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Review

Do studies reporting ‘U’-shaped serum 25-hydroxyvitamin D–health outcome relationships reflect adverse effects?

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Article: e1187349 | Received 28 Apr 2016, Accepted 29 Apr 2016, Published online: 16 May 2016

References

  • Hossein-nezhad A, Holick MF. Vitamin D for health: a global perspective. Mayo Clinic Proc 2013; 88:720-55; PMID:23790560; http://dx.doi.org/10.1016/j.mayocp.2013.05.011
  • Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, Shoenfeld Y, Lerchbaum E, Llewellyn DJ, Kienreich K, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality-a review of recent evidence. Autoimmun Rev 2013; 12:976-89; PMID:23542507; http://dx.doi.org/10.1016/j.autrev.2013.02.004
  • Song Y, Wang L, Pittas AG, Del Gobbo LC, Zhang C, Manson JE, Hu FB. Blood 25-hydroxy vitamin D levels and incident type 2 diabetes: a meta-analysis of prospective studies. Diabetes Care 2013; 36:1422-8; PMID:23613602; http://dx.doi.org/10.2337/dc12-0962
  • Wang L, Song Y, Manson JE, Pilz S, Marz W, Michaelsson K, Lundqvist A, Jassal SK, Barrett-Connor E, Zhang C, et al. Circulating 25-hydroxy-vitamin D and risk of cardiovascular disease: a meta-analysis of prospective studies. Circ Cardiovasc Qual Outcomes 2012; 5:819-29; PMID:23149428; http://dx.doi.org/10.1161/CIRCOUTCOMES.112.967604
  • Garland CF, Gorham ED, Mohr SB, Garland FC. Vitamin D for cancer prevention: global perspective. Ann Epidemiol 2009; 19:468-83; PMID:19523595; http://dx.doi.org/10.1016/j.annepidem.2009.03.021
  • Moukayed M, Grant WB. Molecular link between vitamin D and cancer prevention. Nutrients 2013; 5:3993-4021; PMID:24084056; http://dx.doi.org/10.3390/nu5103993
  • Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM. Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Ann N Y Acad Sci 2014; 1317:57-69; PMID:24738964; http://dx.doi.org/10.1111/nyas.12410
  • Littlejohns TJ, Henley WE, Lang IA, Annweiler C, Beauchet O, Chaves PH, Fried L, Kestenbaum BR, Kuller LH, Langa KM, et al. Vitamin D and the risk of dementia and Alzheimer disease. Neurology 2014; 83:920-8; PMID:25098535; http://dx.doi.org/10.1212/WNL.0000000000000755
  • Cannell JJ, Grant WB. What is the role of vitamin D in autism? Dermatoendocrinology 2013; 5:199-204; PMID:24494055; http://dx.doi.org/10.4161/derm.24356
  • Agmon-Levin N, Theodor E, Segal RM, Shoenfeld Y. Vitamin D in systemic and organ-specific autoimmune diseases. Clin Rev Allergy Immunol 2013; 45:256-66; PMID:23238772; http://dx.doi.org/10.1007/s12016-012-8342-y
  • Wagner CL, Baggerly C, McDonnell SL, Baggerly L, Hamilton SA, Winkler J, Warner G, Rodriguez C, Shary JR, Smith PG, et al. Post-hoc comparison of vitamin D status at three timepoints during pregnancy demonstrates lower risk of preterm birth with higher vitamin D closer to delivery. J Steroid Biochem Mol Biol 2015:148:256-60; PMID:25448734; http://dx.doi.org/10.1016/j.jsbmb.2014.11.013
  • Cannell JJ, Hollis BW, Zasloff M, Heaney RP. Diagnosis and treatment of vitamin D deficiency. Expert Opin Pharmacother 2008; 9:107-18; PMID:18076342; http://dx.doi.org/10.1517/14656566.9.1.107
  • Hujoel PP. Vitamin D and dental caries in controlled clinical trials: systematic review and meta-analysis. Nutr Rev 2013; 71:88-97; PMID:23356636; http://dx.doi.org/10.1111/j.1753-4887.2012.00544.x
  • Ross AC, Manson JE, Abrams SA, Aloia JF, Brannon PM, Clinton SK, Durazo-Arvizu RA, Gallagher JC, Gallo RL, Jones G, et al. The 2011 report on dietary reference intakes for calcium and vitamin D from the Institute of Medicine: what clinicians need to know. J Clin Endocrinol Metab 2011; 96:53-8; PMID:21118827; http://dx.doi.org/10.1210/jc.2010-2704
  • Manson JE, Bassuk SS, Lee IM, Cook NR, Albert MA, Gordon D, Zaharris E, Macfadyen JG, Danielson E, Lin J, et al. The VITamin D and OmegA-3 TriaL (VITAL): rationale and design of a large randomized controlled trial of vitamin D and marine omega-3 fatty acid supplements for the primary prevention of cancer and cardiovascular disease. Contemp Clin Trials 2012; 33:159-71; PMID:21986389; http://dx.doi.org/10.1016/j.cct.2011.09.009
