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Review

Comorbidities and mortality risk factors for patients with bronchiectasis

, , , , &
Pages 623-634 | Received 02 Oct 2020, Accepted 02 Feb 2021, Published online: 17 Feb 2021

References

  • Quint JK, Millett ER, Joshi M, et al. Changes in the incidence, prevalence and mortality of bronchiectasis in the UK from 2004 to 2013: a population-based cohort study. Eur Respir J. 2016;47(1):186–193.
  • Monteagudo M, Rodríguez-Blanco T, Barrecheguren M, et al. Prevalence and incidence of bronchiectasis in Catalonia, Spain: a population-based study. Respir Med. 2016;121:26–31.
  • Martinez-Garcia MA, Polverino E, Aksamit T. Bronchiectasis and chronic airway disease: it is not just about asthma and COPD. Chest. 2018;154(4):737–739.
  • Kwak HJ, Moon JY, Choi YW, et al. High prevalence of bronchiectasis in adults: analysis of CT findings in a health screening program. Tohoku J Exp Med. 2010;222(4):237–242.
  • Dhar R, Singh S, Talwar D, et al. Bronchiectasis in India: results from the European Multicentre bronchiectasis audit and research collaboration (EMBARC) and respiratory research network of India registry. Lancet Glob Health. 2019;7(9):e1269–e1279.
  • Sambamoorthi U, Tan X, Deb A. Multiple chronic conditions and healthcare costs among adults. Expert Rev Pharmacoecon Outcomes Res. 2015;15:823–832.
  • Polverino E, Goeminne PC, McDonnell MJ, et al. European respiratory society guidelines for the management of adult bronchiectasis. Eur Respir J. 2017;50:1700629.
  • Pasteur MC, Bilton D, Hill AT. British thoracic society guideline for non-CF bronchiectasis. Thorax. 2010;65(Suppl. 1):i1–58.
  • Martinez-Garcia MA, Maiz L, Olveira C, et al. Spanish guidelines on treatment of bronchiectasis in adults. Arch Bronconeumol. 2018;54:88–98.
  • Martinez-Garcia MA, Maiz L, Olveira C, et al. Spanish Guidelines on the evaluation and diagnosis of bronchiectasis in adults. Arch Bronconeumol. 2018;54:79–87.
  • Ording AG, Sørensen HT. Concepts of comorbidities, multiple morbidities, complications, and their clinical epidemiologic analogs. Clin Epidemiol. 2013;5:199–203.
  • Feinstein AR. The pre-therapeutic classification of co-morbidity in chronic disease. J Chronic Dis. 1970;23:455–468.
  • McDonnell MJ, Aliberti S, Goeminne PC, et al. Comorbidities and the risk of mortality in patients with bronchiectasis: an international multicentre cohort study. Lancet Respir Med. 2016;4:969–979.
  • Goeminne PC, Nawrot TS, Ruttens D, et al. Mortality in non-cystic fibrosis bronchiectasis: a prospective cohort analysis. Respir Med. 2014;108:287–296.
  • Loebinger MR, Wells AU, Hansell DM, et al. Mortality in bronchiectasis: a long-term study assessing the factors influencing survival. Eur Respir J. 2009;34:843–849.
  • Charlson ME, Pompei P, Ales KL, et al. A new method of classifying prognostic comorbidity in longitudinal studies: development and validation. J Chronic Dis. 1987;40:373–383.
  • Chalmers JD, Goeminne P, Aliberti S, et al. The bronchiectasis severity index. An international derivation and validation study. Am J Respir Crit Care Med. 2014;189:576–585.
  • de la Rosa Carrillo D, Athanazio R, Girón Moreno RM, et al. The annual prognostic ability of FACED and 
E-FACED scores to predict mortality in patients with bronchiectasis. ERJ Open Res. 2018;4:00139–2017.
  • McDonnell MJ, Aliberti S, Goeminne PC, et al. Multidimensional severity assessment in bronchiectasis: an analysis of seven European cohorts. Thorax. 2016;71:1110–1118.
  • Rosales-Mayor E, Polverino E, Raguer L, et al. Comparison of two prognostic scores (BSI and FACED) in a Spanish cohort of adult patients with bronchiectasis and improvement of the FACED predictive capacity for exacerbations. PLoS One. 2017;12(4):e0175171.
