Plant and fungi derived analgesic natural products targeting voltage-gated sodium and calcium channels

References

• Jones AW. Early drug discovery and the rise of pharmaceutical chemistry. Drug Test Anal. 2011;3:337–344.
   PubMed Web of Science ®Google Scholar
• Geck MS, Lecca D, Marchese G, et al. Ethnomedicine and neuropsychopharmacology in Mesoamerica. J Ethnopharmacol. 2021;278:114243.
   PubMed Web of Science ®Google Scholar
• Ramsey JT, Shropshire BC, Nagy TR, et al. Essential oils and health. Yale J Biol Med. 2020;93:291–305.
   PubMed Web of Science ®Google Scholar
• Rivera D, Obon C, Inocencio C, et al. The ethnobotanical study of local Mediterranean food plants as medicinal resources in Southern Spain. J Physiol Pharmacol. 2005;56(Suppl 1):97–114.
   PubMedGoogle Scholar
• Wang WY, Zhou H, Wang YF, et al. Current policies and measures on the development of traditional Chinese medicine in China. Pharmacol Res. 2021;163:105187.
   PubMed Web of Science ®Google Scholar
• Lans C. Possible similarities between the folk medicine historically used by first nations and American Indians in North America and the ethnoveterinary knowledge currently used in British Columbia, Canada. J Ethnopharmacol. 2016;192:53–66.
   PubMed Web of Science ®Google Scholar
• Zeb M, Lee CH. Medicinal properties and bioactive compounds from wild mushrooms native to North America. Molecules. 2021;26. DOI:10.3390/molecules27010026
   PubMedGoogle Scholar
• Brune K. Next generation of everyday analgesics. Am J Ther. 2002;9:215–223.
   PubMedGoogle Scholar
• Korner J, Albani S, Sudha Bhagavath Eswaran V, et al. Sodium channels and local anesthetics-old friends with new perspectives. Front Pharmacol. 2022;13:837088.
   PubMed Web of Science ®Google Scholar
• Ekor M. The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Front Pharmacol. 2014;4:177.
   PubMed Web of Science ®Google Scholar
• Patridge E, Gareiss P, Kinch MS, et al. An analysis of FDA-approved drugs: natural products and their derivatives. Drug Discov Today. 2016;21:204–207.
   PubMed Web of Science ®Google Scholar
• Newman DJ, Cragg GM. Natural products as sources of new drugs from 1981 to 2014. J Nat Prod. 2016;79:629–661.
   PubMed Web of Science ®Google Scholar
• Smith MC, Gestwicki JE. Features of protein-protein interactions that translate into potent inhibitors: topology, surface area and affinity. Expert Rev Mol Med. 2012;14:e16.
   PubMed Web of Science ®Google Scholar
• Arkin MR, Whitty A. The road less traveled: modulating signal transduction enzymes by inhibiting their protein-protein interactions. Curr Opin Chem Biol. 2009;13:284–290.
   PubMed Web of Science ®Google Scholar
• Thiel P, Kaiser M, Ottmann C. Small-molecule stabilization of protein-protein interactions: an underestimated concept in drug discovery? Angew Chem Int Ed Engl. 2012;51:2012–2018.
   PubMed Web of Science ®Google Scholar
• Skerratt SE, West CW. Ion channel therapeutics for pain. Channels (Austin). 2015;9:344–351.
   PubMed Web of Science ®Google Scholar
• Catterall WA, Lenaeus MJ, Gamal El-Din TM. Structure and pharmacology of voltage-gated sodium and calcium channels. Annu Rev Pharmacol Toxicol. 2020;60:133–154.
   PubMed Web of Science ®Google Scholar
• Bourinet E, Altier C, Hildebrand ME, et al. Calcium-permeable ion channels in pain signaling. Physiol Rev. 2014;94:81–140.
   PubMed Web of Science ®Google Scholar
• Bennett DL, Clark AJ, Huang J, et al. The role of voltage-gated sodium channels in pain signaling. Physiol Rev. 2019;99:1079–1151.
   PubMed Web of Science ®Google Scholar
• Ahern CA, Payandeh J, Bosmans F, et al. The hitchhiker’s guide to the voltage-gated sodium channel galaxy. J Gen Physiol. 2016;147:1–24.
