Obstructive sleep apnoea and comorbidity – an overview of the association and impact of continuous positive airway pressure therapy

References

• Levy P, Kohler M, McNicholas WT, et al. Obstructive sleep apnoea syndrome. Nat Rev Dis Primers. 2015;1:1–20.
   Web of Science ®Google Scholar
• Young T, Palta M, Dempsey J, et al. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328(17):1230–1235.
   PubMed Web of Science ®Google Scholar
• Heinzer R, Vat S, Marques-Vidal P, et al. Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study. Lancet Respir Med. 2015;3(4):310–318.
   PubMed Web of Science ®Google Scholar
• Mokhlesi B, Ham SA, Gozal D. The effect of sex and age on the comorbidity burden of OSA: an observational analysis from a large nationwide US health claims database. Eur Respir J. 2016;47(4):1162–1169.
   PubMed Web of Science ®Google Scholar
• Molnar MZ, Mucsi I, Novak M, et al. Association of incident obstructive sleep apnea with outcomes in a large cohort of US Veterans. Thorax. 2015;70(9):888–895.
   PubMed Web of Science ®Google Scholar
• McEvoy RD, Antic NA, Heeley E, et al. CPAP for prevention of cardiovascular events in obstructive sleep apnea. N Engl J Med. 2016;375(10):919–931.
   PubMed Web of Science ®Google Scholar
• Jennum P, Tønnesen P, Ibsen R, et al. Obstructive sleep apnea: effect of comorbidities and positive airway pressure on all-cause mortality. Sleep Med. 2017;36:62–66.
   PubMed Web of Science ®Google Scholar
• Castro-Grattoni AL, Alvarez-Buvé R, Torres M, et al. Intermittent hypoxia-induced cardiovascular remodeling is reversed by normoxia in a mouse model of sleep apnea. Chest. 2016;149(6):1400–1408.
   PubMed Web of Science ®Google Scholar
• Lavie L. Oxidative stress in obstructive sleep apnea and intermittent hypoxia–revisited–the bad ugly and good: implications to the heart and brain. Sleep Med Rev. 2015;20:27–45.
   PubMed Web of Science ®Google Scholar
• Garvey JF, Taylor CT, McNicholas WT. Cardiovascular disease in obstructive sleep apnoea syndrome: the role of intermittent hypoxia and inflammation. Eur Respir J. 2009;33(5):1195–1205.
   PubMed Web of Science ®Google Scholar
• Vgontzas AN, Gaines J, Ryan S, et al. CrossTalk proposal: metabolic syndrome causes sleep apnoea. J Physiol. 2016;594(17):4687–4690.
   PubMed Web of Science ®Google Scholar
• Deegan PC, McNicholas WT. Pathophysiology of obstructive sleep apnoea. Eur Respir J. 1995;8(7):1161–1178.
   PubMed Web of Science ®Google Scholar
• Crinion SJ, Ryan S, McNicholas WT. Obstructive sleep apnoea as a cause of nocturnal nondipping blood pressure: recent evidence regarding clinical importance and underlying mechanisms. Eur Respir J. 2017;49(1):1601818.
   PubMed Web of Science ®Google Scholar
• Ryan S, Taylor CT, McNicholas WT. Selective activation of inflammatory pathways by intermittent hypoxia in obstructive sleep apnea syndrome. Circulation. 2005;112:2660–2667.
   PubMed Web of Science ®Google Scholar
• Hoyos CM, Melehan KL, Liu PY, et al. Does obstructive sleep apnea cause endothelial dysfunction? A critical review of the literature. Sleep Med Rev. 2015;20:15–26.
   PubMed Web of Science ®Google Scholar
• Calvin AD, McKenna M, Borges ÁH, et al. Experimental sleep restriction causes endothelial dysfunction in healthy humans. J Am Heart Assoc. 2014;3(6):e001143.
   PubMed Web of Science ®Google Scholar
• Hoyos CM, Drager LF, Patel SR. OSA and cardiometabolic risk: what’s the bottom line? Respirology. 2017;22(3):420–429.
   PubMed Web of Science ®Google Scholar
• Heinzer R, Marti-Soler H, Haba-Rubio J. Prevalence of sleep apnoea syndrome in the middle to old age general population. Lancet Respir Med. 2016;4(2):e5–e6.
   PubMedGoogle Scholar
• Murphy AM, Thomas A, Crinion SJ, et al. Intermittent hypoxia in obstructive sleep apnoea mediates insulin resistance through adipose tissue inflammation. Eur Respir J. 2017;49(4):1601731.
   PubMed Web of Science ®Google Scholar
• White LH, Bradley TD. Role of nocturnal rostral fluid shift in the pathogenesis of obstructive and central sleep apnoea. J Physiol. 2013;591(Pt 5):1179–1193.
   PubMed Web of Science ®Google Scholar
• Sharma S, Culebras A. Sleep apnoea and stroke. Stroke Vasc Neurol. 2016;1(4):185–191.