  • Cole PJ. Inflammation: a two-edged sword – the model of bronchiectasis. Eur J Respir Dis Suppl. 1986;147:6–15.
  • Saleh AD, Chalmers JD, De Soyza A, et al. The heterogeneity of systemic inflammation in bronchiectasis. Respir Med. 2017;127:33–39.
  • Camus P, Piard F, Ashcroft T, et al. The lung in inflammatory bowel disease. Medicine (Baltimore). 1993;72:151–183.
  • Dumas A, Bernard L, Poquet Y, et al. The role of the lung microbiota and the gut-lung axis in respiratory infectious diseases. Cell Microbiol. 2018;20(12):e12966.
  • D- Marsland BJ, Trompette A, Gollwitzer ES. The gut-lung axis in respiratory disease. Ann Am Thorac Soc. 2015;12(Suppl 2):S150–6.
  • Perez T, Remy-Jardin M, Cortet B. Airways involvement in rheumatoid arthritis: clinical, functional, and HRCT findings. Am J Respir Crit Care Med. 1998;157:1658–1665.
  • Song ST, Kim SS, Kim JY, et al. Association of single nucleotide polymorphisms of PADI4 and HLA-DRB1 alleles with susceptibility to rheumatoid arthritis-related lung diseases. Lung. 2016;194:745–753.
  • Robles-Perez A, Luburich P, Rodriguez-Sanchon B, et al. Preclinical lung disease in early rheumatoid arthritis. Chron Respir Dis. 2016;13:75–81.
  • Perry E, Stenton C, Kelly C, et al. RA autoantibodies as predictors of rheumatoid arthritis in non-cystic fibrosis bronchiectasis patients. Eur Respir J. 2014;44:1082–1085.
  • Quirke AM, Perry E, Cartwright A, et al. Bronchiectasis is a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis. Arthritis Rheumatol. 2015;67:2335–2342.
  • Allain J, Saraux A, Guedes C, et al. Prevalence of symptomatic bronchiectasis in patients with rheumatoid arthritis. Rev Rhum Engl Ed. 1997;64:531–537.
  • Perry E, Kelly C, Eggleton P, et al. The lung in ACPA-positive rheumatoid arthritis: an initiating site of injury? Rheumatology. 2014;53(11):1940–1950.
  • De Soyza A, McDonnell MJ, Goeminne PC, et al. Bronchiectasis rheumatoid overlap syndrome is an independent risk factor for mortality in patients with bronchiectasis: a multicenter cohort study. Chest. 2017;151:1247–1254.
  • Papanikolaou I, Kagouridis K, Papiris SA. Patterns of airway involvement in inflammatory bowel diseases. World J Gastrointest Pathophysiol. 2014;5(4):560–569.
  • Ji XQ, Wang LX, Lu DG. Pulmonary manifestations of inflammatory bowel disease. World J Gastroenterol. 2014;20(37):13501–13511. 7.
  • Lu DG, Ji XQ, Liu X, et al. Pulmonary manifestations of Crohn’s disease. World J Gastroenterol. 2014;20(1):133–141.
  • Malerba M, Ragnoli B, Buffoli L, et al. Exhaled nitric oxide as a marker of lung involvement in Crohn’s disease. Int J Immunopathol Pharmacol. 2011;24:1119–1124.
  • Gathmann B, Mahlaoui N, Gerard L, et al. Clinical picture and treatment of 2212 patients with common variable immunodeficiency. J Allergy Clin Immunol. 2014;134:116–126.
  • Hurst JR, Workman S, Garcha DS, et al. Activity, severity and impact of respiratory disease in primary antibody deficiency syndromes. J Clin Immunol. 2014;34:68–75.
  • de Gracia J, Vendrell M, Alvarez A, et al. Immunoglobulin therapy to control lung damage in patients with 
common variable immunodeficiency. Int Immunopharmacol. 2004;4:745–753.
  • Roifman CM, Levison H, Gelfand EW. High-dose versus low-dose intravenous immunoglobulin in hypogammaglobulinaemia and chronic lung disease. Lancet. 1987;1:1075–1077.
  • Rodman DM, Polis JM, Heltshe SL, et al. Late diagnosis defines a unique population of long-term survivors of cystic fibrosis. Am J Respir Crit Care Med. 2005;171:621–626.
  • Nick JA, Rodman DM. Manifestations of cystic fibrosis diagnosed in adulthood. Curr Opin Pulm Med. 2005;11:513–518.
