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Review

A closer look at the spectrum of drug-induced liver injury in sub-Saharan Africa

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Pages 875-883 | Received 14 Feb 2019, Accepted 27 Jun 2019, Published online: 25 Jul 2019

References

  • Mokdad AA, Lopez AD, Shahraz S, et al. Liver cirrhosis mortality in 187 countries between 1980 and 2010: a systematic analysis. BMC Med. 2014;12:145.
  • Bernal W, Wendon J. Acute liver failure. N Engl J Med. 2013;369(26):2525–2534.
  • Byass P. The global burden of liver disease: a challenge for methods and for public health. BMC Med. 2014;12:159.
  • Asrani SK, Devarbhavi H, Eaton J, et al. Burden of liver diseases in the world. J Hepatol. 2019 Jan;70(1):151–171.
  • Gorkom V. TB control in namibia 2002-2011: progress and technical assistance. Open Infect Dis J. 2013;7:23–29.
  • UNAIDS. Global AIDS update 2016. 2016.
  • Escorsell A, Mas A, de la Mata M. Acute liver failure in Spain: analysis of 267 cases. Liver Transpl. 2007;13(10):1389–1395.
  • Hadem J, Tacke F, Bruns T, et al. Etiologies and outcomes of acute liver failure in Germany. Clin Gastroenterol Hepatol. 2012;10(6):664–9.e2.
  • Lee WM, Squires RH, Nyberg SL, et al. Acute liver failure: summary of a workshop. Hepatology. 2008;47(4):1401–1415.
  • Acharya SK, Panda SK, Saxena A, et al. Acute hepatic failure in India: a perspective from the East. J Gastroenterol Hepatol. 2000;15(5):473–479.
  • Oketani M, Ido A, Tsubouchi H. Changing etiologies and outcomes of acute liver failure: A perspective from Japan. J Gastroenterol Hepatol. 2011;26(Suppl 1):65–71.
  • Zhao P, Wang C, Liu W, et al. Causes and outcomes of acute liver failure in China. PLoS One. 2013;8(11):e80991.
  • Mudawi HM. Epidemiology of viral hepatitis in Sudan. Clin Exp Gastroenterol. 2008;1:9–13.
  • Gow PJ, Jones RM, Dobson JL, et al. Etiology and outcome of fulminant hepatic failure managed at an Australian liver transplant unit. J Gastroenterol Hepatol. 2004;19(2):154–159.
  • Lee WM. Etiologies of acute liver failure. Semin Liver Dis. 2008;28(2):142–152.
  • Teschke R, Danan G. Drug induced liver injury with analysis of alternative causes as confounding variables. Br J Clin Pharmacol. 2018;84(7):1467–1477.
  • Teschke R. Top-ranking drugs out of 3312 drug-induced liver injury cases evaluated by the Roussel Uclaf Causality assessment method. Expert Opin Drug Metab Toxicol. 2018;14(11):1169–1187.
  • Danan G, Teschke R. RUCAM in drug and herb induced liver injury: the update. Int J Mol Sci. 2015;17(1):14.
  • David S, Hamilton JP. Drug-induced liver injury. US Gastroenterol Hepatol Rev. 2010;6:73–80.
  • Fontana RJ, Seeff LB, Andrade RJ, et al. Standardization of nomenclature and causality assessment in drug-induced liver injury: summary of a clinical research workshop. Hepatology. 2010;52(2):730–742.
  • McGill MR, Williams CD, Xie Y, et al. Acetaminophen-induced liver injury in rats and mice: comparison of protein adducts, mitochondrial dysfunction, and oxidative stress in the mechanism of toxicity. Toxicol Appl Pharmacol. 2012;264(3):387–394.
  • Kaplowitz N. Biochemical and cellular mechanisms of toxic liver injury. Semin Liver Dis. 2002;22(2):137–144.
  • Bjornsson ES. Epidemiology and risk factors for idiosyncratic drug-induced liver injury. Semin Liver Dis. 2014;34(2):115–122.
