Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidence

References

• Worms PM. The epidemiology of motor neuron diseases: a review of recent studies. J Neurol Sci. 2001; 191: 3–9
   PubMed Web of Science ®Google Scholar
• Phukan J, Pender NP, Hardiman O. Cognitive impairment in amyotrophic lateral sclerosis. Lancet Neurol. 2007; 6: 994–1003
   PubMed Web of Science ®Google Scholar
• Yoshida M. Amyotrophic lateral sclerosis with dementia: the clinicopathological spectrum. Neuropathology. 2004; 24: 87–102
   PubMed Web of Science ®Google Scholar
• Toepfer M, Folwaczny C, Klauser A, Riepl RL, Muller-Felber W, Pongratz D. Gastrointestinal dysfunction in amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 1999; 1: 15–9
   PubMed Web of Science ®Google Scholar
• Ringholz GM, Appel SH, Bradshaw M, Cooke NA, Mosnik DM, Schulz PE. Prevalence and patterns of cognitive impairment in sporadic ALS. Neurology. 2005; 65: 586–90
   PubMed Web of Science ®Google Scholar
• Forbes RB, Colville S, Parratt J, Swingler RJ. The incidence of motor nueron disease in Scotland. J Neurol. 2007; 254: 866–9
   PubMed Web of Science ®Google Scholar
• Logroscino G, Beghi E, Zoccolella S, Palagano R, Fraddosio A, Simone IL, et al. Incidence of amyotrophic lateral sclerosis in southern Italy: a population based study. J Neurol Neurosurg Psychiatry. 2005; 76: 1094–8
   PubMed Web of Science ®Google Scholar
• O'Toole O, Traynor BJ, Brennan P, Sheehan C, Frost E, Corr B, et al. Epidemiology and clinical features of amyotrophic lateral sclerosis in Ireland between 1995 and 2004. J Neurol Neurosurg Psychiatry. 2008; 79: 30–2
   PubMed Web of Science ®Google Scholar
• Sorenson EJ, Stalker AP, Kurland LT, Windebank AJ. Amyotrophic lateral sclerosis in Olmsted County, Minnesota, 1925 to 1998. Neurology. 2002; 59: 280–2
   PubMed Web of Science ®Google Scholar
• McGuire V, Longstreth WT, Jr, Koepsell TD, van Belle G. Incidence of amyotrophic lateral sclerosis in three counties in western Washington state. Neurology. 1996; 47: 571–3
   PubMed Web of Science ®Google Scholar
• Incidence of ALS in Italy: evidence for a uniform frequency in Western countries. Neurology. 2001;56:239–44.
   PubMed Web of Science ®Google Scholar
• Cronin S, Hardiman O, Traynor BJ. Ethnic variation in the incidence of ALS: a systematic review. Neurology. 2007; 68: 1002–7
   PubMed Web of Science ®Google Scholar
• Abhinav K, Stanton B, Johnston C, Hardstaff J, Orrell RW, Howard R, et al. Amyotrophic lateral sclerosis in south-east England: a population-based study. The South-East England Register for Amyotrophic Lateral Sclerosis (SEALS Registry). Neuroepidemiology. 2007; 29: 44–8
   PubMed Web of Science ®Google Scholar
• Mandrioli J, Faglioni P, Merelli E, Sola P. The epidemiology of ALS in Modena, Italy. Neurology. 2003; 60: 683–9
   PubMed Web of Science ®Google Scholar
• Waring SC, Esteban-Santillan C, Reed DM, Craig UK, Labarthe DR, Petersen RC, et al. Incidence of amyotrophic lateral sclerosis and of the Parkinsonism-dementia complex of Guam, 1950–1989. Neuroepidemiology. 2004; 23: 192–200
   PubMed Web of Science ®Google Scholar
• Kihira T, Yoshida S, Hironishi M, Miwa H, Okamato K, Kondo T. Changes in the incidence of amyotrophic lateral sclerosis in Wakayama, Japan. Amyotroph Lateral Scler Other Motor Neuron Disord. 2005; 6: 155–63