   PubMedGoogle Scholar
• Mims KN, Kirsch D. Sleep and stroke. Sleep Med Clin. 2016;11(1):39–51.
   PubMed Web of Science ®Google Scholar
• Huang T, Lin BM, Stampfer MJ, et al. A population-based study of the bidirectional association between obstructive sleep apnea and type 2 diabetes in three prospective U.S. cohorts. Diabetes Care. 2018;41(10):2111–2119.
   PubMed Web of Science ®Google Scholar
• McNicholas WT, Bonsignore MR, Bonsignore MR. Sleep apnoea as an independent risk factor for cardiovascular disease: current evidence, basic mechanisms and research priorities. Eur Respir J. 2007;29(1):156–178.
   PubMed Web of Science ®Google Scholar
• Dong J-Y, Zhang Y-H, Qin L-Q. Obstructive sleep apnea and cardiovascular risk: meta-analysis of prospective cohort studies. Atherosclerosis. 2013;229(2):489–495.
   PubMed Web of Science ®Google Scholar
• Jenner R, Fatureto-Borges F, Costa-Hong V, et al. Association of obstructive sleep apnea with arterial stiffness and nondipping blood pressure in patients with hypertension. J Clin Hypertens. 2017;19(9):910–918.
   Web of Science ®Google Scholar
• Parati G, Lombardi C, Hedner J, et al. Recommendations for the management of patients with obstructive sleep apnoea and hypertension. Eur Respir J. 2013;41(3):523–538.
   PubMed Web of Science ®Google Scholar
• Ryan S, Ward S, Heneghan C, et al. Predictors of decreased spontaneous baroreflex sensitivity in obstructive sleep apnea syndrome. Chest. 2007;131(4):1100–1107.
   PubMed Web of Science ®Google Scholar
• Zalucky AA, Nicholl DDM, Hanly PJ, et al. Nocturnal hypoxemia severity and renin–angiotensin system activity in obstructive sleep apnea. Am J Respir Crit Care Med. 2015;192(7):873–880.
   PubMed Web of Science ®Google Scholar
• Linz D, McEvoy RD, Cowie MR, et al. Associations of obstructive sleep apnea with atrial fibrillation and continuous positive airway pressure treatment: A review. JAMA Cardiol. 2018;3(6):532–540.
   PubMed Web of Science ®Google Scholar
• Heneghan C, Chua C-P, Garvey JF, et al. A portable automated assessment tool for sleep apnea using a combined holter-oximeter. Sleep. 2008;31(10):1432–1439.
   PubMed Web of Science ®Google Scholar
• Grasso I, Haigney M, Mortara D, et al. Detection of sleep-disordered breathing with ambulatory Holter monitoring. Sleep Breathing. 2018;22:1021–1028.
   PubMed Web of Science ®Google Scholar
• Iwasaki Y-K, Kato T, Xiong F, et al. Atrial fibrillation promotion with long-term repetitive obstructive sleep apnea in a rat model. J Am Coll Cardiol. 2014;64(19):2013–2023.
   PubMed Web of Science ®Google Scholar
• May AM, Van Wagoner DR, Mehra R. OSA and cardiac arrhythmogenesis: mechanistic insights. Chest. 2017;151(1):225–241.
   PubMed Web of Science ®Google Scholar
• Castro-Grattoni AL, Wedzicha JA, Iversen M, et al. Blood pressure response to CPAP treatment in subjects with obstructive sleep apnoea: the predictive value of 24-h ambulatory blood pressure monitoring. Eur Respir J. 2017;50(4).
   PubMed Web of Science ®Google Scholar
• Tung P, Levitzky YS, Wang R, et al. Obstructive and central sleep apnea and the risk of incident atrial fibrillation in a community cohort of men and women. J Am Heart Assoc. 2017;6(7):e004500.
   PubMed Web of Science ®Google Scholar
• Patel NJ, Wells QS, Huang S, et al. Relation of obstructive sleep apnea and a common variant at chromosome 4q25 to atrial fibrillation. Am J Cardiol. 2017;119(9):1387–1391.
   PubMed Web of Science ®Google Scholar
• Kent BD, Garvey JF, Ryan S, et al. Severity of obstructive sleep apnoea predicts coronary artery plaque burden: a coronary computed tomographic angiography study. Eur Respir J. 2013;42(5):1263–1270.
   PubMed Web of Science ®Google Scholar
• Gottlieb DJ, Yenokyan G, Newman AB, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure. Circulation. 2010;122(4):352–360.
   PubMed Web of Science ®Google Scholar
• Javaheri S, Sharma RK, Wang R, et al. Association between obstructive sleep apnea and left ventricular structure by age and gender: the multi-ethnic study of atherosclerosis. Sleep. 2016;39(3):523–529.
