Caveolae, caveolin-1 and lung diseases of aging

References

• Thompson MA, Prakash YS, Pabelick CM. The role of caveolae in the pathophysiology of lung diseases. Expert Rev Respir Med. 2014;8(1):111–122.
   PubMed Web of Science ®Google Scholar
• Gosens R, Roscioni SS, Dekkers BGJ, et al. Pharmacology of airway smooth muscle proliferation. Eur J Pharmacol. 2008;585(2–3):385–397.
   PubMed Web of Science ®Google Scholar
• Prakash YS, Thompson MA, Vaa B, et al. Caveolins and intracellular calcium regulation in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;293(5):L1118–26.
   PubMed Web of Science ®Google Scholar
• Sathish V, Abcejo AJ, Thompson MA, et al. Caveolin-1 regulation of store-operated Ca(2+) influx in human airway smooth muscle. Eur Respir J. 2012;40(2):470–478.
   PubMed Web of Science ®Google Scholar
• Sathish V, Yang B, Meuchel LW, et al. Caveolin-1 and force regulation in porcine airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2011;300(6):L920–9.
   PubMed Web of Science ®Google Scholar
• What is healthy aging. [ cited 2018 Aug 30]. Available from: https://www.who.int/ageing/healthy-ageing/en/
   Google Scholar
• Hanania NA, King MJ, Braman SS, et al. Asthma in the elderly: current understanding and future research needs–a report of a National Institute on Aging (NIA) workshop. J Allergy Clin Immunol. 2011;128(3 Suppl):S4–S24.
   PubMed Web of Science ®Google Scholar
• Gibson PG, McDonald VM, Marks GB. Asthma in older adults. Lancet. 2010;376(9743):803–813.
   PubMed Web of Science ®Google Scholar
• Jones SC, Iverson D, Burns P, et al. Asthma and ageing: an end user’s perspective–the perception and problems with the management of asthma in the elderly. Clin Exp Allergy. 2011;41(4):471–481.
   PubMed Web of Science ®Google Scholar
• King MJ, Hanania NA. Asthma in the elderly: current knowledge and future directions. Curr Opin Pulm Med. 2010;16(1):55–59.
   PubMed Web of Science ®Google Scholar
• Darby PJ, Kwan CY, Daniel EE. Caveolae from canine airway smooth muscle contain the necessary components for a role in Ca(2+) handling. Am J Physiol Lung Cell Mol Physiol. 2000;279(6):L1226–35.
   PubMed Web of Science ®Google Scholar
• Gosens R, Baarsma HA, Heijink IH, et al. De novo synthesis of {beta}-catenin via H-Ras and MEK regulates airway smooth muscle growth. FASEB J. 2010;24(3):757–768.
   PubMed Web of Science ®Google Scholar
• Sathish V, Abcejo AJ, VanOosten SK, et al. Caveolin-1 in cytokine-induced enhancement of intracellular Ca(2+) in human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2011;301(4):L607–14.
   PubMed Web of Science ®Google Scholar
• Sathish V, Delmotte PF, Thompson MA, et al. Sodium-calcium exchange in intracellular calcium handling of human airway smooth muscle. PLoS One. 2011;6(8):e23662.
   PubMed Web of Science ®Google Scholar
• Chidlow JH Jr., Sessa WC. Caveolae, caveolins, and cavins: complex control of cellular signalling and inflammation. Cardiovasc Res. 2010;86(2):219–225.
   PubMed Web of Science ®Google Scholar
• Hansen CG, Nichols BJ. Exploring the caves: cavins, caveolins and caveolae. Trends Cell Biol. 2010;20(4):177–186.
   PubMed Web of Science ®Google Scholar
• Hill MM, Bastiani M, Luetterforst R, et al. PTRF-Cavin, a conserved cytoplasmic protein required for caveola formation and function. Cell. 2008;132(1):113–124.
   PubMed Web of Science ®Google Scholar
• Liu L, Pilch PF. A critical role of cavin (polymerase I and transcript release factor) in caveolae formation and organization. J Biol Chem. 2008;283(7):4314–4322.
   PubMed Web of Science ®Google Scholar
• Nabi IR. Cavin fever: regulating caveolae. Nat Cell Biol. 2009;11(7):789–791.
