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Meta-Analysis

Diagnostic value of fractional exhaled nitric oxide in differentiating the asthma-COPD overlap from COPD: a systematic review and meta-analysis

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Pages 679-687 | Received 05 Aug 2021, Accepted 23 Nov 2021, Published online: 06 Dec 2021

References

  • Lozano R, Naghavi M, Foreman K, et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012 Dec 15;380(9859):2095–2128. PubMed PMID: 23245604; eng.
  • Vos T, Flaxman AD, Naghavi M, et al. Years lived with disability (YLDs) for 1160 sequelae of 289 diseases and injuries 1990-2010: a systematic analysis for the global burden of disease study 2010. Lancet. 2012 Dec 15;380(9859):2163–2196. PubMed PMID: 23245607; PubMed Central PMCID: PMCPMC6350784. eng.
  • Global Initiative for Chronic Obstructive Lung Disease (GOLD) [database on Internet]. Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease; 2021 [cited 2020 Nov 17]. Available from: http://goldcopd.org
  • Miravitlles M, Calle M, Molina J, et al. Spanish COPD guidelines (GesEPOC) 2021: updated pharmacological treatment of stable COPD. Arch Bronconeumol (Engl Ed). 2021 Mar 17. DOI:https://doi.org/10.1016/j.arbres.2021.03.005. PubMed PMID: 33840553; eng. spa.
  • Gibson PG, Simpson JL. The overlap syndrome of asthma and COPD: what are its features and how important is it?. Thorax. 2009 Aug;64(8):728–735. PubMed PMID: 19638566; eng.
  • Miravitlles MJHTiRM. The overlap syndrome between asthma and COPD: Implications for management. Hot Topics in Respiratory Medicine. 2011; 6(16):15–20.
  • Hardin M, Silverman EK, Barr RG, et al. The clinical features of the overlap between COPD and asthma. Respir Res. 2011 Sep 27;12(1):127. PubMed PMID: 21951550; PubMed Central PMCID: PMCPMC3204243. eng.
  • Christenson SA, Steiling K, van Den Berge M, et al. Asthma-COPD overlap. Clinical relevance of genomic signatures of type 2 inflammation in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2015 Apr 1;191(7):758–766. PubMed PMID: 25611785; PubMed Central PMCID: PMCPMC4407484. eng.
  • Hardin M, Cho M, McDonald ML, et al. The clinical and genetic features of COPD-asthma overlap syndrome. Eur Respir J. 2014 Aug;44(2):341–350. PubMed PMID: 24876173; PubMed Central PMCID: PMCPMC4154588. eng
  • Barrecheguren M, Esquinas C, Miravitlles M. The asthma-chronic obstructive pulmonary disease overlap syndrome (ACOS): opportunities and challenges. Curr Opin Pulm Med. 2015 Jan;21(1):74–79. PubMed PMID: 25405671; eng.
  • Miravitlles M, Soriano JB, Ancochea J, et al. Characterisation of the overlap COPD-asthma phenotype. Focus on physical activity and health status. Respir Med. 2013 Jul;107(7):1053–1060. PubMed PMID: 23597591; eng
  • Zeki AA, Schivo M, Chan A, et al. The asthma-COPD overlap syndrome: a common clinical problem in the elderly. J Allergy (Cairo). 2011;2011:861926. PubMed PMID: 22121384; PubMed Central PMCID: PMCPMC3205664. eng.
  • Miravitlles M, Soler-Cataluña JJ, Calle M, et al. Treatment of COPD by clinical phenotypes: putting old evidence into clinical practice. Eur Respir J. 2013 Jun;41(6):1252–1256. PubMed PMID: 23060631; eng
  • Shaya FT, Dongyi D, Akazawa MO, et al. Burden of concomitant asthma and COPD in a medicaid population. Chest. 2008 Jul;134(1):14–19. PubMed PMID: 18339789; eng
  • Kauppi P, Kupiainen H, Lindqvist A, et al. Overlap syndrome of asthma and COPD predicts low quality of life. J Asthma. 2011 Apr;48(3):279–285. PubMed PMID: 21323613; eng
  • Global initiative for asthma, global initiative for chronic obstructive lung disease, diagnosis of disease of chronic airflow limitation. Asthma, COPD, and asthma–COPD overlap syndrome (ACOS); 2015. Available from: http://www.ginasthma.org. Accessed 2021 Apr 27.