   PubMed Web of Science ®Google Scholar
• Lilienfeld DE, Chan E, Ehland J, Godbold J, Landrigan PJ, Marsh G, et al. Rising mortality from motor neuron disease in the USA, 1962–1984. Lancet. 1989; 1: 710–3
   PubMed Web of Science ®Google Scholar
• Riggs JE, Schochet SS, Jr. Rising mortality due to Parkinson's disease and amyotrophic lateral sclerosis: a manifestation of the competitive nature of human mortality. Journal of Clinical Epidemiology. 1992; 45: 1007–12
   PubMed Web of Science ®Google Scholar
• Durrleman S, Alperovitch A. Increasing trend of ALS in France and elsewhere: are the changes real?. Neurology. 1989; 39: 768–73
   PubMed Web of Science ®Google Scholar
• Chio A. Mortality trends in ALS: an increasingly intricate puzzle. Lancet Neurol. 2005; 4: 453–4
   PubMed Web of Science ®Google Scholar
• Strong MJ, Hudson AJ, Alvord WG. Familial amyotrophic lateral sclerosis, 1850–1989: a statistical analysis of the world literature. Can J Neurol Sci. 1991; 18: 45–58
   PubMed Web of Science ®Google Scholar
• Traynor BJ, Codd MB, Corr B, Forde C, Frost E, Hardiman O. Incidence and prevalence of ALS in Ireland, 1995–1997: a population-based study. Neurology. 1999; 52: 504–9
   PubMed Web of Science ®Google Scholar
• Andersen PM, Sims KB, Xin WW, Kiely R, O'Neill G, Ravits J, et al. Sixteen novel mutations in the Cu/Zn superoxide dismutase gene in amyotrophic lateral sclerosis: a decade of discoveries, defects and disputes. Amyotroph Lateral Scler Other Motor Neuron Disord. 2003; 4: 62–73
   PubMed Web of Science ®Google Scholar
• Rosen DR, Siddique T, Patterson D, Figlewicz DA, Sapp P, Hentati A, et al. Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis. Nature. 1993; 362: 59–62
   PubMed Web of Science ®Google Scholar
• Deng HX, Hentati A, Tainer JA, Iqbal Z, Cayabyab A, Hung WY, et al. Amyotrophic lateral sclerosis and structural defects in Cu/Zn superoxide dismutase. Science. 1993; 261: 1047–51
   PubMed Web of Science ®Google Scholar
• Graham AJ, Macdonald AM, Hawkes CH. British motor neuron disease twin study. J Neurol Neurosurg Psychiatry. 1997; 62: 562–9
   PubMed Web of Science ®Google Scholar
• Jackson M, Al-Chalabi A, Enayat ZE, Chioza B, Leigh PN, Morrison KE. Copper/zinc superoxide dismutase 1 and sporadic amyotrophic lateral sclerosis: analysis of 155 cases and identification of a novel insertion mutation. Ann Neurol. 1997; 42: 803–7
   PubMed Web of Science ®Google Scholar
• Corrado L, D'Alfonso S, Bergamaschi L, Testa L, Leone M, Nasuelli N, et al. SOD1 gene mutations in Italian patients with sporadic amyotrophic lateral sclerosis (ALS). Neuromuscul Disord. 2006; 11: 800–4
   Google Scholar
• Luquin N, Yu B, Trent RJ, Morahan JM, Pamphlett R. An analysis of the entire SOD1 gene in sporadic ALS. Neuromuscul Disord. 2008; 18: 545–52
   PubMed Web of Science ®Google Scholar
• Goodall EF, Greenway MJ, van Marion I, Carroll CB, Hardiman O, Morrison KE. Association of the H63D polymorphism in the haemochromatosis gene with sporadic ALS. Neurology. 2005; 65: 934–7
   PubMed Web of Science ®Google Scholar
• Corcia P, Camu W, Halimi JM, Vourc'h P, Antar C, Vedrine S, et al. SMN1 gene, but not SMN2, is a risk factor for sporadic ALS. Neurology. 2006; 67: 1147–50
