Clinical trials with plants in diabetes mellitus therapy: a systematic review

References

• DeFronzo RA, Ferrannini E, Groop L, et al. Type 2 diabetes mellitus. Nat Rev Dis Primers. 2015;1:15019.
   PubMed Web of Science ®Google Scholar
• Stumvoll M, Goldstein BJ, Van Haeften TW. Type 2 diabetes: principles of pathogenesis and therapy. Lancet. 2005;365(9467):1333–1346.
   PubMed Web of Science ®Google Scholar
• Holman N, Young B, Gadsby R. Current prevalence of type 1 and type 2 diabetes in adults and children in the UK. Diabet Med. 2015;32:1119–1120.
   PubMed Web of Science ®Google Scholar
• Fuchsberger C, Flannick J, Teslovich TM, et al. The genetic architecture of type 2 diabetes. Nature. 2016;536:41–47.
   PubMed Web of Science ®Google Scholar
• Chatterjee S, Khunti K, Davies MJ. Type 2 diabetes. Lancet. 2017;389:2239–2251.
   PubMed Web of Science ®Google Scholar
• Schellenberg ES, Dryden DM, Vandermeer B, et al. Lifestyle interventions for patients with and at risk for type 2 diabetes: a systematic review and meta-analysis. Ann Int Med. 2013;159:543–551.
   PubMed Web of Science ®Google Scholar
• Saeedi P, Petersohn I, Salpea P, et al. Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Res Clin Pract. 2019;157:107843.
   PubMed Web of Science ®Google Scholar
• Ríos JL, Francini F, Schinella GR. Natural Products for the Treatment of Type 2 Diabetes Mellitus. Planta Med. 2015;81(12–13):975–994.
   PubMed Web of Science ®Google Scholar
• Xu L, Li Y, Dai Y, et al. Natural products for the treatment of type 2 diabetes mellitus: pharmacology and mechanisms. Pharmacol Res. 2018;130:451–465.
   PubMed Web of Science ®Google Scholar
• Brasil. Ministério da Saúde. Portal da Saúde: relação Nacional de Medicamentos Essenciais (RENAME). 2020. [cited 2021 Jan]. Available in: https://bvsms.saude.gov.br/bvs/publicacoes/relacao_medicamentos_rename_2020.pdf
   Google Scholar
• Marmitt DJ, Bitencourt S, Da Silva GR, et al. RENISUS plants and their potential antitumor effects in Clinical Trials and Registered Patents. Nutrit. Cancer. 2020;72(7):1–28. .
   PubMedGoogle Scholar
• Marmitt DJ, Goettert MI, Rempel C. Compounds of plants with activity against SARS-CoV-2 targets. Expert Rev. Clin. Pharmacol. 2021;14(4):1–12.
   Google Scholar
• Marmitt DJ, Bitencourt S, Silva AC, et al. The healing properties of medicinal plants used in the Brazilian public health system: a systematic review. J Wound Care. 2018;27:S4–S13.
   PubMed Web of Science ®Google Scholar
• Marmitt DJ, Shahrajabian MH. Plant species used in Brazil and Asia regions with toxic Properties. Phytother Res. 2021;35:1–24.
   Google Scholar
• Marmitt DJ, Bitencourt S, Silva AC, et al. Medicinal plants used in Brazil Public Health System with neuroprotective potential – A systematic review. Bol. Latinoam. Caribe Plantas Med. Aromát. 2018;17:84-103.
   Google Scholar
• Salehi B, Ata A, Kumar NVA, et al. Antidiabetic Potential of Medicinal Plants and Their Active Components. Biomolecules. 2019;9(10):551.
   PubMed Web of Science ®Google Scholar
• Chukwuma CI, Matsabisa MG, Ibrahim MA, et al. Medicinal plants with concomitant anti-diabetic and anti-hypertensive effects as potential sources of dual acting therapies against diabetes and hypertension: a review. J Ethnopharmacol. 2019;235:329–360.