   PubMed Web of Science ®Google Scholar
• Xie J, Sert Kuniyoshi FH, Covassin N, et al. Nocturnal hypoxemia due to obstructive sleep apnea is an independent predictor of poor prognosis after myocardial infarction. J Am Heart Assoc. 2016;5(8):e003162.
   PubMed Web of Science ®Google Scholar
• Leão S, Conde B, Fontes P, et al. Effect of obstructive sleep apnea in acute coronary syndrome. Am J Cardiol. 2016;117(7):1084–1087.
   PubMed Web of Science ®Google Scholar
• Roca GQ, Redline S, Claggett B, et al. Sex-specific association of sleep apnea severity with subclinical myocardial injury, ventricular hypertrophy, and heart failure risk in a community dwelling cohort: the atherosclerosis risk in communities-sleep heart health study. Circulation. 2015;132(14):1329–1337.
   PubMed Web of Science ®Google Scholar
• Campos-Rodriguez F, Martinez-Garcia MA, Reyes-Nuñez N, et al. Role of sleep apnea and continuous positive airway pressure therapy in the incidence of stroke or coronary heart disease in women. Am J Respir Crit Care Med. 2014;189(12):1544–1550.
   PubMed Web of Science ®Google Scholar
• Marin JM, Carrizo S, Vicente E, et al. Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet. 2005;365(9464):1046–1053.
   PubMed Web of Science ®Google Scholar
• Doherty LS, Kiely JL, Swan V, et al. Long-term effects of nasal continuous positive airway pressure therapy on cardiovascular outcomes in sleep apnea syndrome*. Chest. 2005;127(6):2076–2084.
   PubMed Web of Science ®Google Scholar
• Martínez-García M-A, Campos-Rodríguez F, Catalán-Serra P, et al. Cardiovascular mortality in obstructive sleep apnea in the elderly: role of long-term continuous positive airway pressure treatment. Am J Respir Crit Care Med. 2012;186(9):909–916.
   PubMed Web of Science ®Google Scholar
• Qureshi WT, Nasir UB, Alqalyoobi S, et al. Meta-analysis of continuous positive airway pressure as a therapy of atrial fibrillation in obstructive sleep apnea. Am J Cardiol. 2015;116(11):1767–1773.
   PubMed Web of Science ®Google Scholar
• Becker HF, Jerrentrup A, Ploch T, et al. Effect of nasal continuous positive airway pressure treatment on blood pressure in patients with obstructive sleep apnea. Circulation. 2003;107(1):68–73.
   PubMed Web of Science ®Google Scholar
• Pepperell JCT, Ramdassingh-Dow S, Crosthwaite N, et al. Ambulatory blood pressure after therapeutic and subtherapeutic nasal continuous positive airway pressure for obstructive sleep apnoea: a randomised parallel trial. Lancet. 2002;359(9302):204–210.
   PubMed Web of Science ®Google Scholar
• Martínez-García M, Capote F, Campos-Rodríguez F, et al. Effect of cpap on blood pressure in patients with obstructive sleep apnea and resistant hypertension: the hiparco randomized clinical trial. JAMA. 2013;310(22):2407–2415.
   PubMed Web of Science ®Google Scholar
• Sapiña-Beltrán E, Santamaria-Martos F, Benítez I, et al. Normotensive patients with obstructive sleep apnoea: changes in 24-h ambulatory blood pressure monitoring with continuous positive airway pressure treatment. J Hypertens. 2018. (Publish Ahead of Print, SEP 2018).
   PubMedGoogle Scholar
• Korcarz CE, Benca R, Barnet JH, et al. Treatment of obstructive sleep apnea in young and middle‐aged adults: effects of positive airway pressure and compliance on arterial stiffness, endothelial function, and cardiac hemodynamics. J Am Heart Assoc. 2016;5(4):e002930.
   PubMed Web of Science ®Google Scholar
• Peker Y, Glantz H, Eulenburg C, et al. Effect of positive airway pressure on cardiovascular outcomes in coronary artery disease patients with nonsleepy obstructive sleep apnea. the riccadsa randomized controlled trial. Am J Respir Crit Care Med. 2016;194(5):613–620.
   PubMed Web of Science ®Google Scholar
• McNicholas WT. Continuous positive airway pressure therapy and cardiovascular outcomes in obstructive sleep apnoea syndrome: where are we now? J Thorac Dis. 2016;8(12):E1644–E1646.
   PubMed Web of Science ®Google Scholar
• Abuzaid AS, Ashry HS, Elbawadi A, et al. Meta-analysis of cardiovascular outcomes with continuous positive airway pressure therapy in patients with obstructive sleep apnea. Am J Cardiol. 2017;120(4):693–699.
   PubMed Web of Science ®Google Scholar
• Kent BD, McNicholas WT, Ryan S. Insulin resistance, glucose intolerance and diabetes mellitus in obstructive sleep apnoea. J Thorac Dis. 2015;7(8):1343–1357.
   PubMed Web of Science ®Google Scholar
• Reutrakul S, Mokhlesi B. Obstructive sleep apnea and diabetes: a state of the art review. Chest. 2017;152(5):1070–1086.