   PubMed Web of Science ®Google Scholar
• Bagal SK, Marron BE, Owen RM, et al. Voltage gated sodium channels as drug discovery targets. Channels (Austin). 2015;9:360–366.
   PubMed Web of Science ®Google Scholar
• Fleckenstein A. History of calcium antagonists. Circ Res. 1983;52:I3–16.
   PubMed Web of Science ®Google Scholar
• Godfraind T. Discovery and development of calcium channel blockers. Front Pharmacol. 2017;8:286.
   PubMed Web of Science ®Google Scholar
• Simms BA, Zamponi GW. Neuronal voltage-gated calcium channels: structure, function, and dysfunction. Neuron. 2014;82:24–45.
   PubMed Web of Science ®Google Scholar
• Catterall WA. Voltage-gated calcium channels. Cold Spring Harb Perspect Biol. 2011;3:a003947.
   PubMed Web of Science ®Google Scholar
• Perez-Reyes E. Molecular physiology of low-voltage-activated t-type calcium channels. Physiol Rev. 2003;83:117–161.
   PubMed Web of Science ®Google Scholar
• Zamponi GW, Striessnig J, Koschak A, et al. The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential. Pharmacol Rev. 2015;67:821–870.
   PubMed Web of Science ®Google Scholar
• Cai S, Gomez K, Moutal A, et al. Targeting T-type/CaV3.2 channels for chronic pain. Transl Res. 2021;234:20–30.
   PubMed Web of Science ®Google Scholar
• Park CK, Li HY, Yeon KY, et al. Eugenol inhibits sodium currents in dental afferent neurons. J Dent Res. 2006;85:900–904.
   PubMed Web of Science ®Google Scholar
• Lionnet L, Beaudry F, Vachon P. Intrathecal eugenol administration alleviates neuropathic pain in male Sprague-Dawley rats. Phytother Res. 2010;24:1645–1653.
   PubMed Web of Science ®Google Scholar
• Shen CL, Wang R, Ji G, et al. Dietary supplementation of gingerols- and shogaols-enriched ginger root extract attenuate pain-associated behaviors while modulating gut microbiota and metabolites in rats with spinal nerve ligation. J Nutr Biochem. 2022;100:108904.
   PubMed Web of Science ®Google Scholar
• Vaisman N, Griffiths A, Pencharz PB. Comparison of nitrogen utilization of two elemental diets in patients with Crohn’s disease. J Pediatr Gastroenterol Nutr. 1988;7:84–88.
   PubMed Web of Science ®Google Scholar
• Sanna MD, Les F, Lopez V, et al. Lavender (Lavandula angustifolia mill.) essential oil alleviates neuropathic pain in mice with spared nerve injury. Front Pharmacol. 2019;10:472.
   PubMed Web of Science ®Google Scholar
• Schuwald AM, Noldner M, Wilmes T, et al. Lavender oil-potent anxiolytic properties via modulating voltage dependent calcium channels. PLoS One. 2013;8:e59998.
   PubMed Web of Science ®Google Scholar
• Kasper S, Gastpar M, Muller WE, et al. Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial. Int Clin Psychopharmacol. 2010;25:277–287.
   PubMed Web of Science ®Google Scholar
• Kasper S. An orally administered Lavandula oil preparation (Silexan) for anxiety disorder and related conditions: an evidence based review. Int J Psychiatry Clin Pract. 2013;17(Suppl 1):15–22.
   PubMedGoogle Scholar
• Francois-Moutal L, Wang Y, Moutal A, et al. A membrane-delimited N-myristoylated CRMP2 peptide aptamer inhibits CaV2.2 trafficking and reverses inflammatory and postoperative pain behaviors. Pain. 2015;156:1247–1264.
   PubMed Web of Science ®Google Scholar
• Gong CL, Wong KL, Cheng KS, et al. Inhibitory effects of magnolol on voltage-gated Na+ and K+ channels of NG108-15 cells. Eur J Pharmacol. 2012;682:73–78.
   PubMed Web of Science ®Google Scholar
• Revuelta M, Urrutia J, Villarroel A, et al. Microglia-mediated inflammation and neural stem cell differentiation in Alzheimer’s disease: possible therapeutic role of KV1.3 channel blockade. Front Cell Neurosci. 2022;16:868842.
