Adjuvant ArtinM favored the host immunity against Cryptococcus gattii infection in C57BL/6 mice

References

• Bongomin F, Gago S, Oladele R, et al. Global and multi-national prevalence of fungal diseases – estimate precision. J Fungi. 2017;3(4):57. doi:10.3390/jof3040057
   Web of Science ®Google Scholar
• Rodrigues ML. Funding and innovation in diseases of neglected populations: the paradox of cryptococcal meningitis. PLoS Negl Trop Dis. 2016;10(3):e0004429. doi:10.1371/journal.pntd.0004429
   PubMed Web of Science ®Google Scholar
• Kumar R, Srivastava V. Application of anti-fungal vaccines as a tool against emerging anti-fungal resistance [Review]. FrontFungal Biol. 2023; 4:1241539. doi:10.3389/ffunb.2023.1241539
   Google Scholar
• Rajasingham R, Smith RM, Park BJ, et al. Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis. Lancet Infect Dis. 2017;17(8):873–881. doi:10.1016/S1473-3099(17)30243-8
   PubMed Web of Science ®Google Scholar
• Hoang LM, Maguire JA, Doyle P, et al. Cryptococcus neoformans infections at Vancouver Hospital and Health Sciences Centre (1997–2002): epidemiology, microbiology and histopathology. J Med Microbiol. 2004;53(Pt 9):935–940. doi:10.1099/jmm.0.05427-0
   PubMed Web of Science ®Google Scholar
• Okubo Y, Wakayama M, Ohno H, et al. Histopathological study of murine pulmonary cryptococcosis induced by Cryptococcus gattii and Cryptococcus neoformans. Jpn J Infect Dis. 2013;66(3):216–221. doi:10.7883/yoken.66.216
   PubMed Web of Science ®Google Scholar
• Dixit A, Carroll SF, Qureshi ST. Cryptococcus gattii: An Emerging Cause of Fungal Disease in North America. Interdiscip Perspect Infect Dis. 2009;2009:840452. doi:10.1155/2009/840452
   PubMedGoogle Scholar
• Bielska E, May RC. What makes Cryptococcus gattii a pathogen? FEMS Yeast Res. 2016;16(1):fov106. doi:10.1093/femsyr/fov106
   PubMed Web of Science ®Google Scholar
• Schoffelen T, Illnait-Zaragozi MT, Joosten LA, et al. Cryptococcus gattii induces a cytokine pattern that is distinct from other cryptococcal species. PLOS ONE. 2013;8(1):e55579. doi:10.1371/journal.pone.0055579
   PubMed Web of Science ®Google Scholar
• Angkasekwinai P, Sringkarin N, Supasorn O, et al. Cryptococcus gattii infection dampens Th1 and Th17 responses by attenuating dendritic cell function and pulmonary chemokine expression in the immunocompetent hosts. Infect Immun. 2014;82(9):3880–3890. doi:10.1128/IAI.01773-14
   PubMed Web of Science ®Google Scholar
• Huston SM, Li SS, Stack D, et al. Cryptococcus gattii is killed by dendritic cells, but evades adaptive immunity by failing to induce dendritic cell maturation. J Immunol. 2013;191(1):249–261. doi:10.4049/jimmunol.1202707
   PubMed Web of Science ®Google Scholar
• Lee Y, Puumala E, Robbins N, et al. Antifungal drug resistance: molecular mechanisms in Candida albicans and beyond. Chem Rev. 2021;121(6):3390–3411. doi:10.1021/acs.chemrev.0c00199
   PubMed Web of Science ®Google Scholar
• Chang Y-L, Yu S-J, Heitman J, et al. New facets of antifungal therapy. Virulence. 2017;8(2):222–236. doi:10.1080/21505594.2016.1257457
   PubMed Web of Science ®Google Scholar
• Enoch DA, Ludlam HA, Brown NM. Invasive fungal infections: a review of epidemiology and management options. J Med Microbiol. 2006;55(Pt 7):809–818. doi:10.1099/jmm.0.46548-0