   PubMed Web of Science ®Google Scholar
• Greenway MJ, Andersen PM, Russ C, Ennis S, Cashman S, Donaghy C, et al. ANG mutations segregate with familial and'sporadic' amyotrophic lateral sclerosis. Nat Genet. 2006; 38: 411–3
   PubMed Web of Science ®Google Scholar
• Del Bo R, Scarlato M, Ghezzi S, Martinelli-Boneschi F, Corti S, Locatelli F, et al. Absence of angiogenic genes modification in Italian ALS patients. Neurobiology of Aging. 2008; 29: 314–6
   PubMed Web of Science ®Google Scholar
• Yen AA, Simpson EP, Henkel JS, Beers DR, Appel SH. HFE mutations are not strongly associated with sporadic ALS. Neurology. 2004; 62: 1611–2
   PubMed Web of Science ®Google Scholar
• Veldink JH, van den Berg LH, Cobben JM, Stulp RP, de Jong JM, Vogels OJ, et al. Homozygous deletion of the survival motor neuron 2 gene is a prognostic factor in sporadic ALS. Neurology. 2001; 56: 749–52
   PubMed Web of Science ®Google Scholar
• Dunckley T, Huentelman MJ, Craig DW, Pearson JV, Szelinger S, Joshipura K, et al. Whole-genome analysis of sporadic amyotrophic lateral sclerosis. The New England Journal of Medicine. 2007; 357: 775–88
   PubMed Web of Science ®Google Scholar
• Cronin S, Berger S, Ding J, Schymick JC, Washecka N, Hernandez DG, et al. A genome-wide association study of sporadic ALS in a homogenous Irish population. Hum Mol Genet. 2008; 17: 768–74
   PubMed Web of Science ®Google Scholar
• Schymick JC, Scholz SW, Fung HC, Britton A, Arepalli S, Gibbs JR, et al. Genome-wide genotyping in amyotrophic lateral sclerosis and neurologically normal controls: first stage analysis and public release of data. Lancet Neurol. 2007; 6: 322–8
   PubMed Web of Science ®Google Scholar
• van Es MA, van Vught PW, Blauw HM, Franke L, Saris CG, Andersen PM, et al. ITPR2 as a susceptibility gene in sporadic amyotrophic lateral sclerosis: a genome-wide association study. Lancet Neurology. 2007; 6: 869–77
   PubMed Web of Science ®Google Scholar
• Sutedja NA, Veldink JH, Fischer K, Kromhout H, Wokke JH, Huisman MH, et al. Lifetime occupation, education, smoking, and risk of ALS. Neurology. 2007; 69: 1508–14
   PubMed Web of Science ®Google Scholar
• Chen H, Richard M, Sandler DP, Umbach DM, Kamel F. Head injury and amyotrophic lateral sclerosis. American Journal of Epidemiology. 2007; 166: 810–6
   PubMed Web of Science ®Google Scholar
• Abhinav K, Al-Chalabi A, Hortobagyi T, Leigh PN. Electrical injury and amyotrophic lateral sclerosis: a systematic review of the literature. J Neurol Neurosurg Psychiatry. 2007; 78: 450–3
   PubMed Web of Science ®Google Scholar
• Roelofs-Iverson RA, Mulder DW, Elveback LR, Kurland LT, Molgaard CA. ALS and heavy metals: a pilot case-control study. Neurology. 1984; 34: 393–5
   PubMed Web of Science ®Google Scholar
• Armon C. An evidence-based medicine approach to the evaluation of the role of exogenous risk factors in sporadic amyotrophic lateral sclerosis. Neuroepidemiology. 2003; 22: 217–28
   PubMed Web of Science ®Google Scholar
• Qureshi MM, Hayden D, Urbinelli L, Ferrante K, Newhall K, Myers D, et al. Analysis of factors that modify susceptibility and rate of progression in amyotrophic lateral sclerosis (ALS). Amyotroph Lateral Scler. 2006; 7: 173–82
   PubMed Web of Science ®Google Scholar
