Efficacy and safety of compound glycyrrhizin in the patients with vitiligo: a systematic review and meta-analysis

References

• Krüger C, Schallreuter KU. A review of the worldwide prevalence of vitiligo in children/adolescents and adults. Int J Dermatol. 2012;51(10):1206–1212. DOI:10.1111/j.1365-4632.2011.05377.x
   PubMed Web of Science ®Google Scholar
• Bibeau K, Pandya AG, Ezzedine K, et al. Vitiligo prevalence and quality of life among adults in Europe, Japan and the USA. J Eur Acad Dermatol Venereol. 2022;36(10):1831–1844. DOI:10.1111/jdv.18257
   PubMed Web of Science ®Google Scholar
• Böhm M, Schunter JA, Fritz K, et al. S1 Guideline: diagnosis and therapy of vitiligo. J Dtsch Dermatol Ges. 2022;20(3):365–378. DOI:10.1111/ddg.14713
   Web of Science ®Google Scholar
• Song H, Hu Z, Zhang S, et al. Effectiveness and safety of tofacitinib combined with narrowband ultraviolet B phototherapy for patients with refractory vitiligo in real-world clinical practice. Dermatol Ther. 2022;35(11):e15821. DOI:10.1111/dth.15821
   PubMed Web of Science ®Google Scholar
• Li X, Sun Y, Du J, et al. Excellent repigmentation of generalized vitiligo with oral baricitinib combined with NB-UVB phototherapy. Clin Cosmet Investig Dermatol. 2023;16:635–638. DOI:10.2147/CCID.S396430
   PubMed Web of Science ®Google Scholar
• Xu W, Li Y, Ju M, et al. A multicenter, randomized, double-blind, placebo-controlled study of compound glycyrrhizin capsules combined with a topical corticosteroid in adults with chronic eczema. Evid Based Complement Alternat Med. 2020;2020:6127327. DOI:10.1155/2020/6127327
   Web of Science ®Google Scholar
• Wen Y, Tang Y, Li M, et al. Efficiency and safety of desloratadine in combination with compound glycyrrhizin in the treatment of chronic urticaria: a meta-analysis and systematic review of randomised controlled trials. Pharm Biol. 2021;59(1):1276–1285. DOI:10.1080/13880209.2021.1973039
   PubMed Web of Science ®Google Scholar
• Yang D, Zheng J, Zhang Y, et al. Total glucosides of paeony capsule plus compound glycyrrhizin tablets for the treatment of severe alopecia areata in children: a randomized controlled trial. Evid Based Complement Alternat Med. 2013;2013:378219. DOI:10.1155/2013/378219
   Google Scholar
• Wu WZ, Zhang FR. Glycyrrhizin combined with acitretin improve clinical symptom of psoriasis via reducing Th17 cell differentiation and related serum cytokine concentrations. Int J Clin Exp Med. 2015;8(9):16266–16272.
   PubMed Web of Science ®Google Scholar
• Wang ZX, Wang HJ, Tang HL, et al. Efficacy of 1% pimecrolimus cream combined with compound glycyrrhizin tablets for the treatment of vitiligo. Chin J Misdiagn. 2012;12(12):2871. Chinese.
   Google Scholar
• Yao Y, Zhang HJ, Wang HF. Efficacy of 308nm excimer laser combined with compound glycyrrhizin tablets in the treatment of vitiligo vulgaris. J Clin Exp Med. 2020;19(3): 303–307. DOI:10.3969/j.issn.1671-4695.2020.03.023. Chinese.
   Google Scholar
• Zeng TT, Liu ZJ. Compound glycyrrhizin combined with narrowband ultraviolet B for the treatment of vitiligo: a meta-analysis. Chin J Aesthet Med. 2022;31(5): 19–22. DOI:10.15909/j.cnki.cn61-1347/r.005064. Chinese.
   Google Scholar
• Page MJ, McKenzie JE, Bossuyt PM, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. 2021;372:n71. DOI:10.1136/bmj.n71
   Web of Science ®Google Scholar
• Pigmentary Disorder Group. Combination of traditional and western medicine dermatology. [Standards of diagnosis and treatment of vitiligo and melasma. Chin J Dermatol. 2010;43(06):373. DOI:10.3760/cma.j.issn.0412-4030.2010.06.001. Chinese.