  • Boyle MP. Nonclassic cystic fibrosis and CFTR-related diseases. Curr Opin Pulm Med. 2003;9:498–503.
  • Shah A, Shoemark A, MacNeill SJ, et al. A longitudinal study characterising a large adult primary ciliary dyskinesia population. Eur Respir J. 2016;48:441–450.
  • Parr DG, Guest PG, Reynolds JH, et al. Prevalence and impact of bronchiectasis in alpha-1 antitrypsin deficiency. Am J Respir Crit Care Med. 2007;176:1215–1221.
  • Friedman KJ, Teichtahl H, De Kretser DM, et al. Screening Young syndrome patients for CFTR mutations. Am J Respir Crit Care Med. 1995;152(4 Pt 1):1353–1357.
  • Agarwal R, Chakrabarti A, Shah A, et al. Allergic bronchopulmonary aspergillosis: review of literature and proposal of new diagnostic and classification criteria. Clin Exp Allergy. 2013;43:850–873.
  • Rosenberg M, Patterson R, Mintzer R, et al. Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med. 1977;86:405–414.
  • Greenberger PA. Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol. 2002;110:685–692.
  • Lonni S, Chalmers JD, Goeminne PC, et al. Etiology of non-cystic fibrosis bronchiectasis in adults and its correlation to disease severity. Ann Am Thorac Soc. 2015;12:1764–1770.
  • Tsikrika S, Dimakou K, Papaioannou AI, et al. The role of non-invasive modalities for assessing inflammation in patients with non-cystic fibrosis bronchiectasis. Cytokine. 2017;99:281–286.
  • Fuschillo S, De Felice A, Balzano G. Mucosal inflammation in idiopathic bronchiectasis: cellular and molecular mechanisms. Eur Respir J. 2008;31(2):396‐406.
  • Mcdonell M, Das J, O´Toole D, et al. Effects of gastro-oesophageal reflux and pulmonary micro-aspiration in bronchiectasis. Eur Respir J. 2018;52:OA4950
  • Radovanovic D, Santus P, Blasi F, et al. A comprehensive approach to lung function in bronchiectasis. Respir Med. 2018;145:120–129.
  • Dimakou K, Gousiou A, Toumbis M, et al. Investigation of bronchiectasis in severe uncontrolled asthma. Clin Respir J. 2018;12:1212–1218.
  • Perez-Miranda J, Traversi L, Polverino E. Bronchiectasis in severe asthma: a distinct phenotype? Curr Opin Pulm Med. 2019;25(1):71–78.
  • Polverino E, Dimakou K, Hurst J, et al. The overlap between bronchiectasis and chronic airway diseases: state of the art and future directions. Eur Respir J. 2018;52(3):1800328.
  • Kang HR, Choi G-S, Park SJ, et al. The effects of bronchiectasis on asthma exacerbation. Tuberc Respir Dis. 2014;77:209–214.
  • Chen FJ, Liao H, Huang XY, et al. Importance of fractional exhaled nitric oxide in diagnosis of bronchiectasis accompanied with bronchial asthma. J Thorac Dis. 2016;8:992–999.
  • Mao B, Yang JW, Lu HW, et al. Asthma and bronchiectasis exacerbation. Eur Respir J. 2016;47:1680–1686.
  • Global Initiative for Asthma. Global strategy for asthma management and prevention, 2020. [cited 2020 Dec]. Available from: www.ginasthma.org
  • Brusselle GG, Vanderstichele C, Jordens P, et al. Azithromycin for prevention of exacerbations in severe asthma (AZISAST): a multicentre randomised double-blind placebo-controlled trial. Thorax. 2013;68(4):322–329.
  • Martínez-García MA, Miravitlles M. Bronchiectasis in COPD patients: more than a comorbidity? Int J COPD. 2017;12:1401–1411.
  • Hurst JR, Elborn JS, De Soyza A, et al. COPD-bronchiectasis overlap syndrome. Eur Respir J. 2015;45:310–313.
  • Agustì A, Calverley PMA, Celli B, et al. Characterisation of COPD heterogeneity in the ECLIPSE cohort. Respir Res. 2010;11:122.
  • Martinez-Garcia MA, de la Rosa-carrillo D, Soler-Cataluña JJ, et al. Bronchial infection and temporal evolution OF bronchiectasis in patients with chronic obstructive pulmonary disease. Clin Infect Dis. 2020;22:ciaa069.
