Diagnosis and treatment of adult asthma patients in Serbia: a 2022 experts group position statement

References

• Soriano JB, Abajobir AA, Abate KH, et al. Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet Respir Med. 2017;5(9): 691–706.
   PubMed Web of Science ®Google Scholar
• Dharmage SC, Perret JL, Custovic A. Epidemiology of Asthma in Children and Adults. Front Pediatr. 2019;7:246.
   PubMed Web of Science ®Google Scholar
• Tabyshova A, Sooronbaev T, Akylbekov A, et al. Medication availability and economic barriers to adherence in asthma and COPD patients in low-resource settings. Npj Prim Care Respir Med. 2022;32(1):20.
   PubMed Web of Science ®Google Scholar
• Borcic K, Vasic M, Grozdanov J, et al. Results of the National Health Survey of the Republic of Serbia 2013. Belgrade, Serbia: Institute of Public Health of Serbia; 2014.
   Google Scholar
• Milenkovic B, Mitic-Milikic M, Rebic P, et al. Asthma and chronic bronchitis symptoms among adult population of Belgrade. Srp Arh Celok Lek. 2011;139(3–4):149–154.
   PubMed Web of Science ®Google Scholar
• Vukoja M, Rebic P, Lazic Z, et al. Early detection of asthma and chronic obstructive pulmonary disease in primary care patients. Med Pregl. 2013;66(1–2): 46–52.
   PubMedGoogle Scholar
• Janković S, Vlajinac H, Bjegović V et al, , The burden of disease and injury in Serbia. Eur J Public Health. 2007;17(1):80–85. doi:10.1093/eurpub/ckl072.
   PubMed Web of Science ®Google Scholar
• European Lung White Book. Available from: www.erswhitebook.org/chapters/the-burden-of-lung-disease. ( Last accesed 12 Dec 2022).
   Google Scholar
• Mediately Baza lekova 2022. Available from: https://mediately.co/rs. ( Last accesed 30 Aug 2022).
   Google Scholar
• Global strategy for asthma management and prevention 2020 (2020 report). Available from: https://ginasthma.org ( Last accesed 14 May 2020).
   Google Scholar
• Reddel HK, FitzGerald JM, Bateman ED, et al. GINA 2019: a fundamental change in asthma management: treatment of asthma with short-acting bronchodilators alone is no longer recommended for adults and adolescents. Eur Respir J. 2019;53(6): 1901046.
   PubMed Web of Science ®Google Scholar
• Beasley R, Holliday M, Reddel HK, et al. Controlled trial of budesonide–formoterol as needed for mild Asthma. N Engl J Med. 2019;380(21):2020–2030.
   PubMed Web of Science ®Google Scholar
• O’Byrne PM, FitzGerald JM, Bateman ED, et al. Inhaled combined budesonide–formoterol as needed in mild Asthma. N Engl J Med. 2018;378(20):1865–1876.
   PubMed Web of Science ®Google Scholar
• Bateman ED, Reddel HK, O’Byrne PM, et al. As-Needed budesonide–formoterol versus maintenance budesonide in Mild Asthma. N Engl J Med. 2018;378(20):1877–1887.
   PubMed Web of Science ®Google Scholar
• Beasley R, Braithwaite I, Semprini A, et al. ICS-formoterol reliever therapy stepwise treatment algorithm for adult asthma. Eur Respir J. 2020;55(1):1901407.
   PubMed Web of Science ®Google Scholar
• Abrams EM, Szefler SJ. Managing Asthma during Coronavirus Disease-2019: an example for other chronic conditions in children and adolescents. J Pediatr. 2020;222:221–226.
   PubMed Web of Science ®Google Scholar
• WHO Coronavirus (COVID-19) Dashboard 2021. Available from: https://covid19.who.int ( Last accesed 31 Aug 2022).
   Google Scholar
• Global strategy for asthma management and prevention 2022. Available from: https://ginasthma.org/ ( Last accesed 6 Jun 2022). •• Global strategy for teratment of asthma based on a review of recent scientific literature by an international panel of experts.