   PubMed Web of Science ®Google Scholar
• Monk BC, Cannon RD. Genomic pathways to antifungal discovery. Curr Drug Targets Infect Disord. 2002;2(4):309–329. doi:10.2174/1568005023342344
   PubMedGoogle Scholar
• Romani L. Immunity to fungal infections. Nat Rev Immunol. 2011;11(4):275–288. doi:10.1038/nri2939
   PubMed Web of Science ®Google Scholar
• Rinaldi MG. Controversies in medical mycology. Dermatology. 1997;194(Suppl. 1):45–47. doi:10.1159/000246186
   PubMedGoogle Scholar
• Hamad M. Antifungal immunotherapy and immunomodulation: a double-hitter approach to deal with invasive fungal infections. Scand J Immunol. 2008;67(6):533–543. doi:10.1111/j.1365-3083.2008.02101.x
   PubMed Web of Science ®Google Scholar
• B P, AJD L, RC M, et al. In vitro evaluation of the acquisition of resistance, antifungal activity and synergism of Brazilian red propolis with antifungal drugs on Candida spp. J Appl Microbiol. 2015;118(4):839–850. doi:10.1111/jam.12746
   PubMed Web of Science ®Google Scholar
• Shikanai-Yasuda MA, Telles Filho Fde Q, Mendes RP, et al. [Guidelines in paracoccidioidomycosis]. Rev Soc Bras Med Trop. 2006;39(3):297–310. doi:10.1590/S0037-86822006000300017
   PubMed Web of Science ®Google Scholar
• Chaturvedi AK, Hameed RS, Wozniak KL, et al. Vaccine-mediated immune responses to experimental pulmonary Cryptococcus gattii infection in mice. PLOS ONE. 2014;9(8):e104316. doi:10.1371/journal.pone.0104316
   PubMed Web of Science ®Google Scholar
• Murphy JW, Schafer F, Casadevall A, et al. Antigen-induced protective and nonprotective cell-mediated immune components against Cryptococcus neoformans [Article]. Infect Immun. 1998;66(6):2632–2639. doi:10.1128/IAI.66.6.2632-2639.1998
   PubMed Web of Science ®Google Scholar
• Ueno K, Kinjo Y, Okubo Y, et al. Dendritic cell-based immunization ameliorates pulmonary infection with highly virulent Cryptococcus gattii. Infect Immun. 2015;83(4):1577–1586. doi:10.1128/IAI.02827-14
   PubMed Web of Science ®Google Scholar
• Ueno K, Urai M, Takatsuka S, et al. Immunization with antigen-pulsed dendritic cells against highly virulent Cryptococcus gattii infection: analysis of cytokine-producing T cells. Methods Mol Biol. 2017;1625:327–339. doi:10.1007/978-1-4939-7104-6_22
   PubMedGoogle Scholar
• Sam QH, Yew WS, Seneviratne CJ, et al. Immunomodulation as therapy for fungal infection: are we closer? Front Microbiol. 2018;9:1612. doi:10.3389/fmicb.2018.01612
   PubMed Web of Science ®Google Scholar
• Oliveira-Brito PK, de Campos GY, Guimarães JG, et al. Adjuvant curdlan contributes to immunization against Cryptococcus gattii infection in a mouse strain-specific manner. Vaccines. 2022;10(4):620. doi:10.3390/vaccines10040620
   Web of Science ®Google Scholar
• da Silva TA, de Souza MA, Cecílio NT, et al. Activation of spleen cells by ArtinM may account for its immunomodulatory properties. Cell Tissue Res. 2014;357(3):719–730. doi:10.1007/s00441-014-1879-8
   PubMed Web of Science ®Google Scholar
• da Silva TA, Mariano VS, Sardinha-Silva A, et al. IL-17 induction by ArtinM is due to stimulation of IL-23 and IL-1 release and/or interaction with CD3 in CD4+ T cells. PLOS ONE. 2016;11(2):e0149721. doi:10.1371/journal.pone.0149721
   PubMed Web of Science ®Google Scholar