   Google Scholar
• Liu X, Yao Z, Wang Y, et al. Vitamin D analogs combined with different types of phototherapy in the treatment of vitiligo: a systematic review of randomized trials and within-patient studies. Int Immunopharmacol. 2022;109:108789. DOI:10.1016/j.intimp.2022.108789
   Web of Science ®Google Scholar
• Phan K, Phan S, Shumack S, et al. Repigmentation in vitiligo using janus kinase (JAK) inhibitors with phototherapy: systematic review and meta-analysis. J Dermatol Treat. 2022;33(1):173–177. DOI:10.1080/09546634.2020.1735615
   PubMed Web of Science ®Google Scholar
• Sun Y, Guan X, Wang H, et al. Randomized clinical trial of combined therapy with oral α-lipoic acid and NB-UVB for nonsegmental stable vitiligo. Dermatol Ther. 2021;34(1):e14610. DOI:10.1111/dth.14610
   PubMed Web of Science ®Google Scholar
• Hu W, Xu Y, Ma Y, et al. Efficacy of the topical calcineurin inhibitors tacrolimus and pimecrolimus in the treatment of vitiligo in infants under 2 years of age: a randomized, open-label pilot study. Clin Drug Investig. 2019;39(12):1233–1238. DOI:10.1007/s40261-019-00845-x
   PubMed Web of Science ®Google Scholar
• Higgins JP, Altman DG, Gøtzsche PC, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343(oct18 2):d5928. DOI:10.1136/bmj.d5928
   PubMed Web of Science ®Google Scholar
• Wei J, Liu LM, Wu SQ. Effect of fractional CO2 laser combined with tacrolimus and compound glycyrrhizin tablets on stable non-segmental vitiligo. Chin J Pract Med. 2022;49(7): 74–76. DOI:10.3760/cma.j.cn115689-20211122-04192. Chinese.
   Google Scholar
• Li L, Zhang DC, Zhao YF. Observation on the effect of compound glycyrrhizin combined with fractional laser and triamcinolone acetonide injection in the treatment of vitiligo. Mod J Integr Trad Chin West Med. 2021;30(27): 3001–3004,3037. DOI:10.3969/j.issn.1008-8849.2021.27.008. Chinese.
   Google Scholar
• Wu LY, Pan YB, Deng GY, et al. Effect of fractional CO2 laser combined with tacrolimus and compound glycyrrhizin tablets for the treatment of stable non-segmental vitiligo. Guangxi Med J. 2021;43(7):882–884. DOI:10.11675/j.issn.0253-4304.2021.07.22. Chinese.
   Google Scholar
• Liu HJ. Efficacy of laser combined with compound glycyrrhizin for the treatment of vitiligo. China Prac Med. 2020;15(4): 122–124. DOI:10.14163/j.cnki.11-5547/r.2020.04.057. Chinese.
   PubMedGoogle Scholar
• Liu SX, Zhang SN. Clinical effect of compound glycyrrhizin for the treatment of vitiligo. J Henan Med Coll. 2019;31(5): 619–621. DOI:10.3969/j.issn.1008-9276.2019.05.019. Chinese.
   Google Scholar
• Cao SX. Effect of tacalcitol ointment and narrowband ultraviolet B combined with compound glycyrrhizin in the treatment of vitiligo. Electronic J Clin Med Lit. 2019;6(104): 117–118. DOI:10.16281/j.cnki.jocml.2019.a4.078. Chinese.
   Google Scholar
• Li L, Ma Q, Li H. Effect of vitiligo treatment using compound glycyrrhizin combined with fractional carbon dioxide laser and topical triamcinolone acetonide on serum interleukin-17 and tissue growth factor-β levels. J Int Med Res. 2019;47(11):5623–5631. DOI:10.1177/0300060519871382
   PubMed Web of Science ®Google Scholar
• Xiao JJ. Efficacy of 308nm excimer laser in combination with compound glycyrrhizin in treating vitiligo: an analysis of 67 cases. Anhui Med Pharmaceutical J. 2018;22(6): 1179–1181. DOI:10.3969/j.issn.1009-6469.2018.06.047. Chinese.
   Google Scholar
• Mou KH, Han D, Liu WL, et al. Combination therapy of orally administered glycyrrhizin and UVB improved active-stage generalized vitiligo. Braz J Med Biol Res. 2016;49(8):e5354. DOI:10.1590/1414-431x20165354
   PubMed Web of Science ®Google Scholar
• Liu XM. Effect of compound glycyrrhizin tablets combined with halometasone cream and narrowband ultraviolet B for the treatment of vitiligo. Contemp Med. 2015;21(16): 25–26. DOI:10.3969/j.issn.1009-4393.2015.16.015. Chinese.
   Google Scholar
• Yu H, Huang J, Ye YW, et al. Compound glycyrrhizin tablets combined with narrowband ultraviolet B for 58 cases with vitiligo. Henan Trad Chin Med. 2014;34(7):1381–1382. DOI:10.16367/j.issn.1003-5028.2014.07.132. Chinese.
   Google Scholar
• Su QB, Peng J. Compound glycyrrhizin tablets combined with halometasone cream for 44 cases with facial vitiligo. China Pharmaceuticals. 2013;22(z1): 56–57. Chinese.
   Google Scholar
• Wang ZX, Wang HJ, Yu ZH, et al. Effect of compound glycyrrhizin combined with narrowband ultraviolet B for the treatment of vitiligo. Chin Community Doct. 2012;14(9):193–194. DOI:10.3969/j.issn.1007-614x.2012.09.180. Chinese.
   Google Scholar
• Zhang N. Clinical efficacy of compound glycyrrhizin combined with narrowband ultraviolet B for 74 cases with vitiligo. China Med Eng. 2012;20(10): 32. Chinese.
