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Acta Clinica Belgica
International Journal of Clinical and Laboratory Medicine
Volume 76, 2021 - Issue 6
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Case Reports

Treatment of a patient with severe cytomegalovirus (CMV) infection after haploidentical stem cell transplantation with donor derived CMV specific T cells

Joline Ingelsa Department of Diagnostic Sciences, Ghent University, Ghent, Belgium;b Cell Therapy Unit, Department of Regenerative Medicine, Ghent University Hospital, Ghent, BelgiumView further author information
,
Saskia De Smetb Cell Therapy Unit, Department of Regenerative Medicine, Ghent University Hospital, Ghent, BelgiumView further author information
,
Kelly Heynsc Department of Respiratory Medicine, Ghent University Hospital, Ghent, BelgiumView further author information
,
Nele Lootensb Cell Therapy Unit, Department of Regenerative Medicine, Ghent University Hospital, Ghent, BelgiumView further author information
,
Jonas Segaertd Department of Internal Medicine, Ghent University Hospital, Ghent, BelgiumView further author information
,
Tom Taghona Department of Diagnostic Sciences, Ghent University, Ghent, BelgiumView further author information
,
Georges Leclercqa Department of Diagnostic Sciences, Ghent University, Ghent, BelgiumView further author information
,
Karim Vermaelenc Department of Respiratory Medicine, Ghent University Hospital, Ghent, BelgiumView further author information
,
Evelyne Willemse Department of Medicine, Division of Hematology, University of Liège, Liège, BelgiumView further author information
,
Etienne Baudouxe Department of Medicine, Division of Hematology, University of Liège, Liège, BelgiumView further author information
,
Tessa Kerrea Department of Diagnostic Sciences, Ghent University, Ghent, Belgium;d Department of Internal Medicine, Ghent University Hospital, Ghent, BelgiumView further author information
,
Frédéric Barone Department of Medicine, Division of Hematology, University of Liège, Liège, BelgiumView further author information
&
Bart Vandekerckhovea Department of Diagnostic Sciences, Ghent University, Ghent, Belgium;b Cell Therapy Unit, Department of Regenerative Medicine, Ghent University Hospital, Ghent, BelgiumCorrespondence[email protected]
View further author information
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Pages 482-486 | Published online: 14 Apr 2020

References

  • Green ML, Leisenring W, Xie H, et al. Cytomegalovirus viral load and mortality after haemopoietic stem cell transplantation in the era of pre-emptive therapy: a retrospective cohort study. Lancet Haematol. 2016;3:e119–e127.
  • Chang Y-J, Zhao X-Y, Huo M-R, et al. Immune reconstitution following unmanipulated HLA-mismatched/haploidentical transplantation compared with HLA-identical sibling transplantation. J Clin Immunol. 2012;32:268–280.
  • Liu J, Kong J, Chang YJ, et al. Patients with refractory cytomegalovirus (CMV) infection following allogeneic haematopoietic stem cell transplantation are at high risk for CMV disease and non-relapse mortality. Clin Microbiol Infect. 2015;21:1121.e9-1121.e15.
  • Ahmed A. Antiviral treatment of cytomegalovirus infection. Infect Disord - Drug Targets. 2011;11: 475–503.
  • Cwynarski K, Ainsworth J, Cobbold M, et al. Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation. Blood. 2001;97:1232–1240.
  • Feuchtinger T, Opherk K, Bethge WA, et al. Adoptive transfer of pp65-specific T cells for the treatment of chemorefractory cytomegalovirus disease or reactivation after haploidentical and matched unrelated stem cell transplantation. Blood. 2010;116:4360–4367.
  • Einsele H, Roosnek E, Rufer N, et al. Infusion of cytomegalovirus (CMV)–specific T cells for the treatment of CMV infection not responding to antiviral chemotherapy. Blood. 2002;99:3916–3922.
  • Chou S, Ercolani RJ, Sahoo MK, et al. Improved detection of emerging drug-resistant mutant cytomegalovirus subpopulations by deep sequencing. Antimicrob Agents Chemother. 2014;58:4697–4702.
  • Laidlaw BJ, Craft JE, Kaech SM. The multifaceted role of CD4+ T cells in CD8+ T cell memory. Nat Rev Immunol. 2016;16:102–111.
  • Janeway’s Immunobiology. Ninth Edition. By Kenneth Murphy and Casey Weaver; with contributions by Allan Mowat, Leslie Berg, and David Chaplin; with acknowledgment to: charles A. Janeway, Jr., Paul Travers, and Mark Walport. New York: Garland Science. Tay Q Rev Biol. 2018;93:59.
  • Crough T, Khanna R. Immunobiology of human cytomegalovirus: from bench to bedside. Clin Microbiol Rev. 2009;22:76–98.
  • Walter EA, Greenberg PD, Gilbert MJ, et al. Reconstitution of cellular immunity against cytomegalovirus in recipients of allogeneic bone marrow by transfer of T-cell clones from the donor. N Engl J Med. 1995;333:1038–1044.

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