  • Bjornsson ES, Bergmann OM, Bjornsson HK, et al. Incidence, presentation, and outcomes in patients with drug-induced liver injury in the general population of Iceland. Gastroenterology. 2013;144(7):1419–25, 1425 e1-3; quiz e19-20.
  • Andrade RJ, Lucena MI, Fernández MC, et al. Drug-induced liver injury: an analysis of 461 incidences submitted to the Spanish registry over a 10-year period. Gastroenterology. 2005;129(2):512–521.
  • Bjornsson ES. Hepatotoxicity by drugs: the most common implicated agents. Int J Mol Sci. 2016;17(2):224.
  • Fisher K, Vuppalanchi R, Saxena R. Drug-induced liver injury. Arch Pathol Lab Med. 2015;139(7):876–887.
  • Chalasani N, Reddy KRK, Fontana RJ, et al. Idiosyncratic drug induced liver injury in African-Americans is associated with greater morbidity and mortality compared to caucasians. Am J Gastroenterol. 2017;112(9):1382–1388.
  • Chalasani N, Bonkovsky HL, Fontana R, et al. Features and outcomes of 899 patients with drug-induced liver injury: the DILIN prospective study. Gastroenterology. 2015;148(7): 1340–1352. e7.
  • Sgro C, Clinard F, Ouazir K, et al. Incidence of drug-induced hepatic injuries: a French population-based study. Hepatology. 2002;36(2):451–455.
  • Bessone F, Hernandez N, Lucena M, et al. The Latin American DILI registry experience: a successful ongoing collaborative strategic initiative. Int J Mol Sci. 2016;17(3):313.
  • Shimakawa Y, Lemoine M, Njai HF, et al. Natural history of chronic HBV infection in West Africa: a longitudinal population-based study from The Gambia. Gut. 2016;65(12):2007–2016.
  • Afum C, Astell-Burt T, Liu J, et al. Association between Aflatoxin M(1) and liver disease in HBV/HCV Infected Persons in Ghana. Int J Environ Res Public Health. 2016;13(4):377.
  • Ocama P, Katwere M, Piloya T, et al. The spectrum of liver diseases in HIV infected individuals at an HIV treatment clinic in Kampala, Uganda. Afr Health Sci. 2008;8(1):8–12.
  • Cainelli F, Vento S. Liver disease in patients with HIV in sub-Saharan Africa. Lancet HIV. 2015;2(10):e412–3.
  • Mouton JP, Deng D, Xiang L, et al. Adverse drug reactions causing admission to medical wards: a cross-sectional survey at 4 hospitals in South Africa. Medicine (Baltimore). 2016;95(19):e3437.
  • Fredy ELM. Etude des hepatites medicamenteuses dans les services de gastroenterologie de l`hopital central et du chu de yaounde (Cameroun). 2007.
  • Cicconi P, Cozzi-Lepri A, Castagna A, et al. Insights into reasons for discontinuation according to year of starting first regimen of highly active antiretroviral therapy in a cohort of antiretroviral-naive patients. HIV Med. 2010;11(2):104–113.
  • WHO. A practical handbook on the pharmacovigilance of medicines used in the treatment of tuberculosis. 2012.
  • WHO. Global tuberculosis report 2018. 2018.
  • Morgan DJ, Okeke IN, Laxminarayan R, et al. Non-prescription antimicrobial use worldwide: a systematic review. Lancet Infect Dis. 2011;11(9):692–701.
  • Auerbach BJ, Reynolds SJ, Lamorde M, et al. Traditional herbal medicine use associated with liver fibrosis in rural Rakai, Uganda. PLoS One. 2012;7(11):e41737.
  • Espinosa-Jovel C, Toledano R, Aledo-Serrano Á, et al. Epidemiological profile of epilepsy in low income populations. Seizure. 2018;56:67–72.
  • Jost J, Ratsimbazafy V, Nguyen TT, et al. Quality of antiepileptic drugs in sub-Saharan Africa: A study in Gabon, Kenya, and Madagascar. Epilepsia. 2018;59(7):1351–1361.
