An update on pulmonary rehabilitation techniques for patients with chronic obstructive pulmonary disease

References

• DALYs GBD, Collaborators H. Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392(10159):1859–1922.
   PubMed Web of Science ®Google Scholar
• Vanfleteren LE, Spruit MA, Groenen M, et al. Clusters of comorbidities based on validated objective measurements and systemic inflammation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2013;187(7):728–735.
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373.
   PubMed Web of Science ®Google Scholar
• Fulton BG, Ryerson CJ. Managing comorbidities in idiopathic pulmonary fibrosis. Int J Gen Med. 2015;8:309–318.
   PubMed Web of Science ®Google Scholar
• Watz H, Pitta F, Rochester CL, et al. An official European respiratory society statement on physical activity in COPD. Eur Respir J. 2014;44(6):1521–1537.
   PubMed Web of Science ®Google Scholar
• Cordova-Rivera L, Gibson PG, Gardiner PA, et al. Physical activity associates with disease characteristics of severe asthma, bronchiectasis and COPD. Respirology. 2019;24(4):352–360.
   PubMed Web of Science ®Google Scholar
• Hodgkin JE, Farrell MJ, Gibson SR, et al. American thoracic society. Medical section of the american lung association. Pulmonary rehabilitation. Am Rev Respir Dis. 1981;124(5):663–666.
   PubMedGoogle Scholar
• Spruit MA, Singh SJ, Garvey C, et al. An official American thoracic society/European respiratory society statement: key concepts and advances in pulmonary rehabilitation. Am J Respir Crit Care Med. 2013;188(8):e13–64.
   PubMed Web of Science ®Google Scholar
• Fishman AP. Pulmonary rehabilitation research. Am J Respir Crit Care Med. 1994;149(3 Pt 1):825–833.
   PubMed Web of Science ®Google Scholar
• Lusuardi M. Respiratory medicine in general practice: what is the role of the pulmonary specialist? Monaldi Arch Chest Dis. 2005;63(1):3–5.
   PubMedGoogle Scholar
• Augustin I, Wouters E. Process of pulmonary rehabilitation and program organization. J Card Pulm Rehabil. 2015;1(1):109.
   Google Scholar
• Vestbo J, Hurd SS, Agusti AG, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med. 2013;187(4):347–365.
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, Laveneziana P, Webb K, et al. Chronic obstructive pulmonary disease: clinical integrative physiology. Clin Chest Med. 2014;35(1):51–69.
   PubMed Web of Science ®Google Scholar
• Smith MC, Wrobel JP. Epidemiology and clinical impact of major comorbidities in patients with COPD. Int J Chron Obstruct Pulmon Dis. 2014;9:871–888.
   PubMed Web of Science ®Google Scholar
• Choudhury G, Rabinovich R, MacNee W. Comorbidities and systemic effects of chronic obstructive pulmonary disease. Clin Chest Med. 2014;35(1):101–130.
   PubMed Web of Science ®Google Scholar
• Guder G, Rutten FH. Comorbidity of heart failure and chronic obstructive pulmonary disease: more than coincidence. Curr Heart Fail Rep. 2014;11(3):337–346.
   PubMedGoogle Scholar
• Divo M, Cote C, de Torres JP, et al. Comorbidities and risk of mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2012;186(2):155–161.
   PubMed Web of Science ®Google Scholar
• American Thoracic Society/European Respiratory S. ATS/ERS Statement on respiratory muscle testing. Am J Respir Crit Care Med. 2002;166(4):518–624.
   PubMed Web of Science ®Google Scholar
• Neder JA, Arbex FF, Alencar MC, et al. Exercise ventilatory inefficiency in mild to end-stage COPD. Eur Respir J. 2015;45(2):377–387.
   PubMed Web of Science ®Google Scholar
• Arbex FF, Alencar MC, Souza A, et al. Exercise ventilation in COPD: influence of systolic heart failure. COPD. 2016;13(6):693–699.
   PubMedGoogle Scholar
• Rocha A, Arbex FF, Sperandio PA, et al. Excess ventilation in chronic obstructive pulmonary disease-heart failure overlap. implications for dyspnea and exercise intolerance. Am J Respir Crit Care Med. 2017;196(10):1264–1274.
   PubMed Web of Science ®Google Scholar
• Aliverti A, Dellaca RL, Lotti P, et al. Influence of expiratory flow-limitation during exercise on systemic oxygen delivery in humans. Eur J Appl Physiol. 2005;95(2–3):229–242.
   PubMed Web of Science ®Google Scholar
• Aliverti A, Macklem PT. The major limitation to exercise performance in COPD is inadequate energy supply to the respiratory and locomotor muscles. J Appl Physiol. (1985)2008;105(2):749–751. discussion 755–747.
   PubMed Web of Science ®Google Scholar
• Poole DC, Hirai DM, Copp SW, et al. Muscle oxygen transport and utilization in heart failure: implications for exercise (in)tolerance. Am J Physiol Heart Circ Physiol. 2012;302(5):H1050–1063.
   PubMed Web of Science ®Google Scholar
• Oliveira MF, Arbex FF, Alencar MC, et al. Heart failure impairs muscle blood flow and endurance exercise tolerance in COPD. COPD. 2016;13(4):407–415.
   PubMedGoogle Scholar
• Rocha A, Arbex FF, Alencar MC, et al. Physiological and sensory consequences of exercise oscillatory ventilation in heart failure-COPD. Int J Cardiol. 2016;224:447–453.
   PubMed Web of Science ®Google Scholar
• Hohlfeld JM, Vogel-Claussen J, Biller H, et al. Effect of lung deflation with indacaterol plus glycopyrronium on ventricular filling in patients with hyperinflation and COPD (CLAIM): a double-blind, randomised, crossover, placebo-controlled, single-centre trial. Lancet Respir Med. 2018;6(5):368–378.
