Snakebite-associated thrombotic microangiopathy: a spotlight on pharmaceutical interventions

References

• Roberts NLS, Johnson EK, Zeng SM, et al. Global mortality of snakebite envenoming between 1990 and 2019. Nat Commun. 2022 2022 Oct 25;13(1):6160. DOI:10.1038/s41467-022-33627-9.
   PubMed Web of Science ®Google Scholar
• Snakebite envenoming: a strategy for prevention and control. World Health Organization: Geneva Switzerland. 2019. Licence: CC BY-NC-SA 3.0 IGO; 2019
   Google Scholar
• Fantom N, Serajuddin U The World Bank’s classification of countries by income. Policy Research Working Paper;No. 7528. World Bank. (WA) DC. License: CC BY 3 0.IGO. 2016. https://openknowledge.worldbank.org/handle/10986/23628.
   Google Scholar
• Gutiérrez JM, Calvete JJ, Habib AG, et al. Snakebite envenoming. Nat Rev Dis Primers. 2017 2017 Oct 14;3(1):17063. DOI:10.1038/nrdp.2017.63.
   PubMedGoogle Scholar
• Slagboom J, Kool J, Harrison RA, et al. Haemotoxic snake venoms: their functional activity, impact on snakebite victims and pharmaceutical promise. Br J Haematol. 2017;177(6):947–959. DOI:10.1111/bjh.14591
   PubMed Web of Science ®Google Scholar
• Maduwage K, Isbister GK. Current treatment for venom-induced consumption coagulopathy resulting from snakebite. PLoS Negl Trop Dis. 2014;8(10):e3220–e3220.
   PubMed Web of Science ®Google Scholar
• Tasoulis T, Isbister GK. A review and database of snake venom proteomes. Toxins (Basel). 2017;9(9):290.
   PubMed Web of Science ®Google Scholar
• Isbister GK, Scorgie FE, O’Leary MA, et al. Factor deficiencies in venom induced consumption coagulopathy resulting from Australian elapid envenomation: Australian Snakebite Project (ASP-10). J Thromb Hemost. 2010;8(11):2504–2513. DOI:10.1111/j.1538-7836.2010.04050.x
   Web of Science ®Google Scholar
• Berling I, Isbister GK. Hematologic effects and complications of snake envenoming. Transfus Med Rev. 2015;29(2):82–89.
   PubMed Web of Science ®Google Scholar
• Isbister GK. Snakebite doesn’t cause disseminated intravascular coagulation: coagulopathy and thrombotic microangiopathy in snake envenoming. Semin Thromb Hemost. 2010;36(4):444–451.
   PubMed Web of Science ®Google Scholar
• Maduwage K. Snakebite coagulopathy: controversies in understanding and management. Sri Lanka Journal Of Medicine. 2017;26(2):38–54.
   Google Scholar
• Scully M, Cataland S, Coppo P, et al. Consensus on the standardization of terminology in thrombotic thrombocytopenic purpura and related thrombotic microangiopathies. J Thromb Hemost. 2017 Feb;15(2):312–322.
   Web of Science ®Google Scholar
• Arnold DM, Patriquin CJ, Nazy I. Thrombotic microangiopathies: a general approach to diagnosis and management. CMAJ. 2017 Jan 30;189(4):E153–e159. DOI:10.1503/cmaj.160142
   PubMed Web of Science ®Google Scholar
• Noutsos T, Currie BJ, Isoardi KZ, et al. Snakebite-associated thrombotic microangiopathy: an Australian prospective cohort study [ASP30]. Clin Toxicol. 2022 2022 Feb 1;60(2):205–213. 10.1080/15563650.2021.1948559
   PubMed Web of Science ®Google Scholar
• Mohan G, Guduri PR, Shastry S, et al. Thrombotic microangiopathy in hematotoxic snakebites and its impact on the prognosis: an entity often overlooked. J Thromb Thrombolysis. 2019;48(3):475–482. doi:10.1007/s11239-019-01868-z.