   PubMed Web of Science ®Google Scholar
• Reutrakul S, Thakkinstian A, Anothaisintawee T, et al. Sleep characteristics in type 1 diabetes and associations with glycemic control: systematic review and meta-analysis. Sleep Med. 2016;23:26–45.
   PubMed Web of Science ®Google Scholar
• Reichmuth KJ, Austin D, Skatrud JB, et al. Association of sleep apnea and type II diabetes. Am J Respir Crit Care Med. 2005;172(12):1590–1595.
   PubMed Web of Science ®Google Scholar
• Kent BD, Grote L, Ryan S, et al. Diabetes mellitus prevalence and control in sleep-disordered breathing: the European sleep apnea cohort (ESADA) study. Chest. 2014;146(4):982–990.
   PubMed Web of Science ®Google Scholar
• Kent BD, Grote L, Bonsignore MR, et al. Sleep apnoea severity independently predicts glycaemic health in nondiabetic subjects: the ESADA study. Eur Respir J. 2014;44(1):130–139.
   PubMed Web of Science ®Google Scholar
• Meslier N, Gagnadoux F, Giraud P, et al. Impaired glucose-insulin metabolism in males with obstructive sleep apnoea syndrome. Eur Respir J. 2003;22(1):156–160.
   PubMed Web of Science ®Google Scholar
• Ronksley PE, Hemmelgarn BR, Heitman SJ, et al. Obstructive sleep apnoea is associated with diabetes in sleepy subjects. Thorax. 2009;64(10):834–839.
   PubMed Web of Science ®Google Scholar
• Botros N, Concato J, Mohsenin V, et al. Obstructive sleep apnea as a risk factor for type II diabetes. Am J Med. 2009;122(12):1122–1127.
   PubMed Web of Science ®Google Scholar
• Whitaker KM, Lutsky PL, Ogilvie RP, et al. Associations between polysomnography and actigraphy-based sleep indices and glycemic control among those with and without type 2 diabetes: the multi-ethnic study of atherosclerosis. Sleep. 2018;zsy172–zsy172.
   Web of Science ®Google Scholar
• Punjabi NM, Sorkin JD, Katzel LI, et al. Sleep-disordered breathing and insulin resistance in middle-aged and overweight men. Am J Respir Crit Care Med. 2002;165(5):677–682.
   PubMed Web of Science ®Google Scholar
• Ip MSM, Lam B, Ng MMT, et al. Obstructive sleep apnea is independently associated with insulin resistance. Am J Respir Crit Care Med. 2002;165(5):670–676.
   PubMed Web of Science ®Google Scholar
• Iftikhar IH, Hoyos CM, Phillips CL, et al. Meta-analyses of the association of sleep apnea with insulin resistance, and the effects of CPAP on HOMA-IR, adiponectin, and visceral adipose fat. J Clin Sleep Med. 2015;11(4):475–485.
   PubMed Web of Science ®Google Scholar
• Drager LF, Li J, Reinke C, et al. Intermittent hypoxia exacerbates metabolic effects of diet-induced obesity. Obesity (Silver Spring). 2011;19(11):2167–2174.
   PubMed Web of Science ®Google Scholar
• Gaines J, Vgontzas AN, Fernandez-Mendoza J, et al. Obstructive sleep apnea and the metabolic syndrome: the road to clinically-meaningful phenotyping, improved prognosis, and personalized treatment. Sleep Med Rev. 2018;42:211–219.
   PubMed Web of Science ®Google Scholar
• Jullian-Desayes I, Joyeux-Faure M, Tamisier R, et al. Impact of obstructive sleep apnea treatment by continuous positive airway pressure on cardiometabolic biomarkers: a systematic review from sham CPAP randomized controlled trials. Sleep Med Rev. 2015;21:23–38.
   PubMed Web of Science ®Google Scholar
• Bonsignore MR, Borel A-L, Machan E, et al. Sleep apnoea and metabolic dysfunction. Eur Respir Rev. 2013;22(129):353–364.
   PubMedGoogle Scholar
• Acosta-Castro P, Page C. REM-associated sleep apnoea: prevalence and clinical significance in the HypnoLaus cohort. Eur Respir J. 2018;52(2).
   PubMed Web of Science ®Google Scholar
• Nobili V, Cutrera R, Liccardo D, et al. Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity/insulin resistance. Am J Respir Crit Care Med. 2014;189(1):66–76.
   PubMed Web of Science ®Google Scholar
• Sundaram SS, Halbower A, Pan Z, et al. Nocturnal hypoxia-induced oxidative stress promotes progression of pediatric non-alcoholic fatty liver disease. J Hepatol. 2016;65(3):560–569.
   PubMed Web of Science ®Google Scholar
• Sookoian S, Pirola CJ. Obstructive sleep apnea is associated with fatty liver and abnormal liver enzymes: a meta-analysis. Obes Surg. 2013;23(11):1815–1825.