  • Stolzenberg-Solomon RZ, Vieth R, Azad A, Pietinen P, Taylor PR, Virtamo J, Albanes D. A prospective nested case-control study of vitamin D status and pancreatic cancer risk in male smokers. Cancer Res 2006; 66:10213-9; PMID:17047087; http://dx.doi.org/10.1158/0008-5472.CAN-06-1876
  • Stolzenberg-Solomon RZ, Hayes RB, Horst RL, Anderson KE, Hollis BW, Silverman DT. Serum vitamin D and risk of pancreatic cancer in the prostate, lung, colorectal, and ovarian screening trial. Cancer Res 2009; 69:1439-47; PMID:19208842; http://dx.doi.org/10.1158/0008-5472.CAN-08-2694
  • Bao Y, Ng K, Wolpin BM, Michaud DS, Giovannucci E, Fuchs CS. Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies. Br J Cancer 2010; 102:1422-7; PMID:20389298; http://dx.doi.org/10.1038/sj.bjc.6605658
  • Wolpin BM, Ng K, Bao Y, Kraft P, Stampfer MJ, Michaud DS, Ma J, Buring JE, Sesso HD, Lee IM, et al. Plasma 25-hydroxyvitamin D and risk of pancreatic cancer. Cancer Epidemiol Biomarkers Prev 2012; 21:82-91; http://dx.doi.org/10.1158/1055-9965.EPI-11-0836
  • Kroll MH, Bi C, Garber CC, Kaufman HW, Liu D, Caston-Balderrama A, Zhang K, Clarke N, Xie M, Reitz RE, et al. Temporal relationship between vitamin D status and parathyroid hormone in the United States. PloS one 2015; 10:e0118108; PMID:25738588; http://dx.doi.org/10.1371/journal.pone.0118108
  • Tuohimaa P, Tenkanen L, Ahonen M, Lumme S, Jellum E, Hallmans G, Stattin P, Harvei S, Hakulinen T, Luostarinen T, et al. Both high and low levels of blood vitamin D are associated with a higher prostate cancer risk: a longitudinal, nested case-control study in the Nordic countries. Int J Cancer 2004; 108:104-8; PMID:14618623; http://dx.doi.org/10.1002/ijc.11375
  • Grant WB. Effect of interval between serum draw and follow-up period on relative risk of cancer incidence with respect to 25-hydroxyvitamin D level: Implications for meta-analyses and setting vitamin D guidelines. Dermatoendocrinol 2011; 3:199-204; PMID:22110780; http://dx.doi.org/10.4161/derm.15364
  • Albanes D, Mondul AM, Yu K, Parisi D, Horst RL, Virtamo J, Weinstein SJ. Serum 25-hydroxy vitamin D and prostate cancer risk in a large nested case-control study. Cancer Epidemiol Biomarkers Prev 2011; 20:1850-60; http://dx.doi.org/10.1158/1055-9965.EPI-11-0403
  • Brandstedt J, Almquist M, Manjer J, Malm J. Vitamin D, PTH, and calcium and the risk of prostate cancer: a prospective nested case-control study. Cancer Causes Control 2012; 23:1377-85; http://dx.doi.org/10.1007/s10552-012-9948-3
  • Meyer HE, Robsahm TE, Bjorge T, Brustad M, Blomhoff R. Vitamin D, season, and risk of prostate cancer: a nested case-control study within Norwegian health studies. Am J Clin Nutr 2013; 97:147-54; PMID:23193007; http://dx.doi.org/10.3945/ajcn.112.039222
  • Kristal AR, Till C, Song X, Tangen CM, Goodman PJ, Neuhauser ML, Schenk JM, Thompson IM, Meyskens FL, Jr., Goodman GE, et al. Plasma vitamin D and prostate cancer risk: results from the Selenium and Vitamin E Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev 2014; 23:1494-504; http://dx.doi.org/10.1158/1055-9965.EPI-14-0115
  • Deschasaux M, Souberbielle JC, Latino-Martel P, Sutton A, Charnaux N, Druesne-Pecollo N, Galan P, Hercberg S, Le Clerc S, Kesse-Guyot E, et al. A prospective study of plasma 25-hydroxyvitamin D concentration and prostate cancer risk. Br J Nutr 2016; 115(2):305-14; PMID: 26568368; http://dx.doi.org/10.1017/S0007114515004353
  • Xu Y, Shao X, Yao Y, Xu L, Chang L, Jiang Z, Lin Z. Positive association between circulating 25-hydroxyvitamin D levels and prostate cancer risk: new findings from an updated meta-analysis. J Cancer Res Clin Oncol 2014; 140:1465-77; PMID:24838848; http://dx.doi.org/10.1007/s00432-014-1706-3
  • Jemal A, Siegel R, Xu J, Ward E. Cancer statistics, 2010. CA Cancer J Clin 2010; 60:277-300; PMID:20610543; http://dx.doi.org/10.3322/caac.20073