  • Wandeler G, Johnson LF, Egger M. Trends in life expectancy of HIV-positive adults on antiretroviral therapy across the globe: comparisons with general population. Curr Opin HIV AIDS. 2016;11(5):492–500.
  • Nunez M. Clinical syndromes and consequences of antiretroviral-related hepatotoxicity. Hepatology. 2010;52(3):1143–1155.
  • Sonderup MW, Wainwright H, Hall P, et al. A clinicopathological cohort study of liver pathology in 301 patients with human immunodeficiency virus/acquired immune deficiency syndrome. Hepatology. 2015;61(5):1721–1729.
  • Kesselring AM, Wit FW, Sabin CA, et al. Risk factors for treatment-limiting toxicities in patients starting nevirapine-containing antiretroviral therapy. Aids. 2009;23(13):1689–1699.
  • Bannister WP, Friis-Møller N, Mocroft A, et al. Incidence of abacavir hypersensitivity reactions in euroSIDA. Antivir Ther. 2008;13(5):687–696.
  • Mallal S, Nolan D, Witt C, et al. Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir. Lancet. 2002;359(9308):727–732.
  • Nunez M. Hepatotoxicity of antiretrovirals: incidence, mechanisms and management. J Hepatol. 2006;44(1 Suppl):S132–9.
  • Martin-Carbonero L, Nunez M, Gonzalez-Lahoz J, et al. Incidence of liver injury after beginning antiretroviral therapy with efavirenz or nevirapine. HIV Clin Trials. 2003;4(2):115–120.
  • Mataranyika PA, Kibuule D, Kalemeera F, et al. Liver enzyme elevations in a cohort of HIV/AIDS patients on first-line antiretroviral therapy in Namibia: findings and implications. Alexandria J Med. 2018;54(1):49–56.
  • Chu KM, Boulle AM, Ford N, et al. Nevirapine-associated early hepatotoxicity: incidence, risk factors, and associated mortality in a primary care ART programme in South Africa. PLoS One. 2010;5(2):e9183.
  • Rodger AJ, Lodwick R, Schechter M, et al. Mortality in well controlled HIV in the continuous antiretroviral therapy arms of the SMART and ESPRIT trials compared with the general population. Aids. 2013;27(6):973–979.
  • WHO. Consolidated guidelines on the use of antiretroviral drugs for treating and preventing HIV infection. 2016.
  • Shubber Z, Calmy A, Andrieux-Meyer I, et al. Adverse events associated with nevirapine and efavirenz-based first-line antiretroviral therapy: a systematic review and meta-analysis. Aids. 2013;27(9):1403–1412.
  • Sonderup MW, Maughan D, Gogela N, et al. Identification of a novel and severe pattern of efavirenz drug-induced liver injury in South Africa. Aids. 2016;30(9):1483–1485.
  • Walmsley SL, Antela A, Clumeck N, et al. Dolutegravir plus abacavir-lamivudine for the treatment of HIV-1 infection. N Engl J Med. 2013;369(19):1807–1818.
  • Wang B, Abbott L, Childs K, et al. Dolutegravir-induced liver injury leading to sub-acute liver failure requiring transplantation: a case report and review of literature. Int J STD AIDS. 2017;29(4):414–417.
  • Saukkonen JJ, Cohn DL, Jasmer RM, et al. An official ATS statement: hepatotoxicity of antituberculosis therapy. Am J Respir Crit Care Med. 2006;174(8):935–952.
  • van der Plas H, Meintjes G, Schutz C, et al. Complications of antiretroviral therapy initiation in hospitalised patients with HIV-associated tuberculosis. PLoS One. 2013;8(2):e54145.
  • Bouazzi OE, Ogbu IA, Dipeolu IO. First line anti-tuberculosis induced hepatotoxicity: incidence and risk factors. Pan Afr Med J. 2016;25:167.
  • Hosford JD, von Fricken ME, Lauzardo M, et al. Hepatotoxicity from antituberculous therapy in the elderly: a systematic review. Tuberculosis (Edinb). 2015;95(2):112–122.