   PubMed Web of Science ®Google Scholar
• Borghi-Silva A, Oliveira CC, Carrascosa C, et al. Respiratory muscle unloading improves leg muscle oxygenation during exercise in patients with COPD. Thorax. 2008;63(10):910–915.
   PubMed Web of Science ®Google Scholar
• Dolmage TE, Goldstein RS. Effects of one-legged exercise training of patients with COPD. Chest. 2008;133(2):370–376.
   PubMed Web of Science ®Google Scholar
• Esposito F, Reese V, Shabetai R, et al. Isolated quadriceps training increases maximal exercise capacity in chronic heart failure: the role of skeletal muscle convective and diffusive oxygen transport. J Am Coll Cardiol. 2011;58(13):1353–1362.
   PubMed Web of Science ®Google Scholar
• Sillen MJ, Wouters EF, Franssen FM, et al. Oxygen uptake, ventilation, and symptoms during low-frequency versus high-frequency NMES in COPD: a pilot study. Lung. 2011;189(1):21–26.
   PubMed Web of Science ®Google Scholar
• Ries AL, Bauldoff GS, Carlin BW, et al. Pulmonary rehabilitation: joint ACCP/AACVPR evidence-based clinical practice guidelines. Chest. 2007;131(5 Suppl):4S–42S.
   PubMed Web of Science ®Google Scholar
• Ries AL. ACCP/AACVPR evidence-based guidelines for pulmonary rehabilitation. Round 3: another step forward. J Cardiopulm Rehabil Prev. 2007;27(4):233–236.
   PubMed Web of Science ®Google Scholar
• Garvey C, Bayles MP, Hamm LF, et al. Pulmonary rehabilitation exercise prescription in chronic obstructive pulmonary disease: review of selected guidelines: an official statement from the American association of cardiovascular and pulmonary rehabilitation. J Cardiopulm Rehabil Prev. 2016;36(2):75–83.
   PubMed Web of Science ®Google Scholar
• Houben-Wilke S, Augustin IM, Vercoulen JH, et al. COPD stands for complex obstructive pulmonary disease. Eur Respir Rev. 2018;27:148.
   Web of Science ®Google Scholar
• Houben-Wilke S, Janssen DJA, Franssen FME, et al. Contribution of individual COPD assessment test (CAT) items to CAT total score and effects of pulmonary rehabilitation on CAT scores. Health Qual Life Outcomes. 2018;16(1):205.
   PubMedGoogle Scholar
• Janssen DJ, Wilke S, Smid DE, et al. Relationship between pulmonary rehabilitation and care dependency in COPD. Thorax. 2016;71(11):1054–1056.
   PubMed Web of Science ®Google Scholar
• Spruit MA, Augustin IM, Vanfleteren LE, et al. Differential response to pulmonary rehabilitation in COPD: multidimensional profiling. Eur Respir J. 2015;46(6):1625–1635.
   PubMed Web of Science ®Google Scholar
• Ries AL, Kaplan RM, Limberg TM, et al. Effects of pulmonary rehabilitation on physiologic and psychosocial outcomes in patients with chronic obstructive pulmonary disease. Ann Intern Med. 1995;122(11):823–832.
   PubMed Web of Science ®Google Scholar
• McCarthy B, Casey D, Devane D, et al. Pulmonary rehabilitation for chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2015;(2):CD003793.
   PubMed Web of Science ®Google Scholar
• Maltais F, LeBlanc P, Jobin J, et al. Intensity of training and physiologic adaptation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1997;155(2):555–561.
   PubMed Web of Science ®Google Scholar
• Spruit MA, Gosselink R, Troosters T, et al. Low-grade systemic inflammation and the response to exercise training in patients with advanced COPD. Chest. 2005;128(5):3183–3190.
   PubMed Web of Science ®Google Scholar
• Breyer MK, Breyer-Kohansal R, Funk GC, et al. Nordic walking improves daily physical activities in COPD: a randomised controlled trial. Respir Res. 2010;11:112.
   PubMed Web of Science ®Google Scholar
• Sillen MJH, Speksnijder CM, Eterman RA, et al. Effects of neuromuscular electrical stimulation of muscles of ambulation in patients with chronic heart failure or COPD: a systematic review of the English-language literature. Chest. 2009;136(1):44–61.
   PubMed Web of Science ®Google Scholar
• Spruit MA, Gosselink R, Troosters T, et al. Resistance versus endurance training in patients with COPD and peripheral muscle weakness. Eur Respir J. 2002;19(6):1072–1078.
   PubMed Web of Science ®Google Scholar
• O’Shea SD, Taylor NF, Paratz JD. Progressive resistance exercise improves muscle strength and may improve elements of performance of daily activities for people with COPD: a systematic review. Chest. 2009;136(5):1269–1283.
   PubMed Web of Science ®Google Scholar
• Sillen MJ, Franssen FM, Vaes AW, et al. Metabolic load during strength training or NMES in individuals with COPD: results from the DICES trial. BMC Pulm Med. 2014;14:146.
   PubMed Web of Science ®Google Scholar
• Sillen MJ, Janssen PP, Akkermans MA, et al. The metabolic response during resistance training and neuromuscular electrical stimulation (NMES) in patients with COPD, a pilot study. Respir Med. 2008;102(5):786–789.
   PubMed Web of Science ®Google Scholar
• Sillen MJ, Franssen FM, Delbressine JM, et al. Efficacy of lower-limb muscle training modalities in severely dyspnoeic individuals with COPD and quadriceps muscle weakness: results from the DICES trial. Thorax. 2014;69(6):525–531.
   PubMed Web of Science ®Google Scholar
• Gloeckl R, Heinzelmann I, Baeuerle S, et al. Effects of whole body vibration in patients with chronic obstructive pulmonary disease–a randomized controlled trial. Respir Med. 2012;106(1):75–83.
   PubMed Web of Science ®Google Scholar
• Spruit MA, Pitta F, Garvey C, et al. Differences in content and organisational aspects of pulmonary rehabilitation programmes. Eur Respir J. 2014;43(5):1326–1337.
