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LETTER TO THE EDITOR

The risk of genito-urinary infections with sodium-glucose cotransporter-2 inhibitors: duration rather than dose matter?

Wan-Chuan Tsaia Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, Taiwan;b Center for General Education, Lee- Ming Institute of Technology, New Taipei, TaiwanORCID Iconhttps://orcid.org/0000-0002-6728-5851View further author information
ORCID Icon,
Yu-Sen Penga Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, Taiwan;c Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan;d Department of Applied Cosmetology, Lee- Ming Institute of Technology, New Taipei, Taiwan;e Department of Electrical Engineering, Yuan Ze University, Taoyuan City, TaiwanView further author information
&
Hon-Yen Wua Division of Nephrology, Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei, Taiwan;c Department of Internal Medicine, National Taiwan University Hospital and College of Medicine, Taipei, Taiwan;f School of Medicine, College of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan;g Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, TaiwanCorrespondence[email protected]
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Received 14 May 2024, Accepted 07 Jun 2024, Published online: 13 Jun 2024

References

  • Sridharan K, Sivaramakrishnan G. Genito-urinary infectious adverse events related to sodium glucose cotransporter-2 inhibitors: a network meta-analysis and meta-regression. Expert Rev Clin Pharmacol. 2024;17(5–6):515–524. doi: 10.1080/17512433.2024.2355287
  • Tsai WC, Hsu SP, Chiu YL, et al. Cardiovascular and renal efficacy and safety of sodium-glucose cotransporter-2 inhibitors in patients without diabetes: a systematic review and meta-analysis of randomised placebo-controlled trials. BMJ Open. 2022;12(10):e060655. doi: 10.1136/bmjopen-2021-060655
  • Baigent C, Emberson J, Haynes R. Impact of diabetes on the effects of sodium glucose co-transporter-2 inhibitors on kidney outcomes: collaborative meta-analysis of large placebo-controlled trials. Lancet. 2022;400(10365):1788–1801. doi:10.1016/S0140-6736(22)02074-8
  • Liu J, Li L, Li S, et al. Effects of SGLT2 inhibitors on UTIs and genital infections in type 2 diabetes mellitus: a systematic review and meta-analysis. Sci Rep. 2017;7(1):2824. doi: 10.1038/s41598-017-02733-w
  • Puckrin R, Saltiel MP, Reynier P, et al. SGLT-2 inhibitors and the risk of infections: a systematic review and meta-analysis of randomized controlled trials. Acta Diabetol. 2018;55(5):503–514. doi: 10.1007/s00592-018-1116-0
  • Fralick M, MacFadden DR. A hypothesis for why sodium glucose co-transporter 2 inhibitors have been found to cause genital infection, but not urinary tract infection. Diab Obes Metab. 2020;22(5):755–758. doi:10.1111/dom.13959
  • Zheng Z, He D, Chen J, et al. Risk of urinary tract infection in patients with type 2 diabetes mellitus treated with Dapagliflozin: a systematic review and meta-analysis of randomized controlled trials. Clin Drug Investig. 2023;43(4):209–225. doi: 10.1007/s40261-023-01256-9
  • Donnan JR, Grandy CA, Chibrikov E, et al. Dose response of sodium glucose cotransporter-2 inhibitors in relation to urinary tract infections: a systematic review and network meta-analysis of randomized controlled trials. CMAJ Open. 2018;6(4):E594–e602. doi: 10.9778/cmajo.20180111

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