   Google Scholar
• Al-Moamary M, Alhaider S, Alangari A, et al. The Saudi initiative for Asthma - 2021 update: guidelines for the diagnosis and management of asthma in adults and children. Ann Thorac Med. 2021;16:4–56.
   PubMed Web of Science ®Google Scholar
• Schellack N, Mokwele N, Mogale K, et al. A 2019 update: approach to asthma management in adults. South Afr Pharm J. 2019;86:38–44.
   Google Scholar
• Pizzichini MMM, de C-PRM, Cançado JED, et al. Brazilian thoracic association recommendations for the management of asthma. J Bras Pneumol. 2020;46(1):e20190307.
   PubMed Web of Science ®Google Scholar
• Asthma: diagnosis, monitoring and chronic asthma management 2017 Available from: https://www.nice.org.uk/guidance/ng80/chapter/Recommendations#objective-tests-for-diagnosing-asthma-in-adults-young-people-and-children-aged-5-and-over ( Last accesed 25 Mar 2021).
   Google Scholar
• Stewart J, O’Halloran C, Harrigan P, et al. Identifying appropriate tasks for the preregistration year: modified Delphi technique. BMJ. 1999;319(7204):224–229.
   PubMed Web of Science ®Google Scholar
• Aaron SD, Vandemheen KL, FitzGerald JM, et al. Reevaluation of diagnosis in adults with physician-diagnosed Asthma. JAMA. 2017;317(3):269.
   PubMed Web of Science ®Google Scholar
• Stanojevic S, Quanjer P, Miller MR, et al. The global lung function initiative: dispelling some myths of lung function test interpretation. Breathe. 2013;9(6):462–474.
   Google Scholar
• Graham BL, Steenbruggen I, Miller MR, et al. Standardization of spirometry 2019 update. An official American Thoracic Society and European Respiratory Society technical statement. Am J Respir Crit Care Med. 2019;200(8):e70–e88.
   PubMed Web of Science ®Google Scholar
• Pellegrino R. Interpretative strategies for lung function tests. Eur Respir J. 2005;26(5):948–968.
   PubMed Web of Science ®Google Scholar
• Albert P, Agusti A, Edwards L, et al. Bronchodilator responsiveness as a phenotypic characteristic of established chronic obstructive pulmonary disease. Thorax. 2012;67(8):701–708.
   PubMed Web of Science ®Google Scholar
• Rogliani P, Ora J, Puxeddu E, et al. Airflow obstruction: is it asthma or is it COPD? Int J Chron Obstruct Pulmon Dis. 2016;11:3007–3013.
   PubMed Web of Science ®Google Scholar
• Stanojevic S, Kaminsky DA, Miller M, et al. ERS/ATS technical standard on interpretive strategies for routine lung function tests. Eur Respir J. 2021;60(1):2101499.
   Web of Science ®Google Scholar
• Louis R, Satia I, Ojanguren I, et al. European Respiratory Society guidelines for the diagnosis of asthma in adults. Eur Respir J. 2022;60(3): 2101585.
   Web of Science ®Google Scholar
• Coates AL, Wanger J, Cockcroft DW, et al. ERS technical standard on bronchial challenge testing: general considerations and performance of methacholine challenge tests. Eur Respir J. 2017;49(5):1601526.
   PubMed Web of Science ®Google Scholar
• Hallstrand TS, Leuppi JD, Joos G, et al. ERS technical standard on bronchial challenge testing: pathophysiology and methodology of indirect airway challenge testing. Eur Respir J. 2018;52(5):1801033.
   PubMed Web of Science ®Google Scholar
• Zappala CJ, Latsi PI, Nicholson AG, et al. Marginal decline in forced vital capacity is associated with a poor outcome in idiopathic pulmonary fibrosis. Eur Respir J. 2010;35(4):830–836.
