Mitochondrial retrograde signaling in the Drosophila nervous system and beyond

References

• Iacovino M, Granycome C, Sembongi H, Bokori-Brown M, Butow RA, Holt IJ, Bateman JM. The conserved translocase Tim17 prevents mitochondrial DNA loss. Hum Mol Genet 2009; 18:65-74; PMID:18826960; http://dx.doi.org/10.1093/hmg/ddn313
   PubMed Web of Science ®Google Scholar
• Schapira AH. Mitochondrial disease. Lancet 2006; 368:70-82; PMID:16815381; http://dx.doi.org/10.1016/S0140-6736(06)68970-8
   PubMed Web of Science ®Google Scholar
• Baloyannis SJ, Costa V, Michmizos D. Mitochondrial alterations in Alzheimer's disease. Am J Alzheimers Dis Other Demen 2004; 19:89-93; PMID:15106389; http://dx.doi.org/10.1177/153331750401900205
   PubMedGoogle Scholar
• Coskun PE, Beal MF, Wallace DC. Alzheimer's brains harbor somatic mtDNA control-region mutations that suppress mitochondrial transcription and replication. Proc Natl Acad Sci U S A 2004; 101:10726-31; PMID:15247418; http://dx.doi.org/10.1073/pnas.0403649101
   PubMed Web of Science ®Google Scholar
• Kim SH, Vlkolinsky R, Cairns N, Fountoulakis M, Lubec G. The reduction of NADH ubiquinone oxidoreductase 24- and 75-kDa subunits in brains of patients with Down syndrome and Alzheimer's disease. Life Sci 2001; 68:2741-50; PMID:11400916; http://dx.doi.org/10.1016/S0024-3205(01)01074-8
   PubMed Web of Science ®Google Scholar
• Dexter DT, Carter CJ, Wells FR, Javoy-Agid F, Agid Y, Lees A, Jenner P, Marsden CD. Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J Neurochem 1989; 52:381-9; PMID:2911023; http://dx.doi.org/10.1111/j.1471-4159.1989.tb09133.x
   PubMed Web of Science ®Google Scholar
• Schapira AH, Cooper JM, Dexter D, Jenner P, Clark JB, Marsden CD. Mitochondrial complex I deficiency in Parkinson's disease. Lancet 1989; 1:1269; PMID:2566813; http://dx.doi.org/10.1016/S0140-6736(89)92366-0
   PubMed Web of Science ®Google Scholar
• Gatt AP, Duncan OF, Attems J, Francis PT, Ballard CG, Bateman JM. Dementia in Parkinson's disease is associated with enhanced mitochondrial complex I deficiency. Mov Disord 2016; 31:352-9; PMID:26853899; http://dx.doi.org/10.1002/mds.26513
   PubMed Web of Science ®Google Scholar
• Gatt AP, Jones EL, Francis PT, Ballard C, Bateman JM. Association of a polymorphism in mitochondrial transcription factor A (TFAM) with Parkinson's disease dementia but not dementia with Lewy bodies. Neurosci Lett 2013; 557 Pt B:177-80; PMID:24184878; http://dx.doi.org/10.1016/j.neulet.2013.10.045
   PubMed Web of Science ®Google Scholar
• Butow RA, Avadhani NG. Mitochondrial signaling: the retrograde response. Mol Cell 2004; 14:1-15; PMID:15068799; http://dx.doi.org/10.1016/S1097-2765(04)00179-0
   PubMed Web of Science ®Google Scholar
• Owusu-Ansah E, Yavari A, Mandal S, Banerjee U. Distinct mitochondrial retrograde signals control the G1-S cell cycle checkpoint. Nat Genet 2008; 40:356-61; PMID:18246068; http://dx.doi.org/10.1038/ng.2007.50
   PubMed Web of Science ®Google Scholar
• Picard M, McManus MJ, Gray JD, Nasca C, Moffat C, Kopinski PK, Seifert EL, McEwen BS, Wallace DC. Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress. Proc Natl Acad Sci U S A 2015; 112:E6614-23; PMID:26627253; http://dx.doi.org/10.1073/pnas.1515733112
   PubMedGoogle Scholar
• Komeili A, Wedaman KP, O'Shea EK, Powers T. Mechanism of metabolic control. Target of rapamycin signaling links nitrogen quality to the activity of the Rtg1 and Rtg3 transcription factors. J Cell Biol 2000; 151:863-78; PMID:11076970; http://dx.doi.org/10.1083/jcb.151.4.863
   PubMed Web of Science ®Google Scholar
• Crespo JL, Powers T, Fowler B, Hall MN. The TOR-controlled transcription activators GLN3, RTG1, and RTG3 are regulated in response to intracellular levels of glutamine. Proc Natl Acad Sci U S A 2002; 99:6784-9; PMID:11997479; http://dx.doi.org/10.1073/pnas.102687599
   PubMed Web of Science ®Google Scholar
