Channels, Volume 16, Issue 1 (2022)

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Channels, Volume 16, Issue 1 (2022)

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Brief Report

Brief Report
Small molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats
Jiahe Li, Harrison J. Stratton, Sabina A. Lorca, Peter M. Grace & Rajesh Khanna
Pages: 1-8
Published online: 05 Jan 2022
AbstractforSmall molecule targeting NaV1.7 via inhibition of the CRMP2-Ubc9 interaction reduces pain in chronic constriction injury (CCI) rats | Full Text | References | PDF (546.5 KB) | EPUB
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Research Paper

Article
Capsaicin as an amphipathic modulator of NaV1.5 mechanosensitivity
Luke M. Cowan, Peter R. Strege, Radda Rusinova, Olaf S. Andersen, Gianrico Farrugia & Arthur Beyder
Pages: 9-26
Published online: 12 Apr 2022
AbstractforCapsaicin as an amphipathic modulator of NaV1.5 mechanosensitivity | Full Text | References | PDF (6.6 MB) | EPUB
  • 2175 Views
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Review

Review Article
A SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC)
Eric E. Figueroa & Jerod S. Denton
Pages: 27-36
Published online: 03 Feb 2022
AbstractforA SWELL time to develop the molecular pharmacology of the volume-regulated anion channel (VRAC) | Full Text | References | PDF (798 KB) | EPUB
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Research Paper

Article
Clinical and molecular characteristics of myotonia congenita in China: Case series and a literature review
Yifan Li, Mao Li, Zhenfu Wang, Fei Yang, Hongfen Wang, Xiujuan Bai, Bo Sun, Siyu Chen & Xusheng Huang
Pages: 35-46
Published online: 16 Feb 2022
AbstractforClinical and molecular characteristics of myotonia congenita in China: Case series and a literature review | Full Text | References | PDF (1.1 MB) | EPUB
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Commentary

Article Commentary
Bibliometric analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN)channels research (2004-2020)
Chuanxi Tian, Xueping Zhu, Qiuyuan Wang, Tianyi Lv, Siyi Cheng & Daowen Yang
Pages: 49-59
Published online: 02 Mar 2022
First Page PreviewforBibliometric analysis of hyperpolarization-activated cyclic nucleotide-gated (HCN)channels research (2004-2020) | Full Text | References | PDF (1.9 MB) | EPUB
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Commentary and Views

Article Commentary
AMP-activated protein kinase(AMPK) channel: A Global Bibliometric analysis From 2012 to 2021
Tianyi Lyu, Chuanxi Tian, Tianyang Tan, Jiaxuan Lyu, Kang Yan, Xirui Zhao, Ruoshui Wang, Chaoyang Zhang, Meng Liu & Yulong Wei
Pages: 60-71
Published online: 21 Mar 2022
AbstractforAMP-activated protein kinase(AMPK) channel: A Global Bibliometric analysis From 2012 to 2021 | Full Text | References | PDF (3.4 MB) | EPUB
  • 3142 Views
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Open Access

Research Paper

Article
Effects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V
Xu Dehong, Wu Wenmei, Hong Siqin, Zeng Peng, Wang Xianchun & Zeng Xiongzhi
Pages: 72-83
Published online: 04 Apr 2022
AbstractforEffects of JZTX-V on the wild type Kv4.3 Expressed in HEK293T and Molecular Determinants in the Voltage-sensing Domains of Kv4.3 Interacting with JZTX-V | Full Text | References | PDF (5.1 MB) | EPUB
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Article
Integrative analysis of TRPV family to prognosis and immune infiltration in renal clear cell carcinoma
Zixuan Gong, Jiaheng Xie, Liang Chen, Qikai Tang, Yiming Hu, Aiming Xu & Zengjun Wang
Pages: 84-96
Published online: 07 Apr 2022
AbstractforIntegrative analysis of TRPV family to prognosis and immune infiltration in renal clear cell carcinoma | Full Text | References | PDF (13.4 MB) | EPUB | Supplemental
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Open Access
Article
Mechanism of carvedilol induced action potential and calcium alternans
Elizabeth Martinez-Hernandez, Giedrius Kanaporis & Lothar A. Blatter
Pages: 97-112
Published online: 02 May 2022
AbstractforMechanism of carvedilol induced action potential and calcium alternans | Full Text | References | PDF (1.4 MB) | EPUB
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Article
Hippocampus-related cognitive disorders develop in the absence of epilepsy and ataxia in the heterozygous Cacna1a mutant mice tottering
Akito Nakao, Katsumi Hayashida, Hiroo Ogura, Yasuo Mori & Keiji Imoto
Pages: 113-126
Published online: 12 May 2022
AbstractforHippocampus-related cognitive disorders develop in the absence of epilepsy and ataxia in the heterozygous Cacna1a mutant mice tottering | Full Text | References | PDF (1.8 MB) | EPUB
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Article
Piezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes
Zhongcheng Liu, Yuchen Tang, Liangzhi He, Bin Geng, Fan Lu, Jinwen He, Qiong Yi, Xuening Liu, Kun Zhang, Lifu Wang, Yayi Xia & Jin Jiang
Pages: 127-136
Published online: 27 Jun 2022
AbstractforPiezo1-mediated fluid shear stress promotes OPG and inhibits RANKL via NOTCH3 in MLO-Y4 osteocytes | Full Text | References | PDF (3.1 MB) | EPUB | Supplemental
  • 2841 Views
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Open Access
Article
Rab35 GTPase positively regulates endocytic recycling of cardiac KATP channels
Bo Yang, Jia-Lu Yao, Jian-Yi Huo, Yu-Long Feng, William A. Coetzee, Guang-Yin Xu & Hua-Qian Yang
Pages: 137-147
Published online: 27 Jun 2022
AbstractforRab35 GTPase positively regulates endocytic recycling of cardiac KATP channels | Full Text | References | PDF (2.8 MB) | EPUB | Supplemental
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Brief Report

