Collaborative approach of individual participant data of prospective studies of de-escalation in non-immunosuppressed critically ill patients with sepsis

References

• Bassetti M , De Waele JJ , Eggimann P , et al. Preventive and therapeutic strategies in critically ill patients with highly resistant bacteria. Intensive Care Med. 2015;41:776–795. DOI:10.1007/s00134-015-3719-z
   PubMed Web of Science ®Google Scholar
• Calandra T , Cohen J. International sepsis forum definition of infection in the ICU consensus conference. The international sepsis forum consensus conference on definitions of infection in the intensive care unit. Crit Care Med. 2005;33:1538–1548.
   PubMed Web of Science ®Google Scholar
• Dellinger RP , Levy MM , Carlet JM , et al. Surviving Sepsis Campaign: international guidelines for management of severe sepsis and septic shock: 2008. Crit Care Med. 2008;36:296–327. DOI:10.1097/01.CCM.0000298158.12101.41
   PubMed Web of Science ®Google Scholar
• Rice LB. Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE. J Infect Dis. 2008;197:1079–1081. DOI:10.1086/533452
   PubMed Web of Science ®Google Scholar
• Knaus WA , Draper EA , Wagner DP , et al. APACHE II: a severity of disease classification system. Crit Care Med. 1985;13:818–829.
   PubMed Web of Science ®Google Scholar
• Pittet D , Thiévent B , Wenzel RP , et al. Importance of pre-existing co-morbidities for prognosis of septicemia in critically ill patients. Intensive Care Med. 1993;19:265–272.
   PubMed Web of Science ®Google Scholar
• Vincent JL , Moreno R , Takala J , et al. The SOFA (sepsis-related organ failure assessment) score to describe organ dysfunction/failure.on behalf of the working group on sepsis-related problems of the european society of intensive care medicine. Intensive Care Med. 1996;22:707–710.
   PubMed Web of Science ®Google Scholar
• Morel J , Casoetto J , Jospe R , et al. De-escalation as part of a global strategy of empiric antibiotherapy management. A retrospective study in a medico-surgical intensive care unit. Crit Care Lond Engl. 2010;14(6):R225. DOI:10.1186/cc9373
   PubMed Web of Science ®Google Scholar
• Gonzalez L , Cravoisy A , Barraud D , et al. Factors influencing the implementation of antibiotic de-escalation and impact of this strategy in critically ill patients. Crit Care Lond Engl. 2013;17:R140. DOI:10.1186/cc12819
   PubMed Web of Science ®Google Scholar
• Leone M , Bechis C , Baumstarck K , et al. De-escalation versus continuation of empirical antimicrobial treatment in severe sepsis: a multicenter non-blinded randomized noninferiority trial. Intensive Care Med. 2014;40:1399–1408.
   PubMed Web of Science ®Google Scholar
• Montravers P , Dupont H , Gauzit R , et al. Strategies of initiation and streamlining of antibiotic therapy in 41 French intensive care units. Crit Care Lond Engl. 2011;15:R17. DOI:10.1186/cc9961
   PubMed Web of Science ®Google Scholar
• Mokart D , Slehofer G , Lambert J , et al. De-escalation of antimicrobial treatment in neutropenic patients with severe sepsis: results from an observational study. Intensive Care Med. 2014;40:41–49. DOI:10.1007/s00134-013-3148-9
   PubMed Web of Science ®Google Scholar
• Montravers P , Gauzit R , Muller C , et al. Emergence of antibiotic-resistant bacteria in cases of peritonitis after intraabdominal surgery affects the efficacy of empirical antimicrobial therapy. Clin Infect Dis. 1996;23:486–494.
   PubMed Web of Science ®Google Scholar
• Rello J , Vidaur L , Sandiumenge A , et al. De-escalation therapy in ventilator-associated pneumonia. Crit Care Med. 2004;32:2183–2190.
   PubMed Web of Science ®Google Scholar
• Garnacho-Montero J , Gutiérrez-Pizarraya A , Escoresca-Ortega A , et al. De-escalation of empirical therapy is associated with lower mortality in patients with severe sepsis and septic shock. Intensive Care Med. 2014;40:32–40. DOI:10.1007/s00134-013-3077-7
   PubMed Web of Science ®Google Scholar
• De Waele JJ , Ravyts M , Depuydt P , et al. De-escalation after empirical meropenem treatment in the intensive care unit: fiction or reality? J Crit Care. 2010;25:641–646. DOI:10.1016/j.jcrc.2009.11.007
   PubMed Web of Science ®Google Scholar
• Paul M , Dickstein Y , Raz-Pasteur A . Antibiotic de-escalation for bloodstream infections and pneumonia: systematic review and meta-analysis. Clin Microbiol Infect. 2016. DOI:10.1016/j.cmi.2016.05.023
   Web of Science ®Google Scholar
• Guo Y , Gao W , Yang H , et al. De-escalation of empiric antibiotics in patients with severe sepsis or septic shock: a meta-analysis. Heart Lung J Crit Care. 2016;45:454–459. DOI:10.1016/j.hrtlng.2016.06.001
   PubMed Web of Science ®Google Scholar
• Salahuddin N , Amer L , Joseph M , et al. 932: de-Escalation of empiric antibiotics in severe sepsis: a situational analysis. [abstract]. Crit Care Med. 2013;41. DOI:10.1097/01.ccm.0000440170.18362.f8.
   Web of Science ®Google Scholar
• Escoresca-Ortega A , Gamacho-Montero J , Herrera-Melero MC , et al. De-escalation therapy strategy in patients admitted to the ICU with severe sepsis. Intensive Care Med. 2009;35:241–241. 233 Spring St, New York, NY 10013 USA; Springer.
   Web of Science ®Google Scholar
• Heenen S , Jacobs F , Vincent J-L . Antibiotic strategies in severe nosocomial sepsis: why do we not de-escalate more often? Crit Care Med. 2012;40:1404–1409. DOI:10.1097/CCM.0b013e3182416ecf
   PubMed Web of Science ®Google Scholar
• Tabah A, Cotta MO, Garnacho-Montero J, et al. A systematic review of the definitions, determinants, and clinical outcomes of antimicrobial de-escalation in the intensive care unit. Clin Infect Dis. 2016;62:1009–1017. DOI:10.1093/cid/civ1199
   Google Scholar
• Paskovaty A , Pastores SM , Gedrimaite Z , et al. Antimicrobial de-escalation in septic cancer patients: is it safe to back down? Intensive Care Med. 2015;41:2022–2023. DOI:10.1007/s00134-015-4016-6
   PubMed Web of Science ®Google Scholar
• Oshima T , Kodama Y , Takahashi W , et al. Empiric antibiotic therapy for severe sepsis and septic shock. Surg Infect. 2015;17:210–216. DOI:10.1089/sur.2014.096
   PubMed Web of Science ®Google Scholar
• Turza KC , Politano AD , Rosenberger LH , et al. De-Escalation of antibiotics does not increase mortality in critically Ill surgical patients. Surg Infect. 2016;17:48–52. DOI:10.1089/sur.2014.202
   PubMed Web of Science ®Google Scholar
• Aguilar-Guisado M, Martín-Peña A, EspigadoI, et al. Universal antifungal therapy is not needed in persistent febrile neutropenia: a tailored diagnostic and therapeutic approach. Haematologica. 2012;97:464–71. DOI:10.3324/haematol.2011.049999
   Google Scholar