• Jia Y, Rothermel B, Thornton J, Butow RA. A basic helix-loop-helix-leucine zipper transcription complex in yeast functions in a signaling pathway from mitochondria to the nucleus. Mol Cell Biol 1997; 17:1110-7; PMID:9032238; http://dx.doi.org/10.1128/MCB.17.3.1110
   PubMed Web of Science ®Google Scholar
• Guha M, Avadhani NG. Mitochondrial retrograde signaling at the crossroads of tumor bioenergetics, genetics and epigenetics. Mitochondrion 2013; 13:577-91; PMID:24004957; http://dx.doi.org/10.1016/j.mito.2013.08.007
   PubMed Web of Science ®Google Scholar
• Haynes CM, Fiorese CJ, Lin YF. Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded-protein response and beyond. Trends Cell Biol 2013; 23:311-8; PMID:23489877; http://dx.doi.org/10.1016/j.tcb.2013.02.002
   PubMed Web of Science ®Google Scholar
• Jazwinski SM. The retrograde response: when mitochondrial quality control is not enough. Biochim Biophys Acta 2013; 1833:400-9; PMID:22374136; http://dx.doi.org/10.1016/j.bbamcr.2012.02.010
   PubMed Web of Science ®Google Scholar
• Arnould T, Vankoningsloo S, Renard P, Houbion A, Ninane N, Demazy C, Remacle J, Raes M. CREB activation induced by mitochondrial dysfunction is a new signaling pathway that impairs cell proliferation. EMBO J 2002; 21:53-63; PMID:11782425; http://dx.doi.org/10.1093/emboj/21.1.53
   PubMed Web of Science ®Google Scholar
• Jones AW, Yao Z, Vicencio JM, Karkucinska-Wieckowska A, Szabadkai G. PGC-1 family coactivators and cell fate: roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signalling. Mitochondrion 2012; 12:86-99; PMID:21983689; http://dx.doi.org/10.1016/j.mito.2011.09.009
   PubMed Web of Science ®Google Scholar
• Cagin U, Duncan OF, Gatt AP, Dionne MS, Sweeney ST, Bateman JM. Mitochondrial retrograde signaling regulates neuronal function. Proc Natl Acad Sci U S A 2015; 112:E6000-9; PMID:26489648; http://dx.doi.org/10.1073/pnas.1505036112
   PubMedGoogle Scholar
• Chelstowska A, Liu Z, Jia Y, Amberg D, Butow RA. Signalling between mitochondria and the nucleus regulates the expression of a new D-lactate dehydrogenase activity in yeast. Yeast 1999; 15:1377-91; PMID:10509019; http://dx.doi.org/10.1002/(SICI)1097-0061(19990930)15:13<1377::AID-YEA473>3.0.CO;2-0
   PubMed Web of Science ®Google Scholar
• Fernandez-Ayala DJ, Chen S, Kemppainen E, O'Dell KM, Jacobs HT. Gene expression in a Drosophila model of mitochondrial disease. PLoS One 2010; 5:e8549; PMID:20066047; http://dx.doi.org/10.1371/journal.pone.0008549
   PubMedGoogle Scholar
• Freije WA, Mandal S, Banerjee U. Expression profiling of attenuated mitochondrial function identifies retrograde signals in Drosophila. G3 (Bethesda) 2012; 2:843-51; PMID:22908033; http://dx.doi.org/full_text
   PubMedGoogle Scholar
• Tufi R, Gandhi S, de Castro IP, Lehmann S, Angelova PR, Dinsdale D, Deas E, Plun-Favreau H, Nicotera P, Abramov AY, et al. Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's disease. Nat Cell Biol 2014; 16:157-66; PMID:24441527; http://dx.doi.org/10.1038/ncb2901
   PubMed Web of Science ®Google Scholar
• Sproule DM, Kaufmann P. Mitochondrial encephalopathy, lactic acidosis, and strokelike episodes: basic concepts, clinical phenotype, and therapeutic management of MELAS syndrome. Ann New York Acad Sci 2008; 1142:133-58; PMID:18990125; http://dx.doi.org/10.1196/annals.1444.011
   PubMed Web of Science ®Google Scholar
• Vincent A, Briggs L, Chatwin GF, Emery E, Tomlins R, Oswald M, Middleton CA, Evans GJ, Sweeney ST, Elliott CJ. parkin-induced defects in neurophysiology and locomotion are generated by metabolic dysfunction and not oxidative stress. Hum Mol Genet 2012; 21:1760-9; PMID:22215442; http://dx.doi.org/10.1093/hmg/ddr609
   PubMed Web of Science ®Google Scholar
