Characterization of Ca_V1.2 exon 33 heterozygous knockout mice and negative correlation between Rbfox1 and Ca_V1.2 exon 33 expressions in human heart failure

References

• Tang ZZ, Liang MC, Lu S, Yu D, Yu CY, Yue DT, Soong TW. Transcript scanning reveals novel and extensive splice variations in human l-type voltage-gated calcium channel, Cav1.2 alpha1 subunit. J Biol Chem. 2004;279:44335–43. doi:10.1074/jbc.M407023200. PMID:15299022.
   PubMed Web of Science ®Google Scholar
• Tang ZZ, Hong X, Wang J, Soong TW. Signature combinatorial splicing profiles of rat cardiac- and smooth-muscle Cav1.2 channels with distinct biophysical properties. Cell Calcium. 2007;41:417–28. doi:10.1016/j.ceca.2006.08.002. PMID:16979758.
   PubMed Web of Science ®Google Scholar
• Tang ZZ, Liao P, Li G, Jiang FL, Yu D, Hong X, Yong TF, Tan G, Lu S, Wang J, et al. Differential splicing patterns of L-type calcium channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats. Biochim Biophys Acta. 2008;1783:118–30. doi:10.1016/j.bbamcr.2007.11.003. PMID:18070605.
   PubMedGoogle Scholar
• Liao P, Li G, Yu DJ, Yong TF, Wang JJ, Wang J, Soong TW. Molecular alteration of Ca(v)1.2 calcium channel in chronic myocardial infarction. Pflugers Arch. 2009;458:701–11. doi:10.1007/s00424-009-0652-4. PMID:19263075.
   PubMed Web of Science ®Google Scholar
• Liao P, Yu D, Li G, Yong TF, Soon JL, Chua YL, Soong TW. A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine. J Biol Chem. 2007;282:35133–42. doi:10.1074/jbc.M705478200. PMID:17916557.
   PubMedGoogle Scholar
• Cheng X, Pachuau J, Blaskova E, Asuncion-Chin M, Liu J, Dopico AM, Jaggar JH. Alternative splicing of Cav1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties. Am J Physiol Heart Circ Physiol. 2009;297:H680–8. doi:10.1152/ajpheart.00109.2009. PMID:19502562.
   PubMedGoogle Scholar
• Li G, Wang J, Liao P, Bartels P, Zhang H, Yu D, Liang MC, Poh KK, Yu CY, Jiang F, et al. Exclusion of alternative exon 33 of CaV1.2 calcium channels in heart is proarrhythmogenic. Proc Natl Acad Sci U S A. 2017;114:E4288–E95. doi:10.1073/pnas.1617205114. PMID:28490495.
   PubMed Web of Science ®Google Scholar
• Tang ZZ, Zheng S, Nikolic J, Black DL. Developmental control of CaV1.2 L-type calcium channel splicing by Fox proteins. Mol Cell Biol. 2009;29:4757–65. doi:10.1128/MCB.00608-09. PMID:19564422.
   PubMedGoogle Scholar
• Damianov A, Black DL. Autoregulation of Fox protein expression to produce dominant negative splicing factors. RNA. 2010;16:405–16. doi:10.1261/rna.1838210. PMID:20042473.
   PubMed Web of Science ®Google Scholar
• Blech-Hermoni Y, Ladd AN. RNA binding proteins in the regulation of heart development. Int J Biochem Cell Biol. 2013;45:2467–78. doi:10.1016/j.biocel.2013.08.008. PMID:23973289.
   PubMedGoogle Scholar
• Frese KS, Meder B, Keller A, Just S, Haas J, Vogel B, Fischer S, Backes C, Matzas M, Köhler D, et al. RNA splicing regulated by RBFOX1 is essential for cardiac function in zebrafish. J Cell Sci. 2015;128:3030–40. doi:10.1242/jcs.166850. PMID:26116573.
   PubMedGoogle Scholar
• Gao C, Ren S, Lee JH, Qiu J, Chapski DJ, Rau CD, Zhou Y, Abdellatif M, Nakano A, Vondriska TM, et al. RBFox1-mediated RNA splicing regulates cardiac hypertrophy and heart failure. J Clin Invest. 2016;126:195–206. doi:10.1172/JCI84015. PMID:26619120.