   PubMed Web of Science ®Google Scholar
• Wijewickrama ES, Gooneratne LV, Gnanathasan A, et al. Severe acute kidney injury following Sri Lankan Hypnale spp. envenoming is associated with thrombotic microangiopathy. Clin Toxicol. 2020;59(4):296–302. DOI:10.1080/15563650.2020.1810695
   Web of Science ®Google Scholar
• George JN, Nester CM. Syndromes of thrombotic microangiopathy. N Engl J Med. 2014;371(7):654–666.
   PubMed Web of Science ®Google Scholar
• Bull BS, Kuhn IN. The production of schistocytes by fibrin strands (a scanning electron microscope study). Blood. 1970;35(1):104–111.
   PubMed Web of Science ®Google Scholar
• Zini G, d’Onofrio G, Erber WN, et al. 2021 update of the 2012 ICSH Recommendations for identification, diagnostic value, and quantitation of schistocytes: impact and revisions. Int J Lab Hematol. 2021;43(6):1264–1271. n/a(n/a). DOI:10.1111/ijlh.13682.
   PubMed Web of Science ®Google Scholar
• World Health Organization. Bench aids for the morphological diagnosis of anaemia. Geneva: World Health Organization; 2001.
   Google Scholar
• World Health Organization and UNICEF, UNDP, World Bank, WHO Special Programme for Research and Training in Tropical Diseases. Microscopy for the detection, identification and quantification of malaria parasites on stained thick and thin blood films in research settings (‎version 1.0)‎: procedure: methods manual. Geneva: World Health Organization; 2015.
   Google Scholar
• Noutsos T, Currie BJ, Lek RA, et al. Snakebite associated thrombotic microangiopathy: a systematic review of clinical features, outcomes, and evidence for interventions including plasmapheresis. PLoS Negl Trop Dis. 2020;14(12):e0008936. doi:10.1371/journal.pntd.0008936.
   PubMed Web of Science ®Google Scholar
• Noutsos T, Laidman AY, Survela L, et al. An evaluation of existing manual blood film schistocyte quantitation guidelines and a new proposed method. Pathology. 2021 Oct;53(6):746–752.
   PubMed Web of Science ®Google Scholar
• Tanos PP, Isbister GK, Lalloo DG, et al. A model for venom-induced consumptive coagulopathy in snake bite. Toxicon. 2008 2008 Dec 1;52(7):769–780. DOI:10.1016/j.toxicon.2008.08.013.
   PubMed Web of Science ®Google Scholar
• Obeidat MB, Al-Swailmeen AM, Al-Sarayreh MM, et al. Thrombotic microangiopathy following Arabian saw-scaled viper (Echis Coloratus) bite: case report. Am J Case Rep. 2020;21:e922000.
   PubMed Web of Science ®Google Scholar
• Warrell DA, Davidson N, Greenwood BM, et al. Poisoning by bites of the saw-scaled or carpet viper (Echis carinatus) in Nigeria. Q J Med. 1977;46(181):33–62.
   PubMedGoogle Scholar
• Wijewickrama ES, Gooneratne LV, Gnanathasan A, et al. Thrombotic microangiopathy and acute kidney injury following Sri Lankan Daboia russelii and Hypnale species envenoming. Clin Toxicol. 2020;58(10):997–1003. doi:10.1080/15563650.2020.1717509.
   PubMed Web of Science ®Google Scholar
• Chugh KS. Snake-bite-induced acute renal failure in India. Kidney Int. 1989;35(3):891–907.
   PubMed Web of Science ®Google Scholar
• Rahmani T-R, Nasasra T, Fuchs L, et al. Acute thrombotic microangiopathic kidney injury due to Echis coloratus envenomation. Clin Toxicol. 2020 2020 Apr 2;58(4):284–286. DOI:10.1080/15563650.2019.1629450.
   PubMed Web of Science ®Google Scholar
• Rathnayaka RN, Ranathunga PEAN, Kularatne SAM. Kidney injury following envenoming by hump-nosed pit viper (Genus: hypnale) in Sri Lanka: proven and probable cases. Trans R Soc Trop Med. 2019;113(3):131–142.
   PubMed Web of Science ®Google Scholar
• Rathnayaka RMMKN, Nishanthi Ranathunga PEA, Kularatne SAM, et al. Therapeutic plasma exchange for venom-induced thrombotic microangiopathy following hump-nosed pit viper (Genus: hypnale) bites: a prospective observational study. Wilderness Environ Med. 2022;33(4):386–398. doi:10.1016/j.wem.2022.07.012.
