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Original Research

Sleep apnea is associated with the increase of certain genera of Ruminococcaceae and Lachnospiraceae in the gut microbiome of hypertensive patients

ORCID Icon, , , & ORCID Icon
Pages 1247-1256 | Received 15 Oct 2022, Accepted 10 Nov 2022, Published online: 20 Nov 2022

References

  • Arnaud C, Bochaton T, Pépin JL, et al. Obstructive sleep apnoea and cardiovascular consequences: pathophysiological mechanisms. Arch Cardiovasc Dis. 2020;113(5):350–358.
  • Gonzaga C, Bertolami A, Bertolami M, et al. Obstructive sleep apnea, hypertension and cardiovascular diseases. J Hum Hypertens. 2015;29(12):705–712.
  • Salman LA, Shulman R, Cohen JB. Obstructive sleep apnea, hypertension, and cardiovascular risk: epidemiology, pathophysiology, and management. Curr Cardiol Rep. 2020;22(2):6.
  • Sapiña-Beltrán E, Torres G, Benitez I, et al. Characteristics, and association of obstructive sleep apnea with blood pressure control in patients with resistant hypertension. Ann Am Thorac Soc. 2019;16(11):1414–1421.
  • Šiarnik P, Klobučníková K, Mucska I, et al. Obstructive sleep apnea and hypertension: the role of gut microbiome. Vnitr Lek. 2020;66(7):415–419.
  • Mashaqi S, Gozal D. Obstructive sleep apnea and systemic hypertension: gut dysbiosis as the mediator? J Clin Sleep Med. 2019;15(10):1517–1527.
  • Qin J, Li R, Raes J, et al. A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 2010;464(7285):59–65.
  • Li J, Raizada MK, Richards EM. Gut-brain-bone marrow axis in hypertension. Curr Opin Nephrol Hypertens. 2021;30(2):159–165.
  • Tang WH, Kitai T, Hazen SL. Gut microbiota in cardiovascular health and disease. Circ Res. 2017;120(7):1183–1196.
  • Walker RL, Vlamakis H, Lee JWJ, et al. Population study of the gut microbiome: associations with diet, lifestyle, and cardiometabolic disease. Genome Med. 2021;13(1):188.
  • Tripathi A, Melnik AV, Xue J, et al. Intermittent hypoxia and hypercapnia, a hallmark of obstructive sleep apnea alters the gut microbiome and metabolome. mSystems. 2018;3(3). 10.1128/mSystems.00020-18
  • Ko CY, Su HZ, Zhang L, et al. Disturbances of the gut microbiota, sleep architecture, and mTOR signaling pathway in patients with severe obstructive sleep apnea-associated hypertension. Int J Hypertens. 2021;2021:9877053.
  • Colgan SP, Campbell EL, Kominsky DJ. Hypoxia and Mucosal Inflammation. Annu Rev Pathol. 2016;11(1):77–100.
  • Durgan DJ, Ganesh BP, Cope JL, et al. Role of the gut microbiome in obstructive sleep apnea-induced hypertension. Hypertension. 2016;67(2):469–474.
  • Moreno-Indias I, Torres M, Montserrat JM, et al. Intermittent hypoxia alters gut microbiota diversity in a mouse model of sleep apnoea. Eur Respir J. 2015;45(4):1055–1065.
  • Valentini F, Evangelisti M, Arpinelli M, et al. Gut microbiota composition in children with obstructive sleep apnoea syndrome: a pilot study. Sleep Med. 2020;76:140–147.
  • Stone KL, Blackwell TL, Ancoli-Israel S, et al. Osteoporotic fractures in men (MrOS) study research group. sleep disordered breathing and risk of stroke in older community-dwelling Men. Sleep. 2016 Mar 1;39(3):531–540.
  • Xie J, Sert Kuniyoshi FH, Covassin N, et al. Nocturnal hypoxemia due to obstructive sleep apnea is an independent predictor of poor prognosis after myocardial infarction. J Am Heart Assoc. 2016 Jul 27;5(8):e003162.
  • Sert Kuniyoshi FH, Singh P, Gami AS, et al. Patients with obstructive sleep apnea exhibit impaired endothelial function after myocardial infarction. Chest. 2011 Jul;140(1):62–67.
  • Gami AS, Olson EJ, Shen WK, et al. Obstructive sleep apnea and the risk of sudden cardiac death: a longitudinal study of 10,701 adults. J Am Coll Cardiol. 2013;62(7):610–616.
  • Chen F, Chen K, Zhang C, et al. Evaluating the clinical value of the hypoxia burden index in patients with obstructive sleep apnea. Postgrad Med. 2018;130(4):436–441.