   PubMed Web of Science ®Google Scholar
• Spruit MA, Troosters T, Gosselink R, et al. Acute inflammatory and anabolic systemic responses to peak and constant-work-rate exercise bout in hospitalized patients with COPD. Int J Chron Obstruct Pulmon Dis. 2007;2(4):575–583.
   PubMedGoogle Scholar
• Vaes AW, Delbressine JML, Mesquita R, et al. Impact of pulmonary rehabilitation on activities of daily living in patients with chronic obstructive pulmonary disease. J Appl Physiol (1985). 2019;126(3):607–615.
   PubMed Web of Science ®Google Scholar
• Vaes AW, Wouters EFM, Franssen FME, et al. Task-related oxygen uptake during domestic activities of daily life in patients with COPD and healthy elderly subjects. Chest. 2011;140(4):970–979.
   PubMed Web of Science ®Google Scholar
• Andrianopoulos V, Celli BR, Franssen FM, et al. Determinants of exercise-induced oxygen desaturation including pulmonary emphysema in COPD: results from the ECLIPSE study. Respir Med. 2016;119:87–95.
   PubMed Web of Science ®Google Scholar
• Andrianopoulos V, Franssen FM, Peeters JP, et al. Exercise-induced oxygen desaturation in COPD patients without resting hypoxemia. Respir Physiol Neurobiol. 2014;190:40–46.
   PubMed Web of Science ®Google Scholar
• Alison JA, McKeough ZJ, Leung RWM, et al. Oxygen compared to air during exercise training in COPD with exercise-induced desaturation. Eur Respir J. 2019.
   Web of Science ®Google Scholar
• van ‘t Hul A, Gosselink R, Hollander P, et al. Acute effects of inspiratory pressure support during exercise in patients with COPD. Eur Respir J. 2004;23(1):34–40.
   PubMed Web of Science ®Google Scholar
• van ‘t Hul A, Gosselink R, Hollander P, et al. Training with inspiratory pressure support in patients with severe COPD. Eur Respir J. 2006;27(1):65–72.
   PubMed Web of Science ®Google Scholar
• Vogiatzis I, Chynkiamis N, Armstrong M, et al. Intermittent use of portable NIV increases exercise tolerance in COPD: a randomised, cross-over trial. J Clin Med. 2019;8:1.
   Web of Science ®Google Scholar
• Mayer AF, Karloh M, Dos Santos K, et al. Effects of acute use of pursed-lips breathing during exercise in patients with COPD: a systematic review and meta-analysis. Physiotherapy. 2018;104(1):9–17.
   PubMed Web of Science ®Google Scholar
• McNamara RJ, McKeough ZJ, McKenzie DK, et al. Water-based exercise in COPD with physical comorbidities: a randomised controlled trial. Eur Respir J. 2013;41(6):1284–1291.
   PubMed Web of Science ®Google Scholar
• Steiner MC, Roberts CM. Pulmonary rehabilitation: the next steps. Lancet Respir Med. 2016;4(3):172–173.
   PubMed Web of Science ®Google Scholar
• Hogg L, Garrod R, Thornton H, et al. Effectiveness, attendance, and completion of an integrated, system-wide pulmonary rehabilitation service for COPD: prospective observational study. COPD. 2012;9(5):546–554.
   PubMedGoogle Scholar
• Abdellaoui A, Prefaut C, Gouzi F, et al. Skeletal muscle effects of electrostimulation after COPD exacerbation: a pilot study. Eur Respir J. 2011;38(4):781–788.
   PubMed Web of Science ®Google Scholar
• Giavedoni S, Deans A, McCaughey P, et al. Neuromuscular electrical stimulation prevents muscle function deterioration in exacerbated COPD: a pilot study. Respir Med. 2012;106(10):1429–1434.
   PubMed Web of Science ®Google Scholar
• Chaplin EJ, Houchen L, Greening NJ, et al. Neuromuscular stimulation of quadriceps in patients hospitalised during an exacerbation of COPD: a comparison of low (35 Hz) and high (50 Hz) frequencies. Physiother Res Int. 2013;18(3):148–156.
   PubMedGoogle Scholar
• Spruit MA, Wouters EF. New modalities of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease. Sports Med. 2007;37(6):501–518.
   PubMed Web of Science ®Google Scholar
• Hultman E, Sjoholm H, Jaderholm-Ek I, et al. Evaluation of methods for electrical stimulation of human skeletal muscle in situ. Pflugers Arch. 1983;398(2):139–141.
   PubMed Web of Science ®Google Scholar
• Maffiuletti NA. Physiological and methodological considerations for the use of neuromuscular electrical stimulation. Eur J Appl Physiol. 2010;110(2):223–234.
   PubMed Web of Science ®Google Scholar
• Vanderthommen M, Duchateau J. Electrical stimulation as a modality to improve performance of the neuromuscular system. Exerc Sport Sci Rev. 2007;35(4):180–185.
   PubMed Web of Science ®Google Scholar
• Henneman E, Somjen G, Carpenter DO. Functional significance of cell size in spinal motoneurons. J Neurophysiol. 1965;28:560–580.
   PubMed Web of Science ®Google Scholar
• Cabric M, Appell HJ, Resic A. Fine structural changes in electrostimulated human skeletal muscle. Evidence for predominant effects on fast muscle fibres. Eur J Appl Physiol Occup Physiol. 1988;57(1):1–5.
   PubMed Web of Science ®Google Scholar
• Trimble MH, Enoka RM. Mechanisms underlying the training effects associated with neuromuscular electrical stimulation. Phys Ther. 1991;71(4):273–280. discussion 280–272.
   PubMed Web of Science ®Google Scholar
• Bickel CS, Gregory CM, Dean JC. Motor unit recruitment during neuromuscular electrical stimulation: a critical appraisal. Eur J Appl Physiol. 2011;111(10):2399–2407.
   PubMed Web of Science ®Google Scholar
• Vanderthommen M, Duteil S, Wary C, et al. A comparison of voluntary and electrically induced contractions by interleaved 1H- and 31P-NMRS in humans. J Appl Physiol. 2003;94(3):1012–1024.
