376
Views
8
CrossRef citations to date
0
Altmetric
Review

Perspectives on the pharmacological management of psoriasis in pediatric and adolescent patients

, &
Pages 807-819 | Received 05 Jan 2021, Accepted 30 Mar 2021, Published online: 22 Apr 2021

References

  • Menter A, Cordoro KM, Davis DMR, et al., Joint american academy of dermatology-national psoriasis foundation guidelines of care for the management and treatment of psoriasis in pediatric patients. J Am Acad Dermatol. 2020;82(1): 161–201.
  • De Jager ME, De Jong EM, Van De Kerkhof PC, et al. Efficacy and safety of treatments for childhood psoriasis: a systematic literature review. J Am Acad Dermatol. 2010;62(6):1013–1030.
  • Eichenfield LF, Paller AS, Tom WL, et al. Pediatric psoriasis: evolving perspectives. Pediatr Dermatol. 2018;35(2):170–181.
  • Mahé E. Childhood psoriasis. Eur J Dermatol. 2016;26(6):537–548.
  • Mahé E, Bursztejn AC, Phan A, et al. Management of childhood psoriasis in France. A national survey among general practitioners, pediatricians, and dermatologists. Dermatol Ther. 2018;31(1):1.
  • Moawad S, Mahé E, Aubert-Wastiaux H, et al. Topical corticosteroid concerns among parents of children with psoriasis versus atopic dermatitis: a french multicenter cross-sectional study. Am J Clin Dermatol. 2018;19(2):261–265.
  • Augustin M, Glaeske G, Radtke MA, et al. Epidemiology and comorbidity of psoriasis in children. Br J Dermatol. 2010;162(3):633–636.
  • Burden-Teh E, Thomas KS, Ratib S, et al. The epidemiology of childhood psoriasis: a scoping review. Br J Dermatol. 2016;174(6):1242–1257.
  • Tollefson MM, Crowson CS, McEvoy MT, et al. Incidence of psoriasis in children: a population-based study. J Am Acad Dermatol. 2010;62(6):979–987.
  • Bonigen J, Phan A, Hadj-Rabia S, et al. Impact of sex and age on the clinical and epidemiological aspects of childhood psoriasis: data from a French cross-sectional multicentre study. Ann Dermatol Venereol. 2016;143(5):354–363. French.
  • Bronckers IM, Paller AS, Van Geel MJ, et al. Psoriasis in children and adolescents: diagnosis, management and comorbidities. Paediatr Drugs. 2015;17(5):373–384.
  • Mahé E. Optimal management of adolescent plaque psoriasis: current perspectives. Psoriasis (Auckl.). 2020;10: 45–56.
  • Burden-Teh E, Thomas KS, Rangaraj S, et al. Early recognition and detection of juvenile psoriatic arthritis: a call for a standardized approach to screening. Clin Exp Dermatol. 2017;42(2):153–160.
  • Galezowski A, Maccari F, Hadj-Rabia S, et al. Psoriatic arthritis in France, from infants to the elderly: findings from two cross-sectional, multicenter studies. Ann Dermatol Venereol. 2018;145(1):13–20. French.
  • Mahé E, Beauchet A, Bodemer C, et al. Psoriasis and obesity in French children: a case-control, multicentre study. Br J Dermatol. 2015;172(6):1593–1600.
  • Paller AS, Mercy K, Kwasny MJ, et al. Association of pediatric psoriasis severity with excess and central adiposity: an international cross-sectional study. JAMA Dermatol. 2013;149(2):166–176.
  • Badaoui A, Tounian P, Mahé E. Psoriasis and metabolic and cardiovascular comorbidities in children: a systematic review. Arch Pediatr. 2019;26(2):86–94.
  • Lavaud J, Mahé E. Severity scores for childhood psoriasis: a systematic literature review. Ann Dermatol Venereol. 2019;146(12):771–782. French.
  • Bakos L, Bakos RM. Focal acne during topical tacrolimus therapy for vitiligo. Arch Dermatol. 2007;143(9):1223–1224.
  • Mahé E, Hadj-Rabia S, De Prost Y. Plane warts in areas of atopic dermatitis treated with tacrolimus ointment. Ann Dermatol Venereol. 2006;133(8–9):705–707. French.
