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Review

Severe acute asthma at the pediatric intensive care unit: can we link the clinical phenotypes to immunological endotypes?

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Pages 25-34 | Received 12 Aug 2021, Accepted 19 Oct 2021, Published online: 18 Nov 2021

References

  • Boeschoten SA, Buysse CMP, Merkus P, et al. Children with severe acute asthma admitted to Dutch PICUs: a changing landscape. Pediatr Pulmonol. 2018;53:857–865.
  • Hartman ME, Linde-Zwirble WT, Angus DC, et al. Trends in admissions for pediatric status asthmaticus in New Jersey over a 15-year period. Pediatrics. 2010;126:e904–911.
  • Al-Eyadhy AA, Temsah MH, Alhaboob AA, et al. Asthma changes at a pediatric intensive care unit after 10 years: observational study. Ann Thorac Med. 2015;10:243–248.
  • Boeschoten SA, Boehmer AL, Merkus PJ, et al. Risk factors for intensive care admission in children with severe acute asthma in the Netherlands: a prospective multicentre study. ERJ Open Res. 2020;6:00126–2020.
  • Moorman JE, Akinbami LJ, Bailey CM, et al. National surveillance of asthma: United States, 2001-2010. Vital Health Stat. 2012;3:1–58.
  • Szefler SJ, Zeiger RS, Haselkorn T, et al. Economic burden of impairment in children with severe or difficult-to-treat asthma. Ann Allergy Asthma Immunol. 2011;107:110–119 e111.
  • Grunwell JR, Travers C, Fitzpatrick AM. Inflammatory and comorbid features of children admitted to a PICU for status asthmaticus. Pediatr Crit Care Med. 2018;19:e585–e594.
  • Boeschoten SA, Dulfer K, Boehmer ALM, et al., Dutch collaborative PrnAclornpipita. Quality of life and psychosocial outcomes in children with severe acute asthma and their parents. Pediatr Pulmonol. 2020;55:2883–2892.
  • Rees G, Gledhill J, Garralda ME, et al. Psychiatric outcome following paediatric intensive care unit (PICU) admission: a cohort study. Intensive Care Med. 2004;30:1607–1614.
  • Fitzpatrick AM, Moore WC. Severe asthma phenotypes - How should they guide evaluation and treatment? J Allergy Clin Immunol Pract. 2017;5:901–908.
  • Licari A, Manti S, Castagnoli R, et al. Measuring inflammation in paediatric severe asthma: biomarkers in clinical practice. Breathe (Sheff). 2020;16:190301.
  • Bush A. Which child with asthma is a candidate for biological therapies? J Clin Med. 2020 9 ;1237.
  • Goodwin R, Chander T, Shah N, et al. Inhaler counselling, the real deal or just fresh air? Arch Dis Child. 2016;101:e2.
  • Bush A, Saglani S, Fleming L. Severe asthma: looking beyond the amount of medication. Lancet Respir Med. 2017;5:844–846.
  • Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43:343–373.
  • van Den Bosch GE, Merkus PJ, Buysse CM, et al. Risk factors for pediatric intensive care admission in children with acute asthma. Respir Care. 2012;57:1391–1397.
  • Belessis Y, Dixon S, Thomsen A, et al. Risk factors for an intensive care unit admission in children with asthma. Pediatr Pulmonol. 2004;37:201–209.
  • McDowell KM, Kercsmar CM, Huang B, et al. Medical and social determinants of health associated with intensive care admission for asthma in children. Ann Am Thorac Soc. 2016;13:1081–1088.
  • Arroyo AJC, Chee CP, Camargo CA Jr., et al. Where do children die from asthma? National data from 2003 to 2015. J Allergy Clin Immunol Pract. 2018;6:1034–1036.
  • Guilbert T, Zeiger RS, Haselkorn T, et al. Racial disparities in asthma-related health outcomes in children with severe/difficult-to-treat asthma. J Allergy Clin Immunol Pract. 2019;7:568–577.