  • Guo FH, Comhair SA, Zheng S, et al. Molecular mechanisms of increased nitric oxide (NO) in asthma: evidence for transcriptional and post-translational regulation of NO synthesis. J Immunol. 2000 Jun 1;164(11):5970–5980. PubMed PMID: 10820280; eng.
  • Dweik RA, Boggs PB, Erzurum SC, et al. An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med. 2011 Sep 1;184(5):602–615. PubMed PMID: 21885636; PubMed Central PMCID: PMCPMC4408724. eng.
  • Alving K, Malinovschi AJERM. Basic aspects of exhaled nitric oxide. European Respiratory Monograph . 2011;49:1–31.
  • de Nijs SB, Fens N, Lutter R, et al. Airway inflammation and mannitol challenge test in COPD. Respir Res. 2011 Jan 18;12(1):11. PubMed PMID: 21241520; PubMed Central PMCID: PMCPMC3036630. eng.
  • Kunisaki KM, Rice KL, Janoff EN, et al. Exhaled nitric oxide, systemic inflammation, and the spirometric response to inhaled fluticasone propionate in severe chronic obstructive pulmonary disease: a prospective study. Ther Adv Respir Dis. 2008 Apr;2(2):55–64. PubMed PMID: 19124359; eng
  • Goto T, Camargo CA Jr, Hasegawa K. Fractional exhaled nitric oxide levels in asthma-COPD overlap syndrome: analysis of the national health and nutrition examination survey, 2007-2012. Int J Chron Obstruct Pulmon Dis. 2016;11:2149–2155. PubMed PMID: 27660432; PubMed Central PMCID: PMCPMC5019187. eng.
  • Çolak Y, Afzal S, Nordestgaard BG, et al. Combined value of exhaled nitric oxide and blood eosinophils in chronic airway disease: the Copenhagen general population study. Eur Respir J. 2018 Aug;52(2):1800616. PubMed PMID: 29903861; eng
  • Shi F, Qiu C, Yu J, et al. Comparison of fractional exhaled nitric oxide in elderly patients with asthma-chronic obstructive pulmonary disease overlap and other airway inflammatory diseases. Iran J Allergy Asthma Immunol. 2018 Jun; 17(3): 232–239. PubMed PMID: 29908540; eng.
  • Ge L, Tian JH, Li YN, et al. Association between prospective registration and overall reporting and methodological quality of systematic reviews: a meta-epidemiological study. J Clin Epidemiol. 2018 Jan;93:45–55. PubMed PMID: 29111471; eng.
  • Wang X, Chen Y, Yao L, et al. Reporting of declarations and conflicts of interest in WHO guidelines can be further improved. J Clin Epidemiol. 2018 Jun;98:1–8. PubMed PMID: 29292204; eng.
  • Song F, Gilbody S. Bias in meta-analysis detected by a simple, graphical test. Increase in studies of publication bias coincided with increasing use of meta-analysis. BMJ (Clin Res Ed). 1998 Feb 7;316(7129):471. PubMed PMID: 9492690; PubMed Central PMCID: PMCPMC2665616. eng.
  • Lau J, Ioannidis JP, Terrin N, et al. The case of the misleading funnel plot. BMJ (Clin Res Ed). 2006 Sep 16;333(7568):597–600. PubMed PMID: 16974018; PubMed Central PMCID: PMCPMC1570006. eng.
  • Taskin V, Akgun N, Kanat F, et al. Using fractional exhaled nitric oxide level to differentiate asthma-COPD overlap syndrome from chronic obstructive pulmonary disease. Eurasian J Pulmonol. 2020 Jan-Apr;22(1):42–47. PubMed PMID: WOS: 000615072300006
  • Li M, Yang T, He R, et al. The value of inflammatory biomarkers in differentiating asthma-COPD overlap from COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:3025–3037. PubMed PMID: 33244228; PubMed Central PMCID: PMCPMC7685357. eng.