   Google Scholar
• Wang FX, Wang YQ, Lian CH, et al. Efficacy observation of compound glycyrrhizin combined with narrowband ultraviolet B for the treatment of vitiligo. J Chin Pract Diagn Ther. 2009;23(4):394–395. Chinese.
   Google Scholar
• Li ZY, Song W, Wei T, et al. Efficacy observation of Kaliziran tincture combined with narrowband ultraviolet B and compound glycyrrhizin tablets in the treatment of vitiligo. Chin J Dermatovenerol Integr Trad West Med. 2009;8(6):357–360. DOI:10.3969/j.issn.1672-0709.2009.06.009. Chinese.
   Google Scholar
• Yuan XH, Yao XM, Wang YP, et al. Observation on therapeutic effect of compound glycyrrhizin combined with halometasone cream in the treatment of vitiligo. China Pharm. 2005;16(14):1092–1093. DOI:10.3969/j.issn.1001-0408.2005.14.023. Chinese.
   Google Scholar
• Marchioro HZ, Silva de Castro CC, Fava VM, et al. Update on the pathogenesis of vitiligo. An Bras Dermatol. 2022;97(4):478–490. DOI:10.1016/j.abd.2021.09.008
   PubMed Web of Science ®Google Scholar
• Sushama S, Dixit N, Gautam RK, et al. Cytokine profile (IL-2, IL-6, IL-17, IL-22, and TNF-α) in vitiligo-new insight into pathogenesis of disease. J Cosmet Dermatol. 2019;18(1):337–341. DOI:10.1111/jocd.12517
   PubMed Web of Science ®Google Scholar
• Karagün E, Baysak S. Levels of TNF-α, IL-6, IL-17, IL-37 cytokines in patients with active vitiligo. Aging Male. 2020;23(5):1487–1492. DOI:10.1080/13685538.2020.1806814.
   PubMed Web of Science ®Google Scholar
• Tembhre MK, Sharma VK, Sharma A, et al. T helper and regulatory T cell cytokine profile in active, stable and narrow band ultraviolet B treated generalized vitiligo. Clin Chim Acta. 2013;424:27–32. DOI:10.1016/j.cca.2013.05.005.
   PubMed Web of Science ®Google Scholar
• Nigam PK, Patra PK, Khodiar PK, et al. A study of blood CD3+, CD4+, and CD8+ T cell levels and CD4+: cD8+ ratio in vitiligo patients. Indian J Dermatol Venereol Leprol. 2011;77(1):111. DOI:10.4103/0378-6323.74993
   PubMed Web of Science ®Google Scholar
• Dwivedi M, Laddha NC, Arora P, et al. Decreased regulatory T-cells and CD4(+)/CD8(+) ratio correlate with disease onset and progression in patients with generalized vitiligo. Pigment Cell Melanoma Res. 2013;26(4):586–591. DOI:10.1111/pcmr.12105
   PubMed Web of Science ®Google Scholar
• Lin X, Tang LY, Fu WW, et al. Childhood vitiligo in China: clinical profiles and immunological findings in 620 cases. Am J Clin Dermatol. 2011;12(4):277–281. DOI:10.2165/11318020-000000000-00000
   PubMed Web of Science ®Google Scholar
• Jiang RH, Zhou MW, Sun J. The influence of compound glycyrrhizin on expression of HMB45, TNF-a and IL-6 in lesion of vitiligo guinea pig model. Chin J Immunol. 2009;25(9): 813–814. Chinese.
   Google Scholar
• Li P, Wen X, Han D, et al. The effects of glycyrrhizin on melanogenesis of primary human melanocyte. Chin J Dermatovenereol. 2019;33(9):1014–1017. DOI:10.13735/j.cjdv.1001-7089.201812164. Chinese.
   Google Scholar
• Hasan MK, Ara I, Mondal MSA, et al. Phytochemistry, pharmacological activity, and potential health benefits of Glycyrrhiza glabra. Heliyon. 2021;7(6):e07240. DOI:10.1016/j.heliyon.2021.e07240
   PubMed Web of Science ®Google Scholar
• Wang N, Zhang L, Cai Y, et al. A retrospective study on the effect of compound glycyrrhetate injection on blood and electrolyte. Pract Pharm Clin Rem. 2021;24(04):357–361. DOI:10.14053/j.cnki.ppcr.202104016. Chinese.
   Google Scholar
• Kurisu S, Inoue I, Kawagoe T, et al. Clinical profile of patients with symptomatic glycyrrhizin-induced hypokalemia. J Am Geriatr Soc. 2008;56(8):1579–1581. DOI:10.1111/j.1532-5415.2008.01781.x
   PubMed Web of Science ®Google Scholar
• Liang SB, Hou WB, Zheng RX, et al. Compound glycyrrhizin injection for improving liver function in children with acute icteric hepatitis: a systematic review and meta-analysis. Integr Med Res. 2022;11(1):100772. DOI:10.1016/j.imr.2021.100772
   PubMed Web of Science ®Google Scholar