Factors associated with risk of death in hospitalized patients for exacerbation of chronic obstructive pulmonary disease: an updated scoping review

References

• Vogelmeier CF, Criner GJ, Martinez FJ, et al. Global strategy for the diagnosis, management, and prevention of chronic obstructive lung disease 2017 report. GOLD executive summary. Am J Respir Crit Care Med. 2017 Mar 1;195(5):557–582. doi: 10.1164/rccm.201701-0218PP
   PubMed Web of Science ®Google Scholar
• Burge S, Wedzicha JA. COPD exacerbations: definitions and classifications. Eur Respir J Suppl. 2003 Jun;41(Supplement 41):46s–53s. doi: 10.1183/09031936.03.00078002
   PubMedGoogle Scholar
• Whittaker H, Rubino A, Müllerová H, et al. Frequency and severity of exacerbations of COPD associated with future risk of exacerbations and mortality: a UK routine health care data study. Int J Chron Obstruct Pulmon Dis. 2022;17:427–437. doi: 10.2147/COPD.S346591
   PubMed Web of Science ®Google Scholar
• Celli BR, Fabbri LM, Aaron SD, et al. An updated definition and severity classification of chronic obstructive pulmonary disease exacerbations: the Rome proposal. Am J Respir Crit Care Med. 2021 Dec 1;204(11):1251–1258. doi: 10.1164/rccm.202108-1819PP
   PubMed Web of Science ®Google Scholar
• Crisafulli E, Sartori G, Huerta A, et al. Association between Rome classification among hospitalized patients with COPD exacerbations and Short-term and intermediate-term outcomes. Chest. 2023 Dec;164(6):1422–1433. doi: 10.1016/j.chest.2023.07.021
   PubMed Web of Science ®Google Scholar
• Çolak Y, Afzal S, Marott JL, et al. Prognosis of COPD depends on severity of exacerbation history: a population-based analysis. Respir med. 2019 Aug;155:141–147. doi: 10.1016/j.rmed.2019.07.021
   PubMed Web of Science ®Google Scholar
• Crisafulli E, Torres A. Hospitalized acute exacerbations of chronic obstructive pulmonary disease: which patients may have a negative clinical outcome? Expert Rev Respir Med. 2019 Aug;13(8):691–693. doi: 10.1080/17476348.2019.1635459
   PubMed Web of Science ®Google Scholar
• Crisafulli E, Barbeta E, Ielpo A, et al. Management of severe acute exacerbations of COPD: an updated narrative review. Multidiscip Respir Med. 2018;13(1):36. doi: 10.1186/s40248-018-0149-0
   PubMedGoogle Scholar
• Crisafulli E, Manco A, Torres A. How may we improve clinical outcomes for patients hospitalized with acute exacerbations of chronic obstructive pulmonary disease? A narrative review about possible therapeutic and preventive strategies. Expert Rev Respir Med. 2020 May;14(5):493–500. doi: 10.1080/17476348.2020.1732823
   PubMed Web of Science ®Google Scholar
• Sakamoto Y, Yamauchi Y, Yasunaga H, et al. Development of a nomogram for predicting in-hospital mortality of patients with exacerbation of chronic obstructive pulmonary disease. Int J Chron Obstruct Pulmon Dis. 2017;12:1605–1611. doi: 10.2147/COPD.S129714
   PubMed Web of Science ®Google Scholar
• Singanayagam A, Schembri S, Chalmers JD. Predictors of mortality in hospitalized adults with acute exacerbation of chronic obstructive pulmonary disease. Ann Am Thorac Soc. 2013 Apr;10(2):81–89. doi: 10.1513/AnnalsATS.201208-043OC
   PubMedGoogle Scholar
• Munn Z, Peters MDJ, Stern C, et al. Systematic review or scoping review? Guidance for authors when choosing between a systematic or scoping review approach. BMC Med Res Methodol. 2018 Nov 19;18(1):143. doi: 10.1186/s12874-018-0611-x
   PubMed Web of Science ®Google Scholar
• Andreassen SL, Liaaen ED, Stenfors N, et al. Impact of pneumonia on hospitalizations due to acute exacerbations of COPD. Clin Respir J. 2014 Jan;8(1):93–99. doi: 10.1111/crj.12043
   PubMed Web of Science ®Google Scholar
