DDR1: A major player in renal diseases

References

• Alves F, Vogel W, Mossie K, et al. Distinct structural characteristics of discoidin I subfamily receptor tyrosine kinases and complementary expression in human cancer. Oncogene. 1995;10:609–18.
   PubMed Web of Science ®Google Scholar
• Alves F, Saupe S, Ledwon M, et al. Identification of two novel, kinase-deficient variants of discoidin domain receptor 1: differential expression in human colon cancer cell lines. FASEB J Off Publ Fed Am Soc Exp Biol. 2001;15:1321–3.
   PubMed Web of Science ®Google Scholar
• Carafoli F, Hohenester E. Collagen recognition and transmembrane signalling by discoidin domain receptors. Biochim Biophys Acta. 2013;1834:2187–94. doi:10.1016/j.bbapap.2012.10.014.
   PubMed Web of Science ®Google Scholar
• Shrivastava A, Radziejewski C, Campbell E, et al. An orphan receptor tyrosine kinase family whose members serve as nonintegrin collagen receptors. Mol Cell. 1997;1:25–34. doi:10.1016/S1097-2765(00)80004-0.
   PubMed Web of Science ®Google Scholar
• Vogel W, Gish GD, Alves F, et al. The discoidin domain receptor tyrosine kinases are activated by collagen. Mol Cell. 1997;1:13–23. doi:10.1016/S1097-2765(00)80003-9.
   PubMed Web of Science ®Google Scholar
• Leitinger B, Steplewski A, Fertala A. The D2 period of collagen II contains a specific binding site for the human discoidin domain receptor, DDR2. J Mol Biol. 2004;344:993–1003. doi:10.1016/j.jmb.2004.09.089.
   PubMed Web of Science ®Google Scholar
• Leitinger B, Kwan APL. The discoidin domain receptor DDR2 is a receptor for type X collagen. Matrix Biol J Int Soc Matrix Biol. 2006;25:355–64. doi:10.1016/j.matbio.2006.05.006.
   PubMed Web of Science ®Google Scholar
• Hou G, Vogel W, Bendeck MP. The discoidin domain receptor tyrosine kinase DDR1 in arterial wound repair. J Clin Invest. 2001;107:727–35. doi:10.1172/JCI10720.
   PubMed Web of Science ®Google Scholar
• Clementz AG, Mutolo MJ, Leir S-H, et al. Collagen XV inhibits epithelial to mesenchymal transition in pancreatic adenocarcinoma cells. PloS One. 2013;8:e72250. doi:10.1371/journal.pone.0072250.
   PubMedGoogle Scholar
• Vogel WF. Ligand-induced shedding of discoidin domain receptor 1. FEBS Lett. 2002;514:175–80. doi:10.1016/S0014-5793(02)02360-8.
   PubMed Web of Science ®Google Scholar
• Leitinger B. Discoidin domain receptor functions in physiological and pathological conditions. Int Rev Cell Mol Biol. 2014;310:39–87. doi:10.1016/B978-0-12-800180-6.00002-5.
   PubMed Web of Science ®Google Scholar
• Lee R, Eidman KE, Kren SM, et al. Localization of discoidin domain receptors in rat kidney. Nephron Exp Nephrol. 2004;97:e62–70. doi:10.1159/000078407.
   PubMed Web of Science ®Google Scholar
• Flamant M, Placier S, Rodenas A, et al. Discoidin domain receptor 1 null mice are protected against hypertension-induced renal disease. J Am Soc Nephrol JASN. 2006;17:3374–81. doi:10.1681/ASN.2006060677.
   PubMed Web of Science ®Google Scholar
• Guerrot D, Kerroch M, Placier S, et al. Discoidin domain receptor 1 is a major mediator of inflammation and fibrosis in obstructive nephropathy. Am J Pathol. 2011;179:83–91. doi:10.1016/j.ajpath.2011.03.023.
   PubMed Web of Science ®Google Scholar
• Kerroch M, Guerrot D, Vandermeersch S, et al. Genetic inhibition of discoidin domain receptor 1 protects mice against crescentic glomerulonephritis. FASEB J Off Publ Fed Am Soc Exp Biol. 2012;26:4079–91.