  • Bouchardy C, Fioretta G, Rapiti E, Verkooijen HM, Rapin CH, Schmidlin F, Miralbell R, Zanetti R. Recent trends in prostate cancer mortality show a continuous decrease in several countries. Int J Cancer 2008; 123:421-9; PMID:18452171; http://dx.doi.org/10.1002/ijc.23520
  • Shui IM, Mucci LA, Kraft P, Tamimi RM, Lindstrom S, Penney KL, Nimptsch K, Hollis BW, Dupre N, Platz EA, et al. Vitamin D-related genetic variation, plasma vitamin D, and risk of lethal prostate cancer: a prospective nested case-control study. J Natl Cancer Inst 2012; 104:690-9; PMID:22499501; http://dx.doi.org/10.1093/jnci/djs189
  • Mondul AM, Weinstein SJ, Moy KA, Männistö S, Albanes D. Circulating 25-Hydroxyvitamin D and Prostate Cancer Survival. Cancer Epidemiol Biomarkers Prev 2016; 25(4); 665-9; PMID: 26809275; http://dx.doi.org/10.1158/1055-9965.EPI-15-0991
  • Marshall DT, Savage SJ, Garrett-Mayer E, Keane TE, Hollis BW, Horst RL, Ambrose LH, Kindy MS, Gattoni-Celli S. Vitamin D3 supplementation at 4000 international units per day for one year results in a decrease of positive cores at repeat biopsy in subjects with low-risk prostate cancer under active surveillance. J Clin Endocrinol Metab 2012; 97:2315-24; PMID:22508710; http://dx.doi.org/10.1210/jc.2012-1451
  • Gilbert R, Metcalfe C, Fraser WD, Donovan J, Hamdy F, Neal DE, Lane JA, Martin RM. Associations of circulating 25-hydroxyvitamin D with prostate cancer diagnosis, stage and grade. Int J Cancer 2012; 131:1187-96; PMID:22033893; http://dx.doi.org/10.1002/ijc.27327
  • Murphy AB, Nyame Y, Martin IK, Catalona WJ, Hollowell CM, Nadler RB, Kozlowski JM, Perry KT, Kajdacsy-Balla A, Kittles R. Vitamin D deficiency predicts prostate biopsy outcomes. Clin Cancer Res 2014; 20:2289-99; PMID:24789033; http://dx.doi.org/10.1158/1078-0432.CCR-13-3085
  • Gilbert R, Bonilla C, Metcalfe C, Lewis S, Evans DM, Fraser WD, Kemp JP, Donovan JL, Hamdy FC, Neal DE, et al. Associations of vitamin D pathway genes with circulating 25-hydroxyvitamin-D, 1,25-dihydroxyvitamin-D, and prostate cancer: a nested case-control study. Cancer Causes Control 2015; 26:205-18; http://dx.doi.org/10.1007/s10552-014-0500-5
  • Schenk JM, Till CA, Tangen CM, Goodman PJ, Song X, Torkko KC, Kristal AR, Peters U, Neuhouser ML. Serum 25-hydroxyvitamin D concentrations and risk of prostate cancer: results from the Prostate Cancer Prevention Trial. Cancer Epidemiol Biomarkers Prev 2014; 23:1484-93; http://dx.doi.org/10.1158/1055-9965.EPI-13-1340
  • Hill G, Connelly J, Hebert R, Lindsay J, Millar W. Neyman's bias re-visited. J Clin Epidemiol 2003; 56:293-6; PMID:12767404; http://dx.doi.org/10.1016/S0895-4356(02)00571-1
  • Travis RC, Crowe FL, Allen NE, Appleby PN, Roddam AW, Tjonneland A, Olsen A, Linseisen J, Kaaks R, Boeing H, et al. Serum vitamin D and risk of prostate cancer in a case-control analysis nested within the European Prospective Investigation into Cancer and Nutrition (EPIC). Am J Epidemiol 2009; 169:1223-32; PMID:19359375; http://dx.doi.org/10.1093/aje/kwp022
  • Michaelsson K, Baron JA, Snellman G, Gedeborg R, Byberg L, Sundstrom J, Berglund L, Arnlov J, Hellman P, Blomhoff R, et al. Plasma vitamin D and mortality in older men: a community-based prospective cohort study. Am J Clin Nutr 2010; 92:841-8; PMID:20720256; http://dx.doi.org/10.3945/ajcn.2010.29749
  • Jorde R, Figenschau Y, Hutchinson M, Emaus N, Grimnes G. High serum 25-hydroxyvitamin D concentrations are associated with a favorable serum lipid profile. Eur J Clin Nutr 2010; 64:1457-64; PMID:20823896; http://dx.doi.org/10.1038/ejcn.2010.176
  • Grant WB. Twenty-five-Hydroxyvitamin D and Breast Cancer, Colorectal Cancer, and Colorectal Adenomas: Case-Control versus Nested Case-Control Studies. Anticancer Res 2015; 35:1153-60; PMID:25667506
  • Dror Y, Giveon SM, Hoshen M, Feldhamer I, Balicer RD, Feldman BS. Vitamin D levels for preventing acute coronary syndrome and mortality: evidence of a nonlinear association. J Clin Endocrinol Metab 2013; 98:2160-7; PMID:23533239; http://dx.doi.org/10.1210/jc.2013-1185