   PubMed Web of Science ®Google Scholar
• Dunn NM, Katial RK, Hoyte FCL. Vocal cord dysfunction: a review. Asthma Res Pract. 2015;1(1). 10.1186/s40733-015-0009-z
   PubMedGoogle Scholar
• Jovanovic V, Ivanovic I, Krstic M Health statistical yearbook of republic of Serbia 2017 Belgrade, 2019 8 August 2019 Available from: https://www.batut.org.rs/download/publikacije/pub2017v026.pdf. ( Available from)
   Google Scholar
• McCreanor J, Cullinan P, Nieuwenhuijsen MJ, et al. Respiratory effects of exposure to diesel traffic in persons with Asthma. N Engl J Med. 2007;357(23):2348–2358.
   PubMed Web of Science ®Google Scholar
• Tiotiu AI, Novakova P, Nedeva D, et al. Impact of air pollution on asthma outcomes. Int J Environ Res Public Health. 2020;17(17):6212.
   PubMed Web of Science ®Google Scholar
• Kowalski ML, Makowska JS, Blanca M, et al. Hypersensitivity to nonsteroidal anti-inflammatory drugs (NSAIDs) - classification, diagnosis and management: review of the EAACI/ENDA# and GA2LEN/HANNA*: hypersensitivity to nonsteroidal anti-inflammatory drugs. Allergy. 2011;66(7):818–829.
   PubMed Web of Science ®Google Scholar
• Jaakkola MS, Aalto SAM, Hyrkäs-Palmu H, et al. Association between regular exercise and asthma control among adults: the population-based Northern Finnish asthma study. PLOS ONE. 2020;15: e0227983 doi:10.1371/journal.pone.0227983.
   PubMed Web of Science ®Google Scholar
• Parsons JP, Hallstrand TS, Mastronarde JG, et al. An official American Thoracic Society clinical practice guideline: exercise-induced bronchoconstriction. Am J Respir Crit Care Med. 2013;187(9):1016–1027.
   PubMed Web of Science ®Google Scholar
• Baur X, Sigsgaard T, Aasen TB, et al. Guidelines for the management of work-related asthma. Eur Respir J. 2012;39(3):529–545.
   PubMed Web of Science ®Google Scholar
• Thomas D, McDonald VM, Pavord ID, et al. Asthma remission: what is it and how can it be achieved? Eur Respir J. 2020;60:2102583.
   Web of Science ®Google Scholar
• Nathan RA, Sorkness CA, Kosinski M, et al. Development of the asthma control test☆A survey for assessing asthma control. J Allergy Clin Immuno. 2004;113(1):59–65.
   PubMed Web of Science ®Google Scholar
• Juniper EF, O′byrne PM, Guyatt G, et al. Development and validation of a questionnaire to measure asthma control. Eur Respir J. 1999;14(4);902–7.
   PubMed Web of Science ®Google Scholar
• Milenkovic B, Ristic S, Mirovic D, et al. Validation of the Serbian version of the Asthma control test. Vojnosanit Pregl. 2019;76:1029–1036.
   Web of Science ®Google Scholar
• Menzies-Gow A, Busse WW, Castro M, et al. Prevention and treatment of asthma exacerbations in adults. J Allergy Clin Immunol Pract. 2021;9(7):2578–2586.
   PubMed Web of Science ®Google Scholar
• Taylor DR, Sears MR, Cockcroft DW. The beta-agonist controversy. Med Clin North Am. 1996;80(4):719–748.
   PubMed Web of Science ®Google Scholar
• Hancox RJ. Concluding Remarks: can we explain the association of β -agonists with asthma mortality?: a hypothesis. Clin Rev Allergy Immunol. 2006;31(2–3):279–288.
   PubMed Web of Science ®Google Scholar
• Anderson HR, Ayres JG, Sturdy PM, et al. Bronchodilator treatment and deaths from asthma: case-control study. BMJ. 2005;330(7483):117.
   PubMedGoogle Scholar
• Grainger J, Woodman K, Pearce N, et al. Prescribed fenoterol and death from asthma in New Zealand, 1981-7: a further case-control study. Thorax. 1991;46(2):105–111.