• Mariano VS, Zorzetto-Fernandes AL, da Silva TA, et al. Recognition of TLR2 N-glycans: critical role in ArtinM immunomodulatory activity. PLOS ONE. 2014;9(6):e98512. doi:10.1371/journal.pone.0098512
   PubMed Web of Science ®Google Scholar
• Alegre AC, Oliveira AF, Dos Reis Almeida FB, et al. Recombinant paracoccin reproduces the biological properties of the native protein and induces protective Th1 immunity against Paracoccidioides brasiliensis infection. PLoS Negl Trop Dis. 2014;8(4):e2788. doi:10.1371/journal.pntd.0002788
   PubMed Web of Science ®Google Scholar
• Alegre-Maller ACP, Mendonça FC, da Silva TA, et al. Therapeutic Administration of Recombinant Paracoccin Confers Protection against Paracoccidioides brasiliensis Infection: Involvement of TLRs. PLoS Neglected Tropical Diseases. 2014;8(12):e3317. doi:10.1371/journal.pntd.0003317
   PubMed Web of Science ®Google Scholar
• Almeida F, Wolf JM, da Silva TA, et al. Galectin-3 impacts Cryptococcus neoformans infection through direct antifungal effects. Nat Commun. 2017;8(1):1968. doi:10.1038/s41467-017-02126-7
   PubMedGoogle Scholar
• de Melo Cristiane Moutinho L, de Castro Maria Carolina Accioly B, de Oliveira Andresa P, et al. Immunomodulatory response of Cramoll 1,4 lectin on experimental lymphocytes. Phytother Res. 2010;24(11):1631–1636. doi:10.1002/ptr.3156
   PubMed Web of Science ®Google Scholar
• Oliveira-Brito PKM, Gonçalves TE, Fernandes FF, et al. Systemic effects in naïve mice injected with immunomodulatory lectin ArtinM. PLOS ONE. 2017;12(10):e0187151. doi:10.1371/journal.pone.0187151
   PubMed Web of Science ®Google Scholar
• Santos-de-Oliveira R, Dias-Baruffi M, Thomaz SM, et al. A neutrophil migration-inducing lectin from Artocarpus integrifolia. J Immunol. 1994;153(4):1798–1807. doi:10.4049/jimmunol.153.4.1798
   PubMed Web of Science ®Google Scholar
• Liu Y, Cecilio NT, Carvalho FC, et al. Glycan microarray analysis of the carbohydrate-recognition specificity of native and recombinant forms of the lectin ArtinM. Data Brief. 2015;5:1035–1047. doi:10.1016/j.dib.2015.11.014
   PubMedGoogle Scholar
• Ganiko L, Martins AR, Espreafico EM, et al. Neutrophil haptotaxis induced by the lectin KM+. Glycoconj J. 1998;15(5):527–530. doi:10.1023/A:1006999323098
   PubMed Web of Science ®Google Scholar
• Pereira-da-Silva G, Moreno AN, Marques F, et al. Neutrophil activation induced by the lectin KM+ involves binding to CXCR2. Biochim Biophys Acta. 2006;1760(1):86–94. doi:10.1016/j.bbagen.2005.09.011
   PubMed Web of Science ®Google Scholar
• Ricci-Azevedo R, Oliveira AF, Conrado MC, et al. Neutrophils contribute to the protection conferred by ArtinM against intracellular pathogens: a study on leishmania major. PLoS Negl Trop Dis. 2016;10(4):e0004609. doi:10.1371/journal.pntd.0004609
   PubMed Web of Science ®Google Scholar
• Moreno AN, Jamur MC, Oliver C, et al. Mast cell degranulation induced by lectins: effect on neutrophil recruitment. Int Arch Allergy Immunol. 2003;132(3):221–230. doi:10.1159/000074303
   PubMed Web of Science ®Google Scholar
• Barbosa-Lorenzi VC, Buranello PA, Roque-Barreira MC, et al. The lectin ArtinM binds to mast cells inducing cell activation and mediator release. Biochem Biophys Res Commun. 2011;416(3–4):318–324. doi:10.1016/j.bbrc.2011.11.033
   PubMed Web of Science ®Google Scholar
