Quantitative efficacy of L-carnitine supplementation on glycemic control in type 2 diabetes mellitus patients

References

• Borum PR. Carnitine. Annu Rev Nutr. 1983;3:233–259.
   PubMed Web of Science ®Google Scholar
• Kido J, Inoue H, Shimotsu H, et al. Effect of L-Carnitine on amino acid metabolism in elderly patients undergoing regular hemodialysis. Blood Purif. 2020;22:1–8.
   Google Scholar
• Shigematsu Y, Hirano S, Hata I, et al. Newborn mass screening and selective screening using electrospray tandem mass spectrometry in Japan. J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Aug 25;776(1):39–48.
   PubMed Web of Science ®Google Scholar
• Nezu J, Tamai I, Oku A, et al. Primary systemic carnitine deficiency is caused by mutations in a gene encoding sodium ion-dependent carnitine transporter. Nat Genet. 1999 Jan;21(1):91–94.
   PubMed Web of Science ®Google Scholar
• Ohtani Y, Endo F, Matsuda I. Carnitine deficiency and hyperammonemia associated with valproic acid therapy. J Pediatr. 1982 Nov;101(5):782–785.
   PubMed Web of Science ®Google Scholar
• Peluso G, Nicolai R, Reda E, et al. Cancer and anticancer therapy-induced modifications on metabolism mediated by carnitine system. J Cell Physiol. 2000 Mar;182(3):339–350.
   PubMed Web of Science ®Google Scholar
• Brass EP, Mayer MD, Mulford DJ, et al. Impact on carnitine homeostasis of short-term treatment with the pivalate prodrug cefditoren pivoxil. Clin Pharmacol Ther. 2003 Apr;73(4):338–347.
   PubMed Web of Science ®Google Scholar
• Rodriguez-Segade S, Alonso De La Pena C, Paz M, et al. Carnitine concentrations in dialysed and undialysed patients with chronic renal insufficiency. Ann Clin Biochem. 1986 Nov;23(Pt 6):671–675.
   PubMedGoogle Scholar
• Golper TA, Wolfson M, Ahmad S, et al. Multicenter trial of L-carnitine in maintenance hemodialysis patients.I. Carnitine concentrations and lipid effects. Kidney Int. 1990 Nov;38(5):904–911.
   PubMed Web of Science ®Google Scholar
• Modanloo M, Shokrzadeh M. Analyzing mitochondrial dysfunction, oxidative stress, and apoptosis: potential role of L-carnitine. Iran J Kidney Dis. 2019 Mar;13(2):74–86.
   PubMed Web of Science ®Google Scholar
• Askarpour M, Hadi A, Symonds ME, et al. Efficacy of l-carnitine supplementation for management of blood lipids: a systematic review and dose-response meta-analysis of randomized controlled trials. Nutr Metab Cardiovasc Dis. 2019 Nov;29(11):1151–1167.
   PubMed Web of Science ®Google Scholar
• Askarpour M, Hadi A, Miraghajani M, et al. Beneficial effects of l-carnitine supplementation for weight management in overweight and obese adults: an updated systematic review and dose-response meta-analysis of randomized controlled trials. Pharmacol Res. 2020 Jan;151:104554.
   PubMed Web of Science ®Google Scholar
• Askarpour M, Hadi A, Dehghani Kari Bozorg A, et al. Effects of L-carnitine supplementation on blood pressure: a systematic review and meta-analysis of randomized controlled trials. J Hum Hypertens. 2019 Oct;33(10):725–734.
   PubMed Web of Science ®Google Scholar
• Song X, Qu H, Yang Z, et al. Efficacy and safety of L-carnitine treatment for chronic heart failure: a meta-analysis of randomized controlled trials. Biomed Res Int. 2017;2017:6274854.
   PubMed Web of Science ®Google Scholar
• Khalatbari-Soltani S, Tabibi H. Inflammation and L-carnitine therapy in hemodialysis patients: a review. Clin Exp Nephrol. 2015 Jun;19(3):331–335.
   PubMed Web of Science ®Google Scholar
• Ribas GS, Vargas CR, Wajner M. L-carnitine supplementation as a potential antioxidant therapy for inherited neurometabolic disorders. Gene. 2014 Jan 10;533(2):469–476.
   PubMed Web of Science ®Google Scholar
• Jiang Q, Jiang G, Shi KQ, et al. Oral acetyl-L-carnitine treatment in hepatic encephalopathy: view of evidence-based medicine. Ann Hepatol. 2013 Sep-Oct;12(5):803–809.
   PubMed Web of Science ®Google Scholar
• Xu Y, Jiang W, Chen G, et al. L-carnitine treatment of insulin resistance: a systematic review and meta-analysis. Adv Clin Exp Med. 2017 Mar-Apr;26(2):333–338.
   PubMed Web of Science ®Google Scholar
• Vidal-Casariego A, Burgos-Pelaez R, Martinez-Faedo C, et al. Metabolic effects of L-carnitine on type 2 diabetes mellitus: systematic review and meta-analysis. Exp Clin Endocrinol Diabetes. 2013 Apr;121(4):234–238.
   PubMed Web of Science ®Google Scholar
• El-Sheikh HM, El-Haggar SM, Elbedewy TA. Comparative study to evaluate the effect of l-carnitine plus glimepiride versus glimepiride alone on insulin resistance in type 2 diabetic patients. Diabetes Metab Syndr. 2019 Jan - Feb;13(1):167–173.