   PubMed Web of Science ®Google Scholar
• Spitzer WO, Buist AS. Case-control study of prescribed fenoterol and death from asthma in New Zealand, 1977-81. Thorax. 1990;45(8):645–646.
   PubMed Web of Science ®Google Scholar
• Hardy J, Baggott C, Fingleton J, et al. Budesonide-formoterol reliever therapy versus maintenance budesonide plus terbutaline reliever therapy in adults with mild to moderate asthma (PRACTICAL): a 52-week, open-label, multicentre, superiority, randomised controlled trial. Lancet. 2019;394(10202):919–928.
   PubMed Web of Science ®Google Scholar
• Kerstjens HAM, Engel M, Dahl R, et al. Tiotropium in Asthma poorly controlled with standard combination therapy. N Engl J Med. 2012;367(13):1198–1207.
   PubMed Web of Science ®Google Scholar
• Virchow JC, Kuna P, Paggiaro P, et al. Single inhaler extrafine triple therapy in uncontrolled asthma (TRIMARAN and TRIGGER): two double-blind, parallel-group, randomised, controlled phase 3 trials. Lancet. 2019;394(10210):1737–1749.
   PubMed Web of Science ®Google Scholar
• Lee LA, Bailes Z, Barnes N, et al. Efficacy and safety of once-daily single-inhaler triple therapy (FF/UMEC/VI) versus FF/VI in patients with inadequately controlled asthma (CAPTAIN): a double-blind, randomised, phase 3A trial. Lancet Respir Med. 2019;9(1):69–84.
   Web of Science ®Google Scholar
• FDA requires boxed warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair) Available from: https://www.fda.gov/drugs/drug-safety-and-availability/fda-requires-boxed-warning-about-serious-mental-health-side-effects-asthma-and-allergy-drug ( Last accesed 12 Dec 2022).
   Google Scholar
• Pfaar O, Agache I, Blay F, et al. Perspectives in allergen immunotherapy: 2019 and beyond. Allergy. 2019;74(S108):3–25.
   PubMedGoogle Scholar
• Agache I, Lau S, Akdis CA, et al. EAACI Guidelines on allergen immunotherapy: house dust mite-driven allergic asthma. Allergy. 2019;74(5):855–873.
   PubMed Web of Science ®Google Scholar
• de Koning HJ, van der Aalst CM, de Jong PA, et al. Reduced lung-cancer mortality with volume CT screening in a randomized trial. N Engl J Med. 2020;382(6):503–513.
   PubMed Web of Science ®Google Scholar
• Bennett M, Chang CL, Tatley M, et al. The safety of cardioselective β1-blockers in asthma: literature review and search of global pharmacovigilance safety reports. ERJ Open Res. 2021;7(1):00801–02020.
   PubMedGoogle Scholar
• Laube BL, Janssens HM, de Jongh FHC, et al. What the pulmonary specialist should know about the new inhalation therapies. Eur Respir J. 2011;37(6):1308–1417.
   PubMed Web of Science ®Google Scholar
• AL-Jahdali H, Ahmed A, AL-Harbi A, et al. Improper inhaler technique is associated with poor asthma control and frequent emergency department visits. Allergy Asthma Clin Immunol. 2013;9(8). 10.1186/1710-1492-9-8.
   PubMedGoogle Scholar
• Price DB, Román-Rodríguez M, McQueen RB, et al. Inhaler errors in the CRITIKAL study: type, frequency, and association with asthma outcomes. J Allergy Clin Immunol Pract. 2017;5(4):1071–1081.
   PubMed Web of Science ®Google Scholar
• Dantic DE. A critical review of the effectiveness of ‘teach-back’ technique in teaching COPD patients self-management using respiratory inhalers. Health Educ J. 2014;73(1):41–50.