   PubMed Web of Science ®Google Scholar
• Hatten BW, Bueso A, French LK, et al. Envenomation by the Great Lakes Bush Viper (Atheris nitschei). Clin Toxicol (Phila). 2013;51(2):114–116. DOI:10.3109/15563650.2012.763134
   PubMed Web of Science ®Google Scholar
• Warrell DA, Ormerod LD, Davidson NM. Bites by puff-adder (Bitis arietans) in Nigeria, and value of antivenom. Br Med J. 1975;4(5998):697–700.
   PubMed Web of Science ®Google Scholar
• Keyler DE. Envenomation by the lowland viper (Proatheris superciliaris): severe case profile documentation. Toxicon. 2008 Dec 15;52(8):836–841. DOI:10.1016/j.toxicon.2008.10.013
   PubMed Web of Science ®Google Scholar
• Pinzon RT, Antonius RA, Veronica V. Ischemic stroke following calloselasma rhodostoma snakebite: a rare case report. Open Access Emergency Medicine. 2022 [2022 Dec 31];14:35–39. DOI:10.2147/OAEM.S352865
   PubMed Web of Science ®Google Scholar
• Wongtongkam N, Wilde H, Sitthi-Amorn C, et al. A study of 225 Malayan pit viper bites in Thailand. Mil Med. 2005;170(4):342–348. DOI:10.7205/MILMED.170.4.342
   PubMed Web of Science ®Google Scholar
• Schneemann M, Cathomas R, Laidlaw ST, et al. Life-threatening envenoming by the Saharan horned viper (Cerastes cerastes) causing micro-angiopathic hemolysis, coagulopathy and acute renal failure: clinical cases and review. QJM. 2004 Nov;97(11):717–727.
   PubMed Web of Science ®Google Scholar
• Amaral CF, Da Silva OA, Goody P, et al. Renal cortical necrosis following Bothrops jararaca and B. jararacussu snake bite. Toxicon. 1985;23(6):877–885. DOI:10.1016/0041-0101(85)90379-4
   PubMed Web of Science ®Google Scholar
• Benvenuti LA, França FOS, Barbaro KC, et al. Pulmonary hemorrhage causing rapid death after Bothrops jararacussu snakebite: a case report. Toxicon: Offl J Int Soc Toxinol. 2003;42(3):331–334. DOI:10.1016/S0041-0101(03)00167-3
   Google Scholar
• Malaque CMS, Duayer IF, Santoro ML. Acute kidney injury induced by thrombotic microangiopathy in two cases of Bothrops envenomation. Clin Toxicol (Phila). 2019;57(3):213–216.
   PubMed Web of Science ®Google Scholar
• Bucaretchi F, Pimenta MMB, Borrasca-Fernandes CF, et al. Thrombotic microangiopathy following Bothrops jararaca snakebite: case report. Clin Toxicol. 2019 2019 Apr 3;57(4):294–299. DOI:10.1080/15563650.2018.1514621.
   PubMed Web of Science ®Google Scholar
• Milani Júnior R, Jorge MT, de Campos FP, et al. Snake bites by the jararacuçu (Bothrops jararacussu): clinicopathological studies of 29 proven cases in São Paulo State, Brazil. QJM. 1997;90(5):323–334. doi:10.1093/qjmed/90.5.323.
   PubMedGoogle Scholar
• Mota SMB, Albuquerque PLMM, Júnior GBd S, et al. Thrombotic microangiopathy due to Bothrops erythromelas: a case report in Northeast Brazil. Rev Inst Med trop S Paulo. 2020;62:62.
   Web of Science ®Google Scholar
• Nicolson IC, Ashby PA, Johnson ND, et al. Boomslang bite with haemorrhage and activation of complement by the alternate pathway. Clin Exp Immunol. 1974;16(2):295–300.
