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Control of sleep by a network of cell cycle genes

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Pages 165-172 | Received 08 Dec 2015, Accepted 05 Feb 2016, Published online: 29 Feb 2016

References

  • Crocker A, Sehgal A. Genetic analysis of sleep. Gen Dev 2010; 24:1220-35; PMID:20551171; http://dx.doi.org/10.1101/gad.1913110
  • Palma J-A, Urrestarazu E, Iriarte J. Sleep loss as risk factor for neurologic disorders: A review. Sleep Med 2013; 14:229-36; PMID:23352029; http://dx.doi.org/10.1016/j.sleep.2012.11.019
  • Wang XS, Armstrong ME, Cairns BJ, Key TJ, Travis RC. Shift work and chronic disease: the epidemiological evidence. Occup Med 2011; 61:78-89; PMID:21355031; http://dx.doi.org/10.1093/occmed/kqr001
  • Buxton OM, Cain SW, O'Connor SP, Porter JH, Duffy JF, Wang W, Czeisler CA, Shea SA. Adverse metabolic consequences in humans of prolonged sleep restriction combined with circadian disruption. Sci Transl Med 2012; 4:129ra43; PMID:22496545; http://dx.doi.org/10.1126/scitranslmed.3003200
  • Tefft BC. Prevalence of motor vehicle crashes involving drowsy drivers, United States, 1999−2008. Accid Anal Prev 2012; 45:180-6; PMID:22269499; http://dx.doi.org/10.1016/j.aap.2011.05.028
  • Tononi G, Cirelli C. Sleep and the price of plasticity: from synaptic and cellular homeostasis to memory consolidation and integration. Neuron 2014; 81:12-34; PMID:24411729; http://dx.doi.org/10.1016/j.neuron.2013.12.025
  • Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, et al. Sleep drives metabolite clearance from the adult brain. Science 2013; 342:373-7; PMID:24136970; http://dx.doi.org/10.1126/science.1241224
  • Schmidt MH. The energy allocation function of sleep: a unifying theory of sleep, torpor, and continuous wakefulness. Neuroscience and biobehavioral reviews 2014; 47:122-53; PMID:25117535; http://dx.doi.org/10.1016/j.neubiorev.2014.08.001
  • Afonso DJ, Liu D, Machado DR, Pan H, Jepson JE, Rogulja D, Koh K. TARANIS Functions with Cyclin A and Cdk1 in a Novel Arousal Center to Control Sleep in Drosophila. Curr Biol 2015; 25:1717-26; PMID:26096977; http://dx.doi.org/10.1016/j.cub.2015.05.037
  • Borbely AA, Achermann P. Sleep homeostasis and models of sleep regulation. J Biol Rhythms 1999; 14:557-68; PMID:10643753
  • Wu MN, Koh K, Yue Z, Joiner WJ, Sehgal A. A genetic screen for sleep and circadian mutants reveals mechanisms underlying regulation of sleep in Drosophila. Sleep 2008; 31:465-72; PMID:18457233
  • Shaw PJ, Tononi G, Greenspan RJ, Robinson DF. Stress response genes protect against lethal effects of sleep deprivation in Drosophila. Nature 2002; 417:287-91; PMID:12015603; http://dx.doi.org/10.1038/417287a
  • Rechtschaffen A, Gilliland MA, Bergmann BM, Winter JB. Physiological correlates of prolonged sleep deprivation in rats. Science 1983; 221:182-4; PMID:6857280; http://dx.doi.org/10.1126/science.6857280
  • Stavropoulos N, Young MW. insomniac and Cullin-3 regulate sleep and wakefulness in Drosophila. Neuron 2011; 72:964-76; PMID:22196332; http://dx.doi.org/10.1016/j.neuron.2011.12.003
  • Koh K, Joiner WJ, Wu MN, Yue Z, Smith CJ, Sehgal A. Identification of SLEEPLESS, a sleep-promoting factor. Science 2008; 321:372-6; PMID:18635795; http://dx.doi.org/10.1126/science.1155942