   Web of Science ®Google Scholar
• Dudvarski Ilic A, Zugic V, Zvezdin B, et al. Influence of inhaler technique on asthma and COPD control: a multicenter experience. Int J Chron Obstruct Pulmon Dis. 2016;11:2509–2517.
   PubMed Web of Science ®Google Scholar
• Benic M, Vukoja M. Frequency and risk factors for suboptimal inspiratory flow in patients with obstructive lung diseases. Med Danas. 2020;19:1–3.
   Google Scholar
• Grant AC, Walker R, Hamilton M, et al. The ELLIPTA® dry powder inhaler: design, functionality, in vitro dosing performance and critical task compliance by patients and caregivers. J Aerosol Med Pulm Drug Deliv. 2015;28(6):474–485.
   PubMed Web of Science ®Google Scholar
• Chung KF, Wenzel SE, Brozek JL, et al. International ERS/ATS guidelines on definition, evaluation and treatment of severe asthma. Eur Respir J. 2014;43(2):343–373.
   PubMed Web of Science ®Google Scholar
• Hekking -P-PW, Wener RR, Amelink M, et al. The prevalence of severe refractory asthma. J Allergy Clin Immunol. 2015;135(4):896–902.
   PubMed Web of Science ®Google Scholar
• Sadatsafavi M, Lynd L, Marra C, et al. Direct Health Care Costs Associated with Asthma in British Columbia. Can Respir J. 2010;17(2):74–80.
   PubMed Web of Science ®Google Scholar
• Israel E, Reddel HK. Severe and difficult-to-treat asthma in adults. In: Drazen JM, editor. N Engl J Med. 2017; Vol. 377:pp. 965–976. doi:10.1056/NEJMra1608969.
   PubMed Web of Science ®Google Scholar
• McGregor MC, Krings JG, Nair P, et al. Role of Biologics in Asthma. Am J Respir Crit Care Med. 2019;199(4):433–445.
   PubMed Web of Science ®Google Scholar
• Gibson PG, Yang IA, Upham JW, et al. Efficacy of azithromycin in severe asthma from the AMAZES randomised trial. ERJ Open Res. 2019;5(4):00056–02019.
   PubMedGoogle Scholar
• Chaudhuri R, Rubin A, Sumino K, et al. Safety and effectiveness of bronchial thermoplasty after 10 years in patients with persistent asthma (BT10+): a follow-up of three randomised controlled trials. Lancet Respir Med. 2021;9(5):457–466.
   PubMed Web of Science ®Google Scholar
• Williamson EJ, Walker AJ, Bhaskaran K, et al. Factors associated with COVID-19-related death using OpenSAFELY. Nature. 2020;584(7821):430–436.
   PubMed Web of Science ®Google Scholar
• Mahdavinia M, Foster KJ, Jauregui E, et al. Asthma prolongs intubation in COVID-19. J Allergy Clin Immunol Pract. 2020;8(7):2388–2391.
   PubMed Web of Science ®Google Scholar
• WHO. Asthma and COVID-19 . Available from: at https://www.who.int/publications/i/item/who-2019-ncov-sci-brief-asthma-2021.1. ( Last accesed 29 Jun 2021).
   Google Scholar
• Peters MC, Sajuthi S, Deford P, et al. COVID-19–related genes in sputum cells in asthma. Relationship to demographic features and corticosteroids. Am J Respir Crit Care Med. 2020;202(1):83–90.
   PubMed Web of Science ®Google Scholar
• Bloom CI, Drake TM, Docherty AB, et al. Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK. Lancet Respir Med. 2021;9(7):699–711.
   PubMed Web of Science ®Google Scholar
• Schultze A, Walker AJ, MacKenna B, et al. Risk of COVID-19-related death among patients with chronic obstructive pulmonary disease or asthma prescribed inhaled corticosteroids: an observational cohort study using the OpenSAFELY platform. Lancet Respir Med. 2020;8(11):1106–1120.