   PubMed Web of Science ®Google Scholar
• Guo S, Li P, Fu B, et al. Systems-biology dissection of mechanisms and chemical basis of herbal formula in treating chronic myocardial ischemia. Pharmacol Res. 2016;114:196–208.
   PubMed Web of Science ®Google Scholar
• Yang X, Dai Y, Ji Z, et al. Allium macrostemon Bunge. exerts analgesic activity by inhibiting NaV1.7 channel. J Ethnopharmacol. 2021;281:114495.
   PubMed Web of Science ®Google Scholar
• Krames ES. The role of the dorsal root ganglion in the development of neuropathic pain. Pain Med. 2014;15:1669–1685.
   PubMed Web of Science ®Google Scholar
• Sekiguchi F, Fujita T, Deguchi T, et al. Blockade of T-type calcium channels by 6-prenylnaringenin, a hop component, alleviates neuropathic and visceral pain in mice. Neuropharmacology. 2018;138:232–244.
   PubMed Web of Science ®Google Scholar
• Zhang J, Chen Y, Yang J, et al. Electrophysiological and trafficking defects of the SCN5A T353I mutation in Brugada syndrome are rescued by alpha-allocryptopine. Eur J Pharmacol. 2015;746:333–343.
   PubMed Web of Science ®Google Scholar
• Chen H, Tian B, Fang X, et al. Injectable erythrocyte gel loaded with bulleyaconitine a for the treatment of rheumatoid arthritis. ACS Biomater Sci Eng. 2021;7:5706–5716.
   PubMed Web of Science ®Google Scholar
• Wang CF, Gerner P, Wang SY, et al. Bulleyaconitine A isolated from aconitum plant displays long-acting local anesthetic properties in vitro and in vivo. Anesthesiology. 2007;107:82–90.
   PubMed Web of Science ®Google Scholar
• Aramwit P, Porasuphatana S, Srichana T, et al. Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity. Nanoscale Res Lett. 2015;10:152.
   PubMed Web of Science ®Google Scholar
• Jiang Q, Lou Z, Wang H, et al. Antimicrobial effect and proposed action mechanism of cordycepin against Escherichia coli and Bacillus subtilis. J Microbiol. 2019;57:288–297.
   PubMed Web of Science ®Google Scholar
• Liu W, Zhang L, Sun S, et al. Cordycepin inhibits inflammatory responses through suppression of ERK activation in zebrafish. Dev Comp Immunol. 2021;124:104178.
   PubMed Web of Science ®Google Scholar
• Dong XP, Xu TL. Radix paeoniae rubra suppression of sodium current in acutely dissociated rat hippocampal CA1 neurons. Brain Res. 2002;940:1–9.
   PubMed Web of Science ®Google Scholar
• Liu ZB, Liu C, Zeng B, et al. Modulation effects of cordycepin on voltage-gated sodium channels in rat hippocampal CA1 pyramidal neurons in the presence/absence of oxygen. Neural Plast. 2017;2017:2459053.
   PubMed Web of Science ®Google Scholar
• Yao LH, Li CH, Yan WW, et al. Cordycepin decreases activity of hippocampal CA1 pyramidal neuron through membrane hyperpolarization. Neurosci Lett. 2011;503:256–260.
   PubMed Web of Science ®Google Scholar
• Cheng Z, He W, Zhou X, et al. Cordycepin protects against cerebral ischemia/reperfusion injury in vivo and in vitro. Eur J Pharmacol. 2011;664:20–28.
   PubMed Web of Science ®Google Scholar
• Tian JJ, Tan CY, Chen QY, et al. Upregulation of Nav1.7 by endogenous hydrogen sulfide contributes to maintenance of neuropathic pain. Int J Mol Med. 2020;46:782–794.
   PubMed Web of Science ®Google Scholar
• Xiao MM, Zhang YQ, Wang WT, et al. Gastrodin protects against chronic inflammatory pain by inhibiting spinal synaptic potentiation. Sci Rep. 2016;6:37251.
   PubMed Web of Science ®Google Scholar
• Wang X, Zhang B, Li X, et al. Mechanisms underlying gastrodin alleviating vincristine-induced peripheral neuropathic pain. Front Pharmacol. 2021;12:744663.