   PubMed Web of Science ®Google Scholar
• Asadi S, Gholami MS, Siassi F, et al. Nano curcumin supplementation reduced the severity of diabetic sensorimotor polyneuropathy in patients with type 2 diabetes mellitus: a randomized double-blind placebo-controlled clinical trial. Complement Ther Med. 2019;43:253–260.
   PubMed Web of Science ®Google Scholar
• Panahi Y, Khalili N, Sahebi E, et al. Curcuminoids modify lipid profile in type 2 diabetes mellitus: a randomized controlled trial. Complement Ther Med. 2017;33:1–5.
   PubMed Web of Science ®Google Scholar
• Kurian GA, Manjusha V, Nair SS, et al. Short-term effect of G-400, polyherbal formulation in the management of hyperglycemia and hyperlipidemia conditions in patients with type 2 diabetes mellitus. Nutrition. 2014;30(10):1158–1164.
   PubMed Web of Science ®Google Scholar
• Jiménez-Osorio AS, García-Niño WR, González-Reyes S, et al. The Effect of Dietary Supplementation With Curcumin on Redox Status and Nrf2 Activation in Patients With Nondiabetic or Diabetic Proteinuric Chronic Kidney Disease: a Pilot Study. J Ren Nutr. 2016;26(4):237–244.
   PubMed Web of Science ®Google Scholar
• Khajehdehi P, Pakfetrat M, Javidnia K, et al. Oral supplementation of turmeric attenuates proteinuria, transforming growth factor-β and interleukin-8 levels in patients with overt type 2 diabetic nephropathy: a randomized, double-blind and placebo-controlled study. Scand J Urol Nephrol. 2011;45(5):365–370.
   PubMed Web of Science ®Google Scholar
• Srinivasan A, Selvarajan S, Kamalanathan S, et al. Effect of Curcuma longa on vascular function in native Tamilians with type 2 diabetes mellitus: a randomized, double-blind, parallel arm, placebo-controlled trial. Phytother Res. 2019;33(7):1898–1911.
   PubMed Web of Science ®Google Scholar
• Adab Z, Eghtesadi S, Vafa MR, et al. Effect of turmeric on glycemic status, lipid profile, hs-CRP, and total antioxidant capacity in hyperlipidemic type 2 diabetes mellitus patients. Phytother Res. 2019;33(4):1173–1181.
   PubMed Web of Science ®Google Scholar
• Adibian M, Hodaei H, Nikpayam O, et al. The effects of curcumin supplementation on high-sensitivity C-reactive protein, serum adiponectin, and lipid profile in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Phytother Res. 2019;33(5):1374–1383.
   PubMed Web of Science ®Google Scholar
• Ahn HY, Kim M, Seo CR, et al. The effects of Jerusalem artichoke and fermented soybean powder mixture supplementation on blood glucose and oxidative stress in subjects with prediabetes or newly diagnosed type 2 diabetes. Nutr Diabetes. 2018;8(1):42.
   PubMedGoogle Scholar
• Sedaghat A, Shahbazian H, Rezazadeh A, et al. The effect of soy nut on serum total antioxidant, endothelial function and cardiovascular risk factors in patients with type 2 diabetes. Diabetes Metab Syndr. 2019;13(2):1387–1391.
   PubMed Web of Science ®Google Scholar
• Fei BB, Ling L, Hua C, et al. Effects of soybean oligosaccharides on antioxidant enzyme activities and insulin resistance in pregnant women with gestational diabetes mellitus. Food Chem. 2014;158:429–432.
   PubMed Web of Science ®Google Scholar
• Kim JI, Kim JC, Kang MJ, et al. Effects of pinitol isolated from soybeans on glycaemic control and cardiovascular risk factors in Korean patients with type II diabetes mellitus: a randomized controlled study. Eur J Clin Nutr. 2005;59(3):456–458.