   PubMed Web of Science ®Google Scholar
• Kerroch M, Alfieri C, Dorison A, et al. Protective effects of genetic inhibition of Discoidin Domain Receptor 1 in experimental renal disease. Sci Rep. 2016;6:21262. doi:10.1038/srep21262.
   PubMed Web of Science ®Google Scholar
• Chen Z, Migeon T, Verpont M-C, et al. HANAC Syndrome Col4a1 Mutation Causes Neonate Glomerular Hyperpermeability and Adult Glomerulocystic Kidney Disease. J Am Soc Nephrol JASN. 2016;27:1042–54. doi:10.1681/ASN.2014121217.
   PubMed Web of Science ®Google Scholar
• Curat CA, Vogel WF. Discoidin domain receptor 1 controls growth and adhesion of mesangial cells. J Am Soc Nephrol JASN. 2002;13:2648–56. doi:10.1097/01.ASN.0000032419.13208.0C.
   PubMed Web of Science ®Google Scholar
• Gross O, Beirowski B, Harvey SJ, et al. DDR1-deficient mice show localized subepithelial GBM thickening with focal loss of slit diaphragms and proteinuria. Kidney Int. 2004;66:102–11. doi:10.1111/j.1523-1755.2004.00712.x.
   PubMed Web of Science ®Google Scholar
• Vogel WF, Aszódi A, Alves F, et al. Discoidin domain receptor 1 tyrosine kinase has an essential role in mammary gland development. Mol Cell Biol. 2001;21:2906–17. doi:10.1128/MCB.21.8.2906-2917.2001.
   PubMed Web of Science ®Google Scholar
• Rubel D, Frese J, Martin M, et al. Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice. Matrix Biol J Int Soc Matrix Biol. 2014;34:13–21. doi:10.1016/j.matbio.2014.01.006.
   PubMed Web of Science ®Google Scholar
• Gross O, Girgert R, Beirowski B, et al. Loss of collagen-receptor DDR1 delays renal fibrosis in hereditary type IV collagen disease. Matrix Biol J Int Soc Matrix Biol. 2010;29:346–56. doi:10.1016/j.matbio.2010.03.002.
   PubMed Web of Science ®Google Scholar
• Borza CM, Su Y, Tran T-L, et al. Discoidin domain receptor 1 kinase activity is required for regulating collagen IV synthesis. Matrix Biol J Int Soc Matrix Biol. 2017;57–58:258–71. doi:10.1016/j.matbio.2016.11.009.
   PubMed Web of Science ®Google Scholar
• Dorison A, Dussaule J-C, Chatziantoniou C. The Role of Discoidin Domain Receptor 1 in Inflammation, Fibrosis and Renal Disease. Nephron. 2017;137:212–220. doi:10.1159/000479119.
   PubMed Web of Science ®Google Scholar
• Song J, Chen X, Bai J, et al. Discoidin domain receptor 1 (DDR1), a promising biomarker, induces epithelial to mesenchymal transition in renal cancer cells. Tumour Biol J Int Soc Oncodevelopmental Biol Med. 2016;37:11509–21. doi:10.1007/s13277-016-5021-2.
   PubMedGoogle Scholar
• Ambrogio C, Gómez-López G, Falcone M, et al. Combined inhibition of DDR1 and Notch signaling is a therapeutic strategy for KRAS-driven lung adenocarcinoma. Nat Med. 2016;22:270–7. doi:10.1038/nm.4041.
   PubMed Web of Science ®Google Scholar
• Kim H-G, Tan L, Weisberg EL, et al. Discovery of a potent and selective DDR1 receptor tyrosine kinase inhibitor. ACS Chem Biol. 2013;8:2145–50. doi:10.1021/cb400430t.
   PubMed Web of Science ®Google Scholar
• Gao M, Duan L, Luo J, et al. Discovery and optimization of 3-(2-(Pyrazolo[1,5-a]pyrimidin-6-yl)ethynyl)benzamides as novel selective and orally bioavailable discoidin domain receptor 1 (DDR1) inhibitors. J Med Chem. 2013;56:3281–95. doi:10.1021/jm301824k.
   PubMed Web of Science ®Google Scholar
• Hahn W-H, Suh J-S, Cho B-S, et al. Linkage and association study of discoidin domain receptor 1 as a novel susceptibility gene for childhood IgA nephropathy. Int J Mol Med. 2010;25:785–91.
   PubMed Web of Science ®Google Scholar