   PubMed Web of Science ®Google Scholar
• Cai S, Bellampalli SS, Yu J, et al. (-)-Hardwickiic acid and hautriwaic acid induce antinociception via blockade of tetrodotoxin-sensitive voltage-dependent sodium channels. ACS Chem Neurosci. 2019;10:1716–1728.
   PubMed Web of Science ®Google Scholar
• Nyirimigabo E, Xu Y, Li Y, et al. A review on phytochemistry, pharmacology and toxicology studies of aconitum. J Pharm Pharmacol. 2015;67:1–19.
   PubMed Web of Science ®Google Scholar
• Zhang L, Miao X, Li Y, et al. Traditional processing, uses, phytochemistry, pharmacology and toxicology of Aconitum sinomontanum Nakai: a comprehensive review. J Ethnopharmacol. 2022;293:115317.
   PubMed Web of Science ®Google Scholar
• Ou S, Zhao YD, Xiao Z, et al. Effect of lappaconitine on neuropathic pain mediated by P2X3 receptor in rat dorsal root ganglion. Neurochem Int. 2011;58:564–573.
   PubMed Web of Science ®Google Scholar
• Wright SN. Irreversible block of human heart (hH1) sodium channels by the plant alkaloid lappaconitine. Mol Pharmacol. 2001;59:183–192.
   PubMed Web of Science ®Google Scholar
• Li YF, Zheng YM, Yu Y, et al. Inhibitory effects of lappaconitine on the neuronal isoforms of voltage-gated sodium channels. Acta Pharmacol Sin. 2019;40:451–459.
   PubMed Web of Science ®Google Scholar
• Chew LA, Bellampalli SS, Dustrude ET, et al. Mining the Nav1.7 interactome: opportunities for chronic pain therapeutics. Biochem Pharmacol. 2019;163:9–20.
   PubMed Web of Science ®Google Scholar
• Tavares-Ferreira D, Ray PR, Sankaranarayanan I, et al. Sex differences in nociceptor translatomes contribute to divergent prostaglandin signaling in male and female mice. Biol Psychiatry. 2022;91:129–140.
   PubMed Web of Science ®Google Scholar
• Li Q, Guan H, Wang X, et al. Fingerprint-efficacy study of the quaternary alkaloids in Corydalis yanhusuo. J Ethnopharmacol. 2017;207:108–117.
   PubMed Web of Science ®Google Scholar
• Wan L, Zhao Y, Zhang Q, et al. Alkaloid extract of Corydalis yanhusuo inhibits angiogenesis via targeting vascular endothelial growth factor receptor signaling. BMC Complement Altern Med. 2019;19:359.
   PubMed Web of Science ®Google Scholar
• Xu Y, Sun J, Li W, et al. Analgesic effect of the main components of Corydalis yanhusuo (yanhusuo in Chinese) is caused by inhibition of voltage gated sodium channels. J Ethnopharmacol. 2021;280:114457.
   PubMed Web of Science ®Google Scholar
• Mainardi T, Kapoor S, Bielory L. Complementary and alternative medicine: herbs, phytochemicals and vitamins and their immunologic effects. J Allergy Clin Immunol. 2009;123:283–294. quiz 95-6
   PubMed Web of Science ®Google Scholar
• Shen JL, Man KM, Huang PH, et al. Honokiol and magnolol as multifunctional antioxidative molecules for dermatologic disorders. Molecules. 2010;15:6452–6465.
   PubMed Web of Science ®Google Scholar
• Huang SH, Chen Y, Tung PY, et al. Mechanisms for the magnolol-induced cell death of CGTH W-2 thyroid carcinoma cells. J Cell Biochem. 2007;101:1011–1022.
   PubMed Web of Science ®Google Scholar
• Teng CM, Yu SM, Chen CC, et al. EDRF-release and Ca+(+)-channel blockade by magnolol, an antiplatelet agent isolated from Chinese herb Magnolia officinalis, in rat thoracic aorta. Life Sci. 1990;47:1153–1161.
   PubMed Web of Science ®Google Scholar
• Maruyama Y, Kuribara H, Morita M, et al. Identification of magnolol and honokiol as anxiolytic agents in extracts of saiboku-to, an oriental herbal medicine. J Nat Prod. 1998;61:135–138.
   PubMed Web of Science ®Google Scholar
• Lin YR, Chen HH, Ko CH, et al. Effects of honokiol and magnolol on acute and inflammatory pain models in mice. Life Sci. 2007;81:1071–1078.
