Nephroprotective effects of febuxostat and/or mirtazapine against gentamicin-induced nephrotoxicity through modulation of ERK 1/2, NF-κB and MCP1

References

• Baradaran A, Nasri H, Nematbakhsh M, et al. Antioxidant activity and preventive effect of aqueous leaf extract of Aloe Vera on gentamicin-induced nephrotoxicity in male Wistar rats. Clin Ter. 2014;165(1):7–11.
   PubMedGoogle Scholar
• Al-Kuraishy HM, Al-Gareeb AI, Al-Nami MS. Vinpocetine improves oxidative stress and pro-inflammatory mediators in acute kidney injury. Int J Prev Med. 2019;10(1):142. DOI: 10.4103/ijpvm.IJPVM_5_19.
   PubMedGoogle Scholar
• Allen LC, Michalko K, Coons C. More on cephalosporin interference with creatinine determinations. Clin Chem. 1982;39(1):519–525.
   Google Scholar
• Kandemir FM, Ozkaraca M, Yildirim BA, et al. Rutin attenuates gentamicin-induced renal damage by reducing oxidative stress, inflammation, apoptosis, and autophagy in rats. Ren Fail. 2015;37(3):518–525. DOI: 10.3109/0886022X.2015.1006100.
   PubMed Web of Science ®Google Scholar
• Al-Kuraishy H, AL-Gareeb A, Naji H. Febuxostat modulates oxidative and apoptotic pathways in acute doxorubicin‑induced cardiotoxicity: an experimental animal model study. Asian J Pharm Clin Res. 2019;12(4):73–76. DOI: 10.22159/ajpcr.2019.v12i4.31162.
   Google Scholar
• Sircar D, Chatterjee S, Waikhom R, et al. Efficacy of febuxostat for slowing the GFR decline in patients with CKD and asymptomatic hyperuricemia: a 6-month, double-blind, randomized, placebo-controlled trial. Am J Kidney Dis. 2015;13(1):945–950.
   Google Scholar
• Lee H-J, Jeong KH, Kim YG, et al. Febuxostat ameliorates diabetic renal injury in a streptozotocin-induced diabetic rat model. Am J Nephrol. 2014;40(1):56–63.
   PubMed Web of Science ®Google Scholar
• Khames A, Khalaf MM, Gad AM, et al. Ameliorative effects of sildenafil and/or febuxostat on doxorubicin-induced nephrotoxicity in rats. Eur J Pharmacol. 2017;805:118–124.
   PubMed Web of Science ®Google Scholar
• Gulec M, Selvi Y, Boysan M, et al. Ongoing or re-emerging subjective insomnia symptoms after full/partial remission or recovery of major depressive disorder mainly with the selective serotonin reuptake inhibitors and risk of relapse or recurrence: a 52-week follow-up study. J Affect Disord. 2011;134(1–3):257–265.
   PubMed Web of Science ®Google Scholar
• Dursun H, Bilici M, Albayrak F, et al. Antiulcer activity of fluvoxamine in rats and its effect on oxidant and antioxidant parameters in stomach tissue. BMC Gastroenterol. 2009;9(1):36.
   PubMedGoogle Scholar
• Uzkeser H, Sener E, Bakan E, et al. Preventive role of mirtazapine in methotrexate induced nephrotoxicity in rats. Sci Asia. 2012;38(2):129–135.
   Google Scholar
• Azouz AA, Abdel-Razek AE, Abo-Youssef AM. Amlodipine alleviates cisplatin-induced nephrotoxicity in rats through gamma-glutamyl transpeptidase (GGT) enzyme inhibition, associated with regulation of Nrf2/HO-1, MAPK/NF-κB, and Bax/Bcl-2 signaling. Saudi Pharm J. 2020;28(11):1317–1325.
   PubMed Web of Science ®Google Scholar
• Ehsani V, Amirteimoury M, Taghipour Z, et al. Protective effect of hydroalcoholic extract of Pistacia vera against gentamicin-induced nephrotoxicity in rats. Ren Fail. 2017;39(1):519–525.
   PubMed Web of Science ®Google Scholar
• Kim HS, Lim SW, Jin L, et al. The protective effect of febuxostat on chronic tacrolimus-induced nephrotoxicity in rats. Nephron. 2017;135(1):61–71.
   PubMed Web of Science ®Google Scholar
• Sener MT, Sener E, Tok A, et al. Biochemical and histologic study of lethal cisplatin nephrotoxicity prevention by mirtazapine. Pharmacol Rep. 2012;64(3):594–602.