  • Chalmers JD, Aliberti S, Filonenko A, et al. Characterisation of the “Frequent Exacerbator Phenotype” in Bronchiectasis. Am J Respir Crit Care Med. 2018;197:1410–1420.
  • Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease. report. GOLD executive summary. Am J Respir Crit Care Med. 2017;195:557–582.
  • Contoli M, Pauletti A, Rossi MR, et al. Long-term effects of inhaled corticosteroids on sputum bacterial and viral loads in COPD. Eur Respir J. 2017;50:1700451.
  • Finney L, Berry M, Singanayagam A, et al. Inhaled corticosteroids and pneumonia in chronic obstructive pulmonary disease. Lancet Respir Med. 2014;2:919–932.
  • Andréjak C, Nielsen R, Thomsen VØ, et al. Chronic respiratory disease, inhaled corticosteroids and risk of non-tuberculous mycobacteriosis. Thorax. 2013;68:256–262.
  • Lee C-H, Kim K, Hyun MK, et al. Use of inhaled corticosteroids and the risk of tuberculosis. Thorax. 2013;68:1105–1113.
  • Pavord ID, Agusti A. Blood eosinophil count: a biomarker of an important treatable trait in patients with airway disease. Eur Respir J. 2016;47:1299–1303.
  • Eusebi LH, Ratnakumaran R, Yuan Y, et al. Global prevalence of, and risk factors for, gastro-oesopha- geal reflux symptoms: a meta-analysis. Gut. 2018;67(3):430–440.
  • Vaezi MF, Katzka D, Zervib F. Extraesophageal symptoms and disease attributed to GERD: where is the pendulum swinging now? Clinical Gastroenterol Hepatol. 2018;16:1018–1029.
  • Trudgill NJ, Sifrim D, Sweiss R, et al. British society of gastroenterology guidelines for oesophageal manometry and oesophageal reflux monitoring. Gu. 2019;68:1731–1750.
  • Araújo D, Shteinberg M, Aliberti S, et al. Standarised classsification of the aetiology of bronchiectasis using an objective algorithm. Eur Respir J. 2017;50:1701289.
  • Mandal P, Morice AH, Chalmers, et al. Symptoms of airway reflux predict exacerbations and quality of life in bronchiectasis. Resp Med. 2013;107(7):1008–1013.
  • Mc Donnell MJ, Ahmed M, Das J, et al. Hiatal hernias are correlated with increased severity of non-cystic fibrosis bronchiectsis. Respiratology. 2015;20:749–757.
  • Donnell M, Michael OM, David B, et al. Increased disease severity and mortality associated with bronchiectasis-GORD phenotype. Eur Respir J. 2015;46: PA366 (suppl 59).
  • McDonnell M, Rutherford R, De Soyza A, et al. Association between gastro-oesophageal reflux and exacerbations in bronchiectasis: data from the EMBARC registry. Eur Respir J. 2017;50(suppl.61):OA1968.
  • Sweet MP, Herbella FA, Leard L, et al. The prevalence of distal and proximal gastrooesophageal reflux in patients awaiting lung transplantation. Ann Surg. 2006;244:491–497.
  • Lee AL, Button BM, Denehy L, et al. Proximal and distal gastro-oesophageal reflux in chronic obstructive pulmonary disease and bronchiestasis. Respiratology. 2014;19(2):211–217.
  • Lee AL, Button BM, Denehy L, et al. Exhaled breath condensate pepsin: potential non-invasive test for gastroespphageal reflux in COPD and bronquiectasis. Respir Care. 2015;60:244–250.
  • Budden KF, Shukla SD, Rehman SF, et al. Functional effects of the microbiota in chronic respiratory disease. Lancet Respir Med. 2019;7:907–920.
  • Ahn B, Lee DH, Lee CM, et al. Effect of proton pump inhibitors in bronchiectasic patients with gastroesophageal reflux disease. Korean J Gastroenterol. 2016;68(1):10–15.
  • Saleh AD, Kwok B, Brown JS, et al. Correlates and assessment of excess cardiovascular risk in bron°Chiectasis. Eur Respir J. 2017;50:1701127.
  • Evans IE, Bedi P, Quinn TM, et al. Bronchiectasis severity is an independent risk factor for vascular disease in a bronchiectasis cohort. Chest. 2017;151:383–388.
