Mechanism of carvedilol induced action potential and calcium alternans

References

• Chinitz JS, Vaishnava P, Narayan RL, et al. Atrial fibrillation through the years: contemporary evaluation and management. Circulation. 2013;127(3):408–416.
   PubMed Web of Science ®Google Scholar
• Kulkarni K, Walton RD, Armoundas AA, et al. Clinical potential of beat-to-beat diastolic interval control in preventing cardiac arrhythmias. J Am Heart Assoc. 2011;10(11):e020750.
   Google Scholar
• Edwards JN, Blatter LA. Cardiac alternans and intracellular calcium cycling. Clin Exp Pharmacol Physiol. 2014;23:1–7.
   Google Scholar
• Weiss JN, Nivala M, Garfinkel A, et al. Alternans and arrhythmias : from cell to heart. Circ Res. 2011;108(1):98–112.
   PubMed Web of Science ®Google Scholar
• Liu T, Xiong F, Qi XY, et al. Altered calcium handling produces reentry-promoting action potential alternans in atrial fibrillation-remodeled hearts. JCI Insight. 2020;5(8):e133754.
   Web of Science ®Google Scholar
• Uzelac I, Ji YC, Hornung D, et al. Simultaneous quantification of spatially discordant alternans in voltage and intracellular calcium in Langendorff-perfused rabbit hearts and inconsistencies with models of cardiac action potentials and Ca transients. Front Physiol. 2017;8:1–14.
   PubMed Web of Science ®Google Scholar
• Zhao N, Li Q, Zhang K, et al. Heart failure-induced atrial remodelling promotes electrical and conduction alternans. PLoS Comput Biol. 2020;16(7):1–24.
   Web of Science ®Google Scholar
• Jordan PN, Christini DJ. Characterizing the contribution of voltage- and calcium-dependent coupling to action potential stability: implications for repolarization alternans. Am J Physiol - Heart Circ Physiol. 2007;293:H2109–H2118.
   PubMed Web of Science ®Google Scholar
• Kanaporis G, Blatter LA. The mechanisms of calcium cycling and action potential dynamics in cardiac alternans. Circ Res. 2015;116:846–856.
   PubMed Web of Science ®Google Scholar
• Kanaporis G, Kalik ZM, Blatter LA. Action potential shortening rescues atrial calcium alternans. J Physiol. 2019;597(3):723–740.
   Web of Science ®Google Scholar
• Pruvot EJ, Katra RP, Rosenbaum DS, et al. Role of calcium cycling versus restitution in the mechanism of repolarization alternans. Circulation Research. 2004;94(8):1083–1090.
   PubMed Web of Science ®Google Scholar
• Farrell MH, Foody JM, Krumholz HM. Beta-blockers in heart failure: Clinical applications. JAMA. 2002;287:890–897.
   PubMed Web of Science ®Google Scholar
• Hove-Madsen L, Llach A, Bayes-Genís A, et al. Atrial fibrillation is associated with increased spontaneous calcium release from the sarcoplasmic reticulum in human atrial myocytes. Circulation. 2004;110:1358–1363.
   PubMed Web of Science ®Google Scholar
• Yao A, Kohmoto O, Oyama T, et al. Characteristic Effects of Alpha1-Beta1,2 Adrenergic Blocking Agent, Carvedilol, on [Ca2+]i in Ventricular Myocytes Compared With Those of Timolol and Atenolol. Circ J. 2003;67(1):83–90.
   PubMed Web of Science ®Google Scholar
• Martinez-Hernandez E, Blatter LA. Effect of carvedilol on atrial excitation-contraction coupling, Ca2+ release, and arrhythmogenicity. Am J Physiol - Heart Circ Physiol. 2020;318:H1245–H1255.
   PubMed Web of Science ®Google Scholar
• Zhou Q, Xiao J, Jiang D, et al. Carvedilol and its new analogs suppress arrhythmogenic store overload–induced Ca2+ release. Nat Med. 2011;17(8):1003–1009.
   PubMed Web of Science ®Google Scholar
• De Diego C, Pai RK, Dave AS, et al. Spatially discordant alternans in cardiomyocyte monolayers. Am J Physiol - Heart Circ Physiol. 2008;294:1417–1425.
   Web of Science ®Google Scholar
• Escobar AL, Valdivia HH. Cardiac alternans and ventricular fibrillation: a bad case of ryanodine receptors reneging on their duty. Circ Res. 2014;114(9):1369–1371.
   PubMed Web of Science ®Google Scholar
• Shkryl VM, Maxwell JT, Domeier TL, et al. Refractoriness of sarcoplasmic reticulum Ca2+ release determines Ca2+ alternans in atrial myocytes. Am J Physiol - Heart Circ Physiol. 2012;302(11):H2310–H2320.
   PubMed Web of Science ®Google Scholar
• Sun B, Wei J, Zhong X, et al. The cardiac ryanodine receptor, but not sarcoplasmic reticulum Ca2+-ATPase, is a major determinant of Ca2+ alternans in intact mouse hearts. J Biol Chem. 2018;293(35):13650–13661.