  • Azarbarzin A, Sands SA, Stone KL, et al. The hypoxic burden of sleep apnoea predicts cardiovascular disease-related mortality: the Osteoporotic Fractures In Men Study And The Sleep Heart Health Study. Eur Heart J. 2019;40(14):1149–1157.
  • Berry RB, Brooks R, Gamaldo CE, et al. The AASM manual scoring manual for the scoring of sleep and associated events. Rules, Terminology and technical specifications (version 2.3). Darien IL: American Academy of Sleep Medicine; 2016.
  • Sateia MJ. International classification of sleep disorders-third edition: highlights and modifications. Chest. 2014;146(5):1387–1394.
  • Jandhyala SM, Talukdar R, Subramanyam C, et al. Role of the normal gut microbiota. World J Gastroenterol. 2015;21(29):8787–8803.
  • Burger-van Paassen N, Vincent A, Puiman PJ, et al. The regulation of intestinal mucin MUC2 expression by short-chain fatty acids: implications for epithelial protection. Biochem J. 2009;420(2):211–219.
  • Peng L, Li ZR, Green RS, et al. Butyrate enhances the intestinal barrier by facilitating tight junction assembly via activation of AMP-activated protein kinase in Caco-2 cell monolayers. J Nutr. 2009;139(9):1619–1625.
  • Biddle A, Stewart L, Blanchard J, et al. Untangling the genetic basis of fibrolytic specialization by Lachnospiraceae and Ruminococcaceae in diverse gut communities. Diversity. 2013;5(3):627–640.
  • Moreno-Indias I, Cardona F, Tinahones FJ, et al. Impact of the gut microbiota on the development of obesity and type 2 diabetes mellitus. Front Microbiol. 2014;5:190.
  • Li T, Zhang T, Gao H, et al. Tempol ameliorates polycystic ovary syndrome through attenuating intestinal oxidative stress and modulating of gut microbiota composition-serum metabolites interaction. Redox Biol. 2021;41:101886.
  • Wang P, Li D, Ke W, et al. Resveratrol-induced gut microbiota reduces obesity in high-fat diet-fed mice. Int J Obes (Lond). 2020;44(1):213–225.
  • Jalanka J, Major G, Murray K, et al. The effect of psyllium husk on intestinal microbiota in constipated patients and healthy controls. Int J Mol Sci. 2019;20(2):433.
  • Poroyko VA, Carreras A, Khalyfa A, et al. Chronic sleep disruption alters gut microbiota, induces systemic and adipose tissue inflammation and insulin resistance in mice. Sci Rep. 2016;6(1):35405.
  • Li J, Zhao F, Wang Y, et al. Gut microbiota dysbiosis contributes to the development of hypertension. Microbiome. 2017;5(1):14.
  • Litvak Y, Byndloss MX, Tsolis RM, et al. Dysbiotic proteobacteria expansion: a microbial signature of epithelial dysfunction. Curr Opin Microbiol. 2017;39:1–6.
  • Bradley PH, Pollard KS. Proteobacteria explain significant functional variability in the human gut microbiome. Microbiome. 2017;5(1):36.
  • Larsen N, Vogensen FK, van den Berg FW, et al. Gut microbiota in human adults with type 2 diabetes differs from non-diabetic adults. PLoS One. 2010;5(2):e9085.
  • Ley RE, Turnbaugh PJ, Klein S, et al. Microbial ecology: human gut microbes associated with obesity. Nature. 2006;444(7122):1022–1023.
  • Kumar H, Lund R, Laiho A, et al. Gut microbiota as an epigenetic regulator: pilot study based on whole-genome methylation analysis. mBio. 2014;5(6):e02113–14.
  • Forslund SK, Chakaroun R, Zimmermann-Kogadeeva M, et al. Combinatorial, additive and dose-dependent drug-microbiome associations. Nature. 2021;600(7889):500–505.
  • Marques FZ, Mackay CR, Kaye DM. Beyond gut feelings: how the gut microbiota regulates blood pressure. Nat Rev Cardiol. 2018;15(1):20–32.
  • Marques FZ, Nelson E, Chu PY, et al. High-fiber diet and acetate supplementation change the gut microbiota and prevent the development of hypertension and heart failure in hypertensive mice. Circulation. 2017;135(10):964–977.
  • Langley-Evans SC. Critical differences between two low protein diet protocols in the programming of hypertension in the rat. Int J Food Sci Nutr. 2000;51(1):11–17.

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