• Pavasini R, d’Ascenzo F, Campo G, et al. Cardiac troponin elevation predicts all-cause mortality in patients with acute exacerbation of chronic obstructive pulmonary disease: systematic review and meta-analysis. Int J Cardiol. 2015 Jul 15;191:187–193. doi: 10.1016/j.ijcard.2015.05.006
   PubMed Web of Science ®Google Scholar
• Søgaard M, Madsen M, Løkke A, et al. Incidence and outcomes of patients hospitalized with COPD exacerbation with and without pneumonia. Int J Chron Obstruct Pulmon Dis. 2016;11:455–465. doi: 10.2147/COPD.S96179
   PubMed Web of Science ®Google Scholar
• Fabbian F, De Giorgi A, Manfredini F, et al. Impact of renal dysfunction on in-hospital mortality of patients with severe chronic obstructive pulmonary disease: a single-center Italian study. Int Urol Nephrol. 2016 Jul;48(7):1121–1127. doi: 10.1007/s11255-016-1272-5
   PubMed Web of Science ®Google Scholar
• Chalela R, González-García JG, Chillarón JJ, et al. Impact of hyponatremia on mortality and morbidity in patients with COPD exacerbations. Respir med. 2016 Aug;117:237–242. doi: 10.1016/j.rmed.2016.05.003
   PubMed Web of Science ®Google Scholar
• Hu G, Wu Y, Zhou Y, et al. Prognostic role of D-dimer for in-hospital and 1-year mortality in exacerbations of COPD. Int J Chron Obstruct Pulmon Dis. 2016;11:2729–2736. doi: 10.2147/COPD.S112882
   PubMed Web of Science ®Google Scholar
• Rahimirad S, Ghaffary MR, Rahimirad MH, et al. Association between admission neutrophil to lymphocyte ratio and outcomes in patients with acute exacerbation of chronic obstructive pulmonary disease. Tuberk Toraks. 2017 Mar;65(1):25–31. doi: 10.5578/tt.27626
   PubMed Web of Science ®Google Scholar
• Vanasse A, Courteau J, Couillard S, et al. Predicting one-year mortality after a “first” hospitalization for chronic obstructive pulmonary disease: an eight-variable assessment score tool. COPD: J Chronic Obstructive Pulmonary Dis. 2017 Oct;14(5):490–497. doi: 10.1080/15412555.2017.1343814
   PubMed Web of Science ®Google Scholar
• Yao C, Liu X, Tang Z. Prognostic role of neutrophil-lymphocyte ratio and platelet-lymphocyte ratio for hospital mortality in patients with AECOPD. Int J Chron Obstruct Pulmon Dis. 2017;12:2285–2290. doi: 10.2147/COPD.S141760
   PubMed Web of Science ®Google Scholar
• Esteban C, Castro-Acosta A, Alvarez-Martínez CJ, et al. Predictors of one-year mortality after hospitalization for an exacerbation of COPD. BMC Pulm Med. 2018 Jan 25;18(1):18. doi: 10.1186/s12890-018-0574-z
   PubMedGoogle Scholar
• Crisafulli E, Ielpo A, Barbeta E, et al. Clinical variables predicting the risk of a hospital stay for longer than 7 days in patients with severe acute exacerbations of chronic obstructive pulmonary disease: a prospective study. Respir Res. 2018 Dec 27;19(1):261. doi: 10.1186/s12931-018-0951-4
   PubMed Web of Science ®Google Scholar
• Godtfredsen NS, Jørgensen DV, Marsaa K, et al. Soluble urokinase plasminogen activator receptor predicts mortality in exacerbated COPD. Respir Res. 2018 May 21;19(1):97. doi: 10.1186/s12931-018-0803-2
   PubMedGoogle Scholar
• Sprooten RTM, Rohde GGU, Lawyer G, et al. Risk stratification for short-term mortality at hospital admission for acute exacerbations of COPD. Respirol. 2019 Aug;24(8):765–776. doi: 10.1111/resp.13538
   PubMed Web of Science ®Google Scholar
• Liu J, Zou Y, Zou Y. Relationship between neutrophil–lymphocyte ratio and short-term prognosis in the chronic obstructive pulmonary patients with acute exacerbation. Bioscience Reports. 2019 May 31;39(5). doi: 10.1042/BSR20190675
   Google Scholar
• Hu GP, Zhou YM, Wu ZL, et al. Red blood cell distribution width is an independent predictor of mortality for an acute exacerbation of COPD. Int J Tuberc Lung Dis. 2019 Jul 1;23(7):817–823. doi: 10.5588/ijtld.18.0429
   PubMed Web of Science ®Google Scholar
• Li H, Zeng Z, Cheng J, et al. Prognostic role of NT-proBNP for in-hospital and 1-year mortality in patients with acute exacerbations of COPD. Int J Chron Obstruct Pulmon Dis. 2020;15:57–67. doi: 10.2147/COPD.S231808