   PubMed Web of Science ®Google Scholar
• Clerici C, Nardi E, Battezzati PM, et al. Novel soy germ pasta improves endothelial function, blood pressure, and oxidative stress in patients with type 2 diabetes. Diabetes Care. 2011;34(9):1946–1948.
   PubMed Web of Science ®Google Scholar
• Choi MS, Ryu R, Seo YR, et al. The beneficial effect of soybean (Glycine max (L.) Merr.) leaf extracts in adults with prediabetes: a randomized placebo controlled trial. Food Funct. 2014;5(7):1621–1630.
   PubMed Web of Science ®Google Scholar
• Jayagopal V, Albertazzi P, Kilpatrick ES, et al. Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care. 2002;25(10):1709–1714.
   PubMed Web of Science ®Google Scholar
• Shidfar F, Rajab A, Rahideh T, et al. The effect of ginger (Zingiber officinale) on glycemic markers in patients with type 2 diabetes. J Complement Integr Med. 2015;12(2):165–170.
   PubMedGoogle Scholar
• Arablou T, Aryaeian N, Valizadeh M, et al. The effect of ginger consumption on glycemic status, lipid profile and some inflammatory markers in patients with type 2 diabetes mellitus. Int J Food Sci Nutr. 2014;65(4):515–520.
   PubMed Web of Science ®Google Scholar
• Mahluji S, Attari VE, Mobasseri M, et al. Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients. Int J Food Sci Nutr. 2013;64(6):682–686.
   PubMed Web of Science ®Google Scholar
• Zarezadeh M, Saedisomeolia A, Khorshidi M, et al. Asymmetric dimethylarginine and soluble inter-cellular adhesion molecule-1 serum levels alteration following ginger supplementation in patients with type 2 diabetes: a randomized double-blind, placebo-controlled clinical trial. J Complement Integr Med. 2018;16(2):2018–2019.
   Google Scholar
• Bordia A, Verma SK, Srivastava KC. Effect of ginger (Zingiber officinale Rosc.) and fenugreek (Trigonella foenumgraecum L.) on blood lipids, blood sugar and platelet aggregation in patients with coronary artery disease. Prostaglandins Leukot Essent Fatty Acids. 1997;56(5):379–384.
   PubMed Web of Science ®Google Scholar
• Mozaffari-Khosravi H, Talaei B, Jalali BA, et al. The effect of ginger powder supplementation on insulin resistance and glycemic indices in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2014;22(1):9–16.
   PubMed Web of Science ®Google Scholar
• Alizadeh-Navaei R, Roozbeh F, Saravi M. et al. Investigation of the effect of ginger on the lipid levels. A double blind controlled clinical trial. Saudi. Med. J. 2008;29(9):1280–1284.
   PubMed Web of Science ®Google Scholar
• Sohrab G, Roshan H, Ebrahimof S, et al. Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: a single-blind randomized clinical trial. Clin Nutr ESPEN. 2019;29:30–35.
   PubMed Web of Science ®Google Scholar
• Khajebishak Y, Payahoo L, Alivand M, et al. Effect of pomegranate seed oil supplementation on the GLUT-4 gene expression and glycemic control in obese people with type 2 diabetes: a randomized controlled clinical trial. J Cell Physiol. 2019;234(11):19621–19628.
   PubMed Web of Science ®Google Scholar
• Sohrab G, Nasrollahzadeh J, Tohidi M, et al. Pomegranate Juice Increases Sirtuin1 Protein in Peripheral Blood Mononuclear Cell from Patients with Type 2 Diabetes: a Randomized Placebo Controlled Clinical Trial. Metab Syndr Relat Disord. 2018;16(8):446–451.
   PubMed Web of Science ®Google Scholar
• Rosenblat M, Hayek T, Aviram M. Anti-oxidative effects of pomegranate juice (PJ) consumption by diabetic patients on serum and on macrophages. Atherosclerosis. 2006;187(2):363–371.