  • Puranik S, Forno E, Bush A, et al. Predicting severe asthma exacerbations in children. Am J Respir Crit Care Med. 2017;195:854–859.
  • Carroll CL, Stoltz P, Raykov N, et al. Childhood overweight increases hospital admission rates for asthma. Pediatrics. 2007;120:734–740.
  • Weinmayr G, Forastiere F, Buchele G, et al. Overweight/obesity and respiratory and allergic disease in children: international study of asthma and allergies in childhood (ISAAC) phase two. PLoS One. 2014;9:e113996.
  • Bush A, Fleming L, Saglani S. Severe asthma in children. Respirology. 2017;22:886–897.
  • Forno E, Lescher R, Strunk R, et al. Childhood Asthma Management Program Research Group. Decreased response to inhaled steroids in overweight and obese asthmatic children. J Allergy Clin Immunol. 2011;127:741–749.
  • Periyalil HA, Wood LG, Scott HA, et al. Macrophage activation, age and sex effects of immunometabolism in obese asthma. Eur Respir J. 2015;45:388–395.
  • Carroll CL, Sala KA, Zucker AR, et al. beta2-adrenergic receptor haplotype linked to intubation and mechanical ventilation in children with asthma. J Asthma. 2012;49:563–568.
  • Carroll CL, Sala KA, Zucker AR, et al. Beta-adrenergic receptor polymorphisms associated with length of ICU stay in pediatric status asthmaticus. Pediatr Pulmonol. 2012;47:233–239.
  • Carroll CL, Stoltz P, Schramm CM, et al. Beta2-adrenergic receptor polymorphisms affect response to treatment in children with severe asthma exacerbations. Chest. 2009;135:1186–1192.
  • Bossley CJ, Fleming L, Ullmann N, et al. Assessment of corticosteroid response in pediatric patients with severe asthma by using a multidomain approach. J Allergy Clin Immunol. 2016;138:413–420 e416.
  • Chung KF, Adcock IM. Precision medicine for the discovery of treatable mechanisms in severe asthma. Allergy. 2019;74:1649–1659.
  • Cazzola M, Ora J, Cavalli F, et al. Treatable mechanisms in asthma. Mol Diagn Ther. 2021;25:111–121.
  • Andersson CK, Adams A, Nagakumar P, et al. Intraepithelial neutrophils in pediatric severe asthma are associated with better lung function. J Allergy Clin Immunol. 2017;139:1819–1829 e1811.
  • Bousquet J. Stratification of patients with severe asthma. Lancet Respir Med. 2015;3:330–331.
  • Hamzaoui A, Berraies A, Kaabachi W, et al. Induced sputum levels of IL-33 and soluble ST2 in young asthmatic children. J Asthma. 2013;50:803–809.
  • Zhang L, Zhang J, Gao P. The potential of interleukin-37 as an effective therapeutic agent in asthma. Respir Res. 2017;18:192.
  • Charrad R, Berraies A, Hamdi B, et al. Anti-inflammatory activity of IL-37 in asthmatic children: correlation with inflammatory cytokines TNF-alpha, IL-beta, IL-6 and IL-17A. Immunobiology. 2016;221:182–187.
  • Zissler UM, Jakwerth CA, Guerth F, et al. Allergen-specific immunotherapy induces the suppressive secretoglobin 1A1 in cells of the lower airways. Allergy. 2021;76:2461–2474.
  • Zhu L, An L, Ran D, et al. The club cell marker SCGB1A1 downstream of FOXA2 is reduced in asthma. Am J Respir Cell Mol Biol. 2019;60:695–704.
  • Teague WG, Lawrence MG, Shirley DT, et al. Lung lavage granulocyte patterns and clinical phenotypes in children with severe, therapy-resistant asthma. J Allergy Clin Immunol Pract. 2019;7:1803–1812 e1810.
  • Steinke JW, Lawrence MG, Teague WG, et al. Bronchoalveolar lavage cytokine patterns in children with severe neutrophilic and paucigranulocytic asthma. J Allergy Clin Immunol. 2021;147:686–693 e683.