   PubMed Web of Science ®Google Scholar
• Briand N, Dugail I, Le Lay S. Cavin proteins: new players in the caveolae field. Biochimie. 2011;93(1):71–77.
   PubMed Web of Science ®Google Scholar
• Briand N, Le Lay S, Sessa WC, et al. Distinct roles of endothelial and adipocyte caveolin-1 in macrophage infiltration and adipose tissue metabolic activity. Diabetes. 2011;60(2):448–453.
   PubMed Web of Science ®Google Scholar
• Maniatis NA, Kardara M, Hecimovich D, et al. Role of caveolin-1 expression in the pathogenesis of pulmonary edema in ventilator-induced lung injury. Pulm Circ. 2012;2(4):452–460.
   PubMedGoogle Scholar
• Williams TM, Lisanti MP. The caveolin proteins. Genome Biol. 2004;5(3):214.
   PubMed Web of Science ®Google Scholar
• Gosens R, Stelmack GL, Dueck G, et al. Role of caveolin-1 in p42/p44 MAP kinase activation and proliferation of human airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2006;291(3):L523–34.
   PubMed Web of Science ®Google Scholar
• Aravamudan B, VanOosten SK, Meuchel LW, et al. Caveolin-1 knockout mice exhibit airway hyperreactivity. Am J Physiol Lung Cell Mol Physiol. 2012;303(8):L669–81.
   PubMed Web of Science ®Google Scholar
• Bai L, Deng X, Li J, et al. Regulation of cellular senescence by the essential caveolar component PTRF/Cavin-1. Cell Res. 2011;21(7):1088–1101.
   PubMed Web of Science ®Google Scholar
• Drab M, Verkade P, Elger M, et al. Loss of caveolae, vascular dysfunction, and pulmonary defects in caveolin-1 gene-disrupted mice. Science. 2001;293(5539):2449–2452.
   PubMed Web of Science ®Google Scholar
• Flowers M. Baby boomers all grown up - the impact of the aging population on healthcare. 2018. [cited 2018 Nov 23]. Available from: https://www.fqhc.org/blog/2017/8/30/baby-boomers-all-grown-up-the-impact-of-the-aging-population-on-healthcare
   Google Scholar
• Miller MR. Structural and physiological age-associated changes in aging lungs. Semin Respir Crit Care Med. 2010;31(5):521–527.
   PubMed Web of Science ®Google Scholar
• Janssens JP, Pache JC, Nicod LP. Physiological changes in respiratory function associated with ageing. Eur Respir J. 1999;13(1):197–205.
   PubMed Web of Science ®Google Scholar
• Yanez, A, Cho SH, Soriano JB, Rosenwasser LJ, et al. Asthma in the elderly: what we know and what we have yet to know. World Allergy Organ J. 2014;7(1):8.
   PubMedGoogle Scholar
• Cerveri I, Bruschi C, Zoia MC, et al. Distribution of bronchial nonspecific reactivity in the general population. Chest. 1988;93(1):26–30.
   PubMed Web of Science ®Google Scholar
• Higgins MW, Enright PL, Kronmal RA, et al. Smoking and lung function in elderly men and women. The cardiovascular health study. JAMA. 1993;269(21):2741–2748.
   PubMed Web of Science ®Google Scholar
• Trigg CJ, Jhalli N, Herdman MJ, et al. The daily variability of bronchial responsiveness to methacholine. Eur Respir J. 1990;3(8):867–871.
   PubMed Web of Science ®Google Scholar
• Bakke PS, Baste V, Hanoa R, et al. Prevalence of obstructive lung disease in a general population: relation to occupational title and exposure to some airborne agents. Thorax. 1991;46(12):863–870.
   PubMed Web of Science ®Google Scholar
• Britton J, Pavord I, Richards K, et al. Dietary magnesium, lung function, wheezing, and airway hyperreactivity in a random adult population sample. Lancet. 1994;344(8919):357–362.
   PubMed Web of Science ®Google Scholar
• Skloot GS. The effects of aging on lung structure and function. Clin Geriatr Med. 2017;33(4):447–457.