   PubMed Web of Science ®Google Scholar
• Wang M, Lin EP, Huang LC, et al. Mortality of cardiovascular events in patients with COPD and preceding hospitalization for acute exacerbation. Chest. 2020 Sep;158(3):973–985. doi: 10.1016/j.chest.2020.02.046
   PubMed Web of Science ®Google Scholar
• Montagnani A, Mathieu G, Pomero F, et al. Hospitalization and mortality for acute exacerbation of chronic obstructive pulmonary disease (COPD): an Italian population-based study. Eur Rev Med Pharmacol Sci. 2020 Jun;24(12):6899–6907. doi: 10.26355/eurrev_202006_21681
   PubMed Web of Science ®Google Scholar
• DeLapp DA, Glick C, Furmanek S, et al. Patients with obesity have better long-term outcomes after hospitalization for COPD exacerbation. COPD: J Chronic Obstructive Pulmonary Dis. 2020 Aug;17(4):373–377. doi: 10.1080/15412555.2020.1781805
   PubMed Web of Science ®Google Scholar
• Janson C, Nwaru BI, Wiklund F, et al. Management and risk of mortality in patients hospitalised due to a first severe COPD exacerbation. Int J Chron Obstruct Pulmon Dis. 2020;15:2673–2682. doi: 10.2147/COPD.S276819
   PubMed Web of Science ®Google Scholar
• Jabarkhil A, Moberg M, Janner J, et al. Elevated blood eosinophils in acute COPD exacerbations: better short- and long-term prognosis. Eur Clin Respir J. 2020;7(1):1757274. doi: 10.1080/20018525.2020.1757274
   PubMed Web of Science ®Google Scholar
• Crisafulli E, Manco A, Guerrero M, et al. Age is a determinant of short-term mortality in patients hospitalized for an acute exacerbation of COPD. Intern Emerg Med. 2021 Mar;16(2):401–408. doi: 10.1007/s11739-020-02420-1
   PubMed Web of Science ®Google Scholar
• Echevarria C, Steer J, Wason J, et al. Oxygen therapy and inpatient mortality in COPD exacerbation. Emerg med J. 2021 Mar;38(3):170–177. doi: 10.1136/emermed-2019-209257
   PubMed Web of Science ®Google Scholar
• Gómez-Rosero JA, Cáceres-Galvis C, Ascuntar J, et al. Biomarkers as a prognostic factor in COPD exacerbation: a cohort study. COPD: J Chronic Obstructive Pulmonary Dis. 2021 Jun;18(3):325–332. doi: 10.1080/15412555.2021.1922370
   PubMed Web of Science ®Google Scholar
• Walsh JA, Barker RE, Kon SSC, et al. Gait speed and adverse outcomes following hospitalised exacerbation of COPD. Eur Respir J. 2021 Nov;58(5):2004047. doi: 10.1183/13993003.04047-2020
   PubMed Web of Science ®Google Scholar
• Mir T, Uddin M, Khalil A, et al. Mortality outcomes associated with invasive aspergillosis among acute exacerbation of chronic obstructive pulmonary disease patient population. Respir med. 2022 Jan;191:106720. doi: 10.1016/j.rmed.2021.106720
   PubMed Web of Science ®Google Scholar
• Gupta A, McKeever TM, Hutchinson JP, et al. Impact of coexisting dementia on inpatient outcomes for patients admitted with a COPD exacerbation. Int J Chron Obstruct Pulmon Dis. 2022;17:535–544. doi: 10.2147/COPD.S345751
   PubMed Web of Science ®Google Scholar
• Chen Z, Zha L, Ma X, et al. Serum creatinine/cystatin C ratio as a predictor of in-hospital mortality in patients hospitalized with acute exacerbation of chronic obstructive pulmonary disease. Lung. 2022 Oct;200(5):609–617. doi: 10.1007/s00408-022-00568-5
   PubMed Web of Science ®Google Scholar
• Zeng Z, Ke X, Gong S, et al. Blood urea nitrogen to serum albumin ratio: a good predictor of in-hospital and 90-day all-cause mortality in patients with acute exacerbations of chronic obstructive pulmonary disease. BMC Pulm Med. 2022 Dec 15;22(1):476. doi: 10.1186/s12890-022-02258-7
   PubMed Web of Science ®Google Scholar
• Bartziokas K, Kyriakopoulos C, Dounousi E, et al. Microalbuminuria on admission for acute exacerbation of COPD as a predictor of all-cause mortality and future exacerbations. Postgrad Med J. 2023 May 19;99(1169):189–197. doi: 10.1136/postgradmedj-2021-141206