   PubMed Web of Science ®Google Scholar
• Esmaillzadeh A, Tahbaz F, Gaieni I, et al. Concentrated pomegranate juice improves lipid profiles in diabetic patients with hyperlipidemia. J Med Food. 2004;7(3):305–308.
   PubMed Web of Science ®Google Scholar
• Sohrab G, Ebrahimof S, Sotoudeh G, et al. Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: a single-blind, randomized clinical trial. Int J Food Sci Nutr. 2017;68(2):249–255.
   PubMed Web of Science ®Google Scholar
• Zarvandi M, Rakhshandeh H, Abazari M, et al. Safety and efficacy of a polyherbal formulation for the management of dyslipidemia and hyperglycemia in patients with advanced-stage of type-2 diabetes. Biomed Pharmacother. 2017;89:69–75.
   PubMed Web of Science ®Google Scholar
• Pradeep AR, Garg V, Raju A, et al. Adjunctive Local Delivery of Aloe Vera Gel in Patients With Type 2 Diabetes and Chronic Periodontitis: a Randomized, Controlled Clinical Trial. J Periodontol. 2016;87(3):268–274.
   PubMed Web of Science ®Google Scholar
• Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78(4):311–316.
   PubMed Web of Science ®Google Scholar
• Choi HC, Kim SJ, Son KY, et al. Metabolic effects of aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial. Nutrition. 2013;29(9):1110–1114.
   PubMed Web of Science ®Google Scholar
• Devaraj S, Yimam M, Brownell LA, et al. Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metab Syndr Relat Disord. 2013;11(1):35–40.
   PubMed Web of Science ®Google Scholar
• Najafian Y, Khorasani ZM, Najafi MN, et al. Efficacy of Aloe vera/Plantago Major Gel in Diabetic Foot Ulcer: a Randomized Double-Blind Clinical Trial. Curr Drug Discov Technol. 2019;16(2):223–231.
   PubMedGoogle Scholar
• Cortez-Navarrete M, Martínez-Abundis E, Pérez-Rubio KG, et al. Momordica charantia Administration Improves Insulin Secretion in Type 2 Diabetes Mellitus. J Med Food. 2018;21(7):672–677.
   PubMed Web of Science ®Google Scholar
• Inayatur R, Malik SA, Bashir M, et al. Serum sialic acid changes in non-insulin-dependent diabetes mellitus (NIDDM) patients following bitter melon (Momordica charantia) and rosiglitazone (Avandia) treatment. Phytomedicine. 2009;16(5):401–405.
   PubMed Web of Science ®Google Scholar
• Dans AM, Villarruz MV, Jimeno CA, et al. The effect of Momordica charantia capsule preparation on glycemic control in Type 2 Diabetes Mellitus needs further studies. J Clin Epidemiol. 2007;60(6):554–559.
   PubMed Web of Science ®Google Scholar
• Krawinkel MB, Ludwig C, Swai ME, et al. Bitter gourd reduces elevated fasting plasma glucose levels in an intervention study among prediabetics in Tanzania. J Ethnopharmacol. 2018;216:1–7.
   PubMed Web of Science ®Google Scholar
• Rahman IU, Khan RU, Rahman KU, et al. Lower hypoglycemic but higher antiatherogenic effects of bitter melon than glibenclamide in type 2 diabetic patients. Nutr J. 2015;14:13.
   PubMed Web of Science ®Google Scholar
• Ashraf R, Khan RA, Ashraf I. Garlic (Allium sativum) supplementation with standard antidiabetic agent provides better diabetic control in type 2 diabetes patients. Pak J Pharm Sci. 2011;24(4):565–570.
   PubMed Web of Science ®Google Scholar
• Ashraf R, Aamir K, Shaikh AR, et al. Effects of garlic on dyslipidemia in patients with type 2 diabetes mellitus. J Ayub Med Coll Abbottabad. 2005;17(3):60–64.
   PubMedGoogle Scholar
• Sobenin IA, Nedosugova LV, Filatova LV, et al. Metabolic effects of time-released garlic powder tablets in type 2 diabetes mellitus: the results of double-blinded placebo-controlled study. Acta Diabetol. 2008;45(1):1–6.