   PubMed Web of Science ®Google Scholar
• Wang L, Myles RC, De Jesus NM, et al. Optical mapping of sarcoplasmic reticulum Ca2+ in the intact heart. Circ Res. 2014;114(9):1410–1421.
   PubMed Web of Science ®Google Scholar
• Weiss JN, Karma A, Shiferaw Y, et al. From pulsus to pulseless: the saga of cardiac alternans. Circ Res. 2006;98(10):1244–1253.
   PubMed Web of Science ®Google Scholar
• Zhong X, Sun B, Vallmitjana A, et al. Suppression of ryanodine receptor function prolongs Ca2+ release refractoriness and promotes cardiac alternans in intact hearts. Biochem J. 2016;473(21):3951–3964.
   PubMedGoogle Scholar
• Hüser J, Wang YG, Sheehan KA, et al. Functional coupling between glycolysis and excitation-contraction coupling underlies alternans in cat heart cells. J Physiol. 2000;524:795–806.
   PubMed Web of Science ®Google Scholar
• Kanaporis G, Blatter LA. Membrane potential determines calcium alternans through modulation of SR Ca2+ load and L-type Ca2+ current. J Mol Cell Cardiol. 2017;105:49–58.
   PubMed Web of Science ®Google Scholar
• Colman MA. The multiple mechanisms of spatially discordant alternans in the heart. Biophys J. 2020;118(10):2336–2338.
   PubMed Web of Science ®Google Scholar
• Hernández-Romero I, Guillem MS, Figuera C, et al. Optical imaging of voltage and calcium in isolated hearts: linking spatiotemporal heterogeneities and ventricular fibrillation initiation. PLoS One. 2019;14(5):1–15.
   Web of Science ®Google Scholar
• Goldhaber JI, Xie LH, Duong T, et al. Action potential duration restitution and alternans in rabbit ventricular myocytes: the key role of intracellular calcium cycling. Circ Res. 2005;96:459–466.
   PubMed Web of Science ®Google Scholar
• Knollmann BC, Schober T, Petersen AO, et al. Action potential characterization in intact mouse heart: steady-state cycle length dependence and electrical restitution. Am J Physiol - Heart Circ Physiol. 2007;292:H614–H621.
   PubMed Web of Science ®Google Scholar
• Parikh A, Patel D, McTiernan CF, et al. Relaxin suppresses atrial fibrillation by reversing fibrosis and myocyte hypertrophy and increasing conduction velocity and sodium current in spontaneously hypertensive rat hearts. Circ Res. 2013;113:313–321.
   PubMed Web of Science ®Google Scholar
• Cice G, Ferrara L, Andrea AD, et al. Carvedilol increases two-year survival in dialysis patients with dilated cardiomyopathy. J Am Coll Cardiol. 2003;41(9):3–9.
   Web of Science ®Google Scholar
• Packer M, Bristow MR, Cohn JN, et al. The effect of carvedilol on morbidity and mortality in patients with chronic heart failure. N Engl J Med. 1996;334(21):1349–1355.
   PubMed Web of Science ®Google Scholar
• Stoschitzky K, Koshucharova G, Zweiker R, et al. Differing beta-blocking effects of carvedilol and metoprolol. Eur J Heart Fail. 2001;3(3):343–349.
   PubMed Web of Science ®Google Scholar
• Diogo CV, Deus CM, Lebiedzinska-Arciszewska M, et al. Carvedilol and antioxidant proteins in a type I diabetes animal model. Eur J Clin Invest. 2017;47(1):19–29.
   PubMed Web of Science ®Google Scholar
• Yue TL, Cheng HY, Lysko PG, et al. Carvedilol, a new vasodilator and beta adrenoceptor antagonist, is an antioxidant and free radical scavenger. J Pharmacol Exp Ther. 1992;263(1):92–98.
   PubMed Web of Science ®Google Scholar
• Ohlstein EH, Douglas SA, Sung CPO, et al. Carvedilol, a cardiovascular drug, prevents vascular smooth muscle cell proliferation, migration, and neointimal formation following vascular injury. Proc Natl Acad Sci USA. 1993;90:6189–6193.
   PubMed Web of Science ®Google Scholar
• Qu Z, Weiss JN. The chicken or the egg? Voltage and calcium dynamics in the heart. Am J Physiol - Heart Circ Physiol. 2007;293(4):H2054–H2055.
   PubMed Web of Science ®Google Scholar
• Walker ML. Repolarization alternans: implications for the mechanism and prevention of sudden cardiac death. Cardiovasc Res. 2003;57(3):599–614.
   PubMed Web of Science ®Google Scholar
• Jordan PN, Christini DJ. Action potential morphology influences intracellular calcium handling stability and the occurrence of alternans. Biophys J. 2006;90:672–680.