• Weisskopf MG, O'Reilly EJ, McCullough ML, Calle EE, Thun MJ, Cudkowicz M, et al. Prospective study of military service and mortality from ALS. Neurology. 2005; 64: 32–7
   PubMed Web of Science ®Google Scholar
• Weisskopf MG, McCullough ML, Morozova N, Calle EE, Thun MJ, Ascherio A. Prospective study of occupation and amyotrophic lateral sclerosis mortality. American Journal of Epidemiology. 2005; 162: 1146–52
   PubMed Web of Science ®Google Scholar
• Armon C. Environmental risk factors for amyotrophic lateral sclerosis. Neuroepidemiology. 2001; 20: 2–6
   PubMed Web of Science ®Google Scholar
• Nelson LM, McGuire V, Longstreth WT, Jr, Matkin C. Population-based case-control study of amyotrophic lateral sclerosis in western Washington State. I. Cigarette smoking and alcohol consumption. American Journal of Epidemiology. 2000; 151: 156–63
   PubMed Web of Science ®Google Scholar
• Kamel F, Umbach DM, Munsat TL, Shefner JM, Sandler DP. Association of cigarette smoking with amyotrophic lateral sclerosis. Neuroepidemiology. 1999; 18: 194–202
   PubMed Web of Science ®Google Scholar
• Fang F, Bellocco R, Hernan MA, Ye W. Smoking, snuff dipping and the risk of amyotrophic lateral sclerosis: a prospective cohort study. Neuroepidemiology. 2006; 27: 217–21
   PubMed Web of Science ®Google Scholar
• Weisskopf MG, McCullough ML, Calle EE, Thun MJ, Cudkowicz M, Ascherio A. Prospective study of cigarette smoking and amyotrophic lateral sclerosis. American Journal of Epidemiology. 2004; 160: 26–33
   PubMed Web of Science ®Google Scholar
• Critchley M. Discussion on motor neuron disease. Proc R Soc Med. 1962; 55: 1032
   Google Scholar
• Felmus MT, Patten BM, Swanke L. Antecedent events in amyotrophic lateral sclerosis. Neurology. 1976; 26: 167–72
   PubMed Web of Science ®Google Scholar
• Bracco L, Antuono P, Amaducci L. Study of epidemiological and aetiological factors of amyotrophic lateral sclerosis in the province of Florence, Italy. Acta Neurol Scand. 1979; 60: 112–24
   PubMed Web of Science ®Google Scholar
• Beghi E, Logroscino G, Chio A, Hardiman O, Mitchell D, Swingler R, et al. The epidemiology of ALS and the role of population-based registries. Biochimica et Biophysica Acta. 2006; 1762: 1150–7
   PubMed Web of Science ®Google Scholar
• Strickland D, Smith SA, Dolliff G, Goldman L, Roelofs RI. Physical activity, trauma, and ALS: a case-control study. Acta Neurol Scand. 1996; 94: 45–50
   PubMed Web of Science ®Google Scholar
• Longstreth WT, McGuire V, Koepsell TD, Wang Y, van Belle G. Risk of amyotrophic lateral sclerosis and history of physical activity: a population-based case-control study. Archives of Neurology. 1998; 55: 201–6
   PubMedGoogle Scholar
• Ainsworth BE, Haskell WL, Whitt MC, Irwin ML, Swartz AM, Strath SJ, et al. Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc. 2000; 32(Suppl 9)S498–504
   PubMed Web of Science ®Google Scholar
• Scarmeas N, Shih T, Stern Y, Ottman R, Rowland LP. Premorbid weight, body mass, and university athletics in ALS. Neurology. 2002; 59: 773–5
   PubMed Web of Science ®Google Scholar
• Valenti M, Pontieri FE, Conti F, Altobelli E, Manzoni T, Frati L. Amyotrophic lateral sclerosis and sports: a case-control study. Eur J Neurol. 2005; 12: 223–5
   PubMed Web of Science ®Google Scholar