   PubMed Web of Science ®Google Scholar
• Karimi N, Roshan VD. Change in adiponectin and oxidative stress after modifiable lifestyle interventions in breast cancer cases. Asian Pac J Cancer Prev. 2013;14(5):2845–2850.
   PubMedGoogle Scholar
• Kadri Y, Nciri R, Brahmi N, et al. Protective effects of Curcuma longa against neurobehavioral and neurochemical damage caused by cerium chloride in mice. Environ Sci Pollut Res Int. 2018;25(20):19555–19565.
   PubMed Web of Science ®Google Scholar
• Yamagata K. Soy Isoflavones Inhibit Endothelial Cell Dysfunction and Prevent Cardiovascular Disease. J Cardiovasc Pharmacol. 2019;74(3):201–209.
   PubMed Web of Science ®Google Scholar
• Andallu B, Suryakantham V, Lakshmi Srikanthi B, et al. Effect of mulberry (Morus indica L.) therapy on plasma and erythrocyte membrane lipids in patients with type 2 diabetes. Clin Chim Acta. 2001;314(1–2):47–53.
   PubMed Web of Science ®Google Scholar
• Kim JY, Ok HM, Kim J, et al. Mulberry leaf extract improves postprandial glucose response in prediabetic subjects: a randomized, double-blind placebo-controlled trial. J Med Food. 2015;18(3):306–313.
   PubMed Web of Science ®Google Scholar
• König A, Schwarzinger B, Stadlbauer V, et al. Guava (Psidium guajava) Fruit Extract Prepared by Supercritical CO2 Extraction Inhibits Intestinal Glucose Resorption in a Double-Blind, Randomized Clinical Study. Nutrients. 2019;11(7):1512.
   Web of Science ®Google Scholar
• Zemestani M, Rafraf M, Asghari-Jafarabadi M. Chamomile tea improves glycemic indices and antioxidants status in patients with type 2 diabetes mellitus. Nutrition. 2016;32(1):66–72.
   PubMed Web of Science ®Google Scholar
• Queiroz MSR, Janebro DI, Da Cunha MAL, et al. Effect of the yellow passion fruit peel flour (Passiflora edulis f. flavicarpa deg.) in insulin sensitivity in type 2 diabetes mellitus patients. Nutr J. 2012;11:89.
   PubMed Web of Science ®Google Scholar
• Mohan V, Gayathri R, Jaacks LM, et al. Cashew Nut Consumption Increases HDL Cholesterol and Reduces Systolic Blood Pressure in Asian Indians with Type 2 Diabetes: a 12-Week Randomized Controlled Trial. J Nutr. 2018;148(1):63–69.
   PubMed Web of Science ®Google Scholar
• Taghizadeh M, Soleimani A, Bahmani F, et al. Metabolic Response to Mulberry Extract Supplementation in Patients With Diabetic Nephropathy: a Randomized Controlled Trial. Iran J Kidney Dis. 2017;11(6):438–446.
   PubMed Web of Science ®Google Scholar
• Córdova Mariángel P, Avello Lorca M, Morales Leon F, et al. Effects of Bauhinia forficata Link Tea on Lipid Profile in Diabetic Patients. J Med Food. 2019;22(3):321–323.
   PubMed Web of Science ®Google Scholar
• Carvalho AF, Feitosa MC, Coelho NP, et al. Low-level laser therapy and Calendula officinalis in repairing diabetic foot ulcers. Rev Esc Enferm USP. 2016;50(4):628–634.
   PubMed Web of Science ®Google Scholar
• Newman DJ, Cragg GM. Natural Products as Sources of New Drugs over the Nearly Four Decades from 01/1981 to 09/2019. J Nat Prod. 2020;83:770–803.