  • Durup D, Jorgensen HL, Christensen J, Tjonneland A, Olsen A, Halkjaer J, Lind B, Heegaard AM, Schwarz P. A Reverse J-Shaped Association Between Serum 25-Hydroxyvitamin D and Cardiovascular Disease Mortality: The CopD Study. J Clin Endocrinol Metab 2015; 100:2339-46; PMID:25710567; http://dx.doi.org/10.1210/jc.2014-4551
  • Zittermann A, Kuhn J, Dreier J, Knabbe C, Gummert JF, Borgermann J. Vitamin D status and the risk of major adverse cardiac and cerebrovascular events in cardiac surgery. Eur Heart J 2013; 34:1358-64; PMID:23315905; http://dx.doi.org/10.1093/eurheartj/ehs468
  • Vimaleswaran KS, Cavadino A, Berry DJ, LifeLines Cohort Study i, Jorde R, Dieffenbach AK, Lu C, Alves AC, Heerspink HJ, Tikkanen E, et al. Association of vitamin D status with arterial blood pressure and hypertension risk: a mendelian randomisation study. Lancet Diabetes Endocrinol 2014; 2:719-29; PMID:24974252; http://dx.doi.org/10.1016/S2213-8587(14)70113-5
  • Zittermann A, Kuhn J, Ernst JB, Becker T, Dreier J, Knabbe C, Gummert JF, Borgermann J. Twenty-five-hydroxyvitamin D, 1,25-dihydroxyvitamin D and postoperative outcome in cardiac surgery. J Clin Endocrinol Metab 2015; 100:72-80; PMID:25365313; http://dx.doi.org/10.1210/jc.2014-3013
  • Beveridge LA, Struthers AD, Khan F, Jorde R, Scragg R, Macdonald HM, Alvarez JA, Boxer RS, Dalbeni A, Gepner AD, et al. Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data. JAMA Intern Med 2015; 175:745-54; PMID:25775274; http://dx.doi.org/10.1001/jamainternmed.2015.0237
  • Ensrud KE, Blackwell TL, Cauley JA, Cummings SR, Barrett-Connor E, Dam TT, Hoffman AR, Shikany JM, Lane NE, Stefanick ML, et al. Circulating 25-hydroxyvitamin D levels and frailty in older men: the osteoporotic fractures in men study. J Am Geriatr Soc 2011; 59:101-6; PMID:21226680; http://dx.doi.org/10.1111/j.1532-5415.2010.03201.x
  • Ensrud KE, Ewing SK, Fredman L, Hochberg MC, Cauley JA, Hillier TA, Cummings SR, Yaffe K, Cawthon PM. Circulating 25-hydroxyvitamin D levels and frailty status in older women. J Clin Endocrinol Metab 2010; 95:5266-73; PMID:21131545; http://dx.doi.org/10.1210/jc.2010-2317
  • Bischoff-Ferrari HA. Relevance of vitamin D in muscle health. Rev Endocr Metab Disord 2012; 13:71-7; PMID:22020957; http://dx.doi.org/10.1007/s11154-011-9200-6
  • Janssen HC, Samson MM, Verhaar HJ. Vitamin D deficiency, muscle function, and falls in elderly people. Am J Clin Nutr 2002; 75:611-5; PMID:11916748
  • Bischoff-Ferrari HA, Borchers M, Gudat F, Durmuller U, Stahelin HB, Dick W. Vitamin D receptor expression in human muscle tissue decreases with age. J Bone Miner Res 2004; 19:265-9; PMID:14969396; http://dx.doi.org/10.1359/jbmr.2004.19.2.265
  • Bouillon R, Bischoff-Ferrari H, Willett W. Vitamin D and health: perspectives from mice and man. J Bone Miner Res 2008; 23:974-9; PMID:18442312; http://dx.doi.org/10.1359/jbmr.080420
  • Ceglia L, da Silva Morais M, Park LK, Morris E, Harris SS, Bischoff-Ferrari HA, Fielding RA, Dawson-Hughes B. Multi-step immunofluorescent analysis of vitamin D receptor loci and myosin heavy chain isoforms in human skeletal muscle. J Mol Histol 2010; 41:137-42; PMID:20549314; http://dx.doi.org/10.1007/s10735-010-9270-x
  • Freedman LP. Transcriptional targets of the vitamin D3 receptor-mediating cell cycle arrest and differentiation. J Nutr 1999; 129:581S-6S; PMID:10064337
  • Bischoff-Ferrari HA, Willett WC, Wong JB, Stuck AE, Staehelin HB, Orav EJ, Thoma A, Kiel DP, Henschkowski J. Prevention of nonvertebral fractures with oral vitamin D and dose dependency: a meta-analysis of randomized controlled trials. Arch Internal Med 2009; 169:551-61; PMID:19307517; http://dx.doi.org/10.1001/archinternmed.2008.600
  • Bischoff-Ferrari HA, Willett WC, Wong JB, Giovannucci E, Dietrich T, Dawson-Hughes B. Fracture prevention with vitamin D supplementation: a meta-analysis of randomized controlled trials. JAMA 2005; 293:2257-64; http://dx.doi.org/10.1001/jama.293.18.2257
