Hypomagnesemia may be related to frailty, gait and balance problems, and basic activities of daily living in older adults

References

• Bohl CH, Volpe SL. Magnesium and exercise. Crit Rev Food Sci Nutr. 2002;42(6):533–563. doi: 10.1080/20024091054247
   PubMed Web of Science ®Google Scholar
• Cirik MÖ, Kilinç M, Doğanay GE, et al. The relationship between magnesium levels and mortality in the respiratory intensive care unit. Medicine (Baltimore). 2020;99(52):e23290. doi: 10.1097/MD.0000000000023290
   PubMed Web of Science ®Google Scholar
• Panahi Y, Mojtahedzadeh M, Najafi A, et al. The role of magnesium sulfate in the intensive care unit. Excli J. 2017;16:464–482. doi: 10.17179/excli2017-182
   PubMed Web of Science ®Google Scholar
• Arinzon Z, Peisakh A, Schrire S, et al. Prevalence of hypomagnesemia (HM) in a geriatric long-term care (LTC) setting. Arch Gerontol Geriatr. 2010;51(1):36–40. doi: 10.1016/j.archger.2009.07.002
   PubMed Web of Science ®Google Scholar
• Barbagallo M, Dominguez LJ. Magnesium and type 2 diabetes. World J Diabetes. 2015;6(10):1152–1157. doi: 10.4239/wjd.v6.i10.1152
   PubMed Web of Science ®Google Scholar
• Veronese N, Custodero C, Demurtas J, et al.; Special Interest Group in Systematic Reviews of the European Geriatric Medicine Society (EuGMS); Special Interest Group in Meta-analyses and Comprehensive Geriatric Assessment of the European Geriatric Medicine Society (EuGMS). Comprehensive geriatric assessment in older people: an umbrella review of health outcomes. Age Ageing. 2022;51(5):afac104. doi: 10.1093/ageing/afac104
   PubMed Web of Science ®Google Scholar
• Morris ME. Brain and CSF magnesium concentrations during magnesium deficit in animals and humans: neurological symptoms. Magnes Res. 1992;5(4):303–313.
   PubMedGoogle Scholar
• Barbagallo M, Belvedere M, Dominguez LJ. Magnesium homeostasis and aging. Magnes Res. 2009;22(4):235–246. doi: 10.1684/mrh.2009.0187
   PubMed Web of Science ®Google Scholar
• Tunc M, Soysal P, Pasin O, et al. Hypomagnesemia is associated with excessive daytime sleepiness, but not insomnia, in older adults. Nutrients. 2023;15(11):2467. doi: 10.3390/nu15112467
   PubMed Web of Science ®Google Scholar
• Barragan-Rodríguez L, Rodríguez-Morán M, Guerrero-Romero F. Depressive symptoms and hypomagnesemia in older diabetic subjects. Arch Med Res. 2007;38(7):752–756. doi: 10.1016/j.arcmed.2007.03.008
   PubMed Web of Science ®Google Scholar
• Boccardi V, Ercolani S, Serra R, et al. Hypomagnesemia and incident delirium in hospitalized older persons. Aging Clin Exp Res. 2023;35(4):847–853. doi: 10.1007/s40520-023-02357-3
   PubMed Web of Science ®Google Scholar
• Charlson M, Szatrowski TP, Peterson J, et al. Validation of a combined comorbidity index. J Clin Epidemiol. 1994;47(11):1245–1251. doi: 10.1016/0895-4356(94)90129-5
   PubMed Web of Science ®Google Scholar
• American Psychiatric Association. Diagnostic and statistical manual of mental disorders. 5th ed. Washington (DC): American Psychiatric Association; 2013.