   PubMed Web of Science ®Google Scholar
• Brasil. ANVISA. Memento Fitoterápico. 2016. [cited 2021 Jan]. Available in: https://www.gov.br/anvisa/pt-br/assuntos/farmacopeia/memento-fitoterapico/memento-fitoterapico.pdf/view
   Google Scholar
• Gilbert ER, Liu D. Anti-diabetic functions of soy isoflavone genistein: mechanisms underlying effects on pancreatic β-cell function. Food Funct. 2013;4(2):200–212.
   PubMed Web of Science ®Google Scholar
• Arora MK, Sarup Y, Tomar R, et al. Amelioration of Diabetes-Induced Diabetic Nephropathy by Aloe vera: implication of Oxidative Stress and Hyperlipidemia. J Diet Suppl. 2019;16(2):227–244.
   PubMed Web of Science ®Google Scholar
• Noor A, Gunasekaran S, Vijayalakshmi MA. Improvement of Insulin Secretion and Pancreatic β-cell Function in Streptozotocin-induced Diabetic Rats Treated with Aloe vera Extract. Pharmacognosy Res. 2017;9(Suppl1):S99–S104.
   PubMedGoogle Scholar
• Hay E, Lucariello A, Contieri M, et al. Therapeutic effects of turmeric in several diseases: an overview. Chem Biol Interact. 2019;310:108729.
   PubMed Web of Science ®Google Scholar
• Nabavi SF, Thiagarajan R, Rastrelli L, et al. Curcumin: a natural product for diabetes and its complications. Curr Top Med Chem. 2015;15(23):2445–2455.
   PubMed Web of Science ®Google Scholar
• Pivari F, Mingione A, Brasacchio C, et al. Curcumin and Type 2 Diabetes Mellitus: prevention and Treatment. Nutrients. 2019;11(8):1837.
   Web of Science ®Google Scholar
• Akash MSH, Rehman K, Tariq M, et al. Zingiber officinale and Type 2 Diabetes Mellitus: evidence from Experimental Studies. Crit Rev Eukaryot Gene Expr. 2015;25(2):91–112.
   PubMed Web of Science ®Google Scholar
• Banihani S, Swedan S, Alguraan Z. Pomegranate and type 2 diabetes. Nutr Res. 2013;33(5):341–348.
   PubMed Web of Science ®Google Scholar
• Reyes BAS, Bautista ND, Tanquilut NC, et al. Anti-diabetic potentials of Momordica charantia and Andrographis paniculata and their effects on estrous cyclicity of alloxan-induced diabetic rats. J Ethnopharmacol. 2006;105:196–200.
   PubMed Web of Science ®Google Scholar
• Fernandes NP, Lagishetty CV, Panda VS, et al. An experimental evaluation of the antidiabetic and antilipidemic properties of a standardized Momordica charantia fruit extract. BMC. Complement. Altern. Med. 2007;7:29. .
   PubMedGoogle Scholar
• Kaur G, Padiya R, Adela R, et al. Garlic and resveratrol attenuate diabetic complications, loss of β-cells, pancreatic and hepatic oxidative stress in streptozotocin-induced diabetic rats. Front Pharmacol. 2016;7:360.
   PubMed Web of Science ®Google Scholar
• Wang J, Zhang XM, Lan HL, et al. Effect of garlic supplement in the management of type 2 diabetes mellitus (T2DM): a meta-analysis of randomized controlled trials. Food. Nutr. Res. 2017;61:1377571. .
   PubMed Web of Science ®Google Scholar
• Higgins C. Diagnosing diabetes: blood glucose and the role of the laboratory. Br J Nurs. 2001;10(4):230–236.
   PubMedGoogle Scholar
• Mauvais-Jarvis F, Manson JE, Stevenson JC, et al. Menopausal hormone therapy and type 2 diabetes prevention: evidence, mechanisms and clinical implications. Endocr Rev. 2017;38(3):173–188.
   PubMed Web of Science ®Google Scholar
• Beale EG. Insulin Signaling and Insulin Resistance. J Investig Med. 2013;61(1):11–14.