   PubMed Web of Science ®Google Scholar
• Aron-Wisnewsky J, Clement K, Pépin J-L. Nonalcoholic fatty liver disease and obstructive sleep apnea. Metabolism. 2016;65(8):1124–1135.
   PubMed Web of Science ®Google Scholar
• Aron-Wisnewsky J, Minville C, Tordjman J, et al. Chronic intermittent hypoxia is a major trigger for non-alcoholic fatty liver disease in morbid obese. J Hepatol. 2012;56(1):225–233.
   PubMed Web of Science ®Google Scholar
• Labarca G, Reyes T, Jorquera J, et al. CPAP in patients with obstructive sleep apnea and type 2 diabetes mellitus: systematic review and meta-analysis. Clin Respir J. 2018;12(8):2361–2368.
   PubMed Web of Science ®Google Scholar
• Ioachimescu OC, Anthony J, Constantin T, et al. VAMONOS (Veterans affairs’ metabolism, obstructed and non-obstructed sleep) study: effects of CPAP therapy on glucose metabolism in patients with obstructive sleep apnea. J Clin Sleep Med. 2017;13(3):455–466.
   PubMed Web of Science ®Google Scholar
• Mokhlesi B, Grimaldi D, Beccuti G, et al. Effect of one week of CPAP treatment of obstructive sleep apnoea on 24-hour profiles of glucose, insulin and counter-regulatory hormones in type 2 diabetes. Diabetes Obesity Metab. 2017;19(3):452–456.
   PubMed Web of Science ®Google Scholar
• Martínez-Cerón E, Barquiel B, Bezos A-M, et al. Effect of continuous positive airway pressure on glycemic control in patients with obstructive sleep apnea and type 2 diabetes. A randomized clinical trial. Am J Respir Crit Care Med. 2016;194(4):476–485.
   PubMed Web of Science ®Google Scholar
• Baslas V, Chand P, Jurel SK, et al. A pilot study to determine the effect of three months of oral appliance therapy using a mandibular advancement device on hba1c in subjects with type 2 diabetes mellitus and obstructive sleep Apnea. J Prosthodontics. 2018 Oct 8. [Epub ahead of print].
   Google Scholar
• Noel P, Nedelcu M, Eddbali I, et al. What are the long-term results 8 years after sleeve gastrectomy? Surg Obesity Related Dis. 2017;13(7):1110–1115.
   PubMed Web of Science ®Google Scholar
• Kim D, Ahmed A, Kushida C. Continuous positive airway pressure therapy on nonalcoholic fatty liver disease in patients with obstructive sleep apnea. J Clin Sleep Med. 2018;14(8):1315–1322.
   PubMed Web of Science ®Google Scholar
• Sundaram SS, Halbower AC, Klawitter J, et al. Treating obstructive sleep apnea and chronic intermittent hypoxia improves the severity of nonalcoholic fatty liver disease in children. J Pediatr. 2018;198:67–75.e1.
   PubMed Web of Science ®Google Scholar
• Gupta MA, Simpson FC. Obstructive sleep apnea and psychiatric disorders: a systematic review. J Clin Sleep Med. 2015;11(2):165–175.
   PubMed Web of Science ®Google Scholar
• Bassetti CL, Ferini-Strambi L, Brown S, et al. Neurology and psychiatry: waking up to opportunities of sleep.: state of the art and clinical/research priorities for the next decade. Eur J Neurol. 2015;22(10):1337–1354.
   PubMed Web of Science ®Google Scholar
• Stubbs B, Vancampfort D, Veronese N, et al. The prevalence and predictors of obstructive sleep apnea in major depressive disorder, bipolar disorder and schizophrenia: A systematic review and meta-analysis. J Affect Disord. 2016;197:259–267.
   PubMed Web of Science ®Google Scholar
• Haba-Rubio J, Marti-Soler H, Tobback N, et al. Sleep characteristics and cognitive impairment in the general population: the HypnoLaus study. Neurology. 2017;88(5):463–469.
   PubMed Web of Science ®Google Scholar
• Sforza E, Saint Martin M, Barthélémy JC, et al. Mood disorders in healthy elderly with obstructive sleep apnea: a gender effect. Sleep Med. 2016;19:57–62.
   PubMed Web of Science ®Google Scholar
• Hermann DM, Bassetti CL. Role of sleep-disordered breathing and sleep-wake disturbances for stroke and stroke recovery. Neurology. 2016;87(13):1407–1416.
   PubMed Web of Science ®Google Scholar
• Chen Y-H, Keller JK, Kang J-H, et al. Obstructive sleep apnea and the subsequent risk of depressive disorder: a population-based follow-up study. J Clin Sleep Med. 2013;9(5):417–423.
   PubMed Web of Science ®Google Scholar
• Buratti L, Luzzi S, Petrelli C, et al. Obstructive sleep apnea syndrome: an emerging risk factor for dementia. CNS Neurol Disord Drug Targets. 2016;15(6):678–682.