  • Fitzpatrick AM, Higgins M, Holguin F, et al.; National Institutes of Health/National Heart L, Blood Institute’s Severe Asthma Research P. The molecular phenotype of severe asthma in children. J Allergy Clin Immunol. 2010;125:851–857 e818.
  • Grunwell JR, Stephenson ST, Tirouvanziam R, et al. Children with neutrophil-predominant severe asthma have proinflammatory neutrophils with enhanced survival and impaired clearance. J Allergy Clin Immunol Pract. 2019;7:516–525 e516.
  • Belvisi MG. Regulation of inflammatory cell function by corticosteroids. Proc Am Thorac Soc. 2004;1:207–214.
  • Schleimer RP. Effects of glucocorticosteroids on inflammatory cells relevant to their therapeutic applications in asthma. Am Rev Respir Dis. 1990;141:S59–69.
  • Nagakumar P, Puttur F, and Gregory LG, et al. Pulmonary type-2 innate lymphoid cells in paediatric severe asthma: phenotype and response to steroids. Eur Respir J. 2019 54 2 ;1801809.
  • Shah SP, Grunwell J, Shih J, et al. Exploring the utility of noninvasive type 2 inflammatory markers for prediction of severe asthma exacerbations in children and adolescents. J Allergy Clin Immunol Pract. 2019;7:2624–2633 e2622.
  • Baumann R, Untersmayr E, Zissler UM, et al. Noninvasive and minimally invasive techniques for the diagnosis and management of allergic diseases. Allergy. 2021;76:1010–1023.
  • Peters MC, Mekonnen ZK, Yuan S, et al. Measures of gene expression in sputum cells can identify TH2-high and TH2-low subtypes of asthma. J Allergy Clin Immunol. 2014;133(388–394):388–394.e5.
  • Nagakumar P, Denney L, Fleming L, et al. Type 2 innate lymphoid cells in induced sputum from children with severe asthma. J Allergy Clin Immunol. 2016;137:624–626 e626.
  • Baigelman W, Chodosh S, Pizzuto D, et al. Sputum and blood eosinophils during corticosteroid treatment of acute exacerbations of asthma. Am J Med. 1983;75:929–936.
  • Gibson PG, Grootendor DC, Henry RL, et al. Sputum induction in children. Eur Respir J Suppl. 2002;37:44s–46s.
  • Bal SM, Golebski K, Spits H. Plasticity of innate lymphoid cell subsets. Nat Rev Immunol. 2020;20::552–565.
  • Golebski K, Layhadi JA, Sahiner U, et al. Induction of IL-10-producing type 2 innate lymphoid cells by allergen immunotherapy is associated with clinical response. Immunity. 2021;54:291–307 e297.
  • Sonnenberg GF, Hepworth MR. Functional interactions between innate lymphoid cells and adaptive immunity. Nat Rev Immunol. 2019;19:599–613.
  • Castanhinha S, Sherburn R, Walker S, et al. Pediatric severe asthma with fungal sensitization is mediated by steroid-resistant IL-33. J Allergy Clin Immunol. 2015;136:312–322 e317.
  • Hussain SMA, Sen A, Barraclough BC, et al. Blood levels of type-2 innate lymphoid cells in preschool children with acute wheeze. Eur Respir J. 2017;50. PA1335.
  • Cianchetti S, Cardini C, Puxeddu I, et al. Distinct profile of inflammatory and remodelling biomarkers in sputum of severe asthmatic patients with or without persistent airway obstruction. World Allergy Organ J. 2019;12:100078.
  • Teague WG, Phillips BR, Fahy JV, et al. Baseline features of the Severe Asthma Research Program (SARP III) cohort: differences with age. J Allergy Clin Immunol Pract. 2018;6:545–554 e544.
  • Wilson NM, Bridge P, Spanevello A, et al. Induced sputum in children: feasibility, repeatability, and relation of findings to asthma severity. Thorax. 2000;55:768–774.