   PubMed Web of Science ®Google Scholar
• Lin YR, Chen HH, Lin YC, et al. Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain. J Biomed Sci. 2009;16:94.
   PubMed Web of Science ®Google Scholar
• Chang CP, Hsu YC, Lin MT. Magnolol protects against cerebral ischaemic injury of rat heatstroke. Clin Exp Pharmacol Physiol. 2003;30:387–392.
   PubMed Web of Science ®Google Scholar
• Matsui N, Takahashi K, Takeichi M, et al. Magnolol and honokiol prevent learning and memory impairment and cholinergic deficit in SAMP8 mice. Brain Res. 2009;1305:108–117.
   PubMed Web of Science ®Google Scholar
• Lin YR, Chen HH, Ko CH, et al. Neuroprotective activity of honokiol and magnolol in cerebellar granule cell damage. Eur J Pharmacol. 2006;537:64–69.
   PubMed Web of Science ®Google Scholar
• Qiu J, Zhang L, Hong J, et al. Magnolol inhibits sodium currents in freshly isolated mouse dorsal root ganglion neurons. Clin Exp Pharmacol Physiol. 2021;48:347–354.
   PubMed Web of Science ®Google Scholar
• Lin B. Polyphenols and neuroprotection against ischemia and neurodegeneration. Mini Rev Med Chem. 2011;11:1222–1238.
   PubMed Web of Science ®Google Scholar
• Ma YL, Bates S, Gurney AM. The effects of paeonol on the electrophysiological properties of cardiac ventricular myocytes. Eur J Pharmacol. 2006;545:87–92.
   PubMed Web of Science ®Google Scholar
• Chen T, Zhong F, Yao C, et al. A systematic review on traditional uses, sources, phytochemistry, pharmacology, pharmacokinetics, and toxicity of Fritillariae cirrhosae bulbus. Evid Based Complement Alternat Med. 2020;2020:1536534.
   PubMed Web of Science ®Google Scholar
• Xu J, Zhao W, Pan L, et al. Peimine, a main active ingredient of Fritillaria, exhibits anti-inflammatory and pain suppression properties at the cellular level. Fitoterapia. 2016;111:1–6.
   PubMed Web of Science ®Google Scholar
• Wang D, Liu Y, Han J, et al. Puerarin suppresses invasion and vascularization of endometriosis tissue stimulated by 17beta-estradiol. PLoS One. 2011;6:e25011.
   PubMed Web of Science ®Google Scholar
• Ahmad B, Khan S, Liu Y, et al. Molecular mechanisms of anticancer activities of puerarin. Cancer Manag Res. 2020;12:79–90.
   PubMed Web of Science ®Google Scholar
• Zhang XL, Cao XY, Lai RC, et al. Puerarin relieves paclitaxel-induced neuropathic pain: the role of Nav1.8 beta1 subunit of sensory neurons. Front Pharmacol. 2018;9:1510.
   PubMed Web of Science ®Google Scholar
• Isom LL, De Jongh KS, Patton DE, et al. Primary structure and functional expression of the beta 1 subunit of the rat brain sodium channel. Science. 1992;256:839–842.
   PubMed Web of Science ®Google Scholar
• Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development. Phytomedicine. 2002;9:478–484.
   PubMed Web of Science ®Google Scholar
• Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development. Trends Pharmacol Sci. 1999;20:191–196.
   PubMed Web of Science ®Google Scholar
• Cheng JT, Wang CJ, Hsu FL. Paeoniflorin reverses guanethidine-induced hypotension via activation of central adenosine A1 receptors in Wistar rats. Clin Exp Pharmacol Physiol. 1999;26:815–816.
   PubMed Web of Science ®Google Scholar
• Lai CW, Hsu FL, Cheng JT. Stimulatory effect of paeoniflorin on adenosine A-1 receptors to increase the translocation of protein kinase C (PKC) and glucose transporter (GLUT 4) in isolated rat white adipocytes. Life Sci. 1998;62:1591–1595.
   PubMed Web of Science ®Google Scholar
• Marala RB, Mustafa SJ. Adenosine A1 receptor-induced upregulation of protein kinase C: role of pertussis toxin-sensitive G protein(s). Am J Physiol. 1995;269:H1619–24.