• Veldink JH, Kalmijn S, Groeneveld GJ, Titulaer MJ, Wokke JH, van den Berg LH. Physical activity and the association with sporadic ALS. Neurology. 2005; 64: 241–5
   PubMed Web of Science ®Google Scholar
• Beretta S, Carri MT, Beghi E, Chio A, Ferrarese C. The sinister side of Italian soccer. Lancet Neurol. 2003; 2: 656–7
   PubMed Web of Science ®Google Scholar
• Belli S, Vanacore N. Proportionate mortality of Italian soccer players: is amyotrophic lateral sclerosis an occupational disease?. Eur J Epidemiol. 2005; 20: 237–42
   PubMed Web of Science ®Google Scholar
• Armon C. Sports and trauma in amyotrophic lateral sclerosis revisited. J Neurol Sci. 2007; 262: 45–53
   PubMed Web of Science ®Google Scholar
• Taioli E. All-causes mortality in male professional soccer players. European Journal of Public Health. 2007; 17: 600–4
   PubMed Web of Science ®Google Scholar
• Hoffman PM, Brody JA. The reliability of death certificate reporting for amyotrophic lateral sclerosis. Journal of Chronic Diseases. 1971; 24: 5–8
   PubMedGoogle Scholar
• Chio A, Magnani C, Oddenino E, Tolardo G, Schiffer D. Accuracy of death certificate diagnosis of amyotrophic lateral sclerosis. Journal of Epidemiology and Community Health. 1992; 46: 517–8
   PubMed Web of Science ®Google Scholar
• Chio A, Benzi G, Dossena M, Mutani R, Mora G. Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players. Brain. 2005; 128: 472–6
   PubMed Web of Science ®Google Scholar
• Al-Chalabi A, Leigh PN. Trouble on the pitch: are professional football players at increased risk of developing amyotrophic lateral sclerosis?. Brain. 2005; 128: 451–3
   PubMed Web of Science ®Google Scholar
• Vanacore N, Binazzi A, Bottazzi M, Belli S. Amyotrophic lateral sclerosis in an Italian professional soccer player. Parkinsonism Relat Disord. 2006; 12: 327–9
   PubMed Web of Science ®Google Scholar
• Wicks P, Ganesalingham J, Collin C, Prevett M, Leigh NP, Al-Chalabi A. Three soccer playing friends with simultaneous amyotrophic lateral sclerosis. Amyotroph Lateral Scler. 2007; 8: 177–9
   PubMed Web of Science ®Google Scholar
• Abel EL. Football increases the risk for Lou Gehrig's disease, amyotrophic lateral sclerosis. Percept Mot Skills. 2007; 104: 1251–4
   PubMed Web of Science ®Google Scholar
• Bogdanov M, Brown RH, Matson W, Smart R, Hayden D, O'Donnell H, et al. Increased oxidative damage to DNA in ALS patients. Free Radic Biol Med. 2001; 29: 652–8
   Web of Science ®Google Scholar
• Shaw PJ, Ince PG, Falkous G, Mantle D. Oxidative damage to protein in sporadic motor neuron disease spinal cord. Ann Neurol. 1995; 38: 691–5
   PubMed Web of Science ®Google Scholar
• Ferrante RJ, Browne SE, Shinobu LA, Bowling AC, Baik MJ, MacGarvey U, et al. Evidence of increased oxidative damage in both sporadic and familial amyotrophic lateral sclerosis. J Neurochem. 1997; 69: 2064–74
   PubMed Web of Science ®Google Scholar
• Barber SC, Mead RJ, Shaw PJ. Oxidative stress in ALS: a mechanism of neurodegeneration and a therapeutic target. Biochimica et Biophysica Acta. 2006; 1762: 1051–67
   PubMed Web of Science ®Google Scholar
• Davies KJ, Quintanilha AT, Brooks GA, Packer L. Free radicals and tissue damage produced by exercise. Biochemical and Biophysical Research Communications. 1982; 107: 1198–205
   PubMed Web of Science ®Google Scholar