   PubMed Web of Science ®Google Scholar
• Taylor R. Type 2 Diabetes. Etiology and reversibility. Diabetes Care. 2013;36(4):1047–1055.
   PubMed Web of Science ®Google Scholar
• Anguizola J, Matsuda R, Barnaby OS, et al. Review: glycation of human serum albumin. Clin Chim Acta. 2013;425:64–76.
   PubMed Web of Science ®Google Scholar
• Yazdanpanah S, Rabiee M, Tahriri M, et al. Evaluation of glycated albumin (GA) and GA/HbA1c ratio for diagnosis of diabetes and glycemic control: a comprehensive review. Crit Rev Clin Lab Sci. 2017;54(4):219–232.
   PubMed Web of Science ®Google Scholar
• Perego C, Da Dalt L, Pirillo A, et al. Cholesterol metabolism, pancreatic β-cell function and diabetes. Biochim Biophys Acta Mol Basis Dis. 2019;1865(9):2149–2156.
   PubMed Web of Science ®Google Scholar
• Higuchi S, Izquierdo MC, Haeusler RA. Unexplained reciprocal regulation of diabetes and lipoproteins. Curr Opin Lipidol. 2018;29(3):186–193.
   PubMed Web of Science ®Google Scholar
• Carrizzo A, Izzo C, Forte M, et al. Novel Promising Frontier for Human Health: the Beneficial Effects of Nutraceuticals in Cardiovascular Diseases. Int J Mol Sci. 2020;21(22):8706.
   Web of Science ®Google Scholar
• Sobczak AIS, Blindauer CA, Stewart AJ. Changes in Plasma Free Fatty Acids Associated with Type-2 Diabetes. Nutrients. 2019;11(9):2022.
   PubMed Web of Science ®Google Scholar
• Abdali D, Samson SE, Grover AK. How effective are antioxidant supplements in obesity and diabetes? Med Princ Pract. 2015;24(3):201–215.
   PubMed Web of Science ®Google Scholar
• Vincent HK, Innes KE, Vincent KR. Oxidative stress and potential interventions to reduce oxidative stress in overweight and obesity. Diabetes Obes Metab. 2007;9:813–839.
   PubMed Web of Science ®Google Scholar
• Lontchi-Yimagou E, Sobngwi E, Matsha TE, et al. Diabetes mellitus and inflammation. Curr Diab Rep. 2013;13(3):435–444.
   PubMed Web of Science ®Google Scholar
• Berbudi A, Rahmadika N, Tjahjadi AI, et al. Type 2 Diabetes and its Impact on the Immune System. Curr Diabetes Rev. 2020;16(5):442–449.
   PubMed Web of Science ®Google Scholar
• Calle MC, Fernandez ML. Inflammation and type 2 diabetes. Diabetes Metab. 2012;38(3):183–191.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Diabetes, 2020. [cited 2020 Dec]. Available in https://www.who.int/news-room/fact-sheets/detail/diabetes
   Google Scholar
• Gourgari E, Wilhelm EE, Hassanzadeh H, et al. A comprehensive review of the FDA-approved labels of diabetes drugs: indications, safety, and emerging cardiovascular safety data. J Diabetes Complications. 2017;31(12):1719–1727.
   PubMed Web of Science ®Google Scholar
• Burcelin R, Gourdy P. Harnessing glucagon-like peptide-1 receptor agonists for the pharmacological treatment of overweight and obesity. Obes Rev. 2017;18(1):86–98.
   PubMed Web of Science ®Google Scholar
• Hsia DS, Grove O, Cefalu WT. An Update on SGLT2 Inhibitors for the Treatment of Diabetes Mellitus. Curr Opin Endocrinol Diabetes Obes. 2017;24(1):73–79.
   PubMedGoogle Scholar
• Siderowf AD. Evidence from Clinical Trials: can We Do Better? NeuroRx. 2004;1(3):363–371.
   PubMedGoogle Scholar