• Jahangir Tafrechi RS, Svensson PJ, Janssen GM, Szuhai K, Maassen JA, Raap AK. Distinct nuclear gene expression profiles in cells with mtDNA depletion and homoplasmic A3243G mutation. Mutat Res 2005; 578:43-52; PMID:16202796; http://dx.doi.org/10.1016/j.mrfmmm.2005.02.002
   PubMed Web of Science ®Google Scholar
• Picard M, Zhang J, Hancock S, Derbeneva O, Golhar R, Golik P, O'Hearn S, Levy S, Potluri P, Lvova M, et al. Progressive increase in mtDNA 3243A>G heteroplasmy causes abrupt transcriptional reprogramming. Proc Natl Acad Sci U S A 2014; 111:E4033-42; PMID:25192935; http://dx.doi.org/10.1073/pnas.1414028111
   PubMedGoogle Scholar
• Lavista-Llanos S, Centanin L, Irisarri M, Russo DM, Gleadle JM, Bocca SN, Muzzopappa M, Ratcliffe PJ, Wappner P. Control of the hypoxic response in Drosophila melanogaster by the basic helix-loop-helix PAS protein similar. Mol Cell Biol 2002; 22:6842-53; PMID:12215541; http://dx.doi.org/10.1128/MCB.22.19.6842-6853.2002
   PubMed Web of Science ®Google Scholar
• Petros JA, Baumann AK, Ruiz-Pesini E, Amin MB, Sun CQ, Hall J, Lim S, Issa MM, Flanders WD, Hosseini SH, et al. mtDNA mutations increase tumorigenicity in prostate cancer. Proc Natl Acad Sci U S A 2005; 102:719-24; PMID:15647368; http://dx.doi.org/10.1073/pnas.0408894102
   PubMed Web of Science ®Google Scholar
• Putignani L, Raffa S, Pescosolido R, Aimati L, Signore F, Torrisi MR, Grammatico P. Alteration of expression levels of the oxidative phosphorylation system (OXPHOS) in breast cancer cell mitochondria. Breast Cancer Res Treat 2008; 110:439-52; PMID:17899367; http://dx.doi.org/10.1007/s10549-007-9738-x
   PubMed Web of Science ®Google Scholar
• Amuthan G, Biswas G, Zhang SY, Klein-Szanto A, Vijayasarathy C, Avadhani NG. Mitochondria-to-nucleus stress signaling induces phenotypic changes, tumor progression and cell invasion. EMBO J 2001; 20:1910-20; PMID:11296224; http://dx.doi.org/10.1093/emboj/20.8.1910
   PubMed Web of Science ®Google Scholar
• Biswas G, Tang W, Sondheimer N, Guha M, Bansal S, Avadhani NG. A distinctive physiological role for IkappaBbeta in the propagation of mitochondrial respiratory stress signaling. J Biol Chem 2008; 283:12586-94; PMID:18272519; http://dx.doi.org/10.1074/jbc.M710481200
   PubMed Web of Science ®Google Scholar
• Prezant TR, Agapian JV, Bohlman MC, Bu X, Oztas S, Qiu WQ, Arnos KS, Cortopassi GA, Jaber L, Rotter JI, et al. Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness. Nat Genet 1993; 4:289-94; PMID:7689389; http://dx.doi.org/10.1038/ng0793-289
   PubMed Web of Science ®Google Scholar
• Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS. Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness. Cell 2012; 148:716-26; PMID:22341444; http://dx.doi.org/10.1016/j.cell.2011.12.027
   PubMed Web of Science ®Google Scholar
• Srinivasan S, Guha M, Dong DW, Whelan KA, Ruthel G, Uchikado Y, Natsugoe S, Nakagawa H, Avadhani NG. Disruption of cytochrome c oxidase function induces the Warburg effect and metabolic reprogramming. Oncogene 2015; 35:1585-95; PMID:26148236
   PubMed Web of Science ®Google Scholar
• MacKenzie ED, Selak MA, Tennant DA, Payne LJ, Crosby S, Frederiksen CM, Watson DG, Gottlieb E. Cell-permeating alpha-ketoglutarate derivatives alleviate pseudohypoxia in succinate dehydrogenase-deficient cells. Mol Cell Biol 2007; 27:3282-9; PMID:17325041; http://dx.doi.org/10.1128/MCB.01927-06
   PubMed Web of Science ®Google Scholar
• Jain IH, Zazzeron L, Goli R, Alexa K, Schatzman-Bone S, Dhillon H, Goldberger O, Peng J, Shalem O, Sanjana NE, et al. Hypoxia as a therapy for mitochondrial disease. Science (New York, NY) 2016; 352:54-61; PMID:26917594; doi: aad9642
   PubMedGoogle Scholar
• Kurihara T, Westenskow PD, Gantner ML, Usui Y, Schultz A, Bravo S, Aguilar E, Wittgrove C, Friedlander MS, Paris LP, et al. Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration. eLife 2016; 5; PMID:26978795; http://dx.doi.org/10.7554/eLife.14319
   PubMed Web of Science ®Google Scholar