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Review

Interstitial lung abnormalities: What do we know and how do we manage?

ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon, ORCID Icon & ORCID Icon
Pages 1551-1561 | Received 11 Jul 2021, Accepted 21 Oct 2021, Published online: 08 Nov 2021

References

  • Hatabu H, Hunninghake G, Richeldi L, et al., Interstitial lung abnormalities detected incidentally on CT: a Position Paper from the Fleischner Society. Lancet Respir Med. 8(7): 726–737. 2020.
  • Tzilas V, Bouros D. Interstitial Lung Abnormalities: a Word of Caution. Chest. 2019;156(6):1037–1038.
  • Hatabu H, Hunninghake GM, Lynch DA. Interstitial Lung Abnormality: recognition and Perspectives. Radiology. 2019;291(1):1–3.
  • Mackintosh JA, Marshall HM, Slaughter R, et al., Interstitial lung abnormalities in the Queensland Lung Cancer Screening Study: prevalence and progression over 2 years of surveillance. Intern Med J. 49(7): 843–849. 2019.
  • Putman RK, Gudmundsson G, Axelsson GT, et al., Imaging Patterns Are Associated with Interstitial Lung Abnormality Progression and Mortality. Am J Respir Crit Care Med. 200(2): 175–183. 2019.
  • Jin GY, Lynch D, Chawla A, et al., Interstitial lung abnormalities in a CT lung cancer screening population: prevalence and progression rate. Radiology. 268(2): 563–571. 2013.
  • Tsushima K, Sone S, Yoshikawa S, et al. The radiological patterns of interstitial change at an early phase: over a 4-year follow-up. Respir Med. 2010;104(11):1712–1721.
  • Miller ER, Putman RK, Vivero M, et al., Histopathology of Interstitial Lung Abnormalities in the Context of Lung Nodule Resections. Am J Respir Crit Care Med. 197(7): 955–958. 2018.
  • Podolanczuk AJ, Oelsner EC, Barr RG, et al. High-Attenuation Areas on Chest Computed Tomography and Clinical Respiratory Outcomes in Community-Dwelling Adults. Am J Respir Crit Care Med. 2017;196(11):1434–1442.
  • Washko GR, Hunninghake GM, Fernandez IE, et al. Lung volumes and emphysema in smokers with interstitial lung abnormalities. N Engl J Med. 2011;364(10):897–906.
  • Lederer DJ, Enright PL, Kawut SM, et al. Cigarette smoking is associated with subclinical parenchymal lung disease: the Multi-Ethnic Study of Atherosclerosis (Mesa)-lung study. Am J Respir Crit Care Med. 2009;180(5):407–414.
  • Hunninghake GM, Hatabu H, Okajima Y, et al., MUC5B promoter polymorphism and interstitial lung abnormalities. N Engl J Med. 368(23): 2192–2200. 2013.
  • Sack C, Vedal S, Sheppard L, et al. Air pollution and subclinical interstitial lung disease: the Multi-Ethnic Study of Atherosclerosis (Mesa) air-lung study. Eur Respir J. 2017;50(6):1700559.
  • Putman RK, Hatabu H, Araki T, et al. Association Between Interstitial Lung Abnormalities and All-Cause Mortality. Jama. 2016;315(7):672–681.
  • Whittaker Brown SA, Padilla M, Mhango G, et al. Interstitial Lung Abnormalities and Lung Cancer Risk in the National Lung Screening Trial. Chest. 2019;156(6):1195–1203.
  • Hoyer N, Wille MMW, Thomsen LH, et al. Interstitial lung abnormalities are associated with increased mortality in smokers. Respir Med. 2018;136:77–82.
  • Oldham JM, Adegunsoye A, Khera S, et al. Underreporting of Interstitial Lung Abnormalities on Lung Cancer Screening Computed Tomography. Ann Am Thorac Soc. 2018;15(6):764–766.
  • Washko GR, Lynch DA, Matsuoka S, et al. Identification of early interstitial lung disease in smokers from the COPDGene Study. Acad Radiol. 2010;17(1):48–53.
  • Lee TS, Jin KN, Lee HW, et al. Interstitial Lung Abnormalities and the Clinical Course in Patients With COPD. Chest. 2021;159(1):128–137.
  • Sanders JL, Putman RK, Dupuis J, et al. The Association of Aging Biomarkers, Interstitial Lung Abnormalities, and Mortality. Am J Respir Crit Care Med. 2021;203(9):1149–1157.
  • Ash SY, Washko GR. Interstitial lung abnormalities: risk and opportunity. Lancet Respir Med. 2017;5(2):95–96.
  • Rice MB, Li W, Schwartz J, et al. Ambient air pollution exposure and risk and progression of interstitial lung abnormalities: the Framingham Heart Study. Thorax. 2019;74(11):1063–1069.
  • Cui X, Li F, Xiang J, et al. Cardiopulmonary effects of overnight indoor air filtration in healthy non-smoking adults: a double-blind randomized crossover study. Environ Int. 2018;114:27–36.
  • Sack CS, Doney BC, Podolanczuk AJ, et al. Occupational Exposures and Subclinical Interstitial Lung Disease. The Mesa (Multi-Ethnic Study of Atherosclerosis) Air and Lung Studies. Am J Respir Crit Care Med. 2017;196(8):1031–1039.
  • Araki T, Putman R, Hatabu H, et al. Development and Progression of Interstitial Lung Abnormalities in the Framingham Heart Study. Am J Respir Crit Care Med. 2016;194(12):1514–1522.