   PubMed Web of Science ®Google Scholar
• Ferraz CR, Arrahman A, Xie C, et al. Multifunctional toxins in snake venoms and therapeutic implications: from pain to hemorrhage and necrosis [Review]. Front Ecol Evol. 2019 2019 Jun 19; 7. 10.3389/fevo.2019.00218
   Web of Science ®Google Scholar
• Albuquerque PLMM, JHHGL P, Martins AMC, et al. Clinical assessment and pathophysiology of Bothrops venom-related acute kidney injury: a scoping review. J Venom Anim Toxins Incl Trop Dis. 2020;26:26.
   Web of Science ®Google Scholar
• Rao IR, Prabhu AR, Nagaraju SP, et al. Thrombotic microangiopathy: an under-recognised cause of snake-bite-related acute kidney injury. Indian J Nephrol. 2019 Sep;29(5):324–328. DOI:10.4103/ijn.IJN_280_18.
   PubMed Web of Science ®Google Scholar
• Noutsos T, Currie BJ, Brown SG, et al. Schistocyte quantitation, thrombotic microangiopathy and acute kidney injury in Australian snakebite coagulopathy [ASP28]. Int J Lab Hematol. 2021;43(5):959–965.
   PubMed Web of Science ®Google Scholar
• Herath N, Wazil A, Kularatne S. Thrombotic microangiopathy and acute kidney injury in hump-nosed viper (Hypnale species) envenoming: a descriptive study in Sri Lanka. Toxicon. 2012;60(1):61–65.
   PubMed Web of Science ®Google Scholar
• Malbranque S, Piercecchi-Marti MD, Thomas L, et al. Case report: fatal diffuse thrombotic microangiopathy after a bite by the “fer-de-lance” pit viper (Bothrops lanceolatus) of Martinique. Am J Trop Med Hyg. 2008;78(6):856–861.
   PubMed Web of Science ®Google Scholar
• Priyamvada PS, Jaswanth C, Zachariah B, et al. Prognosis and long-term outcomes of acute kidney injury due to snake envenomation. Clin Kidney J. 2019;13(4):564–570. DOI:10.1093/ckj/sfz055
   PubMed Web of Science ®Google Scholar
• Waiddyanatha S, Silva A, Weerakoon K, et al. Does snake envenoming cause chronic kidney disease? A cohort study in rural Sri Lanka. Clin Toxicol (Phila). 2023 Jan;61(1):47–55.
   PubMed Web of Science ®Google Scholar
• Potet J, Beran D, Ray N, et al. Access to antivenoms in the developing world: a multidisciplinary analysis. Toxicon X. 2021 Nov;12:100086.
   PubMedGoogle Scholar
• Silva A, Isbister GK. Current research into snake antivenoms, their mechanisms of action and applications. Biochem Soc Trans. 2020;48(2):537–546.
   PubMed Web of Science ®Google Scholar
• Gutiérrez JM, Solano G, Pla D, et al. Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: state-of-the-art and challenges ahead. Toxins (Basel). 2017 May 13;9(5):163. doi:10.3390/toxins9050163
   PubMed Web of Science ®Google Scholar
• World Health Organization. WHO guidelines for the production, control and regulation of snake antivenom immunoglobulins. WHO Technical Report Series, No. 964. Geneva Switzerland: World Health Organization; Oct 2016.
   Google Scholar
• Maduwage K, Buckley NA, De Silva HJ, et al. Snake antivenom for snake venom induced consumption coagulopathy. Cochrane Database Syst Rev. 2015(6). doi:10.1002/14651858.CD011428.pub2.
   PubMed Web of Science ®Google Scholar
• Isbister GK, Duffull SB, Brown SGA, et al. Failure of antivenom to improve recovery in Australian snakebite coagulopathy. QJM. 2009;102(8):563–568.
   PubMed Web of Science ®Google Scholar
• Trevett AJ, Lalloo DG, Nwokolo NC, et al. The efficacy of antivenom in the treatment of bites by the Papuan taipan (Oxyuranus scutellatus canni). Trans R Soc Trop Med. 1995;89(3):322–325. DOI:10.1016/0035-9203(95)90562-6
   PubMed Web of Science ®Google Scholar
• Mion G, Larréché S, Benois A, et al. Hemostasis dynamics during coagulopathy resulting from Echis envenomation. Toxicon: Offl J Int Soc Toxinol. 2013;76:103–109.