   PubMed Web of Science ®Google Scholar
• Sharma G, Goodwin J. Effect of aging on respiratory system physiology and immunology. Clin Interv Aging. 2006;1(3):253–260.
   PubMed Web of Science ®Google Scholar
• Vaz Fragoso CA, Lee PJ. The aging lung. J Gerontol A Biol Sci Med Sci. 2012;67(3):233–235.
   PubMed Web of Science ®Google Scholar
• Janssens JP. Aging of the respiratory system: impact on pulmonary function tests and adaptation to exertion. Clin Chest Med. 2005;26(3): 469–484. vi-vii.
   PubMed Web of Science ®Google Scholar
• Niewoehner DE, Kleinerman J. Morphologic basis of pulmonary resistance in the human lung and effects of aging. J Appl Physiol. 1974;36(4):412–418.
   PubMed Web of Science ®Google Scholar
• Hochhegger B, Alves GRT, Irion KL, et al. Emphysema index in a cohort of patients with no recognizable lung disease: influence of age. J Bras Pneumol. 2012;38(4):494–502.
   PubMed Web of Science ®Google Scholar
• Selman M, Buendia-Roldan I, Pardo A. Aging and pulmonary fibrosis. Rev Invest Clin. 2016;68(2):75–83.
   PubMedGoogle Scholar
• Busse PJ, Mathur SK. Age-related changes in immune function: effect on airway inflammation. J Allergy Clin Immunol. 2010;126(4): 690–699. quiz 700-1.
   PubMed Web of Science ®Google Scholar
• Busse PJ, Zhang TF, Srivastava K, et al. Effect of ageing on pulmonary inflammation, airway hyperresponsiveness and T and B cell responses in antigen-sensitized and -challenged mice. Clin Exp Allergy. 2007;37(9):1392–1403.
   PubMed Web of Science ®Google Scholar
• Gómez R, Conde J, Gómez Reino JJ, et al. Adipocytokines: emerging mediators of the immune response and inflammation. Reumatol Clin. 2009;5 Suppl 1(Suppl 1:):6–12.
   PubMedGoogle Scholar
• Lowery EM, Brubaker AL, Kuhlmann E, et al. The aging lung. Clin Interv Aging. 2013;8:1489–1496.
   PubMed Web of Science ®Google Scholar
• Thannickal VJ, Murthy M, Balch WE, et al. Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med. 2015;191(3):261–269.
   PubMed Web of Science ®Google Scholar
• Ho JC, Chan KN, Hu WH, et al. The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia. Am J Respir Crit Care Med. 2001;163(4):983–988.
   PubMed Web of Science ®Google Scholar
• Hochhegger B, Marchiori E, Irion K, et al. Magnetic resonance of the lung: a step forward in the study of lung disease. J Bras Pneumol. 2012;38(1):105–115.
   PubMed Web of Science ®Google Scholar
• Scichilone N, Pedone C, Battaglia S, et al. Diagnosis and management of asthma in the elderly. Eur J Intern Med. 2014;25(4):336–342.
   PubMed Web of Science ®Google Scholar
• Brandenberger C, Muhlfeld C. Mechanisms of lung aging. Cell Tissue Res. 2017;367(3):469–480.
   PubMed Web of Science ®Google Scholar
• Budde J, Skloot GS. Is aging a “comorbidity” of asthma? Pulm Pharmacol Ther. 2018;52:52–56.
   PubMed Web of Science ®Google Scholar
• Volonte D, Galbiati F. Caveolin-1, cellular senescence and pulmonary emphysema. Aging (Albany NY). 2009;1(9):831–835.
   PubMedGoogle Scholar
• Volonté F, Robert JH, Ratib O, et al. A lung segmentectomy performed with 3D reconstruction images available on the operating table with an iPad. Interact Cardiovasc Thorac Surg. 2011;12(6):1066–1068.
   PubMed Web of Science ®Google Scholar
• Volonte D, Zhang K, Lisanti MP, et al. Expression of caveolin-1 induces premature cellular senescence in primary cultures of murine fibroblasts. Mol Biol Cell. 2002;13(7):2502–2517.