  • Ash SY, Harmouche R, Putman RK, et al. Clinical and Genetic Associations of Objectively Identified Interstitial Changes in Smokers. Chest. 2017;152(4):780–791.
  • Putman RK, Gudmundsson G, Araki T, et al. The MUC5B promoter polymorphism is associated with specific interstitial lung abnormality subtypes. Eur Respir J. 2017;50(3):1700537.
  • Armstrong HF, Podolanczuk AJ, Barr RG, et al. Serum Matrix Metalloproteinase-7, Respiratory Symptoms, and Mortality in Community-Dwelling Adults. Mesa (Multi-Ethnic Study of Atherosclerosis). Am j respir critical care med. 2017;196(10):1311–1317.
  • Antoniou KM, Tzilas V, Vasarmidi E, et al. Interstitial lung abnormalities: ignotum per ignotius. Lancet Respir Med. 2019;7(5):376–378.
  • Alarico Ariani NS, Becciolni A, Milanese G. Mario Silva Using quantitative computed tomography to predict mortality in patients with interstitial lung disease related to systemic sclerosis: implications for personalized medicine. Expert Rev Precis Med Drug Dev. 2021;6:1:31–40.
  • Podolanczuk AJ, Oelsner EC, Barr RG, et al. High attenuation areas on chest computed tomography in community-dwelling adults: the Mesa study. Eur Respir J. 2016;48(5):1442–1452.
  • Podolanczuk AJ, Raghu G, Tsai MY, et al. Cholesterol, lipoproteins and subclinical interstitial lung disease: the Mesa study. Thorax. 2017;72(5):472–474.
  • Bermejo-Pelaez D, Ash SY, Washko GR. Classification of Interstitial Lung Abnormality Patterns with an Ensemble of Deep Convolutional Neural Networks. Sci Rep. 2020;10(1):338.
  • Yoo SJ, Yoon SH, Lee JH, et al. Automated Lung Segmentation on Chest Computed Tomography Images with Extensive Lung Parenchymal Abnormalities Using a Deep Neural Network. Korean J Radiol. 2021;22(3):476–488.
  • Ho JE, Gao W, Levy D, et al. Galectin-3 Is Associated with Restrictive Lung Disease and Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2016;194(1):77–83.
  • Kim SM, Zhao D, Podolanczuk AJ, et al. Serum 25-Hydroxyvitamin D Concentrations Are Associated with Computed Tomography Markers of Subclinical Interstitial Lung Disease among Community-Dwelling Adults in the Multi-Ethnic Study of Atherosclerosis (Mesa). J Nutr. 2018;148(7):1126–1134.
  • Kim JS, Anderson MR, Podolanczuk AJ, et al. Associations of Serum Adipokines With Subclinical Interstitial Lung Disease Among Community-Dwelling Adults: the Multi-Ethnic Study of Atherosclerosis (Mesa). Chest. 2020;157(3):580–589.
  • Ash SY, Harmouche R, Ross JC, et al. The Objective Identification and Quantification of Interstitial Lung Abnormalities in Smokers. Acad Radiol. 2017;24(8):941–946.
  • Axelsson GT, Putman RK, Araki T, et al. Interstitial lung abnormalities and self-reported health and functional status. Thorax. 2018;73(9):884–886.
  • Axelsson GT, Putman RK, Miller ER, et al. Interstitial lung abnormalities and physical function. ERJ Open Res. 2018;4(3):00057–2018.
  • Doyle TJ, Washko GR, Fernandez IE, et al. Interstitial lung abnormalities and reduced exercise capacity. Am J Respir Crit Care Med. 2012;185(7):756–762.
  • Axelsson GT, Putman RK, Aspelund T, et al. The associations of interstitial lung abnormalities with cancer diagnoses and mortality. Eur Respir J. 2020;56(6):548.
  • Wille MM, Thomsen LH, Petersen J, et al. Visual assessment of early emphysema and interstitial abnormalities on CT is useful in lung cancer risk analysis. Eur Radiol. 2016;26(2):487–494.
  • Nishino M, Cardarella S, Dahlberg SE, et al. Interstitial lung abnormalities in treatment-naïve advanced non-small-cell lung cancer patients are associated with shorter survival. Eur J Radiol. 2015;84(5):998–1004.
  • Araki T, Dahlberg S, Hida T, et al. Interstitial lung abnormality in stage IV non-small cell lung cancer: a validation study for the association with poor clinical outcome. Eur J Radiol Open. 2019;6:128–131.
  • Gochuico BR, Avila NA, Chow CK, et al. Progressive preclinical interstitial lung disease in rheumatoid arthritis. Arch Internal Med. 2008;168(2):159–166.
  • Chae KJ, Jin GY, Han YM, et al. Prevalence and progression of combined pulmonary fibrosis and emphysema in asymptomatic smokers: a case-control study. Eur Radiol. 2015;25(8):2326–2334.
  • Lee JS, Collard HR, Raghu G, et al. Does chronic microaspiration cause idiopathic pulmonary fibrosis? Am J Med. 2010;123(4):304–311.
  • Sverzellati N, Guerci L, Randi G, et al. Interstitial lung diseases in a lung cancer screening trial. Eur Respir J. 2011;38(2):392–400.
  • Salvatore M, Henschke CI, Yip R, et al. JOURNAL CLUB: evidence of Interstitial Lung Disease on Low-Dose Chest CT Images: prevalence, Patterns, and Progression. AJR Am J Roentgenol. 2016;206(3):487–494.

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