   Google Scholar
• Silva A, Scorgie FE, Lincz LF, et al. Indian polyvalent antivenom accelerates recovery from venom-induced consumption coagulopathy (VICC) in Sri Lankan Russell’s Viper (Daboia russelii) Envenoming [Original Research]. Front Med (Lausanne). 2022;9 doi:10.3389/fmed.2022.852651. 2022 Mar 7.
   Web of Science ®Google Scholar
• Isbister GK. Antivenom efficacy or effectiveness: the Australian experience.Toxicology. 2010 [2010 Feb 9];268(3):148–154. DOI:10.1016/j.tox.2009.09.013.
   PubMed Web of Science ®Google Scholar
• Ramos-Cerrillo B, de Roodt AR, Chippaux J-P, et al. Characterization of a new polyvalent antivenom (Antivipmyn Africa) against African vipers and elapids. Toxicon. 2008 Dec;52(8):881–888.
   PubMed Web of Science ®Google Scholar
• Gutiérrez JM, Solano G, Pla D, et al. Preclinical evaluation of the efficacy of antivenoms for snakebite envenoming: state-of-the-art and challenges Ahead. Toxins (Basel). 2017;9(5):163.
   PubMed Web of Science ®Google Scholar
• Larréché S, Mion G, Mayet A, et al. Antivenin remains effective against African viperidae bites despite a delayed treatment. Am J Emerg Med. 2011 Feb;29(2):155–161.
   PubMed Web of Science ®Google Scholar
• World Health Organization WHO Essential medicines status. Blood products of human origin and plasma substitutes. Blood and blood components. Fresh frozen plasma eEML - Electronic Essential Medicines List (essentialmeds.org) https://list.essentialmeds.org/recommendations/968.
   Google Scholar
• Nascimento B, Callum J, Rubenfeld G, et al. Clinical review: fresh frozen plasma in massive bleedings - more questions than answers. Crit Care. 2010 2010 Jan 28;14(1):202. DOI:10.1186/cc8205.
   PubMed Web of Science ®Google Scholar
• Shander A, Ozawa S, Hofmann A. Activity-based costs of plasma transfusions in medical and surgical inpatients at a US hospital. Vox Sang. 2016;111(1):55–61.
   PubMed Web of Science ®Google Scholar
• Faber J-C. A global initiative on local preparation of virus inactivated cryoprecipitate in developing countries. Annals Blood. 2017;2(9):21–21.
   Google Scholar
• World Health Organization. Global status report on blood safety and availability. Geneva, WHO Publications 2016 (ISBN 978-92-4-156543-1). Available online: http://apps.who.int/irisGeneva2017 [ cited 2022 28/10/2022].
   Google Scholar
• Isbister GK, Buckley NA, Page CB, et al. A randomized controlled trial of fresh frozen plasma for treating venom-induced consumption coagulopathy in cases of Australian snakebite (ASP-18). J Thromb Hemost. 2013 Jul;11(7):1310–1318.
   Web of Science ®Google Scholar
• Isbister GK, Jayamanne S, Mohamed F, et al. A randomized controlled trial of fresh frozen plasma for coagulopathy in Russell’s viper (Daboia russelii) envenoming. J Thromb Hemost. 2017 Apr;15(4):645–654.
   Web of Science ®Google Scholar
• Ho WK, Verner E, Dauer R, et al. ADAMTS-13 activity, microangiopathic haemolytic anaemia and thrombocytopenia following snake bite envenomation. Pathology. 2010;42(2):200–202. DOI:10.3109/00313020903493955
   PubMed Web of Science ®Google Scholar
• Cobcroft RG, Williams A, Cook D, et al. Hemolytic uremic syndrome following taipan envenomation with response to plasmapheresis. Pathology. 1997;29(4):399–402. DOI:10.1080/00313029700169385
   PubMed Web of Science ®Google Scholar
• Withana M, Rodrigo C, Gnanathasan A, et al. Presumptive thrombotic thrombocytopenic purpura following a hump-nosed viper (Hypnale hypnale) bite: a case report. J Venom Anim Toxins Incl Trop Dis. 2014;20(1):26. DOI:10.1186/1678-9199-20-26
   PubMedGoogle Scholar
• Schmidt JJ, Asper F, Einecke G, et al. Therapeutic plasma exchange in a tertiary care center: 185 patients undergoing 912 treatments - a one-year retrospective analysis. BMC Nephrol. 2018 2018 Jan 15;19(1):12. DOI:10.1186/s12882-017-0803-3.
