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Research Paper

Knockdown of PIK3R6 impedes the onset and advancement of clear cell renal cell carcinoma

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Pages 1-12 | Received 22 Nov 2023, Accepted 07 May 2024, Published online: 03 Jun 2024

References

  • Bukavina L, Bensalah K, Bray F, et al. Epidemiology of renal cell carcinoma: 2022 update. Eur Urol. 2022;82(5):529–542. doi: 10.1016/j.eururo.2022.08.019
  • Moch H, Cubilla AL, Humphrey PA, et al. The 2016 WHO classification of tumours of the urinary system and male genital organs—part A: renal, penile, and Testicular tumours. Eur Urol. 2016;70(1):93–105. doi: 10.1016/j.eururo.2016.02.029
  • Jiang Z, Chu PG, Woda BA, et al. Combination of quantitative IMP3 and tumor stage: a new system to predict metastasis for patients with localized renal cell carcinomas. Clin Cancer Res. 2008;14(17):5579–5584. doi: 10.1158/1078-0432.CCR-08-0504
  • Eggener SE, Yossepowitch O, Pettus JA, et al. Renal cell carcinoma recurrence after nephrectomy for localized disease: predicting survival from time of recurrence. J Clin Oncol. 2006;24(19):3101–3106. doi: 10.1200/JCO.2005.04.8280
  • Sciarra A, Gentile V, Salciccia S, et al. New anti-angiogenic targeted therapy in advanced renal cell carcinoma (RCC): current status and future prospects. Rev Recent Clin Trials. 2008;3(2):97–103. doi: 10.2174/157488708784223808
  • Zhang H, Ma M. Circ_0101692 knockdown retards the development of clear cell renal cell carcinoma through miR-384/FN1 pathway. Transl Oncol. 2023;28:101612. doi: 10.1016/j.tranon.2022.101612
  • Thorpe LM, Yuzugullu H, Zhao JJ. PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting. Nat Rev Cancer. 2015;15(1):7–24. doi: 10.1038/nrc3860
  • Vanhaesebroeck B, Guillermet-Guibert J, Graupera M, et al. The emerging mechanisms of isoform-specific PI3K signalling. Nat Rev Mol Cell Biol. 2010;11(5):329–341. doi: 10.1038/nrm2882
  • Li J, Kaneda MM, Ma J, et al. PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response. Proc Natl Acad Sci USA. 2021;118(16):118. doi: 10.1073/pnas.2009290118
  • Xu Y, Afify SM, Du J, et al. The efficacy of PI3Kγ and EGFR inhibitors on the suppression of the characteristics of cancer stem cells. Sci Rep. 2022;12(1):347. doi: 10.1038/s41598-021-04265-w
  • Becattini B, Breasson L, Sardi C, et al. PI3Kγ promotes obesity-associated hepatocellular carcinoma by regulating metabolism and inflammation. JHEP Rep. 2021;3(6):100359. doi: 10.1016/j.jhepr.2021.100359
  • Wang X, Huang S, Xin X, et al. The antitumor activity of umbelliferone in human renal cell carcinoma via regulation of the p110γ catalytic subunit of PI3Kγ. Acta Pharm. 2019;69(1):111–119. doi: 10.2478/acph-2019-0004
  • Liu YJ, Cui LL, Liu ZS, et al. RBBP6 aggravates the progression of ovarian cancer by targeting PIK3R6. Eur Rev Med Pharmacol Sci. 2020;24(20):10366–10374. doi: 10.26355/eurrev_202010_23386
  • Du Y, Zhao W, Han H, et al. PIK3R6 promotes angiogenesis in hepatocellular carcinoma by activating STAT3 signaling pathway. Altern Ther Health Med. 2023;29(8):704–709.
  • Liu M, Liao L, Gao Y, et al. BCAM deficiency May contribute to preeclampsia by suppressing the PIK3R6/p-STAT3 signaling. Hypertension. 2022;79(12):2830–2842. doi: 10.1161/HYPERTENSIONAHA.122.20085