   PubMed Web of Science ®Google Scholar
• Vivodtzev I, Lacasse Y, Maltais F. Neuromuscular electrical stimulation of the lower limbs in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil Prev. 2008;28(2):79–91.
   PubMed Web of Science ®Google Scholar
• Grimby L, Hannerz J. Firing rate and recruitment order of toe extensor motor units in different modes of voluntary contraction. J Physiol. 1977;264(3):865–879.
   PubMed Web of Science ®Google Scholar
• Taylor A, Stephens JA. Study of human motor unit contractions by controlled intramuscular microstimulation. Brain Res. 1976;117(2):331–335.
   PubMed Web of Science ®Google Scholar
• Edwards RH, Young A, Hosking GP, et al. Human skeletal muscle function: description of tests and normal values. Clin Sci Mol Med. 1977;52(3):283–290.
   PubMedGoogle Scholar
• Kramer JF. Effect of electrical stimulation current frequencies on isometric knee extension torque. Phys Ther. 1987;67(1):31–38.
   PubMed Web of Science ®Google Scholar
• Hill K, Cavalheri V, Mathur S, et al. Neuromuscular electrostimulation for adults with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2018;5:CD010821.
   PubMedGoogle Scholar
• Tasdemir F, Inal-Ince D, Ergun P, et al. Neuromuscular electrical stimulation as an adjunct to endurance and resistance training during pulmonary rehabilitation in stable chronic obstructive pulmonary disease. Expert Rev Respir Med. 2015;9(4):493–502.
   PubMed Web of Science ®Google Scholar
• Zanotti E, Felicetti G, Maini M, et al. Peripheral muscle strength training in bed-bound patients with COPD receiving mechanical ventilation: effect of electrical stimulation. Chest. 2003;124(1):292–296.
   PubMed Web of Science ®Google Scholar
• Akar O, Gunay E, Sarinc Ulasli S, et al. Efficacy of neuromuscular electrical stimulation in patients with COPD followed in intensive care unit. Clin Respir J. 2017;11(6):743–750.
   PubMed Web of Science ®Google Scholar
• Tunsupon P, Lal A, Abo Khamis M, et al. Comorbidities in patients with chronic obstructive pulmonary disease and pulmonary rehabilitation outcomes. J Cardiopulm Rehabil Prev. 2017;37(4):283–289.
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, D’Arsigny C, Webb KA. Effects of hyperoxia on ventilatory limitation during exercise in advanced chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;163(4):892–898.
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, Revill SM, Webb KA. Dynamic hyperinflation and exercise intolerance in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2001;164(5):770–777.
   PubMed Web of Science ®Google Scholar
• Emtner M, Porszasz J, Burns M, et al. Benefits of supplemental oxygen in exercise training in nonhypoxemic chronic obstructive pulmonary disease patients. Am J Respir Crit Care Med. 2003;168(9):1034–1042.
   PubMed Web of Science ®Google Scholar
• Dean NC, Brown JK, Himelman RB, et al. Oxygen may improve dyspnea and endurance in patients with chronic obstructive pulmonary disease and only mild hypoxemia. Am Rev Respir Dis. 1992;146(4):941–945.
   PubMedGoogle Scholar
• Jolly EC, Di Boscio V, Aguirre L, et al. Effects of supplemental oxygen during activity in patients with advanced COPD without severe resting hypoxemia. Chest. 2001;120(2):437–443.
   PubMed Web of Science ®Google Scholar
• Jarosch I, Gloeckl R, Damm E, et al. Short-term effects of supplemental oxygen on 6-min walk test outcomes in patients with COPD: a randomized, placebo-controlled, single-blind, crossover trial. Chest. 2017;151(4):795–803.
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, Bain DJ, Webb KA. Factors contributing to relief of exertional breathlessness during hyperoxia in chronic airflow limitation. Am J Respir Crit Care Med. 1997;155(2):530–535.
   PubMed Web of Science ®Google Scholar
• Rooyackers JM, Dekhuijzen PN, Van Herwaarden CL, et al. Training with supplemental oxygen in patients with COPD and hypoxaemia at peak exercise. Eur Respir J. 1997;10(6):1278–1284.
   PubMed Web of Science ®Google Scholar
• Garrod R, Paul EA, Wedzicha JA. Supplemental oxygen during pulmonary rehabilitation in patients with COPD with exercise hypoxaemia. Thorax. 2000;55(7):539–543.
   PubMed Web of Science ®Google Scholar
• Heraud N, Prefaut C, Durand F, et al. Does correction of exercise-induced desaturation by O(2) always improve exercise tolerance in COPD? A preliminary study. Respir Med. 2008;102(9):1276–1286.
   PubMed Web of Science ®Google Scholar
• on behalf of the Guideline C, Windisch W, Geiseler J, Simon K, et al. German national guideline for treating chronic respiratory failure with invasive and non-invasive ventilation - revised edition 2017: part 2. Respiration. 2018;96(2):171–203.
   PubMed Web of Science ®Google Scholar
• Kohnlein T, Windisch W, Kohler D, et al. Non-invasive positive pressure ventilation for the treatment of severe stable chronic obstructive pulmonary disease: a prospective, multicentre, randomised, controlled clinical trial. Lancet Respir Med. 2014;2(9):698–705.
   PubMed Web of Science ®Google Scholar
• Murphy PB, Rehal S, Arbane G, et al. Effect of home noninvasive ventilation with oxygen therapy vs oxygen therapy alone on hospital readmission or death after an acute COPD exacerbation: a randomized clinical trial. JAMA. 2017;317(21):2177–2186.
   PubMed Web of Science ®Google Scholar
• Duiverman ML, Wempe JB, Bladder G, et al. Two-year home-based nocturnal noninvasive ventilation added to rehabilitation in chronic obstructive pulmonary disease patients: a randomized controlled trial. Respir Res. 2011;12:112.