   PubMedGoogle Scholar
• Nutter CA, Jaworski EA, Verma SK, Deshmukh V, Wang Q, Botvinnik OB, Lozano MJ, Abass IJ, Ijaz T, Brasier AR, et al. Dysregulation of RBFOX2 Is an Early Event in Cardiac Pathogenesis of Diabetes. Cell Rep. 2016;15:2200–13. doi:10.1016/j.celrep.2016.05.002. PMID:27239029.
   PubMedGoogle Scholar
• Wei C, Qiu J, Zhou Y, Xue Y, Hu J, Ouyang K, Banerjee I, Zhang C, Chen B, Li H, et al. Repression of the Central Splicing Regulator RBFox2 Is Functionally Linked to Pressure Overload-Induced Heart Failure. Cell Rep. 2015. pii: S2211-1247(15)00141-2. doi:10.1016/j.celrep.2015.02.013.
   Web of Science ®Google Scholar
• Bogeholz N, Pauls P, Bauer BK, Schulte JS, Dechering DG, Frommeyer G, Kirchhefer U, Goldhaber JI, Müller FU, Eckardt L, et al. Suppression of Early and Late Afterdepolarizations by Heterozygous Knockout of the Na+/Ca2+ Exchanger in a Murine Model. Circ Arrhythm Electrophysiol. 2015;8:1210–8. doi:10.1161/CIRCEP.115.002927. PMID:26338832.
   PubMedGoogle Scholar
• Weiss JN, Garfinkel A, Karagueuzian HS, Chen PS, Qu Z. Early afterdepolarizations and cardiac arrhythmias. Heart Rhythm. 2010;7:1891–9. doi:10.1016/j.hrthm.2010.09.017. PMID:20868774.
   PubMed Web of Science ®Google Scholar
• Goonasekera SA, Hammer K, Auger-Messier M, Bodi I, Chen X, Zhang H, Reiken S, Elrod JW, Correll RN, York AJ, et al. Decreased cardiac L-type Ca(2)(+) channel activity induces hypertrophy and heart failure in mice. J Clin Invest. 2012;122:280–90. doi:10.1172/JCI58227. PMID:22133878.
   PubMed Web of Science ®Google Scholar
• Pragnell M, De Waard M, Mori Y, Tanabe T, Snutch TP, Campbell KP. Calcium channel beta-subunit binds to a conserved motif in the I-II cytoplasmic linker of the alpha 1-subunit. Nature 1994;368:67–70. doi:10.1038/368067a0. PMID:7509046.
   PubMed Web of Science ®Google Scholar
• Navedo MF, Cheng EP, Yuan C, Votaw S, Molkentin JD, Scott JD, Santana LF. Increased coupled gating of L-type Ca2+ channels during hypertension and Timothy syndrome. Circ Res. 2010;106:748–56. doi:10.1161/CIRCRESAHA.109.213363. PMID:20110531.
   PubMed Web of Science ®Google Scholar
• Dixon RE, Yuan C, Cheng EP, Navedo MF, Santana LF. Ca2+ signaling amplification by oligomerization of L-type Cav1.2 channels. Proc Natl Acad Sci U S A. 2012;109:1749–54. doi:10.1073/pnas.1116731109. PMID:22307641.
   PubMedGoogle Scholar
• Kuroyanagi H. Fox-1 family of RNA-binding proteins. Cell Mol Life Sci. 2009;66:3895–907. doi:10.1007/s00018-009-0120-5. PMID:19688295.
   PubMed Web of Science ®Google Scholar
• Chen X, Piacentino V, 3rd, Furukawa S, Goldman B, Margulies KB, Houser SR. L-type Ca2+ channel density and regulation are altered in failing human ventricular myocytes and recover after support with mechanical assist devices. Circ Res. 2002;91:517–24. doi:10.1161/01.RES.0000033988.13062.7C. PMID:12242270.
   PubMed Web of Science ®Google Scholar