  • Navaratnam V, Root AA, Douglas I, et al. Cardiovascular outcomes after a respiratory tract infection among adults with non-cystic fibrosis bronchiectasis: a general population-based study. Ann Am Thorac Soc. 2018;15:315–321.
  • Joshi R, Khandelwal B, Joshi D, et al. Chlamydophila pneumoniae infection and cardiovascular disease. N Am J Med Sci. 2013;5:169–181.
  • Siriwardena AN. Increasing evidence that influenza is a trigger for cardiovascular disease. J Infect Dis. 2012;206:1636–1638.
  • Yende S, D’Angelo G, Kellum JA, et al. Inflammatory markers at hospital discharge predict subsequent mortality after pneumonia and sepsis. Am J Respir Crit Care Med. 2008;177(11):1242–1247. 1.
  • Perry TW, Pugh MJ, Waterer GW, et al. Incidence of cardiovascular events after hospital admission for pneumonia. Am J Med. 2011;124(3):244–251.
  • Ewig S, Torres A. Community-acquired pneumonia as an emergency: time for an aggressive intervention to lower mortality. Eur Respir J Aug. 2011;38(2):253–260.
  • Corrales-Medina VF, Madjid M, Musher DM. Role of acute infection in triggering acute coronary syndromes. Lancet Infect Dis Feb. 2010;10(2):83–92.
  • Yende S, Angus DC, Ali IS, et al. Influence of comorbid conditions on long-term mortality after pneumonia in older people. J Am Geriatr Soc. 2007;55(4):518–525.
  • Mortensen EM, Kapoor WN, Chang CC, et al. Assessment of mortality after long-term follow-up of patients with community-acquired pneumonia. Clin Infect Dis. 2003;37(12):1617–1624. 15.
  • Albrich WC, Dusemund F, Ruegger K, et al. Enhancement of CURB65 score with proadrenomedullin (CURB65-A) for outcome prediction in lower respiratory tract infections: derivation of a clinical algorithm. BMC Infect Dis. 2011;11:112.
  • Kruger S, Ewig S, Marre R, et al. Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes. Eur Respir J. 2008;31(2):349–355.
  • Guertler C, Wirz B, Christ-Crain M, et al. Inflammatory responses predict long-term mortality risk in community-acquired pneumonia. Eur Respir J. 2011;37(6):1439–1446.
  • Navaratnam V, Millett ER, Hurst JR, et al. Bronchiectasis and the risk of cardiovascular disease: a population-based study. Thorax. 2016;72:161–166.
  • Menéndez R, Méndez R, Polverino E, et al. Factors associated with hospitalization in bronchiectasis exacerbations: a one-year follow-up study. A Respir Res. 2017;18(1):176.
  • Gencer M, Ceylan E, Yilmaz R, et al. Impact of bronchiectasis on right and left ventricular functions. Respir Med. 2006;100:1933–1943.
  • Harrison MT, Short P, Williamson PA, et al. Thrombocytosis is associated with increased short and long term mortality after exacerbation of chronic obstructive pulmonary disease: a role for antiplatelet therapy? Thorax. 2014;69:609–615.
  • Renton D, Hill J, Abo-Leyeh H, et al. Thrombocytosis is associated with disease severity and outcomes in stable bronchiectasis. Eur Respir J. 2015;46(Suppl. 59):OA469.
  • Öcal S, Portakal O, Öcal A, et al. Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects. Respir Med. 2016;119:109–114.
  • Devaraj A, Wells AU, Meister MG, et al. Pulmonary hypertension in patients with bronchiectasis: prognostic significance of CT signs. AJR Am J Roentgenol. 2011;196:1300–1304.
  • Wang L, Jiang S, Shi J, et al. Clinical characteristics of pulmonary hypertension in bronchiectasis. Front Med. 2016;10:336–344.
  • Galiè N, Humbert M, Vachiery JL, et al. ESC/ERS guidelines for the diagnosis and treatment of pulmonary hypertension: the joint task force for the diagnosis and treatment of pulmonary hypertension of the European society of cardiology (ESC) and the European respiratory society (ERS): endorsed by: association for European paediatric and congenital cardiology (AEPC), International society for heart and lung transplantation (ISHLT). Eur Respir J. 2015;46(4):903–975.
  • Portillo K, Martinez-Rivera C, Ruiz-Manzano J. Anaemia in chronic obstructive pulmonary disease. Does it really matter? Int J Clin Pract. 2013;67:558–565.