   PubMed Web of Science ®Google Scholar
• van ‘t Hul A, Kwakkel G, Gosselink R. The acute effects of noninvasive ventilatory support during exercise on exercise endurance and dyspnea in patients with chronic obstructive pulmonary disease: a systematic review. J Cardiopulm Rehabil. 2002;22(4):290–297.
   PubMedGoogle Scholar
• Ambrosino N, Xie L. The use of non-invasive ventilation during exercise training in COPD patients. COPD. 2017;14(4):396–400.
   PubMedGoogle Scholar
• Borghi-Silva A, Carrascosa C, Oliveira CC, et al. Effects of respiratory muscle unloading on leg muscle oxygenation and blood volume during high-intensity exercise in chronic heart failure. Am J Physiol Heart Circ Physiol. 2008;294(6):H2465–2472.
   PubMed Web of Science ®Google Scholar
• Babcock MA, Pegelow DF, Harms CA, et al. Effects of respiratory muscle unloading on exercise-induced diaphragm fatigue. J Appl Physiol. 2002;93(1):201–206. (1985)
   PubMed Web of Science ®Google Scholar
• Gagnon P, Guenette JA, Langer D, et al. Pathogenesis of hyperinflation in chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2014;9:187–201.
   PubMed Web of Science ®Google Scholar
• Menadue C, Piper AJ, van ‘t Hul AJ, et al. Non-invasive ventilation during exercise training for people with chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2014;(5):CD007714.
   PubMed Web of Science ®Google Scholar
• Gloeckl R, Halle M, Kenn K. Interval versus continuous training in lung transplant candidates: a randomized trial. J Heart Lung Transplant. 2012;31(9):934–941.
   PubMed Web of Science ®Google Scholar
• Gloeckl R, Andrianopoulos V, Stegemann A, et al. High-pressure non-invasive ventilation during exercise in COPD patients with chronic hypercapnic respiratory failure: A randomized, controlled, cross-over trial. Respirology. 2019;24(3):254–261.
   PubMed Web of Science ®Google Scholar
• Minai OA, Chaouat A, Adnot S. Pulmonary hypertension in COPD: epidemiology, significance, and management: pulmonary vascular disease: the global perspective. Chest. 2010;137(6 Suppl):39S–51S.
   PubMed Web of Science ®Google Scholar
• Weitzenblum E, Mammosser M, Ehrhart M. Evolution and prognosis of pulmonary hypertension in chronic obstructive pulmonary diseases. Herz. 1986;11(3):147–154.
   PubMed Web of Science ®Google Scholar
• Weitzenblum E, Chaouat A, Kessler R. Pulmonary hypertension in chronic obstructive pulmonary disease. Pneumonol Alergol Pol. 2013;81(4):390–398.
   PubMedGoogle Scholar
• Vonbank K, Ziesche R, Higenbottam TW, et al. Controlled prospective randomised trial on the effects on pulmonary haemodynamics of the ambulatory long term use of nitric oxide and oxygen in patients with severe COPD. Thorax. 2003;58(4):289–293.
   PubMed Web of Science ®Google Scholar
• Hajian B, De Backer J, Vos W, et al. Pulmonary vascular effects of pulsed inhaled nitric oxide in COPD patients with pulmonary hypertension. Int J Chron Obstruct Pulmon Dis. 2016;11:1533–1541.
   PubMed Web of Science ®Google Scholar
• Martinez FJ, Foster G, Curtis JL, et al. Predictors of mortality in patients with emphysema and severe airflow obstruction. Am J Respir Crit Care Med. 2006;173(12):1326–1334.
   PubMed Web of Science ®Google Scholar
• Casanova C, Cote C, de Torres JP, et al. Inspiratory-to-total lung capacity ratio predicts mortality in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005;171(6):591–597.
   PubMed Web of Science ®Google Scholar
• Cerveri I, Dore R, Corsico A, et al. Assessment of emphysema in COPD: a functional and radiologic study. Chest. 2004;125(5):1714–1718.
   PubMed Web of Science ®Google Scholar
• Crisafulli E, Venturelli E, Biscione G, et al. Exercise performance after standard rehabilitation in COPD patients with lung hyperinflation. Intern Emerg Med. 2014;9(1):23–31.
   PubMed Web of Science ®Google Scholar
• Vanfleteren MJ, Koopman M, Spruit MA, et al. Effectiveness of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease with different degrees of static lung hyperinflation. Arch Phys Med Rehabil. 2018;99(11):2279–2286. e2273.
   PubMed Web of Science ®Google Scholar
• Fishman A, Martinez F, Naunheim K, et al. A randomized trial comparing lung-volume-reduction surgery with medical therapy for severe emphysema. N Engl J Med. 2003;348(21):2059–2073.
   PubMed Web of Science ®Google Scholar
• Ries AL, Make BJ, Lee SM, et al. The effects of pulmonary rehabilitation in the national emphysema treatment trial. Chest. 2005;128(6):3799–3809.
   PubMed Web of Science ®Google Scholar
• Casaburi R, Kukafka D, Cooper CB, et al. Improvement in exercise tolerance with the combination of tiotropium and pulmonary rehabilitation in patients with COPD. Chest. 2005;127(3):809–817.
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, Fluge T, Gerken F, et al. Effects of tiotropium on lung hyperinflation, dyspnoea and exercise tolerance in COPD. Eur Respir J. 2004;23(6):832–840.
   PubMed Web of Science ®Google Scholar
• Troosters T, Maltais F, Leidy N, et al. Effect of bronchodilation, exercise training, and behavior modification on symptoms and physical activity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2018;198(8):1021–1032.
   PubMed Web of Science ®Google Scholar
• Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report: GOLD executive summary. Eur Respir J. 2017;49:3.
   Web of Science ®Google Scholar
• Klooster K, Ten Hacken NH, Hartman JE, et al. Endobronchial valves for emphysema without interlobar collateral ventilation. N Engl J Med. 2015;373(24):2325–2335.