  • Rogulja D, Young MW. Control of sleep by cyclin A and its regulator. Science 2012; 335:1617-21; PMID:22461610; http://dx.doi.org/10.1126/science.1212476
  • Calgaro S, Boube M, Cribbs DL, Bourbon HM. The Drosophila gene taranis encodes a novel trithorax group member potentially linked to the cell cycle regulatory apparatus. Genetics 2002; 160:547-60; PMID:11861561
  • Zang ZJ, Gunaratnam L, Cheong JK, Lai LY, Hsiao L-L, O'Leary E, Sun X, Salto-Tellez M, Bonventre JV, Hsu SIH. Identification of PP2A as a novel interactor and regulator of TRIP-Br1. Cellular signalling 2009; 21:34-42; PMID:18940248; http://dx.doi.org/10.1016/j.cellsig.2008.09.018
  • Hsu SI, Yang CM, Sim KG, Hentschel DM, O'Leary E, Bonventre JV. TRIP-Br: a novel family of PHD zinc finger- and bromodomain-interacting proteins that regulate the transcriptional activity of E2F-1/DP-1. EMBO J 2001; 20:2273-85; PMID:11331592; http://dx.doi.org/10.1093/emboj/20.9.2273
  • Manansala MC, Min S, Cleary MD. The Drosophila SERTAD protein Taranis determines lineage-specific neural progenitor proliferation patterns. Dev Biol 2013; 376:150-62; PMID:23376107; http://dx.doi.org/10.1016/j.ydbio.2013.01.025
  • Darwish H, Cho JM, Loignon M, Alaoui-Jamali MA. Overexpression of SERTAD3, a putative oncogene located within the 19q13 amplicon, induces E2F activity and promotes tumor growth. Oncogene 2007; 26:4319-28; PMID:17260023; http://dx.doi.org/10.1038/sj.onc.1210195
  • Hayashi R, Goto Y, Ikeda R, Yokoyama KK, Yoshida K. CDCA4 is an E2F transcription factor family-induced nuclear factor that regulates E2F-dependent transcriptional activation and cell proliferation. J Biol Chem 2006; 281:35633-48; PMID:16984923; http://dx.doi.org/10.1074/jbc.M603800200
  • Meyer CA, Jacobs HW, Datar SA, Du W, Edgar BA, Lehner CF. Drosophila Cdk4 is required for normal growth and is dispensable for cell cycle progression. EMBO J 2000; 19:4533-42; PMID:10970847; http://dx.doi.org/10.1093/emboj/19.17.4533
  • Ayeni JO, Varadarajan R, Mukherjee O, Stuart DT, Sprenger F, Srayko M, Campbell SD. Dual phosphorylation of cdk1 coordinates cell proliferation with key developmental processes in Drosophila. Genetics 2014; 196:197-210; PMID:24214341; http://dx.doi.org/10.1534/genetics.113.156281
  • Lin W-H, He M, Baines RA. Seizure suppression through manipulating splicing of a voltage-gated sodium channel. Brain 2015; 138:891-901; PMID:25681415; http://dx.doi.org/10.1093/brain/awv012
  • Cirelli C, Bushey D, Hill S, Huber R, Kreber R, Ganetzky B, Tononi G. Reduced sleep in Drosophila Shaker mutants. Nature 2005; 434:1087-92; PMID:15858564; http://dx.doi.org/10.1038/nature03486
  • Bushey D, Huber R, Tononi G, Cirelli C. Drosophila Hyperkinetic mutants have reduced sleep and impaired memory. J Neurosci 2007; 27:5384-93; PMID:17507560; http://dx.doi.org/10.1523/JNEUROSCI.0108-07.2007
  • Rihel J, Prober DA, Arvanites A, Lam K, Zimmerman S, Jang S, Haggarty SJ, Kokel D, Rubin LL, Peterson RT, et al. Zebrafish behavioral profiling links drugs to biological targets and rest/wake regulation. Science 2010; 327:348-51; PMID:20075256; http://dx.doi.org/10.1126/science.1183090
  • Shi M, Yue Z, Kuryatov A, Lindstrom JM, Sehgal A. Identification of Redeye, a new sleep-regulating protein whose expression is modulated by sleep amount. 2014.
