1,383
Views
10
CrossRef citations to date
0
Altmetric
Autocommentary

ENT3 utilizes a pH Sensing Mechanism for Transport

&
Pages 78-80 | Received 30 Sep 2017, Accepted 03 Oct 2017, Published online: 15 Nov 2017

References

  • Hsu CL, Lin W, Seshasayee D, Chen YH, Ding X, Lin Z, Suto E, Huang Z, Lee WP, Park H, et al. Equilibrative nucleoside transporter 3 deficiency perturbs lysosome function and macrophage homeostasis. Science. 2012;335:89-92. doi:10.1126/science.1213682. PMID:22174130.
  • Govindarajan R, Leung GP, Zhou M, Tse CM, Wang J, Unadkat JD. Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3. Am J Physiol Gastrointest Liver Physiol. 2009;296:G910-922. doi:10.1152/ajpgi.90672.2008. PMID:19164483.
  • Bissa B, Beedle AM, Govindarajan R. Lysosomal solute carrier transporters gain momentum in research. Clin Pharmacol Ther. 2016;100:431-6. doi:10.1002/cpt.450. PMID:27530302.
  • Rahman MF, Askwith C, Govindarajan R. Molecular determinants of acidic pH-dependent transport of human equilibrative nucleoside transporter 3. J Biol Chem. 2017;292:14775-85. doi:10.1074/jbc.M117.787952. PMID:28729424.
  • Baldwin SA, Yao SY, Hyde RJ, Ng AM, Foppolo S, Barnes K, Ritzel MW, Cass CE, Young JD. Functional characterization of novel human and mouse equilibrative nucleoside transporters (hENT3 and mENT3) located in intracellular membranes. J Biol Chem. 2005;280:15880-87. doi:10.1074/jbc.M414337200. PMID:15701636.
  • Porcelli AM, Ghelli A, Zanna C, Pinton P, Rizzuto R, Rugolo M. pH difference across the outer mitochondrial membrane measured with a green fluorescent protein mutant. Biochem Biophys Res Commun. 2005;326, 799-804. doi:10.1016/j.bbrc.2004.11.105. PMID:15607740.
  • Vural S, Ertop P, Durmaz CD, Şanlı H, Okçu Heper A, Kundakçı N, Karabulut HG, Ilgın Ruhi H. Skin-Dominant Phenotype in a Patient with H Syndrome: Identification of a Novel Mutation in the SLC29A3 Gene. Cytogenet Genome Res. 2017;151:186-90. doi:10.1159/000475908. PMID:28554179.
  • Kang N, Jun AH, Bhutia YD, Kannan N, Unadkat JD, and Govindarajan R. Human equilibrative nucleoside transporter-3 (hENT3) spectrum disorder mutations impair nucleoside transport, protein localization, and stability. J Biol Chem. 2010;285:28343-52. doi:10.1074/jbc.M110.109199. PMID:20595384.