  • Cameron ID, Murray GR, Gillespie LD, Robertson MC, Hill KD, Cumming RG, Kerse N. Interventions for preventing falls in older people in nursing care facilities and hospitals. Cochrane Database Syst Rev 2010; CD005465; PMID:20091578; http://dx.doi.org/10.1002/14651858.CD005465.pub2
  • Kalyani RR, Stein B, Valiyil R, Manno R, Maynard JW, Crews DC. Vitamin D treatment for the prevention of falls in older adults: systematic review and meta-analysis. J Am Geriatr Soc 2010; 58:1299-310; PMID:20579169; http://dx.doi.org/10.1111/j.1532-5415.2010.02949.x
  • Bischoff-Ferrari HA. Vitamin D and fracture prevention. Rheum Dis Clin North Am 2012; 38:107-13; PMID:22525846; http://dx.doi.org/10.1016/j.rdc.2012.03.010
  • Bolland MJ, Grey A, Gamble GD, Reid IR. The effect of vitamin D supplementation on skeletal, vascular, or cancer outcomes: a trial sequential meta-analysis. Lancet Diabetes Endocrinol 2014; 2:307-20; PMID:24703049; http://dx.doi.org/10.1016/S2213-8587(13)70212-2
  • Boonen S, Bischoff-Ferrari HA, Cooper C, Lips P, Ljunggren O, Meunier PJ, Reginster JY. Addressing the musculoskeletal components of fracture risk with calcium and vitamin D: a review of the evidence. Calcif Tissue Int 2006; 78:257-70; PMID:16622587; http://dx.doi.org/10.1007/s00223-005-0009-8
  • Bischoff-Ferrari HA, Dawson-Hughes B, Whiting SJ. Vitamin D supplementation and fracture risk. Arch Intern Med 2011; 171:265; author reply -6; PMID:21325121; http://dx.doi.org/10.1001/archinternmed.2010.531
  • Bischoff-Ferrari HA. Vitamin D and fracture prevention. Endocrinol Metab Clin North Am 2010; 39:347-53, table of contents; PMID:20511056; http://dx.doi.org/10.1016/j.ecl.2010.02.009
  • Bischoff-Ferrari HA, Dawson-Hughes B, Platz A, Orav EJ, Stahelin HB, Willett WC, Can U, Egli A, Mueller NJ, Looser S, et al. Effect of high-dosage cholecalciferol and extended physiotherapy on complications after hip fracture: a randomized controlled trial. Arch Intern Med 2010; 170:813-20; PMID:20458090; http://dx.doi.org/10.1001/archinternmed.2010.67
  • Sanders KM, Stuart AL, Williamson EJ, Simpson JA, Kotowicz MA, Young D, Nicholson GC. Annual high-dose oral vitamin D and falls and fractures in older women: a randomized controlled trial. JAMA 2010; 303:1815-22; http://dx.doi.org/10.1001/jama.2010.594
  • Bischoff-Ferrari HA, Dawson-Hughes B, Orav EJ, Staehelin HB, Meyer OW, Theiler R, Dick W, Willett WC, Egli A. Monthly High-Dose Vitamin D Treatment for the Prevention of Functional Decline: A Randomized Clinical Trial. JAMA Intern Med 2016; 176:175-83; PMID:26747333; http://dx.doi.org/10.1001/jamainternmed.2015.7148
  • Bischoff-Ferrari HA, Shao A, Dawson-Hughes B, Hathcock J, Giovannucci E, Willett WC. Benefit-risk assessment of vitamin D supplementation. Osteoporos Int 2010; 21:1121-32; PMID:19957164; http://dx.doi.org/10.1007/s00198-009-1119-3
  • Bischoff-Ferrari HA, Willett WC, Orav EJ, Lips P, Meunier PJ, Lyons RA, Flicker L, Wark J, Jackson RD, Cauley JA, et al. A pooled analysis of vitamin D dose requirements for fracture prevention. N Engl J Med 2012; 367:40-9; PMID:22762317; http://dx.doi.org/10.1056/NEJMoa1109617
  • Trivedi DP, Doll R, Khaw KT. Effect of four monthly oral vitamin D3 (cholecalciferol) supplementation on fractures and mortality in men and women living in the community: randomised double blind controlled trial. BMJ 2003; 326:469; PMID:12609940; http://dx.doi.org/10.1136/bmj.326.7387.469
  • Smith H, Anderson F, Raphael H, Maslin P, Crozier S, Cooper C. Effect of annual intramuscular vitamin D on fracture risk in elderly men and women–a population-based, randomized, double-blind, placebo-controlled trial. Rheumatology (Oxford) 2007; 46:1852-7; PMID:17998225; http://dx.doi.org/10.1093/rheumatology/kem240