   PubMed Web of Science ®Google Scholar
• Plate AYA, Crankshaw DL, Gallaher DD. The effect of anesthesia by diethyl ether or isoflurane on activity of cytochrome P450 2E1 and P450 reductases in rat liver. Anesth Analg. 2005;101(4):1063–1064.
   PubMed Web of Science ®Google Scholar
• Fawcett JK, Scott JE. A rapid and precise method for the determination of urea. J Clin Pathol. 1960;13(2):156–159.
   PubMed Web of Science ®Google Scholar
• Nishikimi M, Appaji N, Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem Biophys Res Commun. 1972;46(2):849–854.
   PubMed Web of Science ®Google Scholar
• Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal Biochem. 1979;95(2):351–358.
   PubMed Web of Science ®Google Scholar
• Paglia DE, Valentine WN. Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase. J Lab Clin Med. 1967;70(1):158–169.
   PubMed Web of Science ®Google Scholar
• Vásquez-Loarte T, Trubnykova M, Guio H. Genetic association meta-analysis: a new classification to assess ethnicity using the association of MCP-1 −2518 polymorphism and tuberculosis susceptibility as a model. BMC Genet. 2015;16(1):128.
   PubMedGoogle Scholar
• Bottero V, Imbert V, Frelin C, et al. Monitoring NF-kappa B transactivation potential via real-time PCR quantification of I kappa B-alpha gene expression. Mol Diagn. 2003;7(3–4):187–194.
   PubMedGoogle Scholar
• Pfaffl MW. Quantification strategies in real-time RT-PCR (RT-qPCR). In: Filion M, editors. Quantitative real-time PCR in applied microbiology. UK: Caister Academic Press. 2012. p. 23–37.
   Google Scholar
• Banchroft JD, Stevens A, Turner DR. Theory and practice of histological techniques. New York: Churchill Livingstone; 1996.
   Google Scholar
• Ma X, Jiao Z, Liu Y, et al. Probucol protects against contrast-induced acute kidney injury via the extracellular signal-regulated kinases 1 and 2 (ERK1/2)/JNK-caspase 3 pathway in diabetic rats. Med Sci Monit. 2019;165:7–11.
   Google Scholar
• Kirkpatrick L, Feeney B. A simple guide to IBM SPSS statistics for version 20.0. Student ed. Wadsworth: Cengage Learning; 2013.
   Google Scholar
• Jha V, Garcia-Garcia G, Iseki K, et al. Chronic kidney disease: global dimension and perspectives. Lancet. 2013;9(1):260–272.
   Google Scholar
• Heidarian E, Jafari-Dehkordi E, Valipour P, et al. Nephroprotective and anti-inflammatory effects of Pistacia atlantica leaf hydroethanolic extract against gentamicin-induced nephrotoxicity in rats. J Diet Suppl. 2017;14(5):489–502.
   PubMedGoogle Scholar
• Katary M, Salahuddin A. Ameliorative effect of gossypin against gentamicin-induced nephrotoxicity in rats. Life Sci. 2017;176:75–81.
   PubMed Web of Science ®Google Scholar
• Alkuraishy HM, Al-Gareeb AI, Al-Naimi MS. Pomegranate protects renal proximal tubules during gentamicin induced-nephrotoxicity in rats. J Contempor Med Sci. 2019;5(1):35–40.
   Web of Science ®Google Scholar
• Al-Kuraishy HM, Al-Gareeb AI, Rasheed HA. Antioxidant and anti-inflammatory effects of curcumin contribute into attenuation of acute gentamicin-induced nephrotoxicity in rats. Asian J Pharm Clin Res. 2019;12(3):466–468.
   Google Scholar
• Al-Kuraishy HM, Al-Gareeb AI, Al-Nami MS. Irbesartan attenuates gentamicin-induced nephrotoxicity in rats through modulation of oxidative stress and endogenous antioxidant capacity. Int J Prev Med. 2020;11:16.
   PubMed Web of Science ®Google Scholar
• Sahu BD, Tatireddy S, Koneru M, et al. Naringin ameliorates gentamicin-induced nephrotoxicity and associated mitochondrial dysfunction, apoptosis and inflammation in rats: possible mechanism of nephroprotection. Toxicol Appl Pharmacol. 2014;10(1):8–20.
   Google Scholar
• Jaikumkao K, Pongchaidecha A, Thongnak LO, et al. Amelioration of renal inflammation, endoplasmic reticulum stress and apoptosis underlies the protective effect of low dosage of atorvastatin in gentamicin-induced nephrotoxicity. PLoS One. 2016;11(10):e0164528.