   Google Scholar
• Unutmaz GD, Soysal P, Tuven B, et al. Costs of medication in older patients: before and after comprehensive geriatric assessment. Clin Interv Aging. 2018;13:607–613. doi: 10.2147/CIA.S159966
   PubMed Web of Science ®Google Scholar
• Fried LP, Tangen CM, Walston J, et al.; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001;56(3):M146–56. doi: 10.1093/gerona/56.3.m146
   PubMed Web of Science ®Google Scholar
• Ates Bulut E, Soysal P, Dokuzlar O, et al. Validation of population-based cutoffs for low muscle mass and strength in a population of Turkish elderly adults. Aging Clin Exp Res. 2020;32(9):1749–1755. doi: 10.1007/s40520-019-01448-4
   PubMed Web of Science ®Google Scholar
• The consensus committee of the American Autonomic Society and the American Academy of Neurology. Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy. Neurology. 1996;46(5):1470. doi: 10.1212/wnl.46.5.1470
   PubMed Web of Science ®Google Scholar
• Kim JY, Lee HJ, Lee HY, et al. The effects of hypomagnesemia on delirium in middle-aged and older adult patients admitted to medical intensive care units. Acute Crit Care. 2022;37(3):407–414. doi: 10.4266/acc.2022.00164
   PubMed Web of Science ®Google Scholar
• Kao WH, Folsom AR, Nieto FJ, et al. Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the atherosclerosis risk in communities study. Arch Intern Med. 1999;159(18):2151–2159. doi: 10.1001/archinte.159.18.2151
   PubMedGoogle Scholar
• Nadler JL, Malayan S, Luong H, et al. Intracellular free magnesium deficiency plays a key role in increased platelet reactivity in type II diabetes mellitus. Diabetes Care. 1992;15(7):835–841. doi: 10.2337/diacare.15.7.835
   PubMed Web of Science ®Google Scholar
• Sjögren A, Florén CH, Nilsson A. Magnesium, potassium and zinc deficiency in subjects with type II diabetes mellitus. Acta Med Scand. 1988;224(5):461–466. doi: 10.1111/j.0954-6820.1988.tb19611.x
   PubMedGoogle Scholar
• Chrysant SG, Chrysant GS. Association of hypomagnesemia with cardiovascular diseases and hypertension. Int J Cardiol Hypertens. 2019;1:100005. doi: 10.1016/j.ijchy.2019.100005
   PubMedGoogle Scholar
• Hori M, Yasuda K, Takahashi H, et al. The association of low serum magnesium levels with frailty among hemodialysis patients. Sci Rep. 2023;13(1):14982. doi: 10.1038/s41598-023-42187-x
   PubMed Web of Science ®Google Scholar
• Dominguez LJ, Barbagallo M, Lauretani F, et al. Magnesium and muscle performance in older persons: the InCHIANTI study. Am J Clin Nutr. 2006;84(2):419–426. doi: 10.1093/ajcn/84.2.419
   PubMed Web of Science ®Google Scholar
• Killilea DW, Ames BN. Magnesium deficiency accelerates cellular senescence in cultured human fibroblasts. Proc Natl Acad Sci. 2008;105(15):5768–5773. doi: 10.1073/pnas.0712401105
   PubMed Web of Science ®Google Scholar
• Christensen KE, Mirza IA, Berghuis AM, et al. Magnesium and phosphate ions enable NAD binding to methylenetetrahydrofolate dehydrogenase-methenyltetrahydrofolate cyclohydrolase. J Biol Chem. 2005;280(40):34316–34323. doi: 10.1074/jbc.M505210200
   PubMed Web of Science ®Google Scholar
• Botturi A, Ciappolino V, Delvecchio G, et al. The role and the effect of magnesium in mental disorders: A systematic review. Nutrients. 2020;12(6):1661. doi: 10.3390/nu12061661
   PubMed Web of Science ®Google Scholar
• El Assar M, Angulo J, Rodríguez- MañMañAs L. Frailty as a phenotypic manifestation of underlying oxidative stress. Free Radic Biol Med. 2020;149:72–77. doi: 10.1016/j.freeradbiomed.2019.08.011
   PubMed Web of Science ®Google Scholar
• Günther T. Magnesium in bone and the magnesium load test. Magnes Res. 2011;24(4):223–224. doi: 10.1684/mrh.2011.0297
   PubMed Web of Science ®Google Scholar
• Saris NE, Mervaala E, Karppanen H, et al. Magnesium. An update on physiological, clinical and analytical aspects. Clin Chim Acta. 2000;294(1–2):1–26. doi: 10.1016/s0009-8981(99)00258-2
   PubMed Web of Science ®Google Scholar
• Clegg A, Hassan-Smith Z. Frailty and the endocrine system. Lancet Diabetes Endocrinol. 2018;6(9):743–752. doi: 10.1016/S2213-8587(18)30110-4
   PubMed Web of Science ®Google Scholar
• Cameron D, Welch AA, Adelnia F, et al. Age and muscle function are more closely associated with intracellular magnesium, as assessed by 31P magnetic resonance spectroscopy, than with serum magnesium. Front Physiol. 2019;10:1454. doi: 10.3389/fphys.2019.01454
   PubMed Web of Science ®Google Scholar
• Ray S, Park KW. Movement disorders and other neurologic impairment associated with hypomagnesemia: A systematic review. Neurol Clin Pract. 2023;13(6):e200202. doi: 10.1212/CPJ.0000000000200202
   PubMedGoogle Scholar
• Pall HS, Williams AC, Heath DA, et al. Hypomagnesaemia causing myopathy and hypocalcaemia in an alcoholic. Postgrad Med J. 1987;63(742):665–667. doi: 10.1136/pgmj.63.742.665
   PubMed Web of Science ®Google Scholar
• Fishman RA. Neurological aspects of magnesium metabolism. Arch Neurol. 1965;12(6):562–569. doi: 10.1001/archneur.1965.00460300010002
   PubMedGoogle Scholar
• Souza ACR, Vasconcelos AR, Dias DD, et al. The integral role of magnesium in muscle integrity and aging: A comprehensive review. Nutrients. 2023;15(24):5127. doi: 10.3390/nu15245127
   PubMed Web of Science ®Google Scholar