   PubMed Web of Science ®Google Scholar
• Australian National Asthma Council managing asthma during the COVID-19 (SARS-CoV-2) pandemic Available from: https://www.asthmahandbook.org.au/clinical-issues/covid-19 ( Last accesed 29 Jun 2021).
   Google Scholar
• National Institute for Health and Care Excellence COVID-19 rapid guideline: severe asthma (NICE guideline [NG166]) 2020 Available from: /www.nice.org.uk/guidance/ng166 ( Last accesed 21 Jul 2021).
   Google Scholar
• British Thoracic Society COVID-19: information for the respiratory community. Advice about the safety of nebuliser use. 2021 Available from: www.brit-thoracic.org.uk/about-us/covid-19-information-for-the-respiratory-communit. (Last accesed 2021 Jul 29).
   Google Scholar
• Fink JB, Ehrmann S, Li J, et al. Reducing aerosol-related risk of transmission in the era of COVID-19: an interim guidance endorsed by the International Society of Aerosols in Medicine. J Aerosol Med Pulm Drug Deli. 2020;33(6):300–304.
   PubMed Web of Science ®Google Scholar
• Cazzola M, Ora J, Bianco A, et al. Guidance on nebulization during the current COVID-19 pandemic. Respir Med. 2021;176:106236.
   PubMed Web of Science ®Google Scholar
• Lung function testing during COVID-19 pandemic and beyond. Available from: https://ers.app.box.com/s/zs1uu88wy51monr0ewd990itoz4tsn2h ( Last accesed 29 Jul 2021).
   Google Scholar
• Caminati M, Morais-Almeida M, Bleecker E, et al. Biologics and global burden of asthma: a worldwide portrait and a call for action. World Allergy Organ J. 2021;14(2):100502.
   PubMed Web of Science ®Google Scholar
• Abuzakouk M, Jacob S, Ghorab O Are the global initiative for asthma (GINA) guidelines being correctly used to diagnose severe asthma in the UAE? Cureus 2020 Available from: https://www.cureus.com/articles/45982-are-the-global-initiative-for-asthma-gina-guidelines-being-correctly-used-to-diagnose-severe-asthma-in-the-uae ( Last accesed 18 Jul 2022).
   Google Scholar
• Baldacci S, Simoni M, Maio S, et al. Prescriptive adherence to GINA guidelines and asthma control: an Italian cross sectional study in general practice. Respir Med. 2019;146:10–17.
   PubMed Web of Science ®Google Scholar
• Rauh S, Arnold D, Braga S, et al. Challenge of implementing clinical practice guidelines. Getting ESMO’s guidelines even closer to the bedside: introducing the ESMO practising oncologists’ checklists and knowledge and practice questions. ESMO Open. 2018;3(5):e000385.
   PubMed Web of Science ®Google Scholar
• Richardson CH, Orr NJ, Ollosson SL, et al. Initiating home spirometry for children during the COVID-19 pandemic – a practical guide. Paediatr Respir Rev. 2022;42:43–48.
   PubMed Web of Science ®Google Scholar
• Sylvester KP, Youngs L, Rutter MA, et al. Early respiratory diagnosis: benefits of enhanced lung function assessment. BMJ Open Respir Res. 2021;8(1):e001012.
   PubMed Web of Science ®Google Scholar
• Ilic M, Kopitovic I, Vulin A, et al. Frequency and effects of seasonal flu vaccines on exacerbations of chronic obstructive pulmonary disease in Serbia. Vojnosanit Pregl. 2021;78(2):179–185.
   Web of Science ®Google Scholar
• Comaru T, Pitrez PM, Friedrich FO, et al. Free asthma medications reduces hospital admissions in Brazil (Free asthma drugs reduces hospitalizations in Brazil). Respir Med. 2016;121:21–25.
   PubMed Web of Science ®Google Scholar
• Laba T-L, Jan S, Zwar NA, et al. Cost-related underuse of medicines for asthma—opportunities for improving adherence. J Allergy Clin Immunol Pract. 2019;7(7):2298–2306.e12.
   PubMed Web of Science ®Google Scholar