Brief Report
Genetic and cellular characterization of MscS-like putative channels in the filamentous fungus Aspergillus nidulans
Mariangela Dionysopoulou, Nana Yan, Bolin Wang, Christos Pliotas & George Diallinas
Pages: 148-158
Published online: 08 Aug 2022
AbstractforGenetic and cellular characterization of MscS-like putative channels in the filamentous fungus Aspergillus nidulans | Full Text | References | PDF (5.5 MB) | EPUB | Supplemental
  • 1834 Views
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Research Paper

Article
Piezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis
Yanjie Xiong, Liru Dong, Yun Bai, Hui Tang, Shuang Li, Dan Luo, Fang Liu, Jie Bai, Shikun Yang & Xudong Song
Pages: 159-166
Published online: 08 Aug 2022
AbstractforPiezo1 activation facilitates ovarian cancer metastasis via Hippo/YAP signaling axis | Full Text | References | PDF (3.5 MB) | EPUB | Supplemental
  • 3009 Views
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Brief Report

Brief Report
Cardiogenic shock due to yew poisoning rescued by VA-ECMO: case report and literature review
Nikolaus Schreiber, Martin Manninger, Sascha Pätzold, Alexander C. Reisinger, Stefan Hatzl, Gerald Hackl, Christoph Högenauer & Philipp Eller
Pages: 167-172
Published online: 08 Aug 2022
AbstractforCardiogenic shock due to yew poisoning rescued by VA-ECMO: case report and literature review | Full Text | References | PDF (8.4 MB) | EPUB
  • 1720 Views
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Research Paper

Article
Exploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers
Thomas W. Comollo, Xinle Zou, Chuangeng Zhang, Divya Kesters, Thomas Hof, Kevin J. Sampson & Robert S. Kass
Pages: 173-184
Published online: 10 Aug 2022
AbstractforExploring mutation specific beta blocker pharmacology of the pathogenic late sodium channel current from patient-specific pluripotent stem cell myocytes derived from long QT syndrome mutation carriers | Full Text | References | PDF (2.4 MB) | EPUB | Supplemental
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Review

Review Article
Non-conducting functions of ion channels: The case of integrin-ion channel complexes
Elena Forzisi & Federico Sesti
Pages: 185-197
Published online: 08 Aug 2022
AbstractforNon-conducting functions of ion channels: The case of integrin-ion channel complexes | Full Text | References | PDF (1.7 MB) | EPUB
  • 1738 Views
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Review Article
Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels
Aida Calderon-Rivera, Santiago Loya-Lopez, Kimberly Gomez & Rajesh Khanna
Pages: 198-215
Published online: 26 Aug 2022
AbstractforPlant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels | Full Text | References | PDF (1.8 MB) | EPUB
  • 2372 Views
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Review
Pleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters
Sharon R. Stevens & Matthew N. Rasband
Pages: 216-229
Published online: 08 Sep 2022
AbstractforPleiotropic Ankyrins: Scaffolds for Ion Channels and Transporters | Full Text | References | PDF (1.5 MB) | EPUB
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Research Paper

Article
Association of respiratory failure with inhibition of NaV1.6 in the phrenic nerve
Rebecca M. Klein, Mark E. Layton, Hillary Regan, Christopher P. Regan, Yuxing Li, Tracey Filzen, Matt Cato, Michelle K. Clements, Jixin Wang, Raul Sanoja, Thomas J. Greshock, Anthony J. Roecker, Joseph E. Pero, Ron Kim, Christopher Burgey, Christopher T. John, Ying-Hong Wang, Neetesh Bhandari, Arie Struyk, Richard L. Kraus, Darrell A. Henze & Andrea K. Houghton
Pages: 230-243
Published online: 14 Oct 2022
AbstractforAssociation of respiratory failure with inhibition of NaV1.6 in the phrenic nerve | Full Text | References | PDF (1 MB) | EPUB | Supplemental
  • 1288 Views
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