   PubMed Web of Science ®Google Scholar
• Tóth N, Szlovák J, Kohajda Z, et al. The development of L-type Ca2+ current mediated alternans does not depend on the restitution slope in canine ventricular myocardium. Scientific Reports. 2021;11(1):16652.
   PubMed Web of Science ®Google Scholar
• Cui X, Rovetti RJ, Yang L, et al. Period-doubling bifurcation in an array of coupled stochastically-excitable elements subjected to global periodic forcing. Phys Rev Lett. 2009;103:044102.
   PubMed Web of Science ®Google Scholar
• Nivala M, Qu Z. Calcium alternans in a couplon network model of ventricular myocytes: role of sarcoplasmic reticulum load. Am J Physiol - Heart Circ Physiol. 2012 Epub 2012 Jun 1;303:H341–H352.
   PubMed Web of Science ®Google Scholar
• Qu Z, Nivala NM, Weiss JN. Calcium alternans in cardiac myocytes: order from disorder. J Mol Cell Cardiol. 2013;58:100–109.
   PubMed Web of Science ®Google Scholar
• Rovetti R, Cui X, Garfinkel A, et al. Spark-induced Sparks as a mechanism of intracellular calcium alternans in cardiac myocytes. Circ Res. 2010;106(10):1582–1591.
   PubMed Web of Science ®Google Scholar
• Chudin E, Goldhaber J, Garfinkel A, et al. Intracellular Ca2+ Dynamics and the Stability of Ventricular Tachycardia. Biophys J. 1999;77(6):2930–2941.
   PubMed Web of Science ®Google Scholar
• Sham JSK, Song L-S, Chen Y, et al. Termination of Ca2+ release by a local inactivation of ryanodine receptors in cardiac myocytes. Proc Natl Acad Sci USA. 1998;95(25):15096–15101.
   PubMed Web of Science ®Google Scholar
• Alvarez-Lacalle E, Cantalapiedra IR, Peñaranda A, et al. Dependency of calcium alternans on ryanodine receptor refractoriness. PLoS One. 2013;8(2):e55042.
   PubMed Web of Science ®Google Scholar
• Cantalapiedra IR, Alvarez-Lacalle E, Peñaranda A, et al. Minimal model for calcium alternans due to SR release refractoriness. Chaos. 2017;27(9):093928.
   Web of Science ®Google Scholar
• Lugo CA, Cantalapiedra IR, Peñaranda A, et al. Are SR Ca content fluctuations or SR refractoriness the key to atrial cardiac alternans?: insights from a human atrial model. Am J Physiol - Heart Circ Physiol. 2014;306:H1540–H1552.
   PubMed Web of Science ®Google Scholar
• Cheng J, Niwa R, Kamiya K, et al. Carvedilol blocks the repolarizing K+ currents and the L-type Ca2+ current in rabbit ventricular myocytes. Eur J Pharmacol. 1999;376(1-2):189–201.
   Web of Science ®Google Scholar
• Deng C, Rao F, Wu S, et al. Pharmacological effects of carvedilol on T-type calcium current in murine HL-1 cells. Eur J Pharmacol. 2009;621(1–3):19–25.
   PubMed Web of Science ®Google Scholar
• Nakajima T, Ma J, Iida H, et al. Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells. Jpn Heart J. 2003;44:963–978.
   PubMedGoogle Scholar
• Atkin TA, Maher CM, Gerlach AC, et al. A comprehensive approach to identifying repurposed drugs to treat SCN8A epilepsy. Epilepsia. 2018;59:802–813.
   PubMed Web of Science ®Google Scholar
• Bankston JR, Kass RS. Molecular determinants of local anesthetic action of beta-blocking drugs : implications for therapeutic management of long QT syndrome variant 3. J Mol Cell Cardiol. 2010;48:246–253.
   PubMed Web of Science ®Google Scholar
• Tashiro M, Watanabe Y, Yamakawa T, et al. Suppressive effect of carvedilol on Na+/Ca2+ exchange current in isolated guinea-pig cardiac ventricular myocytes. Pharmacology. 2017;99(1–2):40–47.
   PubMed Web of Science ®Google Scholar
• Deng C, Yu X, Kuang S, et al. Effects of carvedilol on transient outward and ultra-rapid delayed rectifier potassium currents in human atrial myocytes. Life Sci. 2007;80(7):665–671.
   PubMed Web of Science ®Google Scholar
• Karle CA, Kreye VA, Thomas D, et al. Antiarrhythmic drug carvedilol inhibits HERG potassium channels. Cardiovasc Res. 2001;49:361–370.
   PubMed Web of Science ®Google Scholar
• Florea SM, Blatter LA. Regulation of cardiac alternans by β-adrenergic signaling pathways. Am J Physiol - Heart Circ Physiol. 2012;303:H1047–H1056.
   PubMed Web of Science ®Google Scholar
• Senior R, Müller-Beckmann B, DasGupta P, et al. Effects of carvedilol on ventricular arrhythmias. J Cardiovasc Pharmacol. 1992;19(Supplement 1):17–21.
   PubMedGoogle Scholar