• Coltri KC, Oliveira LL, Pinzan CF, et al. Therapeutic administration of KM+ lectin protects mice against Paracoccidioides brasiliensis infection via interleukin-12 production in a toll-like receptor 2-dependent mechanism. Am J Pathol. 2008;173(2):423–432. doi:10.2353/ajpath.2008.080126
   PubMed Web of Science ®Google Scholar
• da Silva TA, Zorzetto-Fernandes ALV, Cecílio NT, et al. CD14 is critical for TLR2-mediated M1 macrophage activation triggered by N-glycan recognition. Scientific Reports. 2017;7(1):7083. doi:10.1038/s41598-017-07397-0
   PubMedGoogle Scholar
• da Silva TA, Oliveira-Brito PKM, de Oliveira Thomaz SM, et al. ArtinM: purification and evaluation of biological activities. Methods Mol Biol. 2020;2132:349–358. doi:10.1007/978-1-0716-0430-4_34
   PubMedGoogle Scholar
• Oliveira-Brito PKM, Rezende CP, Almeida F, et al. iNOS/Arginase-1 expression in the pulmonary tissue over time during Cryptococcus gattii infection. Innate immunity. 2020;26(2):117–129. doi:10.1177/1753425919869436
   PubMed Web of Science ®Google Scholar
• Antachopoulos C, Walsh TJ. Immunotherapy of Cryptococcus infections. Clin Microbiol Infect. 2012;18(2):126–133. doi:10.1111/j.1469-0691.2011.03741.x
   PubMed Web of Science ®Google Scholar
• Jarvis JN, Meintjes G, Rebe K, et al. Adjunctive interferon-gamma immunotherapy for the treatment of HIV-associated cryptococcal meningitis: a randomized controlled trial. AIDS. 2012;26(9):1105–1113. doi:10.1097/QAD.0b013e3283536a93
   PubMed Web of Science ®Google Scholar
• Iyer KR, Revie NM, Fu C, et al. Treatment strategies for cryptococcal infection: challenges, advances and future outlook. Nat Rev Microbiol. 2021;19(7):454–466. doi:10.1038/s41579-021-00511-0
   PubMed Web of Science ®Google Scholar
• Kullberg BJ, van de Veerdonk F, Netea MG. Immunotherapy: a potential adjunctive treatment for fungal infection. Curr Opin Infect Dis. 2014;27(6):511–516. doi:10.1097/QCO.0000000000000105
   PubMed Web of Science ®Google Scholar
• Caballero Van Dyke MC, Wormley FL. A call to arms: quest for a cryptococcal vaccine. Trends Microbiol. 2018;26(5):436–446. doi:10.1016/j.tim.2017.10.002
   PubMed Web of Science ®Google Scholar
• Specht CA, Lee CK, Huang H, et al. Vaccination with recombinant cryptococcus proteins in glucan particles protects mice against cryptococcosis in a manner dependent upon mouse strain and cryptococcal species. mBio. 2017;8(6):e01872–17. doi:10.1128/mBio.01872-17
   PubMed Web of Science ®Google Scholar
• Hester MM, Lee CK, Abraham A, et al. Protection of mice against experimental cryptococcosis using glucan particle-based vaccines containing novel recombinant antigens. Vaccine. 2020;38(3):620–626. doi:10.1016/j.vaccine.2019.10.051
   PubMed Web of Science ®Google Scholar
• Wang Y, Wang K, Masso-Silva JA, et al. A heat-killed Cryptococcus mutant strain induces host protection against multiple invasive mycoses in a murine vaccine model. mBio. 2019;10(6):e02145–19. doi:10.1128/mBio.02145-19
   PubMed Web of Science ®Google Scholar
• Basto AP, Leitao A. Targeting TLR2 for vaccine development. J Immunol Res. 2014;2014:619410. doi:10.1155/2014/619410
   PubMed Web of Science ®Google Scholar
• Coltri KC, Oliveira LL, Ruas LP, et al. Protection against Paracoccidioides brasiliensis infection conferred by the prophylactic administration of native and recombinant ArtinM. Med Mycol. 2010;48(6):792–799. doi:10.3109/13693780903501671