   PubMedGoogle Scholar
• Zhou X, Cheng H, Xu D, et al. Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury. Neurochem Res. 2014;39:2136–2142.
   PubMed Web of Science ®Google Scholar
• Xu Y, Yu Y, Wang Q, et al. Active components of Bupleurum Chinese and Angelica biserrata showed analgesic effects in formalin induced pain by acting on Nav1.7. J Ethnopharmacol. 2021;269:113736.
   PubMed Web of Science ®Google Scholar
• Mao X, Miao G, Tao X, et al. Saikosaponin a protects TBI rats after controlled cortical impact and the underlying mechanism. Am J Transl Res. 2016;8:133–141.
   PubMed Web of Science ®Google Scholar
• Li X, Li X, Huang N, et al. A comprehensive review and perspectives on pharmacology and toxicology of saikosaponins. Phytomedicine. 2018;50:73–87.
   PubMed Web of Science ®Google Scholar
• Black JA, Nikolajsen L, Kroner K, et al. Multiple sodium channel isoforms and mitogen-activated protein kinases are present in painful human neuromas. Ann Neurol. 2008;64:644–653.
   PubMed Web of Science ®Google Scholar
• Watkins AR. Cannabinoid interactions with ion channels and receptors. Channels (Austin). 2019;13:162–167.
   PubMed Web of Science ®Google Scholar
• Gadotti VM, Huang S, Zamponi GW. The terpenes camphene and alpha-bisabolol inhibit inflammatory and neuropathic pain via Cav3.2 T-type calcium channels. Mol Brain. 2021;14:166.
   PubMed Web of Science ®Google Scholar
• Rocha NF, Rios ER, Carvalho AM, et al. Anti-nociceptive and anti-inflammatory activities of (-)-α-bisabolol in rodents. Naunyn Schmiedebergs Arch Pharmacol. 2011;384:525–533.
   PubMed Web of Science ®Google Scholar
• Park J, Luo ZD. Calcium channel functions in pain processing. Channels (Austin). 2010;4:510–517.
   PubMed Web of Science ®Google Scholar
• Riaz A, Rasul A, Hussain G, et al. Astragalin: a bioactive phytochemical with potential therapeutic activities. Adv Pharmacol Sci. 2018;2018:9794625.
   PubMed Web of Science ®Google Scholar
• Rorsman P, Ashcroft FM. Pancreatic beta-cell electrical activity and insulin secretion: of mice and men. Physiol Rev. 2018;98:117–214.
   PubMed Web of Science ®Google Scholar
• Rey D, Miranda Sulis P, Alves Fernandes T, et al. Astragalin augments basal calcium influx and insulin secretion in rat pancreatic islets. Cell Calcium. 2019;80:56–62.
   PubMed Web of Science ®Google Scholar
• Bellampalli SS, Ji Y, Moutal A, et al. Betulinic acid, derived from the desert lavender Hyptis emoryi, attenuates paclitaxel-, HIV-, and nerve injury-associated peripheral sensory neuropathy via block of N- and T-type calcium channels. Pain. 2019;160:117–135.
   PubMed Web of Science ®Google Scholar
• Matsuda LA, Lolait SJ, Brownstein MJ, et al. Structure of a cannabinoid receptor and functional expression of the cloned cDNA. Nature. 1990;346:561–564.
   PubMed Web of Science ®Google Scholar
• Munro S, Thomas KL, Abu-Shaar M. Molecular characterization of a peripheral receptor for cannabinoids. Nature. 1993;365:61–65.
   PubMed Web of Science ®Google Scholar
• Thomas A, Baillie GL, Phillips AM, et al. Cannabidiol displays unexpectedly high potency as an antagonist of CB1 and CB2 receptor agonists in vitro. Br J Pharmacol. 2007;150:613–623.
   PubMed Web of Science ®Google Scholar
• Zimmer A, Zimmer AM, Hohmann AG, et al. Increased mortality, hypoactivity, and hypoalgesia in cannabinoid CB1 receptor knockout mice. Proc Natl Acad Sci U S A. 1999;96:5780–5785.
   PubMed Web of Science ®Google Scholar
• Bourinet E, Alloui A, Monteil A, et al. Silencing of the Cav3.2 T-type calcium channel gene in sensory neurons demonstrates its major role in nociception. EMBO J. 2005;24:315–324.
