer M, Boehler A, et al. Posttransplant sinus surgery in lung transplant recipients with cystic fibrosis: a single institutional experience. Eur Arch Otorhinolaryngol. 2013;270(1):135–139.
   PubMed Web of Science ®Google Scholar
• Seiler A, Klaghofer R, Ture M, et al. A systematic review of health-related quality of life and psychological outcomes after lung transplantation. J Heart Lung Transplant. 2016;35(2):195–202.
   PubMed Web of Science ®Google Scholar
• Sermet-Gaudelus I, De Villartay P, de Dreuzy P, et al. Pain in children and adults with cystic fibrosis: a comparative study. J Pain Symptom Manage. 2009;38(2):281–290.
   PubMed Web of Science ®Google Scholar
• Hayes M, Yaster M, Haythornthwaite JA, et al. Pain is a common problem affecting clinical outcomes in adults with cystic fibrosis. Chest. 2011;140(6):1598–1603.
   PubMed Web of Science ®Google Scholar
• Lechtzin N, Allgood S, Hong G, et al. The association between pain and clinical outcomes in adolescents with cystic fibrosis. J Pain Symptom Manage. 2016;52(5):681–687.
   PubMed Web of Science ®Google Scholar
• Forsberg A, Claeson M, Dahlman GB, et al. Pain, fatigue and well-being one to five years after lung transplantation - a nationwide cross-sectional study. Scand J Caring Sci. 2018;32:971-978.
   Web of Science ®Google Scholar
• Ravilly S, Robinson W, Suresh S, et al. Chronic pain in cystic fibrosis. Pediatrics. 1996;98(4 Pt 1):741–747.
   PubMed Web of Science ®Google Scholar
• Konstan MW, Byard PJ, Hoppel CL, et al. Effect of high-dose ibuprofen in patients with cystic fibrosis. N Engl J Med. 1995;332(13):848–854.
   PubMed Web of Science ®Google Scholar
• Colman R, Singer LG, Barua R, et al. Outcomes of lung transplant candidates referred for co-management by palliative care: a retrospective case series. Palliat Med. 2015;29(5):429–435.
   PubMed Web of Science ®Google Scholar
• Colman RE, Curtis JR, Nelson JE, et al. Barriers to optimal palliative care of lung transplant candidates. Chest. 2013;143(3):736–743.
   PubMed Web of Science ®Google Scholar
• Abbott J, Hart A, Morton AM, et al. Can health-related quality of life predict survival in adults with cystic fibrosis? Am J Respir Crit Care Med. 2009;179(1):54–58.
   PubMed Web of Science ®Google Scholar
• Hogg M, Braithwaite M, Bailey M, et al. Work disability in adults with cystic fibrosis and its relationship to quality of life. J Cyst Fibros. 2007;6(3):223–227.
   PubMed Web of Science ®Google Scholar
• Cicutto L, Braidy C, Moloney S, et al. Factors affecting attainment of paid employment after lung transplantation. J Heart Lung Transplant. 2004;23(4):481–486.
   PubMed Web of Science ®Google Scholar
• Krivchenia K, Hayes D Jr., Tobias JD, et al. Long-term work participation among cystic fibrosis patients undergoing lung transplantation. J Cyst Fibros. 2016;15(6):846–849.
   PubMed Web of Science ®Google Scholar
• Swatek AM, Lynch TJ, Crooke AK, et al. Depletion of airway submucosal glands and TP63(+)KRT5(+) basal cells in obliterative bronchiolitis. Am J Respir Crit Care Med. 2018;197(8):1045–1057.
   PubMed Web of Science ®Google Scholar