   PubMed Web of Science ®Google Scholar
• Ding X, Kryscio RJ, Turner J, et al. Self-reported sleep apnea and Dementia risk: findings from the prevention of alzheimer’s disease with vitamin E and selenium trial. J Am Geriatr Soc. 2016;64(12):2472–2478.
   PubMed Web of Science ®Google Scholar
• Lutsey PL, Norby FL, Gottesman RF, et al. Sleep Apnea, sleep duration and brain MRI markers of cerebral vascular disease and alzheimer’s disease: the atherosclerosis risk in communities study (ARIC). PLoS One. 2016;11(7):e0158758.
   PubMed Web of Science ®Google Scholar
• Redine S, Yenokyan G, Gottlieb DJ, et al. Obstructive sleep apnea hypopnea and incident stroke. Am J Respir Crit Care Med. 2010;182(2):269–277.
   PubMed Web of Science ®Google Scholar
• Stone KL, Blackwell TL, Ancoli-Israel S, et al. Sleep disordered breathing and risk of stroke in older community-dwelling men. Sleep. 2016;39(3):531–540.
   PubMed Web of Science ®Google Scholar
• Poli M, Philip P, Taillard J, et al. Atrial fibrillation is a major cause of stroke in apneic patients: a prospective study. Sleep Med. 2017;30:251–254.
   PubMed Web of Science ®Google Scholar
• Dong R, Dong Z, Liu H, et al. Prevalence, risk factors, outcomes, and treatment of obstructive sleep apnea in patients with cerebrovascular disease: a systematic review. J Stroke Cerebrovascular Dis. 2018;27(6):1471–1480.
   PubMed Web of Science ®Google Scholar
• Canessa N, Castronovo V, Cappa SF, et al. Obstructive sleep apnea: brain structural changes and neurocognitive function before and after treatment. Am J Respir Crit Care Med. 2011;183(10):1419–1426.
   PubMed Web of Science ®Google Scholar
• Castronovo V, Scifo P, Castellano A, et al. White matter integrity in obstructive sleep apnea before and after treatment. Sleep. 2014;37(9):1465–1475.
   PubMed Web of Science ®Google Scholar
• Rosenzweig I, Glasser M, Polsek D, et al. Sleep apnoea and the brain: a complex relationship. Lancet Respir Med. 2015;3(5):404–414.
   PubMed Web of Science ®Google Scholar
• Kerner NA, Roose SP. Obstructive sleep apnea is linked to depression and cognitive impairment: evidence and potential mechanisms. Am J Geriatr Psychiatry. 2016;24(6):496–508.
   PubMed Web of Science ®Google Scholar
• Osorio RS, Gumb T, Pirraglia E, et al. Sleep-disordered breathing advances cognitive decline in the elderly. Neurology. 2015;84(19):1964–1971.
   PubMed Web of Science ®Google Scholar
• Snyder, B., Shell, B., Cunningham, J.T., et al. Chronic intermittent hypoxia induces oxidative stress and inflammation in brain regions associated with early-stage neurodegeneration. Physiol Rep. 2017;5(9).
   Web of Science ®Google Scholar
• Daulatzai MA. Evidence of neurodegeneration in obstructive sleep apnea: relationship between obstructive sleep apnea and cognitive dysfunction in the elderly. J Neurosci Res. 2015;93(12):1778–1794.
   PubMed Web of Science ®Google Scholar
• Yaffe K, Falvey CM, Hoang T. Connections between sleep and cognition in older adults. Lancet Neurol. 2014;13(10):1017–1028.
   PubMed Web of Science ®Google Scholar
• Kim Y, Koo YS, Lee HY, et al. Can continuous positive airway pressure reduce the risk of stroke in obstructive sleep apnea patients? A systematic review and meta-analysis. PLoS ONE. 2016;11(1):e0146317.
   PubMed Web of Science ®Google Scholar
• Iranzo A, Santamaría J, Berenguer J, et al. Prevalence and clinical importance of sleep apnea in the first night after cerebral infarction. Neurology. 2002;58(6):911–916.
   PubMed Web of Science ®Google Scholar
• Gupta A, Shukla G, Afsar M, et al. Role of positive airway pressure therapy for obstructive sleep apnea in patients with stroke: a randomized controlled trial. J Clin Sleep Med. 2018;14(4):511–521.
   PubMed Web of Science ®Google Scholar
• Povitz M, Bolo CE, Heitman SJ, et al. Effect of treatment of obstructive sleep apnea on depressive symptoms: systematic review and meta-analysis. PLoS Med. 2014;11(11):e1001762.
   PubMed Web of Science ®Google Scholar
• McNicholas WT. COPD-OSA overlap syndrome: evolving evidence regarding epidemiology, clinical consequences, and management. Chest. 2017;152(6):1318–1326.