  • Takayama Y, Ohnishi H, Ogasawara F, et al. Clinical utility of fractional exhaled nitric oxide and blood eosinophils counts in the diagnosis of asthma-COPD overlap. Int J Chron Obstruct Pulmon Dis. 2018;13:2525–2532. PubMed PMID: 30174422; PubMed Central PMCID: PMCPMC6110157. eng.
  • Río Ramírez MT, Juretschke Moragues MA, Fernández González R, et al. Value of exhaled nitric oxide (FeNO) and eosinophilia during the exacerbations of chronic obstructive pulmonary disease requiring hospital admission. Copd. 2018 Jun-Aug;15(4):369–376. PubMed PMID: 30064275; eng.
  • Guo Y, Hong C, Liu Y, et al. Diagnostic value of fractional exhaled nitric oxide for asthma-chronic obstructive pulmonary disease overlap syndrome. Medicine (Baltimore). 2018 Jun;97(23):e10857. PubMed PMID: 29879019; PubMed Central PMCID: PMCPMC5999511. eng.
  • Kobayashi S, Hanagama M, Yamanda S, et al. Inflammatory biomarkers in asthma-COPD overlap syndrome. Int J Chron Obstruct Pulmon Dis. 2016;11:2117–2123. PubMed PMID: 27660429; PubMed Central PMCID: PMCPMC5021052. eng.
  • Chen FJ, Huang XY, Liu YL, et al. Importance of fractional exhaled nitric oxide in the differentiation of asthma-COPD overlap syndrome, asthma, and COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2385–2390. PubMed PMID: 27713629; PubMed Central PMCID: PMCPMC5045026. eng.
  • Alcázar-Navarrete B, Romero-Palacios PJ, Ruiz-Sancho A, et al. Diagnostic performance of the measurement of nitric oxide in exhaled air in the diagnosis of COPD phenotypes. Nitric Oxide. 2016 Apr 1;54:67–72. PubMed PMID: 26916083; eng.
  • Plaza V, Álvarez F, Calle M, et al. Consensus on the asthma-COPD overlap syndrome (ACOS) between the Spanish COPD guidelines (GesEPOC) and the Spanish guidelines on the management of asthma (GEMA). Arch Bronconeumol. 2017 Aug;53(8):443–449. PubMed PMID: 28495077; eng. spa
  • Paliogiannis P, Fois AG, Sotgia S, et al. The neutrophil-to-lymphocyte ratio as a marker of chronic obstructive pulmonary disease and its exacerbations: a systematic review and meta-analysis. Eur J Clin Invest. 2018 Aug;48(8):e12984. PubMed PMID: 29924383; eng
  • Platts-Mills TA. The role of immunoglobulin E in allergy and asthma. Am J Respir Crit Care Med. 2001 Oct 15;164(8 Pt 2):S1–5. PubMed PMID: 11704610; eng.
  • Vedel-Krogh S, Nielsen SF, Lange P, et al. Blood eosinophils and exacerbations in chronic obstructive pulmonary disease. The Copenhagen general population study. Am J Respir Crit Care Med. 2016 May 1;193(9):965–974. PubMed PMID: 26641631; eng.
  • Petsky HL, Li A, Chang AB. Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults. Cochrane Database Syst Rev. 2017 Aug 24;8(8):Cd005603. PubMed PMID: 28837221; PubMed Central PMCID: PMCPMC6483759. eng.
  • Pilaczyńska-Cemel M, Gołda R, Dąbrowska A, et al. Analysis of the level of selected parameters of inflammation, circulating immune complexes, and related indicators (neutrophil/lymphocyte, platelet/ lymphocyte,CRP/CIC) in patients with obstructive diseases. Cent Eur J Immunol. 2019;44(3):292–298. PubMed PMID: 31871418; PubMed Central PMCID: PMCPMC6925570. eng.
  • Furutate R, Ishii T, Motegi T, et al. The neutrophil to lymphocyte ratio is related to disease severity and exacerbation in patients with chronic obstructive pulmonary disease. Intern Med. 2016;55(3):223–229. PubMed PMID: 26831014; eng.