   PubMedGoogle Scholar
• Mokrzycki MH, Kaplan AA. Therapeutic plasma exchange: complications and management. Am J Kidney Diseases. 1994;23(6):817–827.
   PubMed Web of Science ®Google Scholar
• Shemin D, Briggs D, Greenan M. Complications of therapeutic plasma exchange: a prospective study of 1,727 procedures. J Clin Apheresis. 2007;22(5):270–276.
   PubMed Web of Science ®Google Scholar
• Sadler JE. Pathophysiology of thrombotic thrombocytopenic purpura. Blood. 2017;130(10):1181–1188.
   PubMed Web of Science ®Google Scholar
• Moschcowitz F. Hyaline thrombosis of the terminal arterioles and capillaries: a hitherto undescribed disease. Proc N Y Pathol Soc. 1924;24:21–24.
   Google Scholar
• Fox LC, Cohney SJ, Kausman JY, et al. Consensus opinion on diagnosis and management of thrombotic microangiopathy in Australia and New Zealand. Intern Med J. 2018;48(6):624–636. DOI:10.1111/imj.13804
   PubMed Web of Science ®Google Scholar
• Tsai HM, Lian EC. Antibodies to von willebrand factor–cleaving protease in acute thrombotic thrombocytopenic purpura. N Engl J Med. 1998;339(22):1585–1594.
   PubMed Web of Science ®Google Scholar
• Brunskill SJ, Tusold A, Benjamin S, et al. A systematic review of randomized controlled trials for plasma exchange in the treatment of thrombotic thrombocytopenic purpura. Transfus Med. 2007 Feb;17(1):17–35.
   PubMed Web of Science ®Google Scholar
• Henon P. Thrombotic thrombocytopenic purpura: clinical results of a French controlled trial.Transfusion Sci. 1992 [1992 Jan 1];13(1):63–72. DOI:10.1016/0955-3886(92)90123-X.
   Google Scholar
• Joly BS, Coppo P, Veyradier A. Thrombotic thrombocytopenic purpura. Blood. 2017;129(21):2836–2846.
   PubMed Web of Science ®Google Scholar
• Winters JL. Plasma exchange in thrombotic microangiopathies (TMAs) other than thrombotic thrombocytopenic purpura (TTP). Hematology Am Soc Hematol Educ Program. 2017;2017(1):632–638.
   PubMedGoogle Scholar
• Kaplan AA. A simple and accurate method for prescribing plasma exchange. ASAIO Trans. 1990 Jul;36(3):M597–9.
   PubMedGoogle Scholar
• Isbister GK, Little M, Cull G, et al. Thrombotic microangiopathy from Australian brown snake (Pseudonaja) envenoming. Intern Med J. 2007;37(8):523–528. DOI:10.1111/j.1445-5994.2007.01407.x
   PubMed Web of Science ®Google Scholar
• Heatwole C, Johnson N, Holloway R, et al. Plasma exchange versus intravenous immunoglobulin for myasthenia gravis crisis: an acute hospital cost comparison study. J Clin Neuromuscul Dis. 2011 Dec;13(2):85–94.
   PubMedGoogle Scholar
• Nikapitiya B, Maduwage K. Pharmacodynamics and pharmacokinetics of snake antivenom. Sri Lanka Journal Of Medicine. 2018;27(1):54–65.