   PubMed Web of Science ®Google Scholar
• Custodio LA, Loyola W, Conchon-Costa I, et al. Protective effect of Artin M from extract of Artocarpus integrifolia seeds by Th1 and Th17 immune response on the course of infection by Candida albicans. Int Immunopharmacol. 2011;11(10):1510–1515. doi:10.1016/j.intimp.2011.05.005
   PubMed Web of Science ®Google Scholar
• Loyola W, Custodio LA, Felipe I, et al. Artin M enhances TNF-α production and phagocytosis of Candida albicans mediated by dectin-1 and mannose receptors. Inter Immunopharmacol. 2012;12(2):378–383. doi:10.1016/j.intimp.2011.12.010
   PubMed Web of Science ®Google Scholar
• Hu J, Qiu L, Wang X, et al. Carbohydrate-based vaccine adjuvants - discovery and development. Expert Opin Drug Discov. 2015;10(10):1133–1144. doi:10.1517/17460441.2015.1067198
   PubMed Web of Science ®Google Scholar
• Li M, Zhao Y, Chen X, et al. Contribution of sex-based immunological differences to the enhanced immune response in female mice following vaccination with hepatitis B vaccine. Mol Med Rep. 2019;20(1):103–110. doi:10.3892/mmr.2019.10231
   PubMed Web of Science ®Google Scholar
• Zorzella-Pezavento SFG, Chiuso-Minicucci F, França TGD, et al. pVAXhsp65 vaccination primes for high IL-10 production and decreases experimental encephalomyelitis severity. J Immunol Res. 2017;2017:6257958. doi:10.1155/2017/6257958
   PubMed Web of Science ®Google Scholar
• Retini C, Kozel TR, Pietrella D, et al. Interdependency of interleukin-10 and interleukin-12 in regulation of T-cell differentiation and effector function of monocytes in response to stimulation with Cryptococcus neoformans. Infect Immun. 2001;69(10):6064–6073. doi:10.1128/IAI.69.10.6064-6073.2001
   PubMed Web of Science ®Google Scholar
• Xu X, Liu X, Long J, et al. Interleukin-10 reorganizes the cytoskeleton of mature dendritic cells leading to their impaired biophysical properties and motilities. PLOS ONE. 2017;12(2):e0172523. doi:10.1371/journal.pone.0172523
   PubMed Web of Science ®Google Scholar
• Jamil K, Polyak MJ, Feehan DD, et al. Phagosomal F-actin retention by Cryptococcus gattii induces dendritic cell immunoparalysis. mBio. 2020;11(6):e01821–20. doi:10.1128/mBio.01821-20
   PubMed Web of Science ®Google Scholar
• Ruas LP, Carvalho FC, Roque-Barreira MC. ArtinM offers new perspectives in the development of antifungal therapy. Front Microbiol. 2012;3:218. doi:10.3389/fmicb.2012.00218
   PubMed Web of Science ®Google Scholar
• Toledo KA, Scwartz C, Oliveira AF, et al. Neutrophil activation induced by ArtinM: release of inflammatory mediators and enhancement of effector functions. Immunol Lett. 2009;123(1):14–20. doi:10.1016/j.imlet.2009.01.009
   PubMed Web of Science ®Google Scholar
• Chahud F, Ramalho LN, Ramalho FS, et al. The lectin KM+ induces corneal epithelial wound healing in rabbits. Int J Exp Pathol. 2009;90(2):166–173. doi:10.1111/j.1365-2613.2008.00626.x
   PubMed Web of Science ®Google Scholar
• de Almeida Buranello PA, Moulin MR, Souza DA, et al. The lectin ArtinM induces recruitment of rat mast cells from the bone marrow to the peritoneal cavity. PLOS ONE. 2010;5(3):e9776. doi:10.1371/journal.pone.0009776
   PubMed Web of Science ®Google Scholar