  • Lee MJ, Jin N, Grandis JR, et al. Alterations and molecular targeting of the GSK-3 regulator, PI3K, in head and neck cancer. Biochim Biophys Acta, Mol Cell Res. 2020;1867(6):118679. doi: 10.1016/j.bbamcr.2020.118679
  • Okkenhaug K, Graupera M, Vanhaesebroeck B. Targeting PI3K in cancer: impact on tumor cells, their protective stroma, angiogenesis, and immunotherapy. Cancer Discov. 2016;6(10):1090–1105. doi: 10.1158/2159-8290.CD-16-0716
  • Liu X, Xu Y, Zhou Q, et al. PI3K in cancer: its structure, activation modes and role in shaping tumor microenvironment. Future Oncol. 2018;14(7):665–674. doi: 10.2217/fon-2017-0588
  • Kobialka P, Sabata H, Vilalta O, et al. The onset of PI3K-related vascular malformations occurs during angiogenesis and is prevented by the AKT inhibitor miransertib. EMBO Mol Med. 2022;14(7):e15619. doi: 10.15252/emmm.202115619
  • Hopkins BD, Pauli C, Du X, et al. Suppression of insulin feedback enhances the efficacy of PI3K inhibitors. Nature. 2018;560(7719):499–503. doi: 10.1038/s41586-018-0343-4
  • Janku F, Yap TA, Meric-Bernstam F. Targeting the PI3K pathway in cancer: are we making headway? Nat Rev Clin Oncol. 2018;15(5):273–291. doi: 10.1038/nrclinonc.2018.28
  • Tang SW, Chang WH, Su YC, et al. MYC pathway is activated in clear cell renal cell carcinoma and essential for proliferation of clear cell renal cell carcinoma cells. Cancer Lett. 2009;273(1):35–43. doi: 10.1016/j.canlet.2008.07.038
  • Helsten T, Kato S, Schwaederle M, et al. Cell-cycle gene alterations in 4,864 tumors analyzed by next-generation sequencing: implications for targeted therapeutics. Mol Cancer Ther. 2016;15(7):1682–1690. doi: 10.1158/1535-7163.MCT-16-0071
  • Kõivomägi M, Swaffer MP, Turner JJ, et al. G1cyclin–cdk promotes cell cycle entry through localized phosphorylation of RNA polymerase II. Science. 2021;374(6565):347–351. doi: 10.1126/science.aba5186
  • Sun F, Li N, Tong X, et al. Ara-c induces cell cycle G1/S arrest by inducing upregulation of the INK4 family gene or directly inhibiting the formation of the cell cycle-dependent complex CDK4/cyclin D1. Cell Cycle. 2019;18(18):2293–2306. doi: 10.1080/15384101.2019.1644913
  • Xu H, He L, Feng X, et al. Specific reduction of fas-associated protein with death domain (FADD) in clear cell renal cell carcinoma. Cancer Invest. 2009;27(8):836–843. doi: 10.1080/07357900902849681
  • Brunelle JK, Letai A. Control of mitochondrial apoptosis by the Bcl-2 family. J Cell Sci. 2009;122(4):437–441. doi: 10.1242/jcs.031682
  • Hanahan D. Hallmarks of cancer: new dimensions. Cancer Discov. 2022;12(1):31–46. doi: 10.1158/2159-8290.CD-21-1059
  • Zhao J, Dong D, Sun L, et al. Prognostic significance of the epithelial-to-mesenchymal transition markers e-cadherin, vimentin and twist in bladder cancer. Int Braz J Urol. 2014;40(2):179–189. doi: 10.1590/S1677-5538.IBJU.2014.02.07
  • Yuan M, Zou X, Liu S, et al. Modified jian-pi-yang-zheng decoction inhibits gastric cancer progression via the macrophage immune checkpoint PI3Kgamma. Biomed Pharmacother. 2020;129:110440. doi: 10.1016/j.biopha.2020.110440
  • Fan D, Liu Q, Wu F, et al. Prognostic significance of PI3K/AKT/mTOR signaling pathway members in clear cell renal cell carcinoma. PeerJ. 2020;8:e9261. doi: 10.7717/peerj.9261
  • Chen L, Qing J, Xiao Y, et al. TIM-1 promotes proliferation and metastasis, and inhibits apoptosis, in cervical cancer through the PI3K/AKT/p53 pathway. BMC Cancer. 2022;22(1):370. doi: 10.1186/s12885-022-09386-7