   PubMed Web of Science ®Google Scholar
• Todorovic SM, Jevtovic-Todorovic V, Meyenburg A, et al. Redox modulation of T-type calcium channels in rat peripheral nociceptors. Neuron. 2001;31:75–85.
   PubMed Web of Science ®Google Scholar
• Anderson MP, Mochizuki T, Xie J, et al. Thalamic Cav3.1 T-type Ca2+ channel plays a crucial role in stabilizing sleep. Proc Natl Acad Sci U S A. 2005;102:1743–1748.
   PubMed Web of Science ®Google Scholar
• Feinberg I, Jones R, Walker JM, et al. Effects of high dosage delta-9-tetrahydrocannabinol on sleep patterns in man. Clin Pharmacol Ther. 1975;17:458–466.
   PubMed Web of Science ®Google Scholar
• Tsakiridou E, Bertollini L, de Curtis M, et al. Selective increase in T-type calcium conductance of reticular thalamic neurons in a rat model of absence epilepsy. J Neurosci. 1995;15:3110–3117.
   PubMed Web of Science ®Google Scholar
• Ross HR, Napier I, Connor M. Inhibition of recombinant human T-type calcium channels by delta9-tetrahydrocannabinol and cannabidiol. J Biol Chem. 2008;283:16124–16134.
   PubMed Web of Science ®Google Scholar
• Carre G, Carreyre H, Ouedraogo M, et al. The hypotensive agent dodoneine inhibits L-type Ca2+ current with negative inotropic effect on rat heart. Eur J Pharmacol. 2014;728:119–127.
   PubMed Web of Science ®Google Scholar
• Luo C, Ai J, Ren E, et al. Research progress on evodiamine, a bioactive alkaloid of evodiae fructus: focus on its anti-cancer activity and bioavailability (review). Exp Ther Med. 2021;22:1327.
   PubMed Web of Science ®Google Scholar
• Tan Q, Zhang J. Evodiamine and its role in chronic diseases. Adv Exp Med Biol. 2016;929:315–328.
   PubMed Web of Science ®Google Scholar
• Wang GX, Xiang YL, Wang HG, et al. An indole alkaloid extracted from evodia rutaecarpa inhibits colonic motility of rats in vitro. Gastroenterol Res Pract. 2020;2020:8610653.
   PubMed Web of Science ®Google Scholar
• Shan Z, Cai S, Yu J, et al. Reversal of peripheral neuropathic pain by the small-molecule natural product physalin F via block of CaV2.3 (R-Type) and CaV2.2 (N-Type) voltage-gated calcium channels. ACS Chem Neurosci. 2019;10:2939–2955.
   PubMed Web of Science ®Google Scholar
• Lima Mda S, Evangelista AF, Santos GG, et al. Antinociceptive properties of physalins from physalis angulata. J Nat Prod. 2014;77:2397–2403.
   PubMed Web of Science ®Google Scholar
• Guan S, Ma J, Chu X, et al. Effects of total flavones from acanthopanax senticosus on L-type calcium channels, calcium transient and contractility in rat ventricular myocytes. Phytother Res. 2015;29:533–539.
   PubMed Web of Science ®Google Scholar
• Torrente AG, Mesirca P, Bidaud I, et al. Channelopathies of voltage-gated L-type Cav1.3/alpha1D and T-type Cav3.1/alpha1G Ca(2+) channels in dysfunction of heart automaticity. Pfluger Arch. 2020;472:817–830.
   PubMed Web of Science ®Google Scholar
• Cribbs L. T-type calcium channel expression and function in the diseased heart. Channels (Austin). 2010;4:447–452.
   PubMed Web of Science ®Google Scholar
• Deng ZT, Li WY, Wang L, et al. Monoterpene indole alkaloids with Cav3.1 T-type calcium channel inhibitory activity from Catharanthus roseus. Molecules. 2021;26:6516.
   PubMed Web of Science ®Google Scholar
• Hitomi S, Ujihara I, Ono K. Pain mechanism of oral ulcerative mucositis and the therapeutic traditional herbal medicine hangeshashinto. J Oral Biosci. 2019;61:12–15.