  • Petsky HL, Kew KM, Turner C, et al. Exhaled nitric oxide levels to guide treatment for adults with asthma. Cochrane Database Syst Rev. 2016 Sep 1;9(9):Cd011440. PubMed PMID: 27580628; PubMed Central PMCID: PMCPMC6457753 in children on this subject. KK: none known. eng.
  • Arnold RJ, Massanari M, Lee TA, et al. A Review of the Utility and Cost Effectiveness of Monitoring Fractional Exhaled Nitric Oxide (FeNO) in Asthma Management. Managed care (Langhorne, Pa.). 2018 Jul;27(7):34–41. PubMed PMID: 29989900; eng.
  • Jacinto T, Malinovschi A, Janson C, et al. Differential effect of cigarette smoke exposure on exhaled nitric oxide and blood eosinophils in healthy and asthmatic individuals. J Breath Res. 2017 Aug 21;11(3):036006. PubMed PMID: 28825404; eng.
  • Al-Sawalha NA, Migdadi AM, Alzoubi KH, et al. Effect of waterpipe tobacco smoking on airway inflammation in murine model of asthma. Inhal Toxicol. 2017 Feb;29(2):46–52. PubMed PMID: 28330430; eng
  • Malinovschi A, Janson C, Holmkvist T, et al. Effect of smoking on exhaled nitric oxide and flow-independent nitric oxide exchange parameters. Eur Respir J. 2006 Aug;28(2):339–345. PubMed PMID: 16641119; eng.
  • Kharitonov SA, Robbins RA, Yates D, et al. Acute and chronic effects of cigarette smoking on exhaled nitric oxide. Am J Respir Crit Care Med. 1995 Aug;152(2):609–612. PubMed PMID: 7543345; eng
  • Jin H, Webb-Robertson BJ, Peterson ES, et al. Smoking, COPD, and 3-nitrotyrosine levels of plasma proteins. Environ Health Perspect. 2011 Sep;119(9):1314–1320. PubMed PMID: 21652289; PubMed Central PMCID: PMCPMC3230408. eng.
  • Kharitonov SA, Yates DH, Barnes PJ. Inhaled glucocorticoids decrease nitric oxide in exhaled air of asthmatic patients. Am J Respir Crit Care Med. 1996 Jan;153(1):454–457. PubMed PMID: 8542158; eng.
  • Ichinose M, Takahashi T, Sugiura H, et al. Baseline airway hyperresponsiveness and its reversible component: role of airway inflammation and airway calibre. Eur Respir J. 2000 Feb;15(2):248–253. PubMed PMID: 10706487; eng
  • Huang T, Liu B, Yang D, et al. Fractional exhaled nitric oxide measurement: comparison between the Sunvou-CA2122 analyzer and the NIOX VERO analyzer. J Asthma. 2021 Jan;58(1):52–59. PubMed PMID: 31512532; eng
  • Brooks CR, Brogan SB, van Dalen CJ, et al. Measurement of exhaled nitric oxide in a general population sample: a comparison of the medisoft hypair FE(NO) and Aerocrine NIOX analyzers. J Asthma. 2011 May;48(4):324–328. PubMed PMID: 21385111; eng
  • Inoue Y, Sato S, Manabe T, et al. Measurement of exhaled nitric oxide in children: a comparison between NObreath® and NIOX VERO® analyzers. Allergy Asthma Immunol Res. 2018 Sep;10(5):478–489. PubMed PMID: 30088368; PubMed Central PMCID: PMCPMC6082813. eng
  • Tanabe Y, Harada N, Ito J, et al. Difference between two exhaled nitric oxide analyzers, NIOX VERO(®) electrochemical hand-held analyzer and NOA280i(®) chemiluminescence stationary analyzer. J Asthma. 2019 Feb;56(2):167–172. PubMed PMID: 30335533; eng
  • Blake TL, Chang AB, Chatfield MD, et al. Does ethnicity influence fractional exhaled nitric oxide in healthy individuals?. A Syst Rev Chest. 2017 Jul;152(1):40–50. PubMed PMID: 28215791; eng.

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