  • Lavaud J, Mahé E. Proactive treatment in childhood psoriasis. Ann Dermatol Venereol. 2020;147(1):29–35.
  • Fortina AB, Bardazzi F, Berti S, et al. Treatment of severe psoriasis in children: recommendations of an Italian expert group. Eur J Pediatr. 2017;176(10):1339–1354.
  • Eisert L, Augustin M, Bach S, et al. S2k guidelines for the treatment of psoriasis in children and adolescents - Short version part 2. J Dtsch Dermatol Ges. 2019;17:959–973.
  • Man MQ, Ye L, Hu L, et al. Improvements in epidermal function prevent relapse of psoriasis: a Self-Controlled Study. Clin Exp Dermatol. 2019;44(6):654–657.
  • Dubertret LMM. Pioneers in dermatology and venereology: an interview with Prof. Louis M.M. Dubertret. J Eur Acad Dermatol Venereol. 2020;34(5):922–925.
  • World Health Organization. WHO traditional medicine strategy 2014-2023. 2013. Available at: http://www.who.int/medicines/publications/traditional/trm_strategy14_23/en/. Last access: November 1, 2020
  • Italia S, Brüske I, Heinrich J, et al. Complementary and alternative medicine use among chronically ill adolescents from 2 German birth cohorts. Forsch Komplementmed. 2016;23(4):246–252.
  • Gamret AC, Price A, Fertig RM, et al. Complementary and alternative medicine therapies for psoriasis: a systematic review. JAMA Dermatol. 2018;154(11):1330–1337.
  • Bilgic A, Bilgic Ö, Akış HK, et al. Psychiatric symptoms and health-related quality of life in children and adolescents with psoriasis. Pediatr Dermatol. 2010;27(6):614–617.
  • Fry L, Baker BS. Triggering psoriasis: the role of infections and medications. Clin Dermatol. 2007;25(6):606–615.
  • Phan C, Touvier M, Kesse-Guyot E, et al. Association between mediterranean anti-inflammatory dietary profile and severity of psoriasis: results from the nutrinet-santé cohort. JAMA Dermatol. 2018;154(9):1017–1024.
  • Dupire G, Droitcourt C, Hughes C, et al. Antistreptococcal interventions for guttate and chronic plaque psoriasis. Cochrane Database Syst Rev. 2019;3(3):CD011571.
  • Ramos Pinheiro R, Matos-Pires E, Baptista J, et al. Granuloma glutaeale infantum: a re-emerging complication of diaper dermatitis. Pediatrics. 2018;141(2):e20162064.
  • Oranje AP, Marcoux D, Svensson A, et al. Topical calcipotriol in childhood psoriasis. J Am Acad Dermatol. 1997;36(2):203–208.
  • Brune A, Miller DW, Lin P, et al. Tacrolimus ointment is effective for psoriasis on the face and intertriginous areas in pediatric patients. Pediatr Dermatol. 2007;24(1):76–80.
  • Kravvas G, Gholam K. Use of topical therapies for pediatric psoriasis: a systematic review. Pediatr Dermatol. 2018;35(3):296–302.
  • Oostveen AM, Beulens CA, Van De Kerkhof PC, et al. The effectiveness and safety of short-contact dithranol therapy in paediatric psoriasis: a prospective comparison of regular day care and day care with telemedicine. Br J Dermatol. 2014;170(2):454–457.
  • Subissi A, Monti D, Togni G, et al. Ciclopirox: recent nonclinical and clinical data relevant to its use as a topical antimycotic agent. Drugs. 2010;70(16):2133–2152.
  • Van Geel MJ, Mul K, Oostveen AM, et al., Calcipotriol/betamethasone dipropionate ointment in mild-to-moderate paediatric psoriasis: long-term daily clinical practice data in a prospective cohort. Br J Dermatol. 2014;171(2): 363–369.
  • Mahé E, Corgibet F, Maccari F, et al. Off-label drugs in childhood psoriasis. Ann Dermatol Venereol. 2020;147:429–438
  • Seyger M, Abramovits W, Liljedahl M, et al. Safety and efficacy of fixed-dose combination calcipotriol (50 μg/g) and betamethasone dipropionate (0.5 mg/g) cutaneous foam in adolescent patients (aged 12 to <17 years) with plaque psoriasis: results of a phase II, open-label trial. J Eur Acad Dermatol Venereol. 2020;19(34):2026–2034.