   PubMed Web of Science ®Google Scholar
• Wheaton K, Sampsel K, Boisvert FM, et al. Loss of functional caveolae during senescence of human fibroblasts. J Cell Physiol. 2001;187(2):226–235.
   PubMed Web of Science ®Google Scholar
• Wang XM, Zhang Y, Kim HP, et al. Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis. J Exp Med. 2006;203(13):2895–2906.
   PubMed Web of Science ®Google Scholar
• Tourkina E, Gooz P, Pannu J, et al. Opposing effects of protein kinase calpha and protein kinase cepsilon on collagen expression by human lung fibroblasts are mediated via MEK/ERK and caveolin-1 signaling. J Biol Chem. 2005;280(14):13879–13887.
   PubMed Web of Science ®Google Scholar
• Tourkina E, Hoffman S. Caveolin-1 signaling in lung fibrosis. Open Rheumatol J. 2012;6:116–122.
   PubMedGoogle Scholar
• Kerstjens HA, Rijcken B, Schouten JP, et al. Decline of FEV1 by age and smoking status: facts, figures, and fallacies. Thorax. 1997;52(9):820–827.
   PubMed Web of Science ®Google Scholar
• Yoo SH, Abdelmegeed MA, Song BJ. Activation of PPARalpha by Wy-14643 ameliorates systemic lipopolysaccharide-induced acute lung injury. Biochem Biophys Res Commun. 2013;436(3):366–371.
   PubMed Web of Science ®Google Scholar
• Alexeeff SE, Litonjua AA, Wright RO, et al. Ozone exposure, antioxidant genes, and lung function in an elderly cohort: VA normative aging study. Occup Environ Med. 2008;65(11):736–742.
   PubMed Web of Science ®Google Scholar
• Gosens R, Stelmack GL, Dueck G, et al. Caveolae facilitate muscarinic receptor-mediated intracellular Ca2+ mobilization and contraction in airway smooth muscle. Am J Physiol Lung Cell Mol Physiol. 2007;293(6):L1406–18.
   PubMed Web of Science ®Google Scholar
• Schlenz H, Kummer W, Jositsch G, et al. Muscarinic receptor-mediated bronchoconstriction is coupled to caveolae in murine airways. Am J Physiol Lung Cell Mol Physiol. 2010;298(5):L626–36.
   PubMed Web of Science ®Google Scholar
• Bousquet J, Jeffery PK, Busse WW, et al. Asthma. From bronchoconstriction to airways inflammation and remodeling. Am J Respir Crit Care Med. 2000;161(5):1720–1745.
   PubMed Web of Science ®Google Scholar
• Wang J, Shang Y-X, Cai -X-X, et al. Vasoactive intestinal peptide inhibits airway smooth muscle cell proliferation in a mouse model of asthma via the ERK1/2 signaling pathway. Exp Cell Res. 2018;364(2):168–174.
   PubMed Web of Science ®Google Scholar
• Fang P, Shi H-Y, Wu X-M, et al. Targeted inhibition of GATA-6 attenuates airway inflammation and remodeling by regulating caveolin-1 through TLR2/MyD88/NF-κB in murine model of asthma. Mol Immunol. 2016;75:144–150.
   PubMed Web of Science ®Google Scholar
• Xia Y, Cai P-C, Yu F, et al. IL-4-induced caveolin-1-containing lipid rafts aggregation contributes to MUC5AC synthesis in bronchial epithelial cells. Respir Res. 2017;18(1):174.
   PubMedGoogle Scholar
• Hackett T-L, de Bruin HG, Shaheen F, et al. Caveolin-1 controls airway epithelial barrier function. Implications for asthma. Am J Respir Cell Mol Biol. 2013;49(4):662–671.
   PubMed Web of Science ®Google Scholar
• Townsend EA, Meuchel LW, Thompson MA, et al. Estrogen increases nitric-oxide production in human bronchial epithelium. J Pharmacol Exp Ther. 2011;339(3):815–824.
   PubMed Web of Science ®Google Scholar
• Kone BC. Protein-protein interactions controlling nitric oxide synthases. Acta Physiol Scand. 2000;168(1):27–31.
   PubMedGoogle Scholar
• Le Saux CJ, Teeters K, Miyasato SK, et al. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. J Biol Chem. 2008;283(9):5760–5768.