  • Parisky KM, Agosto J, Pulver SR, Shang Y, Kuklin E, Hodge JJ, Kang K, Liu X, Garrity PA, Rosbash M, et al. PDF cells are a GABA-responsive wake-promoting component of the Drosophila sleep circuit. Neuron 2008; 60:672-82; PMID:19038223; http://dx.doi.org/10.1016/j.neuron.2008.10.042
  • Chung BY, Kilman VL, Keath JR, Pitman JL, Allada R. The GABA(A) receptor RDL acts in peptidergic PDF neurons to promote sleep in Drosophila. Curr Biol 2009; 19:386-90; PMID:19230663; http://dx.doi.org/10.1016/j.cub.2009.01.040
  • Choi S-H, Lee G, Monahan P, Park JH. Spatial regulation of Corazonin neuropeptide expression requires multiple cis-acting elements in Drosophila melanogaster. J Comparative Neurol 2008; 507:1184-95; PMID:18181151; http://dx.doi.org/10.1002/cne.21594
  • Hergarden AC, Tayler TD, Anderson DJ. Allatostatin-A neurons inhibit feeding behavior in adult Drosophila. Proc Natl Acad Sci 2012; 109:3967-72; http://dx.doi.org/10.1073/pnas.1200778109
  • Miyamoto T, Slone J, Song X, Amrein H. A Fructose Receptor Functions as a Nutrient Sensor in the Drosophila Brain. Cell 2012; 151:1113-25; PMID:23178127; http://dx.doi.org/10.1016/j.cell.2012.10.024
  • Miyamoto T, Amrein H. Diverse roles for the Drosophila fructose sensor Gr43a. Fly 2014; 8:19-25; PMID:24406333; http://dx.doi.org/10.4161/fly.27241
  • Keene AC, Duboué ER, McDonald DM, Dus M, Suh GSB, Waddell S, Blau J. Clock and cycle Limit Starvation-Induced Sleep Loss in Drosophila. Curr Biol 2010; 20:1209-15; PMID:20541409; http://dx.doi.org/10.1016/j.cub.2010.05.029
  • Liew CW, Boucher J, Cheong JK, Vernochet C, Koh HJ, Mallol C, Townsend K, Langin D, Kawamori D, Hu J, et al. Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance. Nat Med 2013; 19:217-26; PMID:23291629; http://dx.doi.org/10.1038/nm.3056
  • Fernandez-Marcos PJ, Pantoja C, Gonzalez-Rodriguez A, Martin N, Flores JM, Valverde AM, Hara E, Serrano M. Normal Proliferation and Tumorigenesis but Impaired Pancreatic Function in Mice Lacking the Cell Cycle Regulator Sei1. PloS one 2010; 5:e8744; PMID:20090907
  • Cavanaugh Daniel J, Geratowski Jill D, Wooltorton Julian RA, Spaethling Jennifer M, Hector Clare E, Zheng X, Johnson Erik C, Eberwine James H, Sehgal A. Identification of a Circadian Output Circuit for Rest:Activity Rhythms in Drosophila. Cell 2014; 157:689-701; PMID:24766812; http://dx.doi.org/10.1016/j.cell.2014.02.024
  • Dus M, Lai Jason S-Y, Gunapala Keith M, Min S, Tayler Timothy D, Hergarden Anne C, Geraud E, Joseph Christina M, Suh Greg SB. Nutrient Sensor in the Brain Directs the Action of the Brain-Gut Axis in Drosophila. Neuron 2015; 87:139-51; PMID:26074004; http://dx.doi.org/10.1016/j.neuron.2015.05.032
  • de Velasco B, Erclik T, Shy D, Sclafani J, Lipshitz H, McInnes R, Hartenstein V. Specification and development of the pars intercerebralis and pars lateralis, neuroendocrine command centers in the Drosophila brain. Dev Biol 2007; 302:309-23; PMID:17070515; http://dx.doi.org/10.1016/j.ydbio.2006.09.035
  • Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature 2005; 437:1257-63; PMID:16251950; http://dx.doi.org/10.1038/nature04284
  • Waterson Michael J, Horvath Tamas L. Neuronal Regulation of Energy Homeostasis: Beyond the Hypothalamus and Feeding. Cell metabolism 2015; 22:962-70; PMID:26603190; http://dx.doi.org/10.1016/j.cmet.2015.09.026