   PubMed Web of Science ®Google Scholar
• Krachman SL, Tiwari R, Vega ME, et al. Effect of emphysema severity on the Apnea–hypopnea index in smokers with obstructive sleep Apnea. Ann Am Thorac Soc. 2016;13(7):1129–1135.
   PubMed Web of Science ®Google Scholar
• Zhao YY, Blackwell T, Ensrud KE, et al. Sleep apnea and obstructive airway disease in older men: outcomes of sleep disorders in older men study. Sleep. 2016;39(7):1343–1351.
   PubMed Web of Science ®Google Scholar
• Greenberg-Dotan S, Reuveni H, Tal A, et al. Increased prevalence of obstructive lung disease in patients with obstructive sleep apnea. Sleep Breathing. 2014;18(1):69–75.
   PubMed Web of Science ®Google Scholar
• Sanders MH, Newman AB, Haggerty CL, et al. Sleep and sleep-disordered breathing in adults with predominantly mild obstructive airway disease. Am J Respir Crit Care Med. 2003;167(1):7–14.
   PubMed Web of Science ®Google Scholar
• McNicholas WT. Chronic obstructive pulmonary disease and obstructive sleep apnea: overlaps in pathophysiology, systemic inflammation, and cardiovascular disease. Am J Respir Crit Care Med. 2009;180(8):692–700.
   PubMed Web of Science ®Google Scholar
• Chaouat A, Naeije R, Weitzenblum E. Pulmonary hypertension in COPD. Eur Resp J. 2008;32(5):1371–1385.
   PubMed Web of Science ®Google Scholar
• Kim MY, Jo E-J, Kang S-Y, et al. Obstructive sleep apnea is associated with reduced quality of life in adult patients with asthma. Ann Allergy Asthma Immunol. 2013;110(4):253–7, 257 e1.
   PubMed Web of Science ®Google Scholar
• Luyster FS, Teodorescu M, Bleecker E, et al. Sleep quality and asthma control and quality of life in non-severe and severe asthma. Sleep Breath. 2012;16(4):1129–1137.
   PubMed Web of Science ®Google Scholar
• Kong DL, Qin Z, Shen H, et al. Association of obstructive sleep apnea with asthma: A meta-analysis. Sci Rep. 2017;7(1):4088.
   PubMed Web of Science ®Google Scholar
• Teodorescu M, Consens FB, Bria WF, et al. Correlates of daytime sleepiness in patients with asthma. Sleep Med. 2006;7(8):607–613.
   PubMed Web of Science ®Google Scholar
• Teodorescu M, Polomis DA, Hall SV, et al. Association of obstructive sleep apnea risk with asthma control in adults. Chest. 2010;138(3):543–550.
   PubMed Web of Science ®Google Scholar
• Broytman O, Braun RK, Morgan BJ, et al. Effects of chronic intermittent hypoxia on allergen-induced airway inflammation in rats. Am J Respir Cell Mol Biol. 2015;52(2):162–170.
   PubMed Web of Science ®Google Scholar
• Mermigkis C, Bouloukaki I, Schiza SE. Sleep as a new target for improving outcomes in idiopathic pulmonary fibrosis. Chest. 2017;152(6):1327–1338.
   PubMed Web of Science ®Google Scholar
• Bosi M, Milioli G, Fanfulla F, et al. OSA and prolonged oxygen desaturation during sleep are strong predictors of poor outcome in IPF. Lung. 2017;195(5):643–651.
   PubMed Web of Science ®Google Scholar
• Lee RN, Kelly E, Nolan G, et al. Disordered breathing during sleep and exercise in idiopathic pulmonary fibrosis and the role of biomarkers. Qjm. 2015;108(4):315–323.
   PubMed Web of Science ®Google Scholar
• Braun, R.K., Broytman, O., Braun, F.M., et al. Chronic intermittent hypoxia worsens bleomycin-induced lung fibrosis in rats. Respir Physiol Neurobiol. 2018;256:97-108.
   Web of Science ®Google Scholar
• van Hees HWH, Dekhuijzen PNR, Heunks LMA. Levosimendan enhances force generation of diaphragm muscle from patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2009;179:41–47.
   PubMed Web of Science ®Google Scholar
• Gille T, Didier M, Boubaya M, et al. Obstructive sleep apnoea and related comorbidities in incident idiopathic pulmonary fibrosis. Eur Respir J. 2017;49(6):1601934.
   PubMed Web of Science ®Google Scholar
• Struik, F.M., Lacasse, Y., Goldstein, R., et al. Nocturnal non-invasive positive pressure ventilation for stable chronic obstructive pulmonary disease. Cochrane Database Rev. 2013;13:CD002878.
   Google Scholar
• Köhnlein T, Windisch W, Köhler D, et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med. 2014;2(9):698–705.
   PubMed Web of Science ®Google Scholar
• Murphy PB, Rehal S, Arbane G, et al. Effect of home noninvasive ventilation with oxygen therapy vs oxygen therapy alone on hospital readmission or death after an acute copd exacerbation: A randomized clinical trial. JAMA. 2017;317(21):2177–2186.