  • Sharma SK, Balamurugan A, Saha PK, et al. Evaluation of clinical and immunogenetic risk factors for the development of hepatotoxicity during antituberculosis treatment. Am J Respir Crit Care Med. 2002;166(7):916–919.
  • Ngouleun W, Biapa Nya PC, Pieme AC, et al. Risk assessment of hepatotoxicity among tuberculosis and human immunodeficiency virus/AIDS-coinfected patients under tuberculosis treatment. Int J Mycobacteriol. 2016;5(4):482–488.
  • Bonnet M, Bhatt N, Baudin E, et al. Nevirapine versus efavirenz for patients co-infected with HIV and tuberculosis: a randomised non-inferiority trial. Lancet Infect Dis. 2013;13(4):303–312.
  • Jong E, Conradie F, Berhanu R, et al. Consensus statement: management of drug-induced liver injury in HIV-positive patients treated for TB. S Afr J HIV Med. 2013;14(3):113–119.
  • Hoffmann CJ, Charalambous S, Thio CL, et al. Hepatotoxicity in an African antiretroviral therapy cohort: the effect of tuberculosis and hepatitis B. Aids. 2007;21(10):1301–1308.
  • Naidoo S, Evans D, Jong E, et al. Outcomes of TB/HIV co-infected patients presenting with antituberculosis drug-induced liver injury. S Afr Med J. 2015;105(5):393–396.
  • Schutz C, Ismail Z, Proxenos CJ, et al. Burden of antituberculosis and antiretroviral drug-induced liver injury at a secondary hospital in South Africa. S Afr Med J. 2012;102(6):506–511.
  • Van Boeckel TP, Gandra S, Ashok A, et al. Global antibiotic consumption 2000 to 2010: an analysis of national pharmaceutical sales data. Lancet Infect Dis. 2014;14(8):742–750.
  • Lucena MI, Molokhia M, Shen Y, et al. Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles. Gastroenterology. 2011;141(1):338–347.
  • Klein EY, Van Boeckel TP, Martinez EM, et al. Global increase and geographic convergence in antibiotic consumption between 2000 and 2015. Proc Natl Acad Sci U S A. 2018;115(15). E3463-E3470.
  • Prah J, Samwel A, Ng’ang’a Z, et al. Antibiotic prescription pattern in a Ghanaian primary health care facility. Pan Afr Med J. 2017;28:214.
  • Mahmoud R, Kheder S, Ali H. Prescribing rationality in Khartoum state, Sudan: an update. Sudan Med Monitor. 2014;9(2):61–66.
  • Ibrahim M. Physicians’ prescribing behaviour in two tertiary health care facilities in north-western Nigeria – Analysis of 518 prescriptions. Sahel Med J. 2004;7(4):115–118.
  • Chem ED, Anong DN, Akoachere JKT. Prescribing patterns and associated factors of antibiotic prescription in primary health care facilities of Kumbo East and Kumbo West Health Districts, North West Cameroon. PLoS One. 2018;13(3):e0193353.
  • Kalungia AC, Burger J, Godman B, et al. Non-prescription sale and dispensing of antibiotics in community pharmacies in Zambia. Expert Rev Anti Infect Ther. 2016;14(12):1215–1223.
  • Ba-Diop A, Marin B, Druet-Cabanac M, et al. Epidemiology, causes, and treatment of epilepsy in sub-Saharan Africa. Lancet Neurol. 2014;13(10):1029–1044.
  • Devarbhavi H, Andrade RJ. Drug-induced liver injury due to antimicrobials, central nervous system agents, and nonsteroidal anti-inflammatory drugs. Semin Liver Dis. 2014;34:145–161.
  • Stirnimann G, Kessebohm K, Lauterburg B. Liver injury caused by drugs: an update. Swiss Med Wkly. 2010;140:w13080.
  • Townsend E, Hawton K, Harriss L, et al. Substances used in deliberate self-poisoning 1985-1997: trends and associations with age, gender, repetition and suicide intent. Soc Psychiatry Psychiatr Epidemiol. 2001;36(5):228–234.