  • Bleicher K, Cumming RG, Naganathan V, Blyth FM, Le Couteur DG, Handelsman DJ, Waite LM, Seibel MJ. U-shaped association between serum 25-hydroxyvitamin D and fracture risk in older men: results from the prospective population-based CHAMP study. J Bone Miner Res 2014; 29:2024-31; PMID:24677358; http://dx.doi.org/10.1002/jbmr.2230
  • Pradhan AD, Manson JE. Update on the Vitamin D and OmegA-3 trial (VITAL). J Steroid Biochem Mol Biol 2016; 155(Pt B):252-6; PMID: 25864623; http://dx.doi.org/10.1016/j.jsbmb.2015.04.006
  • Kalueff AV, Tuohimaa P. Neurosteroid hormone vitamin D and its utility in clinical nutrition. Curr Opin Clin Nutr Metab Care 2007; 10:12-9; PMID:17143049; http://dx.doi.org/10.1097/MCO.0b013e328010ca18
  • Annweiler C, Schott AM, Berrut G, Chauvire V, Le Gall D, Inzitari M, Beauchet O. Vitamin D and ageing: neurological issues. Neuropsychobiology 2010; 62:139-50; PMID:20628264; http://dx.doi.org/10.1159/000318570
  • Oudshoorn C, Mattace-Raso FU, van der Velde N, Colin EM, van der Cammen TJ. Higher serum vitamin D3 levels are associated with better cognitive test performance in patients with Alzheimer disease. Dement Geriatr Cogn Disord 2008; 25:539-43; PMID:18503256; http://dx.doi.org/10.1159/000134382
  • Etgen T, Sander D, Bickel H, Sander K, Forstl H. Vitamin D deficiency, cognitive impairment and dementia: a systematic review and meta-analysis. Dement Geriatr Cogn Disord 2012; 33:297-305; PMID:22759681; http://dx.doi.org/10.1159/000339702
  • Annweiler C, Montero-Odasso M, Llewellyn DJ, Richard-Devantoy S, Duque G, Beauchet O. Meta-analysis of memory and executive dysfunctions in relation to vitamin D. J Alzheimer Dis 2013; 37:147-71; PMID:23948884
  • McGrath J, Scragg R, Chant D, Eyles D, Burne T, Obradovic D. No association between serum 25-hydroxyvitamin D3 level and performance on psychometric tests in NHANES III. Neuroepidemiology 2007; 29:49-54; PMID:17898524; http://dx.doi.org/10.1159/000108918
  • Maddock J, Geoffroy MC, Power C, Hypponen E. Twenty-five-Hydroxyvitamin D and cognitive performance in mid-life. Br J Nutr 2014; 111:904-14; PMID:24135155; http://dx.doi.org/10.1017/S0007114513003176
  • Granic A, Hill TR, Kirkwood TB, Davies K, Collerton J, Martin-Ruiz C, von Zglinicki T, Saxby BK, Wesnes KA, Collerton D, et al. Serum 25-hydroxyvitamin D and cognitive decline in the very old: the Newcastle 85+ Study. Eur J Neurol 2015; 22:106-15, e6-7; http://dx.doi.org/10.1111/ene.12539
  • Annweiler C, Llewellyn DJ, Beauchet O. Low serum vitamin D concentrations in Alzheimer disease: a systematic review and meta-analysis. J Alzheimer Dis 2013; 33:659-74; PMID:23042216
  • Garland CF, Kim JJ, Mohr SB, Gorham ED, Grant WB, Giovannucci EL, Baggerly L, Hofflich H, Ramsdell JW, Zeng K, et al. Meta-analysis of All-Cause Mortality According to Serum 25-Hydroxyvitamin D. Am J Public Health 2014; 104:e43-50; PMID:24922127; http://dx.doi.org/10.2105/AJPH.2014.302034
  • Zittermann A, Iodice S, Pilz S, Grant WB, Bagnardi V, Gandini S. Vitamin D deficiency and mortality risk in the general population: a meta-analysis of prospective cohort studies. Am J Clin Nutr 2012; 95:91-100; PMID:22170374; http://dx.doi.org/10.3945/ajcn.111.014779
  • Durup D, Jorgensen HL, Christensen J, Schwarz P, Heegaard AM, Lind B. A reverse J-shaped association of all-cause mortality with serum 25-hydroxyvitamin D in general practice: the CopD study. J Clin Endocrinol Metab 2012; 97:2644-52; PMID:22573406; http://dx.doi.org/10.1210/jc.2012-1176
  • Schwarz P. Response to the letter by Grant. J Clin Endocrinol Metab 2015; 100:L51; PMID:26047083; http://dx.doi.org/10.1210/jc.2015-1809
  • Amrein K, Quraishi SA, Litonjua AA, Gibbons FK, Pieber TR, Camargo CA, Jr., Giovannucci E, Christopher KB. Evidence for a U-shaped relationship between prehospital vitamin D status and mortality: a cohort study. J Clin Endocrinol Metab 2014; 99:1461-9; PMID:24423347; http://dx.doi.org/10.1210/jc.2013-3481
  • Amrein K, Schnedl C, Holl A, Riedl R, Christopher KB, Pachler C, Urbanic Purkart T, Waltensdorfer A, Munch A, Warnkross H, et al. Effect of high-dose vitamin D3 on hospital length of stay in critically ill patients with vitamin D deficiency: the VITdAL-ICU randomized clinical trial. JAMA 2014; 312:1520-30; http://dx.doi.org/10.1001/jama.2014.13204
