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Expert Review of Clinical Pharmacology Volume 11, 2018 - Issue 8
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Editorial

The benefits of practical clinical trials over traditional randomized clinical trials for opioid management

Sebastiano MercadanteMain Regional Center Regional for Pain Relief & Supportive Care, La Maddalena Cancer center, Palermo, Italy;Supportive Care, MD Anderson, University of Houston, Houston, TX, USA;Pain Therapy and Palliative Medicine, University of Palermo, Palliative Care Program SAMO, Palermo, ItalyCorrespondence[email protected]
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Pages 741-742 | Received 21 Feb 2018, Accepted 12 Jul 2018, Published online: 23 Jul 2018

References

  • Óa S, Landmark T, Macfarlane GJ, et al. Defining chronic pain in epidemiological studies: a systematic review and meta-analysis. Pain. 2017;158:2092–2107.
  • Currow DC, Phillips J, Clark K. Using opioids in general practice for chronic non-cancer pain: an overview of current evidence. Med J Aust. 2016;204:305–309.
  • Chou R, Fanciullo GJ, Fine PG, et al. Clinical guidelines for the use of chronic opioid therapy in chronic noncancer pain. J Pain. 2009;10:113–130.
  • Schwartz D, Lellouch J. Explanatory and pragmatic attitudes in therapeutical trials. J Clin Epidemiol. 2009;62:499–505.
  • Tunis SR, Stryer DB, Clancy CM. Practical clinical trials: increasing the value of clinical research for decision making in clinical and health policy. JAMA. 2003;290:1624–1632.
  • Krebs EE, Gravely A, Nugent S, et al. Effect of opioid vs Nonopioid medications on pain-related function in patients with chronic back pain or hip or knee osteoarthritis pain: the SPACE randomized clinical trial. JAMA. 2018;319:872–882.
  • Thorpe KE, Zwarenstein M, Oxman AD, et al. A pragmatic-explanatory continuum indicator summary (PRECIS): a tool to help trial designers. J Clin Epidemiol. 2009;62:464–475.
  • Moore RA, Derry S, McQuay HJ. Clinical effectiveness: an approach to clinical trial design more relevant to clinical practice, acknowledging the importance of individual differences. Pain. 2010;149:173–176.
  • Loudon K, Zwarenstein M, Sullivan FM, et al. The PRECIS-2 tool has good interrater reliability and modest discriminant validity. J Clin Epidemiol. 2017;88:113–121.
  • Ali J, Andrews JE, Somkin CP, et al. Harms, benefits, and the nature of interventions in pragmatic clinical trials. Clin Trials. 2015;12:467–475.

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