   PubMed Web of Science ®Google Scholar
• Derosa G, Maffioli P, Ferrari I, et al. Comparison between orlistat plus l-carnitine and orlistat alone on inflammation parameters in obese diabetic patients. Fundam Clin Pharmacol. 2011 Oct;25(5):642–651.
   PubMed Web of Science ®Google Scholar
• Derosa G, Maffioli P, Salvadeo SA, et al. Sibutramine and L-carnitine compared to sibutramine alone on insulin resistance in diabetic patients. Int Med. 2010;49(16):1717–1725.
   PubMed Web of Science ®Google Scholar
• Malaguarnera M, Vacante M, Motta M, et al. Effect of L-carnitine on the size of low-density lipoprotein particles in type 2 diabetes mellitus patients treated with simvastatin. Metabolism. 2009 Nov;58(11):1618–1623.
   PubMed Web of Science ®Google Scholar
• Malaguarnera M, Vacante M, Avitabile T, et al. L-carnitine supplementation reduces oxidized LDL cholesterol in patients with diabetes. Am J Clin Nutr. 2009 Jan;89(1):71–76.
   PubMed Web of Science ®Google Scholar
• Derosa G, Cicero AF, Gaddi A, et al. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. Clin Ther. 2003 May;25(5):1429–1439.
   PubMed Web of Science ®Google Scholar
• Galvano F, Li Volti G, Malaguarnera M, et al. Effects of simvastatin and carnitine versus simvastatin on lipoprotein(a) and apoprotein(a) in type 2 diabetes mellitus. Expert Opin Pharmacother. 2009 Aug;10(12):1875–1882.
   PubMed Web of Science ®Google Scholar
• Morano S, Mandosi E, Fallarino M, et al. Antioxidant treatment associated with sildenafil reduces monocyte activation and markers of endothelial damage in patients with diabetic erectile dysfunction: a double-blind, placebo-controlled study. Eur Urol. 2007 Dec;52(6):1768–1774.
   PubMed Web of Science ®Google Scholar
• Martin-Gronert MS, Ozanne SE. Metabolic programming of insulin action and secretion. Diabetes Obes Metab. 2012 Oct;14(Suppl 3):29–39.
   PubMedGoogle Scholar
• Moser EG, Morris AA, Garg SK. Emerging diabetes therapies and technologies. Diabetes Res Clin Pract. 2012 Jul;97(1):16–26.
   PubMed Web of Science ®Google Scholar
• McKinlay J, Marceau L. US public health and the 21st century: diabetes mellitus. Lancet. 2000 Aug 26;356(9231):757–761.
   PubMed Web of Science ®Google Scholar
• Bird SR, Hawley JA. Exercise and type 2 diabetes: new prescription for an old problem. Maturitas. 2012 Aug;72(4):311–316.
   PubMed Web of Science ®Google Scholar
• El-Kaissi S, Sherbeeni S. Pharmacological management of type 2 diabetes mellitus: an update. Curr Diabetes Rev. 2011 Nov;7(6):392–405.
   PubMedGoogle Scholar
• Hemmingsen B, Lund SS, Gluud C, et al. Targeting intensive glycaemic control versus targeting conventional glycaemic control for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2013 11;Nov(11):CD008143.
   Google Scholar
• Germino FW. Noninsulin treatment of type 2 diabetes mellitus in geriatric patients: a review. Clin Ther. 2011 Dec;33(12):1868–1882.
   PubMed Web of Science ®Google Scholar
• Fathizadeh H, Milajerdi A, Reiner Z, et al. The effects of L-carnitine supplementation on glycemic control: a systematic review and meta-analysis of randomized controlled trials. Excli J. 2019;18:631–643.
   PubMed Web of Science ®Google Scholar
• Wu J, Xu L, Lv Y, et al. Quantitative analysis of efficacy and associated factors of calcium intake on bone mineral density in postmenopausal women. Osteoporos Int. 2017 Jun;28(6):2003–2010.
   PubMed Web of Science ®Google Scholar
• Mould DR. Model-based meta-analysis: an important tool for making quantitative decisions during drug development. Clin Pharmacol Ther. 2012 Sep;92(3):283–286.
   PubMed Web of Science ®Google Scholar
• Ota R, Ishii H, Tsuda M, et al. A model-based comparative meta-analysis of the efficacy of dolutegravir-based and efavirenz-based regimens in HIV-infected patients. J Infect Chemother. 2019 Sep;25(9):687–694.
   PubMed Web of Science ®Google Scholar
• Xu R, Shi D, Ge W, et al. Quantitative efficacy of topical administration of tranexamic acid on postoperative bleeding in total knee arthroplasty. Br J Clin Pharmacol. 2017 Nov;83(11):2485–2493.
   PubMed Web of Science ®Google Scholar
• Li L, Lv Y, Xu L, et al. Quantitative efficacy of soy isoflavones on menopausal hot flashes. Br J Clin Pharmacol. 2015 Apr;79(4):593–604.
   PubMed Web of Science ®Google Scholar
• Pooyandjoo M, Nouhi M, Shab-Bidar S, et al. The effect of (L-)carnitine on weight loss in adults: a systematic review and meta-analysis of randomized controlled trials. Obes Rev. 2016 Oct;17(10):970–976.
   PubMed Web of Science ®Google Scholar