  • Ramachandran V, Bertus B, Bashyam AM, et al. Treating psoriasis with halobetasol propionate and tazarotene combination: a review of phase II and III clinical trials. Ann Pharmacother. 2020;54(9):872–878.
  • Kim E, Lee G, Fischer G. Use of narrowband ultraviolet B (NBUVB) in paediatric psoriasis: a systematic literature review and meta-analysis. Australas J Dermatol. 2020 Oct 18. Epub ahead of print. 10.1111/ajd.13471
  • Nguyen MO, Watson AJ, Joyce C, et al. Long-term use of home narrowband ultraviolet B phototherapy demonstrates high patient satisfaction, compliance, and low rates of adverse effects: a survey study. J Am Acad Dermatol. 2020;83(1):267–269.
  • Gerber W, Arheilger B, Ha TA, et al. Ultraviolet B 308-nm excimer laser treatment of psoriasis: a new phototherapeutic approach. Br J Dermatol. 2003;149(6):1250–1258.
  • Di Lernia V, Bonamonte D, Lasagni C, et al. Effectiveness and safety of acitretin in children with plaque psoriasis: a multicenter retrospective analysis. Pediatr Dermatol. 2016;33(5):530–535.
  • Bronckers IMGJ, Seyger MMB, West DP, et al., Safety of systemic agents for the treatment of pediatric psoriasis. JAMA Dermatol. 2017;153(11): 1147–1157.
  • Charbit L, Mahé E, Phan A, et al. Systemic treatments in childhood psoriasis: a French multicentre study on 154 children. Br J Dermatol. 2016;174(5):1118–1121.
  • Mahé E. Cushing’s syndrome induced by high-potency topical corticosteroids in two children with palmoplantar psoriasis taking acitretin. Pediatr Dermatol. 2017;34(2):219–220.
  • Bronckers IMGJ, Paller AS, West DP, et al. A comparison of psoriasis severity in pediatric patients treated with methotrexate vs biologic agents. JAMA Dermatol. 2020;156(4):384–392.
  • Papp K, Thaçi D, Marcoux D, et al. Efficacy and safety of adalimumab every other week versus methotrexate once weekly in children and adolescents with severe chronic plaque psoriasis: a randomised, double-blind, phase 3 trial. Lancet. 2017;390(10089):40–49.
  • Van Geel MJ, Oostveen AM, Hoppenreijs EP, et al. Methotrexate in pediatric plaque-type psoriasis: long-term daily clinical practice results from the Child-CAPTURE registry. J Dermatolog Treat. 2015;26(5):406–412.
  • Van Geel MJ, Van De Kerkhof PC, Oostveen AM, et al. Fumaric acid esters in recalcitrant pediatric psoriasis: a prospective, daily clinical practice case series. J Dermatolog Treat. 2016;27(3):214–220.
  • Tzaneva S, Geroldinger A, Trattner H, et al. Fumaric acid esters in combination with a 6-week course of narrowband ultraviolet B provides an accelerated response compared with fumaric acid esters monotherapy in patients with moderate-to-severe plaque psoriasis: a randomized prospective clinical study. Br J Dermatol. 2018;178(3):682–688.
  • Paller AS, Hong Y, Becker EM, et al. Pharmacokinetics and safety of apremilast in pediatric patients with moderate to severe plaque psoriasis: results from a phase 2 open-label study. J Am Acad Dermatol. 2020;82(2):389–397.
  • Richard MA. Groupe de recherche sur le psoriasis de la Société française de dermatologie. [Psoriasis: initial assessment and practical therapy evaluation]. Ann Dermatol Venereol. 2019;146(6–7):440–449. French.
  • Phan C, Beauchet A, Burztejn AC, et al., Biological treatments for paediatric psoriasis: a retrospective observational study on biological drug survival in daily practice in childhood psoriasis. J Eur Acad Dermatol Venereol. 2019;33(10): 1984–1992.
  • Paller AS, Siegfried EC, Langley RG, et al. Etanercept treatment for children and adolescents with plaque psoriasis. N Engl J Med. 2008;358(3):241–251.
  • Paller AS, Siegfried EC, Pariser DM, et al. Long-term safety and efficacy of etanercept in children and adolescents with plaque psoriasis. J Am Acad Dermatol. 2016;74(2):280–287.