• Sen CK, Packer L. Thiol homeostasis and supplements in physical exercise. Am J Clin Nutr. 2000; 72(Suppl 2)S653–9
   Web of Science ®Google Scholar
• Radak Z, Chung HY, Goto S. Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med. 2008; 44: 153–9
   PubMed Web of Science ®Google Scholar
• Sjodin B, Hellsten Westing Y, Apple FS. Biochemical mechanisms for oxygen free radical formation during exercise. Sports Med. 1990; 10: 236–54
   PubMed Web of Science ®Google Scholar
• Banerjee AK, Mandal A, Chanda D, Chakraborti S. Oxidant, antioxidant and physical exercise. Mol Cell Biochem. 2003; 253: 307–12
   PubMed Web of Science ®Google Scholar
• Packer L. Oxidants, antioxidant nutrients and the athlete. Journal of Sports Sciences. 1997; 15: 353–63
   PubMed Web of Science ®Google Scholar
• Heath PR, Shaw PJ. Update on the glutamatergic neurotransmitter system and the role of excitotoxicity in amyotrophic lateral sclerosis. Muscle Nerve. 2002; 26: 438–58
   PubMed Web of Science ®Google Scholar
• van den Bosch L, van Damme P, Bogaert E, Robberecht W. The role of excitotoxicity in the pathogenesis of amyotrophic lateral sclerosis. Biochim Biophys Acta. 2006; 1762: 1068–82
   PubMed Web of Science ®Google Scholar
• van Damme P, Dewil M, Robberecht W, van den Bosch L. Excitotoxicity and amyotrophic lateral sclerosis. Neurodegener Dis. 2005; 2: 147–59
   PubMed Web of Science ®Google Scholar
• Ludolph AC, Meyer T, Riepe MW. The role of excitotoxicity in ALS: what is the evidence?. J Neurol. 2000; 247(Suppl 1)I7–16
   PubMedGoogle Scholar
• Longstreth WT, Nelson LM, Koepsell TD, van Belle G. Hypotheses to explain the association between vigorous physical activity and amyotrophic lateral sclerosis. Med Hypotheses. 1991; 34: 144–8
   PubMed Web of Science ®Google Scholar
• Kiaei M, Kipiani K, Petri S, Choi DK, Chen J, Calingasan NY, et al. Integrative role of cPLA with COX-2 and the effect of non-steroidal anti-inflammatory drugs in a transgenic mouse model of amyotrophic lateral sclerosis. Journal of Neurochemistry. 2005; 93: 403–11
   PubMed Web of Science ®Google Scholar
• Almer G, Teismann P, Stevic Z, Halaschek-Wiener J, Deecke L, Kostic V, et al. Increased levels of the pro-inflammatory prostaglandin PGE2 in CSF from ALS patients. Neurology. 2002; 58: 1277–9
   PubMed Web of Science ®Google Scholar
• Piazza O, Siren AL, Ehrenreich H. Soccer, neurotrauma and amyotrophic lateral sclerosis: is there a connection?. Current Medical Research and Opinion. 2004; 20: 505–8
   PubMed Web of Science ®Google Scholar
• Rankinen T, Bray MS, Hagberg JM, Perusse L, Roth SM, Wolfarth B, et al. The human gene map for performance and health-related fitness phenotypes: the 2005 update. Med Sci Sports Exerc. 2006; 38: 1863–88
   PubMed Web of Science ®Google Scholar
• Bray MS. Genomics, genes, and environmental interaction: the role of exercise. J Appl Physiol. 2000; 88: 788–92
   PubMed Web of Science ®Google Scholar
• Oosthuyse B, Moons L, Storkebaum E, Beck H, Nuyens D, Brusselmans K, et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat Genet. 2001; 28: 131–8
   PubMed Web of Science ®Google Scholar
• Lambrechts D, Storkebaum E, Morimoto M, Del-Favero J, Desmet F, Marklund SL, et al. VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motor neurons against ischaemic death. Nat Genet. 2003; 34: 383–94