   Google Scholar
• Cheng CW, Hendrickson JE, Tormey CA, et al. Therapeutic plasma exchange and its impact on drug levels: an ACLPS critical review. Am J Clin Pathol. 2017;148(3):190–198. DOI:10.1093/ajcp/aqx056
   PubMed Web of Science ®Google Scholar
• Jenny HE, Saluja S, Sood R, et al. Access to safe blood in low-income and middle-income countries: lessons from India. BMJ Global Health. 2017;2(2):bmjgh-2016–000167. DOI:10.1136/bmjgh-2016-000167
   Web of Science ®Google Scholar
• Scully M, Cataland SR, Peyvandi F, et al. Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med. 2019;380(4):335–346. DOI:10.1056/NEJMoa1806311
   PubMed Web of Science ®Google Scholar
• Murthy PR, Kumar AKA, Karanth S, et al. Thrombotic thrombocytopenic purpura in a patient with snake bite. Indian Journal Case Reports. 2019;5(3):277–279. DOI:10.32677/IJCR.2019.v05.i03.028
   Google Scholar
• Pollissard L, Leinwand BI, Fournier M, et al. Cost analysis of the impact of caplacizumab in the treatment of acquired thrombotic thrombocytopenic purpura from a US hospital perspective. J Med Econ. 2021 2021 Jan 1;24(1):1178–1184. DOI:10.1080/13696998.2021.1992413.
   PubMed Web of Science ®Google Scholar
• Rathbone J, Kaltenthaler E, Richards A, et al. A systematic review of eculizumab for atypical hemolytic uraemic syndrome (aHUS). BMJ Open. 2013;3(11):e003573. DOI:10.1136/bmjopen-2013-003573
   PubMed Web of Science ®Google Scholar
• Jokiranta TS. HUS and atypical HUS. Blood. 2017;129(21):2847–2856.
   PubMed Web of Science ®Google Scholar
• Fakhouri F, Zuber J, Frémeaux-Bacchi V, et al. Hemolytic uraemic syndrome. Lancet. 2017;390(10095):681–696. DOI:10.1016/S0140-6736(17)30062-4
   PubMed Web of Science ®Google Scholar
• Dragon-Durey MA, Frémeaux-Bacchi V. Atypical hemolytic uraemic syndrome and mutations in complement regulator genes. Springer Seminars In Immunopathology. 2005;27(3):359–374.
   PubMed Web of Science ®Google Scholar
• Mathern DR, Heeger PS. Molecules great and Small: the complement system. Clin J Am Soc Nephrol. 2015;10(9):1636–1650.
   PubMed Web of Science ®Google Scholar
• Horowitz MS, Pehta JC. SD Plasma in TTP and coagulation factor deficiencies for which no concentrates are available. Vox Sang. 1998;74(S1):231–235.
   PubMedGoogle Scholar
• Stone SF, Isbister GK, Shahmy S, et al. Immune response to snake envenoming and treatment with antivenom; complement activation, cytokine production and mast cell degranulation. PLoS Negl Trop Dis. 2013;7(7):e2326. DOI:10.1371/journal.pntd.0002326
   PubMed Web of Science ®Google Scholar
• Teixeira C, Fernandes CM, Leiguez E, et al. Inflammation induced by platelet-activating viperid snake venoms: perspectives on thromboinflammation. Front Immunol. 2019;10:2082.
   PubMed Web of Science ®Google Scholar
• Jackson SP, Darbousset R, Schoenwaelder SM. Thromboinflammation: challenges of therapeutically targeting coagulation and other host defense mechanisms. Blood. 2019 2019 Feb 28;133(9):906–918.
   PubMed Web of Science ®Google Scholar
• Pucca MB, Cerni FA, Janke R, et al. History of envenoming therapy and current perspectives [Review]. Front Immunol. 2019 2019 Jul 10;10:10.
   PubMed Web of Science ®Google Scholar
• Lewin MR, Carter RW, Matteo IA, et al. Varespladib in the Treatment of Snakebite Envenoming: development History and Preclinical Evidence Supporting Advancement to Clinical Trials in Patients Bitten by Venomous Snakes. Toxins (Basel). 2022;14(11):783. DOI:10.3390/toxins14110783
   PubMed Web of Science ®Google Scholar
• Xie C, Albulescu LO, Still KBM, et al. Varespladib Inhibits the Phospholipase A(2) and coagulopathic activities of venom components from hemotoxic snakes. Biomedicines. 2020 Jun 17;8(6):165. DOI:10.3390/biomedicines8060165
   PubMed Web of Science ®Google Scholar
• Long C, Liu M, Tian H, et al. Potential role of platelet-activating C-Type lectin-like proteins in viper envenomation induced thrombotic microangiopathy symptom. Toxins (Basel). 2020 Nov 27;12(12):749. DOI:10.3390/toxins12120749
   PubMed Web of Science ®Google Scholar