  • van de Kant KD, van der Sande LJ, Jobsis Q, et al. Clinical use of exhaled volatile organic compounds in pulmonary diseases: a systematic review. Respir Res. 2012;13:117.
  • Neerincx AH, Vijverberg SJH, Bos LDJ, et al. Breathomics from exhaled volatile organic compounds in pediatric asthma. Pediatr Pulmonol. 2017;52:1616–1627.
  • van Vliet D, Smolinska A, Jobsis Q, et al. Can exhaled volatile organic compounds predict asthma exacerbations in children? J Breath Res. 2017;11:016016.
  • Robroeks CM, van Berkel JJ, Jobsis Q, et al. Exhaled volatile organic compounds predict exacerbations of childhood asthma in a 1-year prospective study. Eur Respir J. 2013;42:98–106.
  • van Oort PM, de Bruin S, and Weda H, et al., On Behalf Of The Mars C. Exhaled breath metabolomics for the diagnosis of pneumonia in intubated and mechanically-ventilated Intensive Care Unit (ICU)-patients. Int J Mol Sci. 2017 18 2 ;449.
  • Hong H, Liao S, Chen F, et al. Role of IL-25, IL-33, and TSLP in triggering united airway diseases toward type 2 inflammation. Allergy. 2020;75::2794–2804.
  • Zissler UM, Ulrich M, Jakwerth CA, et al. Biomatrix for upper and lower airway biomarkers in patients with allergic asthma. J Allergy Clin Immunol. 2018;142:1980–1983.
  • Cardenas A, Sordillo JE, Rifas-Shiman SL, et al. The nasal methylome as a biomarker of asthma and airway inflammation in children. Nat Commun. 2019;10:3095.
  • Bergougnoux A, Claustres M, De Sario A. Nasal epithelial cells: a tool to study DNA methylation in airway diseases. Epigenomics. 2015;7:119–126.
  • Zhu T, Zhang X, Chen X, et al. Nasal DNA methylation differentiates severe from non-severe asthma in African-American children. Allergy. 2021;76:1836–1845.
  • Goodman MA, Moradi Manesh D, Malik P, et al. CRISPR/Cas9 in allergic and immunologic diseases. Expert Rev Clin Immunol. 2017;13:5–9.
  • Agache I, Akdis CA, Akdis M, et al. EAACI biologicals guidelines-recommendations for severe asthma. Allergy. 2021;76:14–44.
  • Teach SJ, Gill MA, Togias A, et al. Preseasonal treatment with either omalizumab or an inhaled corticosteroid boost to prevent fall asthma exacerbations. J Allergy Clin Immunol. 2015;136:1476–1485.
  • Vijverberg SJH, Brinkman P, Rutjes NWP, et al. Precision medicine in severe pediatric asthma: opportunities and challenges. Curr Opin Pulm Med. 2020;26:77–83.
  • Israel E, Mb H. Personalizing precision medicine. J Allergy Clin Immunol Pract. 2020;8:1614–1615.
  • Jang YJ, Kwon HJ, Lee BJ. Effect of clarithromycin on rhinovirus-16 infection in A549 cells. Eur Respir J. 2006;27:12–19.
  • Richeldi L, Ferrara G, and Fabbri LM, et al. Macrolides for chronic asthma. Cochrane Database Syst Rev. 2005 3 ;CD002997.
  • Golebski K, Kabesch M, Melen E, et al. Childhood asthma in the new omics era: challenges and perspectives. Curr Opin Allergy Clin Immunol. 2020;20:155–161.
  • Fleming L, Murray C, Bansal AT, et al. The burden of severe asthma in childhood and adolescence: results from the paediatric U-BIOPRED cohorts. Eur Respir J. 2015;46:1322–1333.
  • Ivanova O, Richards LB, Vijverberg SJ, et al. What did we learn from multiple omics studies in asthma? Allergy. 2019;74:2129–2145.
  • Roberts J, Bratton SL, Brogan TV. Acute severe asthma: differences in therapies and outcomes among pediatric intensive care units. Crit Care Med. 2002;30:581–585.