   PubMed Web of Science ®Google Scholar
• Brockington A, Wharton SB, Fernando M, Gelsthorpe CH, Baxter L, Ince PG, et al. Expression of vascular endothelial growth factor and its receptors in the central nervous system in amyotrophic lateral sclerosis. J Neuropathol Exp Neurol. 2006; 65: 26–36
   PubMed Web of Science ®Google Scholar
• Sopher BL, Thomas PS, Jr, LaFevre-Bernt MA, Holm IE, Wilke SA, Ware CB, et al. Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration. Neuron. 2004; 41: 687–99
   PubMed Web of Science ®Google Scholar
• Silverman WF, Krum JM, Mani N, Rosenstein JM. Vascular, glial and neuronal effects of vascular endothelial growth factor in mesencephalic explant cultures. Neuroscience. 1999; 90: 1529–41
   PubMed Web of Science ®Google Scholar
• Sondell M, Lundborg G, Kanje M. Vascular endothelial growth factor has neurotrophic activity and stimulates axonal outgrowth, enhancing cell survival and Schwann cell proliferation in the peripheral nervous system. J Neurosci. 1999; 19: 5731–40
   PubMed Web of Science ®Google Scholar
• Czarkowska-Paczek B, Bartlomiejczyk I, Przybylski J. The serum levels of growth factors: PDGF, TGF-beta and VEGF are increased after strenuous physical exercise. J Physiol Pharmacol. 2006; 57: 189–97
   PubMed Web of Science ®Google Scholar
• Laufs U, Werner N, Link A, Endres M, Wassmann S, Jurgens K, et al. Physical training increases endothelial progenitor cells, inhibits neointima formation, and enhances angiogenesis. Circulation. 2004; 109: 220–6
   PubMed Web of Science ®Google Scholar
• Bloor CM. Angiogenesis during exercise and training. Angiogenesis. 2005; 8: 263–71
   PubMedGoogle Scholar
• Greenway MJ, Alexander MD, Ennis S, Traynor BJ, Corr B, Frost E, et al. A novel candidate region for ALS on chromosome 14q11.2. Neurology. 2004; 63: 1936–8
   PubMed Web of Science ®Google Scholar
• Hayward C, Colville S, Swingler RJ, Brock DJ. Molecular genetic analysis of the APEX nuclease gene in amyotrophic lateral sclerosis. Neurology. 1999; 52: 1899–901
   PubMed Web of Science ®Google Scholar
• Bruserud O, Grovan F, Lindas R, Blymke Moinichen C, Osterhus KK. Serum levels of angioregulatory mediators in healthy individuals depend on age and physical activity: studies of angiogenin, basic fibroblast growth factor, leptin and endostatin. Scand J Clin Lab Invest. 2005; 65: 505–11
   PubMed Web of Science ®Google Scholar
• Wu D, Yu W, Kishikawa H, Folkerth RD, Iafrate AJ, Shen Y, et al. Angiogenin loss-of-function mutations in amyotrophic lateral sclerosis. Ann Neurol. 2007; 62: 609–17
   PubMed Web of Science ®Google Scholar
• Mitsumoto H, Ikeda K, Klinkosz B, Cedarbaum JM, Wong V, Lindsay RM. Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science. 1994; 265: 1107–10
   PubMed Web of Science ®Google Scholar
• Arakawa Y, Sendtner M, Thoenen H. Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motor neurons in culture: comparison with other neurotrophic factors and cytokines. J Neurosci. 1990; 10: 3507–15
   PubMed Web of Science ®Google Scholar
• Bongioanni, P, Reali, C, Sogos, V. Ciliary neurotrophic factor (CNTF) for amyotrophic lateral sclerosis/motor neuron disease. Cochrane database of systematic reviews (Online). 2004, (3):CD004302.