   PubMed Web of Science ®Google Scholar
• Bledsoe G, Crickman S, Mao J, et al. Kallikrein/kinin protects against gentamicin-induced nephrotoxicity by inhibition of inflammation and apoptosis. Nephrol Dial Transplant. 2006;21(3):624–633.
   PubMed Web of Science ®Google Scholar
• Mizuno Y, Yamamotoya T, Nakatsu Y, et al. Xanthine oxidase inhibitor febuxostat exerts an anti-inflammatory action and protects against diabetic nephropathy development in KK-Ay obese diabetic mice. Int J Mol Sci. 2019;20(19):4680.
   Web of Science ®Google Scholar
• Komers R, Xu B, Schneider J, et al. Effects of xanthine oxidase inhibition with febuxostat on the development of nephropathy in experimental type 2 diabetes. Br J Pharmacol. 2016;173(17):2573–2588.
   PubMed Web of Science ®Google Scholar
• He L, Fan Y, Xiao W, et al. Febuxostat attenuates ER stress mediated kidney injury in a rat model of hyperuricemic nephropathy. Oncotarget. 2017;8(67):111295–111308.
   PubMedGoogle Scholar
• Ran J, Xu G, Ma H, et al. Febuxostat attenuates renal damage besides exerting hypouricemic effect in streptozotocin-induced diabetic rats. Int J Nephrol. 2017;2017:2739539.
   PubMed Web of Science ®Google Scholar
• Li Y, Chen F, Deng L, et al. Febuxostat attenuates paroxysmal atrial fibrillation-induced regional endothelial dysfunction. Thromb Res. 2017;149:17–24.
   PubMed Web of Science ®Google Scholar
• Granger DN, Kvietys PR. Reperfusion injury and reactive oxygen species: the evolution of a concept. Redox Biol. 2015;6:524–551.
   PubMed Web of Science ®Google Scholar
• Wang S, Li Y, Song X, et al. Febuxostat pretreatment attenuates myocardial ischemia/reperfusion injury via mitochondrial apoptosis. J Transl Med. 2015;13(1):209.
   PubMedGoogle Scholar
• Nomura J, Busso N, Ives A, et al. Febuxostat, an inhibitor of xanthine oxidase, suppresses lipopolysaccharide-induced MCP-1 production via MAPK phosphatase-1-mediated inactivation of JNK. PLoS One. 2013;8(9):e75527.
   PubMed Web of Science ®Google Scholar
• Fekry E, Rahman AA, Awny MM, et al. Protective effect of mirtazapine versus ginger against cisplatin-induced testicular damage in adult male albino rats. Ultrastruct Pathol. 2019;43(1):66–79.
   PubMed Web of Science ®Google Scholar
• Khaksari M, Esmaili S, Abedloo R, et al. Palmatine ameliorates nephrotoxicity and hepatotoxicity induced by gentamicin in rats. Arch Physiol Biochem. 2019;26:1–6.
   Google Scholar
• Bilici M, Ozturk C, Dursun H, et al. Protective effect of mirtazapine on indomethacin-induced ulcer in rats and its relationship with oxidant and antioxidant parameters. Dig Dis Sci. 2009;54(9):1868–1875.
   PubMed Web of Science ®Google Scholar
• Gupta R, Gupta K, Tripathi AK, et al. Effect of mirtazapine treatment on serum levels of brain-derived neurotrophic factor and tumor necrosis factor-a in patients of major depressive disorder with severe depression. Pharmacology. 2016;97(3–4):184–188.
   PubMed Web of Science ®Google Scholar
• Zhu C-B, Blakely RD, Hewlett WA. The proinflammatory cytokines interleukin-1beta and tumor necrosis factor-alpha activate serotonin transporters. Neuropsychopharmacology. 2006;31(10):2121–2131.
   PubMed Web of Science ®Google Scholar
• Zhu CB, Lindler KM, Owens AW, et al. Interleukin-1 receptor activation by systemic lipopolysaccharide induces behavioral despair linked to MAPK regulation of CNS serotonin transporters. Neuropsychopharmacology. 2010;35(13):2510–2520.
   PubMed Web of Science ®Google Scholar
• El-Tanbouly DM, Wadie W, Sayed RH. Modulation of TGF-beta/Smad and ERK signaling pathways mediates the anti-fibrotic effect of mirtazapine in mice. Toxicol Appl Pharmacol. 2017;329:224–230.
   PubMed Web of Science ®Google Scholar