  • Bodnar LM, Catov JM, Zmuda JM, Cooper ME, Parrott MS, Roberts JM, Marazita ML, Simhan HN. Maternal serum 25-hydroxyvitamin D concentrations are associated with small-for-gestational age births in white women. J Nutr 2010; 140:999-1006; PMID:20200114; http://dx.doi.org/10.3945/jn.109.119636
  • Ramon R, Ballester F, Aguinagalde X, Amurrio A, Vioque J, Lacasana M, Rebagliato M, Murcia M, Iniguez C. Fish consumption during pregnancy, prenatal mercury exposure, and anthropometric measures at birth in a prospective mother-infant cohort study in Spain. Am J Clin Nutr 2009; 90:1047-55; PMID:19710189; http://dx.doi.org/10.3945/ajcn.2009.27944
  • Zhu P, Tong SL, Hu WB, Hao JH, Tao RX, Huang K, Mou Z, Zhou QF, Jiang XM, Tao FB. Cord blood 25-hydroxyvitamin D and fetal growth in the China-Anhui Birth Cohort Study. Sci Rep 2015; 5:14930; PMID:26450157; http://dx.doi.org/10.1038/srep14930
  • Hypponen E, Sovio U, Wjst M, Patel S, Pekkanen J, Hartikainen AL, Jarvelinb MR. Infant vitamin d supplementation and allergic conditions in adulthood: northern Finland birth cohort 1966. Ann N Y Acad Sci 2004; 1037:84-95; PMID:15699498; http://dx.doi.org/10.1196/annals.1337.013
  • Nehra D, Carlson SJ, Fallon EM, Kalish B, Potemkin AK, Gura KM, Simpser E, Compher C, Puder M, American Society for P, et al. A.S.P.E.N. clinical guidelines: nutrition support of neonatal patients at risk for metabolic bone disease. JPEN J Parenter Enteral Nutr 2013; 37:570-98; PMID:23685349; http://dx.doi.org/10.1177/0148607113487216
  • Kull I, Bergstrom A, Melen E, Lilja G, van Hage M, Pershagen G, Wickman M. Early-life supplementation of vitamins A and D, in water-soluble form or in peanut oil, and allergic diseases during childhood. J Allergy Clin Immunol 2006; 118:1299-304; PMID:17157660; http://dx.doi.org/10.1016/j.jaci.2006.08.022
  • Schuster GU, Kenyon NJ, Stephensen CB. Vitamin A deficiency decreases and high dietary vitamin A increases disease severity in the mouse model of asthma. J Immunol 2008; 180:1834-42; PMID:18209081; http://dx.doi.org/10.4049/jimmunol.180.3.1834
  • Back O, Blomquist HK, Hernell O, Stenberg B. Does vitamin D intake during infancy promote the development of atopic allergy? Acta Derm Venereol 2009; 89:28-32; PMID:19197538; http://dx.doi.org/10.2340/00015555-0541
  • Gale CR, Robinson SM, Harvey NC, Javaid MK, Jiang B, Martyn CN, Godfrey KM, Cooper C, Princess Anne Hospital Study G. Maternal vitamin D status during pregnancy and child outcomes. Eur J Clin Nutr 2008; 62:68-77; PMID:17311057; http://dx.doi.org/10.1038/sj.ejcn.1602680
  • Urashima M, Segawa T, Okazaki M, Kurihara M, Wada Y, Ida H. Randomized trial of vitamin D supplementation to prevent seasonal influenza A in schoolchildren. Am J Clin Nutr 2010; 91:1255-60; PMID:20219962; http://dx.doi.org/10.3945/ajcn.2009.29094
  • Hypponen E, Berry DJ, Wjst M, Power C. Serum 25-hydroxyvitamin D and IgE - a significant but nonlinear relationship. Allergy 2009; 64:613-20; PMID:19154546; http://dx.doi.org/10.1111/j.1398-9995.2008.01865.x
  • Rothers J, Wright AL, Stern DA, Halonen M, Camargo CA, Jr. Cord blood 25-hydroxyvitamin D levels are associated with aeroallergen sensitization in children from Tucson, Arizona. J Allergy Clin Immunol 2011; 128:1093-9 e1-5; PMID:21855975; http://dx.doi.org/10.1016/j.jaci.2011.07.015
  • Tolppanen AM, Sayers A, Granell R, Fraser WD, Henderson J, Lawlor DA. Prospective association of 25-hydroxyvitamin d3 and d2 with childhood lung function, asthma, wheezing, and flexural dermatitis. Epidemiology 2013; 24:310-9; PMID:23377091; http://dx.doi.org/10.1097/EDE.obo13e318280dd5e
  • Niruban SJ, Alagiakrishnan K, Beach J, Senthilselvan A. Association of vitamin D with respiratory outcomes in Canadian children. Eur J Clin Nutr 2014; 68:1334-40; PMID:24986817; http://dx.doi.org/10.1038/ejcn.2014.121