  • Joiner WJ, Crocker A, White BH, Sehgal A. Sleep in Drosophila is regulated by adult mushroom bodies. Nature 2006; 441:757-60; PMID:16760980; http://dx.doi.org/10.1038/nature04811
  • Pitman JL, McGill JJ, Keegan KP, Allada R. A dynamic role for the mushroom bodies in promoting sleep in Drosophila. Nature 2006; 441:753-6; PMID:16760979; http://dx.doi.org/10.1038/nature04739
  • Sitaraman D, Aso Y, Jin X, Chen N, Felix M, Rubin GM, Nitabach MN. Propagation of Homeostatic Sleep Signals by Segregated Synaptic Microcircuits of the Drosophila Mushroom Body. Curr Biol 2015; 25(22):2915-27; PMID:26455303
  • Donlea JM, Thimgan MS, Suzuki Y, Gottschalk L, Shaw PJ. Inducing sleep by remote control facilitates memory consolidation in Drosophila. Science 2011; 332:1571-6; PMID:21700877; http://dx.doi.org/10.1126/science.1202249
  • Crocker A, Shahidullah M, Levitan IB, Sehgal A. Identification of a neural circuit that underlies the effects of octopamine on sleep:wake behavior. Neuron 2010; 65:670-81; PMID:20223202; http://dx.doi.org/10.1016/j.neuron.2010.01.032
  • Sheeba V, Fogle KJ, Kaneko M, Rashid S, Chou YT, Sharma VK, Holmes TC. Large ventral lateral neurons modulate arousal and sleep in Drosophila. Curr Biol 2008; 18:1537-45; PMID:18771923; http://dx.doi.org/10.1016/j.cub.2008.08.033
  • Odajima J, Wills ZP, Ndassa YM, Terunuma M, Kretschmannova K, Deeb TZ, Geng Y, Gawrzak S, Quadros IM, Newman J, et al. Cyclin E constrains Cdk5 activity to regulate synaptic plasticity and memory formation. Dev Cell 2011; 21:655-68; PMID:21944720; http://dx.doi.org/10.1016/j.devcel.2011.08.009
  • Nagy Z, Esiri MM. Neuronal cyclin expression in the hippocampus in temporal lobe epilepsy. Exp Neurol 1998; 150:240-7; PMID:9527893; http://dx.doi.org/10.1006/exnr.1997.6753
  • Quinones-Coello AT, Petrella LN, Ayers K, Melillo A, Mazzalupo S, Hudson AM, Wang S, Castiblanco C, Buszczak M, Hoskins RA, et al. Exploring strategies for protein trapping in Drosophila. Genetics 2007; 175:1089-104; PMID:17179094; http://dx.doi.org/10.1534/genetics.106.065995
  • Kume K, Kume S, Park SK, Hirsh J, Jackson FR. Dopamine is a regulator of arousal in the fruit fly. J Neurosci 2005; 25:7377-84; PMID:16093388; http://dx.doi.org/10.1523/JNEUROSCI.2048-05.2005
  • Ueno T, Tomita J, Tanimoto H, Endo K, Ito K, Kume S, Kume K. Identification of a dopamine pathway that regulates sleep and arousal in Drosophila. Nat Neurosci 2012; 15:1516-23; PMID:23064381; http://dx.doi.org/10.1038/nn.3238
  • Yuan Q, Joiner WJ, Sehgal A. A sleep-promoting role for the Drosophila serotonin receptor 1A. Curr Biol 2006; 16:1051-62; PMID:16753559; http://dx.doi.org/10.1016/j.cub.2006.04.032
  • Crocker A, Sehgal A. Octopamine regulates sleep in Drosophila through protein kinase A-dependent mechanisms. J Neurosci 2008; 28:9377-85; PMID:18799671; http://dx.doi.org/10.1523/JNEUROSCI.3072-08a.2008
  • Crocker A, Shahidullah M, Levitan IB, Sehgal A. Identification of a Neural Circuit that Underlies the Effects of Octopamine on Sleep:Wake Behavior. Neuron 2010; 65:670-81; PMID:20223202; http://dx.doi.org/10.1016/j.neuron.2010.01.032
  • Agosto J, Choi JC, Parisky KM, Stilwell G, Rosbash M, Griffith LC. Modulation of GABAA receptor desensitization uncouples sleep onset and maintenance in Drosophila. Nat Neurosci 2008; 11:354-9; PMID:18223647; http://dx.doi.org/10.1038/nn2046