   PubMed Web of Science ®Google Scholar
• Vogel ER, Britt RD, Faksh A, et al. Moderate hyperoxia induces extracellular matrix remodeling by human fetal airway smooth muscle cells. Pediatr Res. 2017;81(2):376–383.
   PubMed Web of Science ®Google Scholar
• Skloot GS, Busse PJ, Braman SS, et al. An official american thoracic society workshop report: evaluation and management of asthma in the elderly. Ann Am Thorac Soc. 2016;13(11):2064–2077.
   PubMed Web of Science ®Google Scholar
• Glasser SW, Senft AP, Maxfield MD, et al. Genetic replacement of surfactant protein-C reduces respiratory syncytial virus induced lung injury. Respir Res. 2013;14:110.
   PubMed Web of Science ®Google Scholar
• Cosio Piqueras MG, Cosio MG. Disease of the airways in chronic obstructive pulmonary disease. Eur Respir J Suppl. 2001;34:41s–49s.
   PubMedGoogle Scholar
• Singh DP, Kaur G, Bagam P, et al. Membrane microdomains regulate NLRP10- and NLRP12-dependent signalling in A549 cells challenged with cigarette smoke extract. Arch Toxicol. 2018;92(5):1767–1783.
   PubMed Web of Science ®Google Scholar
• Yu Q, Chen X, Fang X, et al. Caveolin-1 aggravates cigarette smoke extract-induced MUC5AC secretion in human airway epithelial cells. Int J Mol Med. 2015;35(5):1435–1442.
   PubMed Web of Science ®Google Scholar
• Bhowmik A, Seemungal TA, Sapsford RJ, et al. Relation of sputum inflammatory markers to symptoms and lung function changes in COPD exacerbations. Thorax. 2000;55(2):114–120.
   PubMed Web of Science ®Google Scholar
• Donaldson GC, Seemungal TAR, Patel IS, et al. Airway and systemic inflammation and decline in lung function in patients with COPD. Chest. 2005;128(4):1995–2004.
   PubMed Web of Science ®Google Scholar
• Sun N, Wei X, Wang J, et al. Caveolin-1 promotes the imbalance of Th17/Treg in patients with chronic obstructive pulmonary disease. Inflammation. 2016;39(6):2008–2015.
   PubMed Web of Science ®Google Scholar
• Zhang J-C, Chen G, Chen L, et al. TGF-β/BAMBI pathway dysfunction contributes to peripheral Th17/Treg imbalance in chronic obstructive pulmonary disease. Sci Rep. 2016;6:31911.
   PubMed Web of Science ®Google Scholar
• Haines P, Samuel GH, Cohen H, et al. Caveolin-1 is a negative regulator of MMP-1 gene expression in human dermal fibroblasts via inhibition of Erk1/2/Ets1 signaling pathway. J Dermatol Sci. 2011;64(3):210–216.
   PubMed Web of Science ®Google Scholar
• Volonte D, Kahkonen B, Shapiro S, et al. Caveolin-1 expression is required for the development of pulmonary emphysema through activation of the ATM-p53-p21 pathway. J Biol Chem. 2009;284(9):5462–5466.
   PubMed Web of Science ®Google Scholar
• Franchi L, Warner N, Viani K, et al. Function of Nod-like receptors in microbial recognition and host defense. Immunol Rev. 2009;227(1):106–128.
   PubMedGoogle Scholar
• King TE Jr., Pardo A, Selman M. Idiopathic pulmonary fibrosis. Lancet. 2011;378(9807):1949–1961.
   PubMed Web of Science ®Google Scholar
• Raghu G, Collard HR, Egan JJ, et al. An official ATS/ERS/JRS/ALAT statement: idiopathic pulmonary fibrosis: evidence-based guidelines for diagnosis and management. Am J Respir Crit Care Med. 2011;183(6):788–824.
   PubMed Web of Science ®Google Scholar
• Schafer MJ, White TA, Iijima K, et al. Cellular senescence mediates fibrotic pulmonary disease. Nat Commun. 2017;8:14532.