   PubMed Web of Science ®Google Scholar
• Marin JM, Soriano JB, Carrizo SJ, et al. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep Apnea. Am J Respir Crit Care Med. 2010;182(3):325–331.
   PubMed Web of Science ®Google Scholar
• Machado, M.-C.L., Vollmer, W.M., Togeiro, S.M., et al. CPAP and survival in moderate-to-severe obstructive sleep apnoea syndrome and hypoxaemic COPD. Eur Respir J. 2010;35(1):132–137.
   PubMed Web of Science ®Google Scholar
• Lyons OD, Inami T, Perger E, et al. The effect of fluid overload on sleep apnoea severity in haemodialysis patients. Eur Respir J. 2017;49(4):1601789.
   Web of Science ®Google Scholar
• Adams, R.J., Appleton, S.L., Vakulin, A., et al. Chronic kidney disease and sleep apnea association of kidney disease with obstructive sleep apnea in a population study of men. Sleep. 2017;40(1):zsw015–zsw015.
   Web of Science ®Google Scholar
• Marrone O, Battaglia S, Steiropoulos P, et al. Chronic kidney disease in European patients with obstructive sleep apnea: the ESADA cohort study. J Sleep Res. 2016;25(6):739–745.
   PubMed Web of Science ®Google Scholar
• Jaussent, I., Cristol, J.P., Stengel, B., et al. Impact of sleep disturbances on kidney function decline in the elderly. Eur Respir J. 2016;47(3):860–868.
   PubMed Web of Science ®Google Scholar
• Nicholl, D.D.M., Hanly, P.J., Poulin, M.J., et al. Evaluation of continuous positive airway pressure therapy on renin–angiotensin system activity in obstructive sleep apnea. Am J Respir Crit Care Med. 2014;190(5):572–580.
   PubMed Web of Science ®Google Scholar
• Marrone O, Cibella F, Pépin JL, et al. Fixed But Not Autoadjusting Positive Airway Pressure Attenuates the Time-dependent Decline in Glomerular Filtration Rate in Patients With OSA. ESADA Network. Chest. 2018 Aug;154(2):326–334.
   PubMed Web of Science ®Google Scholar
• Mahajan, S., Gupta, K., Sinha, S., et al. Effect of kidney transplantation on sleep-disordered breathing in patients with end stage renal disease: a polysomnographic study. Sleep Med. 2018;45:140–145.
   PubMed Web of Science ®Google Scholar
• Zhang XB, Peng L-H, Lyu Z, et al. Obstructive sleep apnoea and the incidence and mortality of cancer: a meta-analysis. Eur J Cancer Care (Engl). 2017;26(2).
   Web of Science ®Google Scholar
• Martínez-García MÁ, Campos-Rodríguez F, Almendros I, et al. Relationship between sleep apnea and cancer. Archivos de Bronconeumología. 2015;51(9):456–461.
   PubMed Web of Science ®Google Scholar
• Campos-Rodriguez F, Martinez-Garcia MA, Martinez M, et al. Association between obstructive sleep apnea and cancer incidence in a large multicenter Spanish cohort. Am J Respir Crit Care Med. 2013;187(1):99–105.
   PubMed Web of Science ®Google Scholar
• Zhang X-B, Peng L-H, Lyu Z, et al. Obstructive sleep apnoea and the incidence and mortality of cancer: a meta-analysis. Eur J Cancer Care (Engl). 2017;26(2):e12427.
   Web of Science ®Google Scholar
• Gozal D, Farré R, Nieto FJ. Obstructive sleep apnea and cancer: epidemiologic links and theoretical biological constructs. Sleep Med Rev. 2016;27:43–55.
   PubMed Web of Science ®Google Scholar
• Almendros I, Montserrat JM, Torres M, et al. Obesity and intermittent hypoxia increase tumor growth in a mouse model of sleep apnea. Sleep Med. 2012;13(10):1254–1260.
   PubMed Web of Science ®Google Scholar
• Gozal D, Farré R, Nieto FJ. Putative links between sleep apnea and cancer: from hypotheses to evolving evidence. Chest. 2015;148(5):1140–1147.
   PubMed Web of Science ®Google Scholar
• Almendros I, Montserrat JM, Ramírez J, et al. Intermittent hypoxia enhances cancer progression in a mouse model of sleep apnoea. Eur Respir J. 2012;39(1):215–217.
   PubMed Web of Science ®Google Scholar
• Gupta MA, Simpson FC, Gupta AK. Psoriasis and sleep disorders: A systematic review. Sleep Med Rev. 2016;29:63–75.
   PubMed Web of Science ®Google Scholar
• Gupta MA, Simpson FC, Vujcic B, et al. Obstructive sleep apnea and dermatologic disorders. Clin Dermatol. 2017;35(3):319–327.
   PubMed Web of Science ®Google Scholar