   PubMed Web of Science ®Google Scholar
• Criner GJ, Sue R, Wright S, et al. A multicenter randomized controlled trial of zephyr endobronchial valve treatment in heterogeneous emphysema (LIBERATE). Am J Respir Crit Care Med. 2018;198(9):1151–1164.
   PubMed Web of Science ®Google Scholar
• Martinez FJ, de Oca MM, Whyte RI, et al. Lung-volume reduction improves dyspnea, dynamic hyperinflation, and respiratory muscle function. Am J Respir Crit Care Med. 1997;155(6):1984–1990.
   PubMed Web of Science ®Google Scholar
• O’Donnell DE, Guenette JA, Maltais F, et al. Decline of resting inspiratory capacity in COPD: the impact on breathing pattern, dyspnea, and ventilatory capacity during exercise. Chest. 2012;141(3):753–762.
   PubMed Web of Science ®Google Scholar
• Hartman JE, Vanfleteren L, van Rikxoort EM, et al. on behalf of the Sc. Bronchoscopic lung volume reduction treatment using endobronchial valves for emphysema: emerging questions. Respiration. 2018;96(6):588–589.
   PubMed Web of Science ®Google Scholar
• Annegarn J, Meijer K, Passos VL, et al. Problematic activities of daily life are weakly associated with clinical characteristics in COPD. J Am Med Dir Assoc. 2012;13(3):284–290.
   PubMed Web of Science ®Google Scholar
• Pitta F, Troosters T, Spruit MA, et al. Characteristics of physical activities in daily life in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2005;171(9):972–977.
   PubMed Web of Science ®Google Scholar
• Annegarn J, Spruit MA, Savelberg HH, et al. Differences in walking pattern during 6-min walk test between patients with COPD and healthy subjects. PloS One. 2012;7(5):e37329.
   PubMed Web of Science ®Google Scholar
• Lahousse L, Verlinden VJ, van der Geest JN, et al. Gait patterns in COPD: the rotterdam study. Eur Respir J. 2015;46(1):88–95.
   PubMed Web of Science ®Google Scholar
• Nantsupawat N, Lane P, Siangpraipunt O, et al. Gait characteristics in patients with chronic obstructive pulmonary disease. J Prim Care Community Health. 2015;6(4):222–226.
   PubMed Web of Science ®Google Scholar
• Yentes JM, Schmid KK, Blanke D, et al. Gait mechanics in patients with chronic obstructive pulmonary disease. Respir Res. 2015;16:31.
   PubMed Web of Science ®Google Scholar
• Yentes JM, Rennard SI, Schmid KK, et al. Patients with chronic obstructive pulmonary disease walk with altered step time and step width variability as compared with healthy control subjects. Ann Am Thorac Soc. 2017;14(6):858–866.
   PubMed Web of Science ®Google Scholar
• Yentes JM, Sayles H, Meza J, et al. Walking abnormalities are associated with COPD: an investigation of the NHANES III dataset. Respir Med. 2011;105(1):80–87.
   PubMed Web of Science ®Google Scholar
• Sloot LH, van der Krogt MM, Harlaar J. Self-paced versus fixed speed treadmill walking. Gait Posture. 2014;39(1):478–484.
   PubMed Web of Science ®Google Scholar
• Sloot LH, van der Krogt MM, Harlaar J. Effects of adding a virtual reality environment to different modes of treadmill walking. Gait Posture. 2014;39(3):939–945.
   PubMed Web of Science ®Google Scholar
• Plotnik M, Azrad T, Bondi M, et al. Self-selected gait speed–over ground versus self-paced treadmill walking, a solution for a paradox. J Neuroeng Rehabil. 2015;12:20.
   PubMed Web of Science ®Google Scholar
• Liu WY, Meijer K, Delbressine JM, et al. Reproducibility and validity of the 6-minute walk test using the gait real-time analysis interactive lab in patients with COPD and healthy elderly. PLoS One. 2016;11(9):e0162444.
   PubMed Web of Science ®Google Scholar
• Liu WY, Meijer K, Delbressine JM, et al. Effects of pulmonary rehabilitation on gait characteristics in patients with COPD. J Clin Med. 2019;8:459. Submitted.
   Web of Science ®Google Scholar
• Liu WY, Spruit MA, Delbressine JM, et al. Spatiotemporal gait characteristics in patients with COPD during the gait real-time analysis interactive lab-based 6-minute walk test. PLoS One. 2017;12(12):e0190099.
   PubMed Web of Science ®Google Scholar
• Maki BE. Gait changes in older adults: predictors of falls or indicators of fear. J Am Geriatr Soc. 1997;45(3):313–320.
   PubMed Web of Science ®Google Scholar
• Beauchamp MK, Sibley KM, Lakhani B, et al. Impairments in systems underlying control of balance in COPD. Chest. 2012;141(6):1496–1503.
   PubMed Web of Science ®Google Scholar
• Roig M, Eng JJ, MacIntyre DL, et al. Falls in people with chronic obstructive pulmonary disease: an observational cohort study. Respir Med. 2011;105(3):461–469.
   PubMed Web of Science ®Google Scholar
• Baarends EM, Schols AM, Mostert R, et al. Peak exercise response in relation to tissue depletion in patients with chronic obstructive pulmonary disease. Eur Respir J. 1997;10(12):2807–2813.
   PubMed Web of Science ®Google Scholar
• Landbo C, Prescott E, Lange P, et al. Prognostic value of nutritional status in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 1999;160(6):1856–1861.
   PubMed Web of Science ®Google Scholar
• Lainscak M, von Haehling S, Doehner W, et al. Body mass index and prognosis in patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease. J Cachexia Sarcopenia Muscle. 2011;2(2):81–86.
   PubMed Web of Science ®Google Scholar
• Franssen FM, Broekhuizen R, Janssen PP, et al. Limb muscle dysfunction in COPD: effects of muscle wasting and exercise training. Med Sci Sports Exerc. 2005;37(1):2–9.