   PubMed Web of Science ®Google Scholar
• Hecker L, Logsdon NJ, Kurundkar D, et al. Reversal of persistent fibrosis in aging by targeting Nox4-Nrf2 redox imbalance. Sci Transl Med. 2014;6(231):231ra47.
   PubMed Web of Science ®Google Scholar
• Sanders YY, Cui Z, Le Saux CJ, et al. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts. PLoS One. 2015;10(2):e0116995.
   PubMed Web of Science ®Google Scholar
• Xing Y, Wang L, Wang H, et al. Dynamic expression of transformating growth factor-β1 and caveolin-1 in the lung of Bleomycin-induced interstitial lung disease. J Thorac Dis. 2017;9(8):2360–2368.
   PubMed Web of Science ®Google Scholar
• Sanders YY, Liu H, Scruggs AM, et al. Epigenetic regulation of caveolin-1 gene expression in lung fibroblasts. Am J Respir Cell Mol Biol. 2017;56(1):50–61.
   PubMed Web of Science ®Google Scholar
• Shivshankar P, Brampton C, Miyasato S, et al. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. Am J Respir Cell Mol Biol. 2012;47(1):28–36.
   PubMed Web of Science ®Google Scholar
• Tourkina E, Richard M, Gööz P, et al. Antifibrotic properties of caveolin-1 scaffolding domain in vitro and in vivo. Am J Physiol Lung Cell Mol Physiol. 2008;294(5):L843–61.
   PubMed Web of Science ®Google Scholar
• Xia H, Khalil W, Kahm J, et al. Pathologic caveolin-1 regulation of PTEN in idiopathic pulmonary fibrosis. Am J Pathol. 2010;176(6):2626–2637.
   PubMed Web of Science ®Google Scholar
• Nho RS, Peterson M, Hergert P, et al. FoxO3a (Forkhead Box O3a) deficiency protects idiopathic pulmonary fibrosis (IPF) fibroblasts from type I polymerized collagen matrix-induced apoptosis via caveolin-1 (cav-1) and Fas. PLoS One. 2013;8(4):e61017.
   PubMed Web of Science ®Google Scholar
• Zou H, Stoppani E, Volonte D, et al. Caveolin-1, cellular senescence and age-related diseases. Mech Ageing Dev. 2011;132(11–12):533–542.
   PubMed Web of Science ®Google Scholar
• Volonte D, Galbiati F. Inhibition of thioredoxin reductase 1 by caveolin 1 promotes stress-induced premature senescence. EMBO Rep. 2009;10(12):1334–1340.
   PubMed Web of Science ®Google Scholar
• Aga M, Bradley JM, Wanchu R, et al. Differential effects of caveolin-1 and −2 knockdown on aqueous outflow and altered extracellular matrix turnover in caveolin-silenced trabecular meshwork cells. Invest Ophthalmol Vis Sci. 2014;55(9):5497–5509.
   PubMed Web of Science ®Google Scholar
• Jin Y, Lee S-J, Minshall RD, et al. Caveolin-1: a critical regulator of lung injury. Am J Physiol Lung Cell Mol Physiol. 2011;300(2):L151–60.
   PubMed Web of Science ®Google Scholar
• Sundivakkam PC, Kwiatek AM, Sharma TT, et al. Caveolin-1 scaffold domain interacts with TRPC1 and IP3R3 to regulate Ca2+ store release-induced Ca2+ entry in endothelial cells. Am J Physiol Cell Physiol. 2009;296(3):C403–13.
   PubMed Web of Science ®Google Scholar
• Sun X-H, Liu Z-Y, Chen H, et al. A conserved sequence in caveolin-1 is both necessary and sufficient for caveolin polarity and cell directional migration. FEBS Lett. 2009;583(22):3681–3689.
   PubMed Web of Science ®Google Scholar
• Ingbar DH. Mechanisms of repair and remodeling following acute lung injury. Clin Chest Med. 2000;21(3):589–616.
   PubMed Web of Science ®Google Scholar
• Garrean S, Gao X-P, Brovkovych V, et al. Caveolin-1 regulates NF-kappaB activation and lung inflammatory response to sepsis induced by lipopolysaccharide. J Immunol. 2006;177(7):4853–4860.