   Google Scholar
• Ochs G, Penn RD, York M, Giess R, Beck M, Tonn J, et al. A phase I/II trial of recombinant methionyl human brain derived neurotrophic factor administered by intrathecal infusion to patients with amyotrophic lateral sclerosis. Amyotroph Lateral Scler Other Motor Neuron Disord. 2000; 1: 201–6
   PubMed Web of Science ®Google Scholar
• Mitchell, JD, Wokke, JH, Borasio, GD. Recombinant human insulin-like growth factor I (rhIGF-I) for amyotrophic lateral sclerosis/motor neuron disease. Cochrane database of systematic reviews (Online). 2007, (4):CD002064.
   Google Scholar
• Giess R, Holtmann B, Braga M, Grimm T, Muller-Myhsok B, Toyka KV, et al. Early onset of severe familial amyotrophic lateral sclerosis with a SOD1 mutation: potential impact of CNTF as a candidate modifier gene. American Journal of Human Genetics. 2002; 70: 1277–86
   PubMed Web of Science ®Google Scholar
• Giess R, Goetz R, Schrank B, Ochs G, Sendtner M, Toyka K. Potential implications of a ciliary neurotrophic factor gene mutation in a German population of patients with motor neuron disease. Muscle & Nerve. 1998; 21: 236–8
   PubMed Web of Science ®Google Scholar
• Ilzecka J. Increased serum CNTF level in patients with amyotrophic lateral sclerosis. European Cytokine Network. 2003; 14: 192–4
   PubMed Web of Science ®Google Scholar
• Jiang YM, Yamamoto M, Kobayashi Y, Yoshihara T, Liang Y, Terao S, et al. Gene expression profile of spinal motor neurons in sporadic amyotrophic lateral sclerosis. Ann Neurol. 2005; 57: 236–51
   PubMed Web of Science ®Google Scholar
• Molteni R, Ying Z, Gomez-Pinilla F. Differential effects of acute and chronic exercise on plasticity-related genes in the rat hippocampus revealed by microarray. Eur J Neurosci. 2002; 16: 1107–16
   PubMed Web of Science ®Google Scholar
• Gomez-Pinilla F, Ying Z, Opazo P, Roy RR, Edgerton VR. Differential regulation by exercise of BDNF and NT-3 in rat spinal cord and skeletal muscle. Eur J Neurosci. 2001; 13: 1078–84
   PubMed Web of Science ®Google Scholar
• Macias M, Fehr S, Dwornik A, Sulejczak D, Wiater M, Czarkowska-Bauch J, et al. Exercise increases mRNA levels for adhesion molecules N-CAM and L1 correlating with BDNF response. Neuroreport. 2002; 13: 2527–30
   PubMed Web of Science ®Google Scholar
• Wehrwein EA, Roskelley EM, Spitsbergen JM. GDNF is regulated in an activity-dependent manner in rat skeletal muscle. Muscle Nerve. 2002; 26: 206–11
   PubMed Web of Science ®Google Scholar
• Ferraiuolo, L, De Bono, JP, Heath, PR, Holden, H, Kasher, P, Channon, KM, , et al. Transcriptional response of the neuromuscular system to exercise training and potential implications for ALS. Submitted to Journal of Neurochemistry. 2008.
   Google Scholar
• Kirby J, Halligan E, Baptista MJ, Allen S, Heath PR, Holden H, et al. Mutant SOD1 alters the motor neuronal transcriptome: implications for familial ALS. Brain. 2005; 128: 1686–706
   PubMed Web of Science ®Google Scholar
• Vargas MR, Pehar M, Cassina P, Martinez-Palma L, Thompson JA, Beckman JS, et al. Fibroblast growth factor-1 induces heme oxygenase-1 via nuclear factor erythroid 2-related factor 2 (Nrf2) in spinal cord astrocytes: consequences for motor neuron survival. The Journal of Biological Chemistry. 2005; 280: 25571–9
   PubMed Web of Science ®Google Scholar
• Kraft AD, Resch JM, Johnson DA, Johnson JA. Activation of the Nrf2-ARE pathway in muscle and spinal cord during ALS-like pathology in mice expressing mutant SOD1. Exp Neurol. 2007; 207: 107–17
   PubMed Web of Science ®Google Scholar