   PubMed Web of Science ®Google Scholar
• Schols AM, Soeters PB, Dingemans AM, et al. Prevalence and characteristics of nutritional depletion in patients with stable COPD eligible for pulmonary rehabilitation. Am Rev Respir Dis. 1993;147(5):1151–1156.
   PubMed Web of Science ®Google Scholar
• Mostert R, Goris A, Weling-Scheepers C, et al. Tissue depletion and health related quality of life in patients with chronic obstructive pulmonary disease. Respir Med. 2000;94(9):859–867.
   PubMed Web of Science ®Google Scholar
• Schols AM, Broekhuizen R, Weling-Scheepers CA, et al. Body composition and mortality in chronic obstructive pulmonary disease. Am J Clin Nutr. 2005;82(1):53–59.
   PubMed Web of Science ®Google Scholar
• Franssen FM, O’Donnell DE, Goossens GH, et al. Obesity and the lung: 5. Obesity and COPD. Thorax. 2008;63(12):1110–1117.
   PubMed Web of Science ®Google Scholar
• Cecere LM, Littman AJ, Slatore CG, et al. Obesity and COPD: associated symptoms, health-related quality of life, and medication use. COPD. 2011;8(4):275–284.
   PubMedGoogle Scholar
• Bautista J, Ehsan M, Normandin E, et al. Physiologic responses during the six minute walk test in obese and non-obese COPD patients. Respir Med. 2011;105(8):1189–1194.
   PubMed Web of Science ®Google Scholar
• Divo MJ, Cabrera C, Casanova C, et al. comorbidity distribution, clinical expression and survival in COPD patients with different body mass index. Chronic Obstr Pulm Dis. 2014;1(2):229–238.
   PubMedGoogle Scholar
• Schols AM, Ferreira IM, Franssen FM, et al. Nutritional assessment and therapy in COPD: a European respiratory society statement. Eur Respir J. 2014;44(6):1504–1520.
   PubMed Web of Science ®Google Scholar
• Franssen FM, Rutten EP, Groenen MT, et al. New reference values for body composition by bioelectrical impedance analysis in the general population: results from the UK Biobank. J Am Med Dir Assoc. 2014;15:448.e1–448.e6.
   Web of Science ®Google Scholar
• Ferreira IM, Brooks D, White J, et al. Nutritional supplementation for stable chronic obstructive pulmonary disease. Cochrane Database Syst Rev. 2012;12:CD000998.
   PubMedGoogle Scholar
• Schols AM, Soeters PB, Mostert R, et al. Physiologic effects of nutritional support and anabolic steroids in patients with chronic obstructive pulmonary disease. A placebo- controlled randomized trial. Am J Respir Crit Care Med. 1995;152(4 Pt 1):1268–1274.
   PubMed Web of Science ®Google Scholar
• Casaburi R, Bhasin S, Cosentino L, et al. Effects of testosterone and resistance training in men with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2004;170(8):870–878.
   PubMed Web of Science ®Google Scholar
• Creutzberg EC, Wouters EF, Mostert R, et al. A role for anabolic steroids in the rehabilitation of patients with COPD? A double-blind, placebo-controlled, randomized trial. Chest. 2003;124(5):1733–1742.
   PubMed Web of Science ®Google Scholar
• Svartberg J, Aasebo U, Hjalmarsen A, et al. Testosterone treatment improves body composition and sexual function in men with COPD, in a 6-month randomized controlled trial. Respir Med. 2004;98(9):906–913.
   PubMed Web of Science ®Google Scholar
• McDonald VM, Gibson PG, Scott HA, et al. Should we treat obesity in COPD? The effects of diet and resistance exercise training. Respirology. 2016;21:875–882.
   Web of Science ®Google Scholar
• Sava F, Laviolette L, Bernard S, et al. The impact of obesity on walking and cycling performance and response to pulmonary rehabilitation in COPD. BMC Pulm Med. 2010;10:55.
   PubMed Web of Science ®Google Scholar
• Watson NF, Badr MS, Belenky G, et al. Recommended amount of sleep for a healthy adult: a joint consensus statement of the American academy of sleep medicine and sleep research society. Sleep. 2015;38(6):843–844.
   PubMed Web of Science ®Google Scholar
• Kripke DF, Langer RD, Elliott JA, et al. Mortality related to actigraphic long and short sleep. Sleep Med. 2011;12(1):28–33.
   PubMed Web of Science ®Google Scholar
• Vico-Romero J, Cabre-Roure M, Monteis-Cahis R, et al. [Prevalence of sleep disorders and associated factors in inpatient]. Enferm Clin. 2014;24(5):276–282.
   PubMedGoogle Scholar
• Cormick W, Olson LG, Hensley MJ, et al. Nocturnal hypoxaemia and quality of sleep in patients with chronic obstructive lung disease. Thorax. 1986;41(11):846–854.
   PubMed Web of Science ®Google Scholar
• Budhiraja R, Roth T, Hudgel DW, et al. Prevalence and polysomnographic correlates of insomnia comorbid with medical disorders. Sleep. 2011;34(7):859–867.
   PubMed Web of Science ®Google Scholar
• Ohayon MM. Chronic Obstructive Pulmonary Disease and its association with sleep and mental disorders in the general population. J Psychiatr Res. 2014;54:79–84.
   PubMed Web of Science ®Google Scholar
• Valipour A, Lavie P, Lothaller H, et al. Sleep profile and symptoms of sleep disorders in patients with stable mild to moderate chronic obstructive pulmonary disease. Sleep Med. 2011;12(4):367–372.
   PubMed Web of Science ®Google Scholar
• Price D, Small M, Milligan G, et al. Impact of night-time symptoms in COPD: a real-world study in five European countries. Int J Chron Obstruct Pulmon Dis. 2013;8:595–603.
   PubMed Web of Science ®Google Scholar
• Parish JM. Sleep-related problems in common medical conditions. Chest. 2009;135(2):563–572.