   PubMed Web of Science ®Google Scholar
• Hu G, Ye RD, Dinauer MC, et al. Neutrophil caveolin-1 expression contributes to mechanism of lung inflammation and injury. Am J Physiol Lung Cell Mol Physiol. 2008;294(2):L178–86.
   PubMed Web of Science ®Google Scholar
• Jin Y, Kim HP, Chi M, et al. Deletion of caveolin-1 protects against oxidative lung injury via up-regulation of heme oxygenase-1. Am J Respir Cell Mol Biol. 2008;39(2):171–179.
   PubMed Web of Science ®Google Scholar
• Zhang M, Lin L, Lee S-J, et al. Deletion of caveolin-1 protects hyperoxia-induced apoptosis via survivin-mediated pathways. Am J Physiol Lung Cell Mol Physiol. 2009;297(5):L945–53.
   PubMed Web of Science ®Google Scholar
• Miller EJ, Linge HM. Age-related changes in immunological and physiological responses following pulmonary challenge. Int J Mol Sci. 2017;18(6):E1294.
   Web of Science ®Google Scholar
• Erickson SE, Martin GS, Davis JL, et al. Recent trends in acute lung injury mortality: 1996-2005. Crit Care Med. 2009;37(5):1574–1579.
   PubMed Web of Science ®Google Scholar
• Pulmonary Hypertension Association. 2018. [cited 2018 Nov 26]. Available from: http://pulmonaryhypertensionrn.com/types-of-pulmonary-hypertension/
   Google Scholar
• Types of Pulmonary Hypertension. 2018. [cited 2018 Aug 20]. Available from: http://pulmonaryhypertensionrn.com/types-of-pulmonary-hypertension/
   Google Scholar
• Mathew R. Cell-specific dual role of caveolin-1 in pulmonary hypertension. Pulm Med. 2011:573432.
   PubMedGoogle Scholar
• Ryter SW, Choi AM. Caveolin-1: a critical regulator of pulmonary vascular architecture and nitric oxide bioavailability in pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2008;294(5):L862–4.
   PubMed Web of Science ®Google Scholar
• Huang J, Wolk JH, Gewitz MH, et al. Caveolin-1 expression during the progression of pulmonary hypertension. Exp Biol Med (Maywood). 2012;237(8):956–965.
   PubMed Web of Science ®Google Scholar
• Zhao -Y-Y, Zhao YD, Mirza MK, et al. Persistent eNOS activation secondary to caveolin-1 deficiency induces pulmonary hypertension in mice and humans through PKG nitration. J Clin Invest. 2009;119(7):2009–2018.
   PubMed Web of Science ®Google Scholar
• Mathew R, Huang J, Shah M, et al. Disruption of endothelial-cell caveolin-1alpha/raft scaffolding during development of monocrotaline-induced pulmonary hypertension. Circulation. 2004;110(11):1499–1506.
   PubMed Web of Science ®Google Scholar
• Mathew R. Pathogenesis of pulmonary hypertension: a case for caveolin-1 and cell membrane integrity. Am J Physiol Heart Circ Physiol. 2014;306(1):H15–H25.
   PubMed Web of Science ®Google Scholar
• Wunderlich C, Schmeisser A, Heerwagen C, et al. Chronic NOS inhibition prevents adverse lung remodeling and pulmonary arterial hypertension in caveolin-1 knockout mice. Pulm Pharmacol Ther. 2008;21(3):507–515.
   PubMed Web of Science ®Google Scholar
• Razani B, Engelman JA, Wang XB, et al. Caveolin-1 null mice are viable but show evidence of hyperproliferative and vascular abnormalities. J Biol Chem. 2001;276(41):38121–38138.
   PubMed Web of Science ®Google Scholar
• Wang KY, Lee MF, Ho HC, et al. Serum caveolin-1 as a novel biomarker in idiopathic pulmonary artery hypertension. Biomed Res Int. 2015;2015:173970.
   PubMedGoogle Scholar
• Jasmin J-F, Mercier I, Hnasko R, et al. Lung remodeling and pulmonary hypertension after myocardial infarction: pathogenic role of reduced caveolin expression. Cardiovasc Res. 2004;63(4):747–755.
   PubMed Web of Science ®Google Scholar