  • Liu S, Lamaze A, Liu Q, Tabuchi M, Yang Y, Fowler M, Bharadwaj R, Zhang J, Bedont J, Blackshaw S, et al. WIDE AWAKE Mediates the Circadian Timing of Sleep Onset. Neuron 2014; 82:151-66; PMID:24631345; http://dx.doi.org/10.1016/j.neuron.2014.01.040
  • Maguire SE, Rhoades S, Chen W-F, Sengupta A, Yue Z, Lim JC, Mitchell CH, Weljie AM, Sehgal A. Independent Effects of γ-Aminobutyric Acid Transaminase (GABAT) on Metabolic and Sleep Homeostasis. J Biol Chem 2015; 290:20407-16; PMID:26124278; http://dx.doi.org/10.1074/jbc.M114.602276
  • Wu M, Robinson James E, Joiner William J. SLEEPLESS Is a Bifunctional Regulator of Excitability and Cholinergic Synaptic Transmission. Curr Biol 2014; 24:621-9; PMID:24613312; http://dx.doi.org/10.1016/j.cub.2014.02.026
  • Tomita J, Ueno T, Mitsuyoshi M, Kume S, Kume K. The NMDA Receptor Promotes Sleep in the Fruit Fly, Drosophila melanogaster. PloS one 2015; 10:e0128101; PMID:26023770; http://dx.doi.org/10.1371/journal.pone.0128101
  • Ishimoto H, Kitamoto T. The Steroid Molting Hormone Ecdysone Regulates Sleep in Adult Drosophila melanogaster. Genetics 2010; 185:269-81; PMID:20215472; http://dx.doi.org/10.1534/genetics.110.114587
  • Isaac RE, Li C, Leedale AE, Shirras AD. Drosophila male sex peptide inhibits siesta sleep and promotes locomotor activity in the post-mated female. Proc Biol Sci 2009; 277:65-70; http://dx.doi.org/10.1098/rspb.2009.1236
  • Oh Y, Yoon SE, Zhang Q, Chae HS, Daubnerova I, Shafer OT, Choe J, Kim YJ. A homeostatic sleep-stabilizing pathway in Drosophila composed of the sex peptide receptor and its ligand, the myoinhibitory peptide. PLoS Biol 2014; 12:e1001974; PMID:25333796; http://dx.doi.org/10.1371/journal.pbio.1001974
  • Shang Y, Donelson Nathan C, Vecsey Christopher G, Guo F, Rosbash M, Griffith Leslie C. Short Neuropeptide F Is a Sleep-Promoting Inhibitory Modulator. Neuron 2013; 80:171-83; PMID:24094110; http://dx.doi.org/10.1016/j.neuron.2013.07.029
  • Kunst M, Hughes ME, Raccuglia D, Felix M, Li M, Barnett G, Duah J, Nitabach MN. Calcitonin gene-related Peptide neurons mediate sleep-specific circadian output in Drosophila. Curr Biol 2014; 24:2652-64; PMID:25455031; http://dx.doi.org/10.1016/j.cub.2014.09.077
  • Park S, Sonn JY, Oh Y, Lim C, and Choe J. SIFamide and SIFamide Receptor Define a Novel Neuropeptide Signaling to Promote Sleep in Drosophila. Mol Cells 2014; 37:295-301; PMID:24658384; http://dx.doi.org/10.14348/molcells.2014.2371
  • Bushey D, Huber R, Tononi G, Cirelli C. Drosophila Hyperkinetic Mutants Have Reduced Sleep and Impaired Memory. J Neurosci 2007; 27:5384-93; PMID:17507560; http://dx.doi.org/10.1523/JNEUROSCI.0108-07.2007
  • Jeong K, Lee S, Seo H, Oh Y, Jang D, Choe J, Kim D, Lee J-H, Jones WD. Ca-α1T, a fly T-type Ca2+ channel, negatively modulates sleep. Scientific Reports 2015; 5:17893; PMID:26647714; http://dx.doi.org/10.1038/srep17893
  • Tomita J, Mitsuyoshi M, Ueno T, Aso Y, Tanimoto H, Nakai Y, Aigaki T, Kume S, Kume K. Pan-Neuronal Knockdown of Calcineurin Reduces Sleep in the Fruit Fly, Drosophila melanogaster. J Neurosci 2011; 31:13137-46; PMID:21917797; http://dx.doi.org/10.1523/JNEUROSCI.5860-10.2011
  • Nakai Y, Horiuchi J, Tsuda M, Takeo S, Akahori S, Matsuo T, Kume K, Aigaki T. Calcineurin and Its Regulator Sra/DSCR1 Are Essential for Sleep in Drosophila. J Neurosci 2011; 31:12759-66; PMID:21900555; http://dx.doi.org/10.1523/JNEUROSCI.1337-11.2011