  • Mowry JB, Spyker DA, Cantilena LR, et al. 2013 Annual Report of the American Association of Poison control centers’ national poison data system (NPDS): 31st annual report. Clin Toxicol (Phila). 2014;52(10):1032–1283.
  • Chandra A, Mullan P, Ho-Foster A, et al. Epidemiology of patients presenting to the emergency centre of Princess Marina Hospital in Gaborone, Botswana. Afr J Emergency Med. 2014;4(3):109–114.
  • House DR, Nyabera SL, Yusi K, et al. Descriptive study of an emergency centre in Western Kenya: challenges and opportunities. Afr J Emergency Med. 2014;4(1):19–24.
  • Mowry JB, Spyker DA, Brooks DE, et al. 2015 Annual Report of the American Association of Poison Control Centers’ National Poison Data System (NPDS): 33rd Annual Report. Clin Toxicol (Phila). 2016;54(10):924–1109.
  • van Hoving DJ, Hunter LD, Gerber REJ, et al. The burden of intentional self-poisoning on a district-level public Hospital in Cape Town, South Africa. Afr J Emerg Med. 2018;8(3):79–83.
  • Navarro VJ, Lucena MI. Hepatotoxicity induced by herbal and dietary supplements. Semin Liver Dis. 2014;34(2):172–193.
  • Radimer K, Bindewald B, Hughes J, et al. Dietary supplement use by US adults: data from the National Health and Nutrition Examination Survey, 1999-2000. Am J Epidemiol. 2004;160(4):339–349.
  • Seeff LB, Curto TM, Szabo G, et al. Herbal product use by persons enrolled in the hepatitis C antiviral long-term treatment against cirrhosis (HALT-C) trial. Hepatology. 2008;47(2):605–612.
  • WHO. Traditional medicine, report by the secretariat. 2013.
  • Wai CT. Presentation of drug-induced liver injury in Singapore. Singapore Med J. 2006;47(2):116–120.
  • Zhao P, Wang C, Liu W, et al. Acute liver failure associated with traditional Chinese medicine: report of 30 cases from seven tertiary hospitals in China*. Crit Care Med. 2014;42(4):e296–9.
  • Dara L, Hewett J, Lim JK. Hydroxycut hepatotoxicity: a case series and review of liver toxicity from herbal weight loss supplements. World J Gastroenterol. 2008;14(45):6999–7004.
  • Nwokediuko SC, Osuala PC, Uduma UV, et al. Pattern of liver disease admissions in a Nigerian tertiary hospital. Niger J Clin Pract. 2013;16(3):339–342.
  • Mattei A, Pierre R, Didier S, et al. Liver transplantation for severe acute liver failure after herbal medicine (Teucrium polium) administration. J Hepatol. 1995;22(5):597.
  • Prakash AS, Pereira TN, Reilly PE, et al. Pyrrolizidine alkaloids in human diet. Mutat Res. 1999;443(1–2):53–67.
  • Chen T, Mei N, Fu PP. Genotoxicity of pyrrolizidine alkaloids. J Appl Toxicol. 2010;30(3):183–196.
  • Chen Z, Huo JR. Hepatic veno-occlusive disease associated with toxicity of pyrrolizidine alkaloids in herbal preparations. Neth J Med. 2010;68(6):252–260.
  • Yeong ML, Wakefield SJ, Ford HC. Hepatocyte membrane injury and bleb formation following low dose comfrey toxicity in rats. Int J Exp Pathol. 1993;74(2):211–217.
  • Andrade RJ, Lucena MI, Kaplowitz N, et al. Outcome of acute idiosyncratic drug-induced liver injury: long-term follow-up in a hepatotoxicity registry. Hepatology. 2006;44(6):1581–1588.
  • Program, U.A.f.I.D.b.t.S.P.S.S. Safety of medicines in Sub-Saharan Africa: assessment of pharmacovigilance systems and their performance. Arlington, VA: Management Sciences for Health.; 2011.

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