  • Niruban SJ, Alagiakrishnan K, Beach J, Senthilselvan A. Association between vitamin D and respiratory outcomes in Canadian adolescents and adults. J Asthma 2015; 52:653-61; PMID:25563060; http://dx.doi.org/10.3109/02770903.2015.1004339
  • Maslova E, Hansen S, Thorne-Lyman AL, Jensen CB, Strom M, Cohen A, Nielsen NO, Olsen SF. Predicted vitamin D status in mid-pregnancy and child allergic disease. Pediatric Allergy Immunol 2014; 25:706-13; PMID:25348236; http://dx.doi.org/10.1111/pai.12295
  • Hansen S, Maslova E, Strom M, Linneberg A, Halldorsson TI, Granstrom C, Dahl R, Hoffmann HJ, Olsen SF. The long-term programming effect of maternal 25-hydroxyvitamin D in pregnancy on allergic airway disease and lung function in offspring after 20 to 25 years of follow-up. J Allergy Clin Immunol 2015; 136:169-76e2; PMID:25649083; http://dx.doi.org/10.1016/j.jaci.2014.12.1924
  • Lerchbaum E, Pilz S, Trummer C, Rabe T, Schenk M, Heijboer AC, Obermayer-Pietsch B. Serum vitamin D levels and hypogonadism in men. Andrology 2014; 2:748-54; PMID:25044703; http://dx.doi.org/10.1111/j.2047-2927.2014.00247.x
  • Karras S, Anagnostis P, Kotsa K, Goulis DG. Vitamin D and gonadal function in men: a potential inverse U-shaped association? Andrology 2016; 4(3):542-4; PMID:26991835
  • Ramlau-Hansen CH, Moeller UK, Bonde JP, Olsen J, Thulstrup AM. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril 2011; 95:1000-4; PMID:21122842; http://dx.doi.org/10.1016/j.fertnstert.2010.11.002
  • Hammoud AO, Meikle AW, Peterson CM, Stanford J, Gibson M, Carrell DT. Association of 25-hydroxy-vitamin D levels with semen and hormonal parameters. Asian J Androl 2012; 14:855-9; PMID:23042450; http://dx.doi.org/10.1038/aja.2012.77
  • Brouwer-Brolsma EM, Bischoff-Ferrari HA, Bouillon R, Feskens EJ, Gallagher CJ, Hypponen E, Llewellyn DJ, Stoecklin E, Dierkes J, Kies AK, et al. Vitamin D: do we get enough? A discussion between vitamin D experts in order to make a step towards the harmonisation of dietary reference intakes for vitamin D across Europe. Osteoporos Int 2013; 24:1567-77; PMID:23229471; http://dx.doi.org/10.1007/s00198-012-2231-3
  • Cantorna MT, Mahon BD. D-hormone and the immune system. J Rheumatol Suppl 2005; 76:11-20; PMID:16142846
  • Boucher BJ. Early pregnancy maternal vitamin D concentrations and risk of gestational diabetes mellitus. Paediatr Perinat Epidemiol 2015; 29:196-9; PMID:25873289; http://dx.doi.org/10.1111/ppe.12187
  • Veldurthy V, Wei R, Campbell M, Lupicki K, Dhawan P, Christakos S. Twenty-five-Hydroxyvitamin D3 24-Hydroxylase: A Key Regulator of 1,25(OH)2D3 Catabolism and Calcium Homeostasis. Vitam Horm 2016; 100:137-50; PMID:26827951; http://dx.doi.org/10.1016/bs.vh.2015.10.005
  • Black LJ, Anderson D, Clarke MW, Ponsonby AL, Lucas RM, Ausimmune Investigator G. Analytical Bias in the Measurement of Serum 25-Hydroxyvitamin D Concentrations Impairs Assessment of Vitamin D Status in Clinical and Research Settings. PloS One 2015; 10:e0135478; PMID:26266807; http://dx.doi.org/10.1371/journal.pone.0135478
  • Sempos CT, Durazo-Arvizu RA, Binkley N, Jones J, Merkel JM, Carter GD. Developing vitamin D dietary guidelines and the lack of 25-hydroxyvitamin D assay standardization: The ever-present past. J Steroid Biochem Mol Biol 2015; pii: S0960-0760(15)30059-5; PMID: 26321386; http://dx.doi.org/10.1016/j.jsbmb.2015.08.027
  • Carter GD. Twenty-five-hydroxyvitamin D: a difficult analyte. Clin Chem 2012; 58:486-8; PMID:22238254; http://dx.doi.org/10.1373/clinchem.2011.180562
  • Hypponen E, Turner S, Cumberland P, Power C, Gibb I. Serum 25-hydroxyvitamin D measurement in a large population survey with statistical harmonization of assay variation to an international standard. J Clin Endocrinol Metab 2007; 92:4615-22; PMID:17726070; http://dx.doi.org/10.1210/jc.2007-1279
  • Boucher BJ. Vitamin D insufficiency and diabetes risks. Curr Drug Targets 2011; 12:61-87; PMID:20795936; http://dx.doi.org/10.2174/138945011793591653