  • Allebrandt KV, Amin N, Muller-Myhsok B, Esko T, Teder-Laving M, Azevedo RVDM, Hayward C, van Mill J, Vogelzangs N, Green EW, et al. A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila. Molecular psychiatry 2013; 18:122-32; PMID:22105623; http://dx.doi.org/10.1038/mp.2011.142
  • Roessingh S, Wolfgang W, Stanewsky R. Loss of Drosophila melanogaster TRPA1 Function Affects “Siesta” Behavior but Not Synchronization to Temperature Cycles. J Biol Rhythms 2015; 30:492-505; PMID:26459465; http://dx.doi.org/10.1177/0748730415605633
  • Bushey D, Tononi G, Cirelli C. The Drosophila fragile X mental retardation gene regulates sleep need. J Neurosci 2009; 29:1948-61; PMID:19228950; http://dx.doi.org/10.1523/JNEUROSCI.4830-08.2009
  • Naidoo N, Ferber M, Galante RJ, McShane B, Hu JH, Zimmerman J, Maislin G, Cater J, Wyner A, Worley P, et al. Role of Homer Proteins in the Maintenance of Sleep-Wake States. PloS one 2012; 7:e35174; PMID:22532843; http://dx.doi.org/10.1371/journal.pone.0035174
  • Li Y, Zhou Z, Zhang X, Tong H, Li P, Zhang ZC, Jia Z, Xie W, Han J. Drosophila Neuroligin 4 Regulates Sleep through Modulating GABA Transmission. J Neurosci 2013; 33:15545-54; PMID:24068821; http://dx.doi.org/10.1523/JNEUROSCI.0819-13.2013
  • Larkin A, Chen MY, Kirszenblat L, Reinhard J, van Swinderen B, Claudianos C. Neurexin-1 regulates sleep and synaptic plasticity in Drosophila melanogaster. Eur J Neurosci 2015; 42(7):2455-66
  • Vanderheyden WM, Gerstner JR, Tanenhaus A, Yin JC, Shaw PJ. ERK Phosphorylation Regulates Sleep and Plasticity in Drosophila. PloS one 2013; 8:e81554; PMID:24244744; http://dx.doi.org/10.1371/journal.pone.0081554
  • Foltenyi K, Greenspan RJ, Newport JW. Activation of EGFR and ERK by rhomboid signaling regulates the consolidation and maintenance of sleep in Drosophila. Nat Neurosci 2007; 10:1160-7; PMID:17694052; http://dx.doi.org/10.1038/nn1957
  • Guo F, Yi W, Zhou M, Guo A. Go signaling in mushroom bodies regulates sleep in Drosophila. Sleep 2011; 34:273-81; PMID:21358844
  • Seugnet L, Suzuki Y, Merlin G, Gottschalk L, Duntley Stephen P, Shaw Paul J. Notch Signaling Modulates Sleep Homeostasis and Learning after Sleep Deprivation in Drosophila. Curr Biol 2011; 21:835-40; PMID:21549599; http://dx.doi.org/10.1016/j.cub.2011.04.001
  • Takahama K, Tomita J, Ueno T, Yamazaki M, Kume S, Kume K. Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila. Biochem Biophy Res Commun 2012; 417:807-11; PMID:22197814; http://dx.doi.org/10.1016/j.bbrc.2011.12.040
  • Donlea J, Leahy A, Thimgan MS, Suzuki Y, Hughson BN, Sokolowski MB, Shaw PJ. foraging alters resilience/vulnerability to sleep disruption and starvation in Drosophila. Proc Natl Acad Sci 2012; 109:2613-8; http://dx.doi.org/10.1073/pnas.1112623109
  • Donlea JM, Pimentel D, Miesenbock G. Neuronal machinery of sleep homeostasis in Drosophila. Neuron 2014; 81:860-72; PMID:24559676; http://dx.doi.org/10.1016/j.neuron.2013.12.013
  • Metaxakis A, Tain LS, Grönke S, Hendrich O, Hinze Y, Birras U, Partridge L. Lowered Insulin Signalling Ameliorates Age-Related Sleep Fragmentation in Drosophila. PLoS Biol 2014; 12:e1001824; PMID:24690889; http://dx.doi.org/10.1371/journal.pbio.1001824
  • Thimgan MS, Suzuki Y, Seugnet L, Gottschalk L, Shaw PJ. The Perilipin Homologue, Lipid Storage Droplet 2, Regulates Sleep Homeostasis and Prevents Learning Impairments Following Sleep Loss. PLoS Biol 2010; 8:e1000466; PMID:20824166; http://dx.doi.org/10.1371/journal.pbio.1000466