  • Siegfried EC, Eichenfield LF, Paller AS, et al. Intermittent etanercept therapy in pediatric patients with psoriasis. J Am Acad Dermatol. 2010;63(5):769–774.
  • Bodemer C, Kaszuba A, Kingo K, et al. Secukinumab demonstrates high efficacy and a favourable safety profile in paediatric patients with severe chronic plaque psoriasis: 52-week results from a Phase 3 double-blind randomised, controlled trial. J Eur Acad Dermatol Venereol. 2020 Oct 17 Epub ahead of print. 10.1111/jdv.17002
  • Paller AS, Seyger MMB, Alejandro Magariños G, et al. Efficacy and safety of ixekizumab in a phase III, randomized, double-blind, placebo-controlled study in paediatric patients with moderate-to-severe plaque psoriasis (IXORA - PEDS). Br J Dermatol. 2020;183(2):231–241.
  • Thaçi D, Papp K, Marcoux D, et al. Sustained long-term efficacy and safety of adalimumab in paediatric patients with severe chronic plaque psoriasis from a randomized, double-blind, phase III study. Br J Dermatol. 2019;181(6):1177–1189.
  • Horneff G, Seyger MMB, Arikan D, et al. Safety of adalimumab in pediatric patients with polyarticular juvenile idiopathic arthritis, enthesitis-related arthritis, psoriasis, and crohn’s disease. J Pediatr. 2018;201:166–175.
  • Landells I, Marano C, Hsu MC, et al. Ustekinumab in adolescent patients age 12 to 17 years with moderate-to-severe plaque psoriasis: results of the randomized phase 3 CADMUS study. J Am Acad Dermatol. 2015;73(4):594–603.
  • Philipp S, Menter A, Nikkels AF, et al. Ustekinumab for the treatment of moderate-to-severe plaque psoriasis in paediatric patients (≥ 6 to < 12=”” years=”” of=”” age):=”” efficacy,=”” safety,=”” pharmacokinetic=”” and=”” biomarker=”” results=”” from=”” the=”” open-label=”” cadmus=”” jr=””>. Br J Dermatol. 2020;183(4):664–672.
  • European Medicines Agency. Assessment report. Cosentyx. 2020. Available at: https://www.ema.europa.eu/en/documents/variation-report/cosentyx-h-c-3729-ii-0057-epar-assessment-report-variation_en.pdf
  • Ollech A, Zvulunov A, Pavlovsky L, et al. Biologic treatment of recalcitrant pediatric psoriasis: a case series from a tertiary medical center. J Dermatolog Treat. 2019;30(2):152–155.
  • Bellodi Schmidt F, Shah KN. Biologic response modifiers and pediatric psoriasis. Pediatr Dermatol. 2015;32(3):303–320.
  • Lu J, Li Y, Yu N, et al. Successful treatment of juvenile generalized pustular psoriasis with infliximab therapy: two case reports. J Int Med Res. 2020;48(3):300060520912091.
  • Pan J, Qiu L, Xiao T, et al. Juvenile generalized pustular psoriasis with IL36RN mutation treated with short-term infliximab. Dermatol Ther. 2016;29(3):164–167.
  • Rossi-Semerano L, Piram M, Chiaverini C, et al. First clinical description of an infant with interleukin-36-receptor antagonist deficiency successfully treated with anakinra. Pediatrics. 2013;132(4):e1043–e1047.
  • Phan C, Beauchet A, Burztejn AC, et al. Evaluation of children with psoriasis from the BiPe cohort: are patients using biotherapies in real life eligible for phase III clinical studies? Paediatr Drugs. 2019;21(3):169–175.
  • Di Lernia V, Bianchi L, Guerriero C, et al. Adalimumab in severe plaque psoriasis of childhood: a multi-center, retrospective real-life study up to 52 weeks observation. Dermatol Ther. 2019;32(6):e13091.
  • Di Lernia V, Guarneri C, Stingeni L, et al. Effectiveness of etanercept in children with plaque psoriasis in real practice: a one-year multicenter retrospective study. J Dermatolog Treat. 2018;29(3):217–219.
  • Bachelez H, Choon SE, Marrakchi S, et al. Inhibition of the interleukin-36 pathway for the treatment of generalized pustular psoriasis. N Engl J Med. 2019;380(10):981–983.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.