   PubMed Web of Science ®Google Scholar
• Hitomi S, Ono K, Terawaki K, et al. [6]-gingerol and [6]-shogaol, active ingredients of the traditional Japanese medicine hangeshashinto, relief oral ulcerative mucositis-induced pain via action on Na(+) channels. Pharmacol Res. 2017;117:288–302.
   PubMed Web of Science ®Google Scholar
• Chen WH, Yang D, Wang WY, et al. Cellular electrophysiological effects of changrolin in isolated rat cardiac myocytes. Eur J Pharmacol. 2010;647:139–146.
   PubMed Web of Science ®Google Scholar
• Aggarwal BB, Sundaram C, Malani N, et al. Curcumin: the Indian solid gold. Adv Exp Med Biol. 2007;595:1–75.
   PubMed Web of Science ®Google Scholar
• Enyeart JA, Liu H, Enyeart JJ. Curcumin inhibits ACTH- and angiotensin II-stimulated cortisol secretion and Ca(v)3.2 current. J Nat Prod. 2009;72:1533–1537.
   PubMed Web of Science ®Google Scholar
• Meng B, Shen LL, Shi XT, et al. Effects of curcumin on TTX-R sodium currents of dorsal root ganglion neurons in type 2 diabetic rats with diabetic neuropathic pain. Neurosci Lett. 2015;605:59–64.
   PubMed Web of Science ®Google Scholar
• Seo H, Li HY, Perez-Reyes E, et al. Effects of eugenol on T-type Ca2+ channel isoforms. J Pharmacol Exp Ther. 2013;347:310–317.
   PubMed Web of Science ®Google Scholar
• Wang ZJ, Tabakoff B, Levinson SR, et al. Inhibition of Nav1.7 channels by methyl eugenol as a mechanism underlying its antinociceptive and anesthetic actions. Acta Pharmacol Sin. 2015;36:791–799.
   PubMed Web of Science ®Google Scholar
• Narusuye K, Kawai F, Matsuzaki K, et al. Linalool suppresses voltage-gated currents in sensory neurons and cerebellar Purkinje cells. J Neural Transm (Vienna). 2005;112:193–203.
   PubMed Web of Science ®Google Scholar
• Hille B. Local anesthetics: hydrophilic and hydrophobic pathways for the drug-receptor reaction. J Gen Physiol. 1977;69:497–515.
   PubMed Web of Science ®Google Scholar
• Kawai F. Odorant suppression of delayed rectifier potassium current in newt olfactory receptor cells. Neurosci Lett. 1999;269:45–48.
   PubMed Web of Science ®Google Scholar
• Kawai F. Odorants suppress T- and L-type Ca2+ currents in olfactory receptor cells by shifting their inactivation curves to a negative voltage. Neurosci Res. 1999;35:253–263.
   PubMed Web of Science ®Google Scholar
• Kawai F, Miyachi E. Odorants suppress voltage-gated currents in retinal horizontal cells in goldfish. Neurosci Lett. 2000;281:151–154.
   PubMed Web of Science ®Google Scholar
• El Alaoui C, Chemin J, Fechtali T, et al. Modulation of T-type Ca2+ channels by lavender and rosemary extracts. PLoS One. 2017;12:e0186864.
   PubMed Web of Science ®Google Scholar
• Pinho-Ribeiro FA, Zarpelon AC, Fattori V, et al. Naringenin reduces inflammatory pain in mice. Neuropharmacology. 2016;105:508–519.
   PubMed Web of Science ®Google Scholar
• Pinho-Ribeiro FA, Zarpelon AC, Mizokami SS, et al. The citrus flavonone naringenin reduces lipopolysaccharide-induced inflammatory pain and leukocyte recruitment by inhibiting NF-kappaB activation. J Nutr Biochem. 2016;33:8–14.
   PubMed Web of Science ®Google Scholar
• Gumushan Aktas H, Akgun T. Naringenin inhibits prostate cancer metastasis by blocking voltage-gated sodium channels. Biomed Pharmacother. 2018;106:770–775.
   PubMed Web of Science ®Google Scholar
• Zhou Y, Cai S, Moutal A, et al. The natural flavonoid naringenin elicits analgesia through inhibition of NaV1.8 voltage-gated sodium channels. ACS Chem Neurosci. 2019;10:4834–4846.
   PubMed Web of Science ®Google Scholar