  • Gerstner JR, Vanderheyden WM, Shaw PJ, Landry CF, Yin JC. Fatty-acid binding proteins modulate sleep and enhance long-term memory consolidation in Drosophila. PloS one 2011; 6:e15890; PMID:21298037; http://dx.doi.org/10.1371/journal.pone.0015890
  • Hendricks JC, Finn SM, Panckeri KA, Chavkin J, Williams JA, Sehgal A, Pack AI. Rest in Drosophila is a sleep-like state. Neuron 2000; 25:129-38; PMID:10707978; http://dx.doi.org/10.1016/S0896-6273(00)80877-6
  • Hendricks JC, Lu S, Kume K, Yin JC, Yang Z, Sehgal A. Gender dimorphism in the role of cycle (BMAL1) in rest, rest regulation, and longevity in Drosophila melanogaster. J Biol Rhythms 2003; 18:12-25; PMID:12568241; http://dx.doi.org/10.1177/0748730402239673
  • Williams JA, Sathyanarayanan S, Hendricks JC, Sehgal A. Interaction Between Sleep and the Immune Response in Drosophila: A Role for the NFκB Relish. Sleep 2007; 30:389-400; PMID:17520783
  • Bai L, Sehgal A. Anaplastic Lymphoma Kinase Acts in the Drosophila Mushroom Body to Negatively Regulate Sleep. PLoS Genet 2015; 11:e1005611; PMID:26536237; http://dx.doi.org/10.1371/journal.pgen.1005611
  • Wu Y, Bolduc FV, Bell K, Tully T, Fang Y, Sehgal A, Fischer JA. A Drosophila model for Angelman syndrome. Proc Natl Acad Sci 2008; 105:12399-404; http://dx.doi.org/10.1073/pnas.0805291105
  • Pfeiffenberger C, Allada R. Cul3 and the BTB adaptor insomniac are key regulators of sleep homeostasis and a dopamine arousal pathway in Drosophila. PLoS Genet 2012; 8:e1003003; PMID:23055946; http://dx.doi.org/10.1371/journal.pgen.1003003
  • Hendricks JC, Williams JA, Panckeri K, Kirk D, Tello M, Yin JC, Sehgal A. A non-circadian role for cAMP signaling and CREB activity in Drosophila rest homeostasis. Nat Neurosci 2001; 4:1108-15; PMID:11687816; http://dx.doi.org/10.1038/nn743
  • Liu W, Guo F, Lu B, Guo A. amnesiac regulates sleep onset and maintenance in Drosophila melanogaster. Biochem Biophy Res Commun 2008; 372:798-803; PMID:18514063; http://dx.doi.org/10.1016/j.bbrc.2008.05.119
  • Harbison ST, Carbone MA, Ayroles JF, Stone EA, Lyman RF, Mackay TFC. Co-regulated transcriptional networks contribute to natural genetic variation in Drosophila sleep. Nat Genet 2009; 41:371-5; PMID:19234472; http://dx.doi.org/10.1038/ng.330
  • Pirooznia SK, Chiu K, Chan MT, Zimmerman JE, Elefant F. Epigenetic regulation of axonal growth of Drosophila pacemaker cells by histone acetyltransferase tip60 controls sleep. Genetics 2012; 192:1327-45; PMID:22982579; http://dx.doi.org/10.1534/genetics.112.144667
  • Soshnev AA, Ishimoto H, McAllister BF, Li X, Wehling MD, Kitamoto T, Geyer PK. A Conserved Long Noncoding RNA Affects Sleep Behavior in Drosophila. Genetics 2011; 189:455-68; PMID:21775470; http://dx.doi.org/10.1534/genetics.111.131706
  • Shimizu H, Shimoda M, Yamaguchi T, Seong K-H, Okamura T, Ishii S. Drosophila ATF-2 Regulates Sleep and Locomotor Activity in Pacemaker Neurons. Mol Cell Biol 2008; 28:6278-89; PMID:18694958; http://dx.doi.org/10.1128/MCB.02242-07
  • Robinson JE, Paluch J, Dickman DK, Joiner WJ. ADAR-mediated RNA editing suppresses sleep by acting as a brake on glutamatergic synaptic plasticity. Nat Commun 2016; 7:10512

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