   PubMed Web of Science ®Google Scholar
• Waeijen-Smit K, Crutsen M, Keene S, et al. Global mortality and readmission rates following COPD exacerbation-related hospitalisation: a meta-analysis of 65 945 individual patients. ERJ Open Res. 2024 Jan;10(1):00838–2023. doi: 10.1183/23120541.00838-2023
   PubMedGoogle Scholar
• Piquet J, Chavaillon JM, David P, et al. High-risk patients following hospitalisation for an acute exacerbation of COPD. Eur Respir J. 2013 Oct;42(4):946–955. doi: 10.1183/09031936.00180312
   PubMed Web of Science ®Google Scholar
• Flattet Y, Garin N, Serratrice J, et al. Determining prognosis in acute exacerbation of COPD. Int J Chron Obstruct Pulmon Dis. 2017;12:467–475. doi: 10.2147/COPD.S122382
   PubMed Web of Science ®Google Scholar
• Li Q, Larivée P, Courteau J, et al. Greater eosinophil counts at first COPD hospitalization are associated with more readmissions and fewer deaths. Int J Chron Obstruct Pulmon Dis. 2019;14:331–341. doi: 10.2147/COPD.S187375
   PubMed Web of Science ®Google Scholar
• Fernández-García S, Represas-Represas C, Ruano-Raviña A, et al. Dependence in performing activities as a predictor of mortality following hospitalization for chronic obstructive pulmonary disease exacerbation. Arch Bronconeumol (Engl Ed). 2020 May;56(5):291–297. doi: 10.1016/j.arbr.2020.03.004
   PubMed Web of Science ®Google Scholar
• Lasman N, Shalom M, Turpashvili N, et al. Baseline low ALT activity is associated with increased long-term mortality after COPD exacerbations. BMC Pulm Med. 2020 May 11;20(1):133. doi: 10.1186/s12890-020-1169-z
   PubMed Web of Science ®Google Scholar
• Zhang Y, Liang LR, Zhang S, et al. Blood eosinophilia and its stability in hospitalized COPD exacerbations are associated with lower risk of all-cause mortality. Int J Chron Obstruct Pulmon Dis. 2020;15:1123–1134. doi: 10.2147/COPD.S245056
   PubMed Web of Science ®Google Scholar
• Arostegui I, Esteban C, García-Gutierrez S, et al. Subtypes of patients experiencing exacerbations of COPD and associations with outcomes. PLoS One. 2014;9(6):e98580. doi: 10.1371/journal.pone.0098580
   PubMed Web of Science ®Google Scholar
• Crisafulli E, Sartori G, Vianello A, et al. Clinical features and outcomes of elderly hospitalised patients with chronic obstructive pulmonary disease, heart failure or both. Intern Emerg Med. 2023 Mar;18(2):523–534. doi: 10.1007/s11739-023-03207-w
   PubMedGoogle Scholar
• Crisafulli E, Manco A, Ferrer M, et al. Pneumonic versus nonpneumonic exacerbations of chronic obstructive pulmonary disease. Semin Respir Crit Care Med. 2020 Dec;41(6):817–829. doi: 10.1055/s-0040-1702196
   PubMedGoogle Scholar
• Crisafulli E, Menéndez R, Huerta A, et al. Systemic inflammatory pattern of patients with community-acquired pneumonia with and without COPD. Chest. 2013 Apr;143(4):1009–1017. doi: 10.1378/chest.12-1684
   PubMed Web of Science ®Google Scholar
• Huerta A, Crisafulli E, Menéndez R, et al. Pneumonic and nonpneumonic exacerbations of COPD: inflammatory response and clinical characteristics. Chest. 2013 Oct;144(4):1134–1142. doi: 10.1378/chest.13-0488
   PubMed Web of Science ®Google Scholar
• Hurst JR, Vestbo J, Anzueto A, et al. Susceptibility to exacerbation in chronic obstructive pulmonary disease. N Engl J Med. 2010 Sep 16;363(12):1128–1138. doi: 10.1056/NEJMoa0909883
   PubMed Web of Science ®Google Scholar
• Crisafulli E, Torres A, Huerta A, et al. C-Reactive protein at discharge, diabetes mellitus and ≥ 1 hospitalization during previous year predict early readmission in patients with acute exacerbation of chronic obstructive pulmonary disease. COPD: J Chronic Obstructive Pulmonary Dis. 2015 Jun;12(3):306–314. doi: 10.3109/15412555.2014.933954
   Web of Science ®Google Scholar