   PubMed Web of Science ®Google Scholar
• George CF, Bayliff CD. Management of insomnia in patients with chronic obstructive pulmonary disease. Drugs. 2003;63(4):379–387.
   PubMed Web of Science ®Google Scholar
• Dodge R, Cline MG, Quan SF. The natural history of insomnia and its relationship to respiratory symptoms. Arch Intern Med. 1995;155(16):1797–1800.
   PubMedGoogle Scholar
• Klink ME, Dodge R, Quan SF. The relation of sleep complaints to respiratory symptoms in a general population. Chest. 1994;105(1):151–154.
   PubMed Web of Science ®Google Scholar
• Tashkin DP, Rennard SI, Martin P, et al. Efficacy and safety of budesonide and formoterol in one pressurized metered-dose inhaler in patients with moderate to very severe chronic obstructive pulmonary disease: results of a 6-month randomized clinical trial. Drugs. 2008;68(14):1975–2000.
   PubMed Web of Science ®Google Scholar
• Kessler R, Partridge MR, Miravitlles M, et al. Symptom variability in patients with severe COPD: a pan-European cross-sectional study. Eur Respir J. 2011;37(2):264–272.
   PubMed Web of Science ®Google Scholar
• Calverley PM, Brezinova V, Douglas NJ, et al. The effect of oxygenation on sleep quality in chronic bronchitis and emphysema. Am Rev Respir Dis. 1982;126(2):206–210.
   PubMed Web of Science ®Google Scholar
• Fleetham J, West P, Mezon B, et al. Sleep, arousals, and oxygen desaturation in chronic obstructive pulmonary disease. The effect of oxygen therapy. Am Rev Respir Dis. 1982;126(3):429–433.
   PubMed Web of Science ®Google Scholar
• Krachman SL, Quaranta AJ, Berger TJ, et al. Effects of noninvasive positive pressure ventilation on gas exchange and sleep in COPD patients. Chest. 1997;112(3):623–628.
   PubMed Web of Science ®Google Scholar
• Ford DE, Kamerow DB. Epidemiologic study of sleep disturbances and psychiatric disorders. An opportunity for prevention? JAMA. 1989;262(11):1479–1484.
   PubMed Web of Science ®Google Scholar
• Soler X, Gaio E, Powell FL, et al. High prevalence of obstructive sleep apnea in patients with moderate to severe chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2015;12(8):1219–1225.
   PubMed Web of Science ®Google Scholar
• Steveling EH, Clarenbach CF, Miedinger D, et al. Predictors of the overlap syndrome and its association with comorbidities in patients with chronic obstructive pulmonary disease. Respiration. 2014;88(6):451–457.
   PubMed Web of Science ®Google Scholar
• Zhao YY, Blackwell T, Ensrud KE, et al. Sleep apnea and obstructive airway disease in older men: outcomes of sleep disorders in older men study. Sleep. 2016;39(7):1343–1351.
   PubMed Web of Science ®Google Scholar
• Spina G, Spruit MA, Alison J, et al. Analysis of nocturnal actigraphic sleep measures in patients with COPD and their association with daytime physical activity. Thorax. 2017;72(8):694–701.
   PubMed Web of Science ®Google Scholar
• Chung WS, Lai CY, Lin CL, et al. Adverse respiratory events associated with hypnotics use in patients of chronic obstructive pulmonary disease: a population-based case-control study. Medicine (Baltimore). 2015;94(27):e1110.
   PubMed Web of Science ®Google Scholar
• Vozoris NT, Fischer HD, Wang X, et al. Benzodiazepine drug use and adverse respiratory outcomes among older adults with COPD. Eur Respir J. 2014;44(2):332–340.
   PubMed Web of Science ®Google Scholar
• Kryger M, Roth T, Wang-Weigand S, et al. The effects of ramelteon on respiration during sleep in subjects with moderate to severe chronic obstructive pulmonary disease. Sleep Breath. 2009;13(1):79–84.
   PubMed Web of Science ®Google Scholar
• Roth T. Hypnotic use for insomnia management in chronic obstructive pulmonary disease. Sleep Med. 2009;10(1):19–25.
   PubMed Web of Science ®Google Scholar
• Sun H, Palcza J, Rosenberg R, et al. Effects of suvorexant, an orexin receptor antagonist, on breathing during sleep in patients with chronic obstructive pulmonary disease. Respir Med. 2015;109(3):416–426.
   PubMed Web of Science ®Google Scholar
• Marin JM, Soriano JB, Carrizo SJ, et al. Outcomes in patients with chronic obstructive pulmonary disease and obstructive sleep apnea: the overlap syndrome. Am J Respir Crit Care Med. 2010;182(3):325–331.
   PubMed Web of Science ®Google Scholar
• Driver HS, Taylor SR. Exercise and sleep. Sleep Med Rev. 2000;4(4):387–402.
   PubMed Web of Science ®Google Scholar
• Passos GS, Poyares D, Santana MG, et al. Effect of acute physical exercise on patients with chronic primary insomnia. J Clin Sleep Med. 2010;6(3):270–275.
   PubMed Web of Science ®Google Scholar
• Kline CE. The bidirectional relationship between exercise and sleep: implications for exercise adherence and sleep improvement. Am J Lifestyle Med. 2014;8(6):375–379.
   PubMedGoogle Scholar
• Mendelson M, Bailly S, Marillier M, et al. Obstructive sleep apnea syndrome, objectively measured physical activity and exercise training interventions: a systematic review and meta-analysis. Front Neurol. 2018;9:73.
   PubMed Web of Science ®Google Scholar
• Soler X, Diaz-Piedra C, Ries AL. Pulmonary rehabilitation improves sleep quality in chronic lung disease. COPD. 2013;10(2):156–163.
   PubMedGoogle Scholar
• Lan CC, Huang HC, Yang MC, et al. Pulmonary rehabilitation improves subjective sleep quality in COPD. Respir Care. 2014;59(10):1569–1576.
   PubMed Web of Science ®Google Scholar