  • Cloonan SM, Mumby S, Adcock IM, et al. The “Iron”-y of iron overload and iron deficiency in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2017;196:1103–1112.
  • Schneckenpointner R, Jörres RA, Meidenbauer N, et al. The clinical significance of anaemia and disturbed iron homeostasis in chronic respiratoryfailure. Int J Clin Pract. 2014;68(1):130–138.
  • Kollert F, Müller C, Tippelt A, et al. Anaemia in chronic respiratory failure. Int J Clin Pract. 2011;65(4):479–486.
  • van den Borst B, Gosker HR, Zeegers MP, et al. Pulmonary function in diabetes: a metaanalysis. Chest. 2010;138:393–406.
  • Kuo MC, Lin SH, Lin CH, et al. Type 2 diabetes: an independent risk factor for tuberculosis: a nationwide population-based study. PloS One. 2013;8:e78924.
  • Patel AR, Hurst JR. Extrapulmonary comorbidities in chronic obstructive pulmonary disease: state of the art. Expert Rev Respir Med. 2011;5:647–662.
  • Chung WS, Lin CL, Lin CL, et al. Bronchiectasis and the risk of cancer: a nationwide retrospective cohort study. Int J Clin Pract. 2015;69:682–688.
  • Chung WS, Lin CL, Hsu WH, et al. Increased risk of lung cancer among patients with bronchiectasis: a nationwide cohort study. QJM. 2016;109:17–25.
  • Chen LW, McShane PJ, Karkowsky W, et al. De novo development of bronchiectasis in patients with hematologic malignancy. Chest. 2017;152:683–685.
  • Contreras-Bolívar V, Olveira G, Porras N, et al. Osteopenia and osteoporosis in patients with bronchiectasis: association with respiratory parameters, body composition, muscle strength and bone remodeling biomarkers. Sci Rep. 2019;9(1):14496. 10.
  • Diehl N, Johnson MM. Prevalence of osteopenia and osteoporosis in patients with noncystic fibrosis bronchiectasis. South Med J. 2016;109(12):779–783.
  • Wijeratne T, Wong C, Jayaram L, et al. Neurological and sleep disturbances in bronchiectasis. J Clin Med. 2017;6(12): 30. doi:https://doi.org/10.3390/jcm6120114.
  • Gulhan PY, Bucun E, Gulhan M, et al. Low cognitive ability in subjects with bronchiectasis. Respir Care. 2015;60:1610–1615.
  • Thakur N, Blanc PD, Julian LJ, et al. COPD and cognitive impairment: the role of hypoxemia and oxygen therapy. Int J Chron Obstruct Pulmon Dis. 2010;5:263–269.
  • Bunce D, Batterham PJ, Mackinnon AJ, et al. Depression, anxiety and cognition in community-dwelling adults aged 70 years and over. J Psychiatr Res. 2012;46:1662–1666.
  • Gao YH, Guan WJ, Zhu YN, et al. Anxiety and depression in adult outpatients with bronchiectasis: associations with disease severity and health-related quality of life. Clin Respir J. 2018;12:1485–1494.
  • Giron Moreno RM, Fernandes Vasconcelos G, Cisneros C, et al. Presence of anxiety and depression in patients with bronchiectasis unrelated to cystic fibrosis. Arch Bronconeumol. 2013;49:415–420.
  • O’Leary CJ, Wilson CB, Hansell DM, et al. Relationship between psychological well-being and lung health status in patients with bronchiectasis. Respir Med. 2002;96:686–692.
  • Olveira C, Olveira G, Gaspar I, et al. Depression and anxiety symptoms in bronchiectasis: associations with health-related quality of life. Qual Life Res. 2013;22:597–605.
  • Ozgun Niksarlioglu EY, Ozkan G, Gunluoglu G, et al. Presence of depression/anxiety and related factors in bronchiectasis. Eur Respir J. 2014;44:P585(Suppl. 58).
  • Ozgun Niksarlioglu EY, Ozkan G, Gunluoglu G, et al. Factors related to depression and anxiety in adults with bronchiectasis. Neuropsychiatr Dis Treat. 2016;12:3005–3010.
  • Faria Júnior NS, Urbano JJ, Santos IR, et al. Evaluation of obstructive sleep apnea in non-cystic fibrosis bronchiectasis: a cross-sectional study. PLoS ONE. 2017;12:e0185413.

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