734
Views
6
CrossRef citations to date
0
Altmetric
Research Paper

Endoscopic biopsy of islet transplants in the gastric submucosal space provides evidence of islet graft rejection in diabetic pigs

, , , , , , , , , , , , , & show all
Pages 1-12 | Received 21 Sep 2015, Accepted 26 Jan 2016, Published online: 02 Mar 2016

References

  • Barton FB, Rickels MR, Alejandro R, Hering BJ, Wease S, Naziruddin B, Oberholzer J, Odorico JS, Garfinkel MR, Levy M, et al. Improvement in outcomes of clinical islet transplantation: 1999–2010. Diabetes Care 2012; 35:1436-45; PMID:22723582; http://dx.doi.org/10.2337/dc12-0063
  • Bellin MD, Barton FB, Heitman A, Harmon JV, Kandaswamy R, Balamurugan AN, Sutherland DE, Alejandro R, Hering BJ. Potent induction immunotherapy promotes long-term insulin independence after islet transplantation in type 1 diabetes. Am J Transplant 2012; 12:1576-83; PMID:22494609; http://dx.doi.org/10.1111/j.1600-6143.2011.03977.x
  • van der Windt DJ, Bottino R, Casu A, Campanile N, Cooper DK. Rapid loss of intraportally transplanted islets: an overview of pathophysiology and preventive strategies. Xenotransplantation 2007; 14:288-97; PMID:17669170; http://dx.doi.org/10.1111/j.1399-3089.2007.00419.x
  • Echeverri GJ, McGrath K, Bottino R, Hara H, Dons EM, van der Windt DJ, Ekser B, Casu A, Houser S, Ezzelarab M, et al. Endoscopic gastric submucosal transplantation of islets (ENDO-STI): technique and initial results in diabetic pigs. Am J Transplant 2009; 9:2485-96; PMID:19775318; http://dx.doi.org/10.1111/j.1600-6143.2009.02815.x
  • Fujita M, McGrath KM, Bottino R, Dons EM, Long C, Kumar G, Ekser B, Echeverri GJ, Hata J, Haruma K, et al. Technique of endoscopic biopsy of islet allografts transplanted into the gastric submucosal space in pigs. Cell Transplant 2013; 22:2335-44; PMID:23336557; http://dx.doi.org/10.3727/096368912X662381
  • Toso C, Isse K, Demetris AJ, Dinyari P, Koh A, Imes S, Kin T, Emamaullee J, Senior P, Shapiro AM. Histologic graft assessment after clinical islet transplantation. Transplantation 2009; 88:1286-93; PMID:19996928; http://dx.doi.org/10.1097/TP.0b013e3181bc06b0
  • Bottino R, Balamurugan AN, Smetanka C, Bertera S, He J, Rood PP, Cooper DK, Trucco M. Isolation outcome and functional characteristics of young and adult pig pancreatic islets for transplantation studies. Xenotransplantation 2007; 14:74-82; PMID:17214707; http://dx.doi.org/10.1111/j.1399-3089.2006.00374.x
  • Batinic-Haberle I, Tovmasyan A, Roberts ER, Vujaskovic Z, Leong KW, Spasojevic I. SOD therapeutics: latest insights into their structure-activity relationships and impact on the cellular redox-based signaling pathways. Antioxid Redox Signal 2014; 20:2372-415; PMID:23875805; http://dx.doi.org/10.1089/ars.2012.5147
  • Hara H, Lin YJ, Zhu X, Tai HC, Ezzelarab M, Balamurugan AN, Bottino R, Houser SL, Cooper DK. Safe induction of diabetes by high-dose streptozotocin in pigs. Pancreas 2008; 36:31-8; PMID:18192878; http://dx.doi.org/10.1097/mpa.0b013e3181452886
  • Tse HM, Milton MJ, Schreiner S, Profozich JL, Trucco M, Piganelli JD. Disruption of innate-mediated proinflammatory cytokine and reactive oxygen species third signal leads to antigen-specific hyporesponsiveness. J Immunol 2007; 178:908-17; PMID:17202352; http://dx.doi.org/10.4049/jimmunol.178.2.908
  • Sklavos MM, Tse HM, Piganelli JD. Redox modulation inhibits CD8 T cell effector function. Free Radic Biol Med 2008; 45:1477-86; PMID:18805480; http://dx.doi.org/10.1016/j.freeradbiomed.2008.08.023
  • Hara H, Witt W, Crossley T, Long C, Isse K, Fan L, Phelps CJ, Ayares D, Cooper DK, Dai Y, et al. Human dominant-negative class II transactivator transgenic pigs - effect on the human anti-pig T-cell immune response and immune status. Immunology 2013; 140:39-46; PMID:23566228; http://dx.doi.org/10.1111/imm.12107
  • Hara H, Long C, Lin YJ, Tai HC, Ezzelarab M, Ayares D, Cooper DK. In vitro investigation of pig cells for resistance to human antibody-mediated rejection. Transpl Int 2008; 21:1163-74; PMID:18764834; http://dx.doi.org/10.1111/j.1432-2277.2008.00736.x
  • Lenzen S, Drinkgern J, Tiedge M. Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. Free Radic Biol Med 1996; 20:463-6; PMID:8720919; http://dx.doi.org/10.1016/0891-5849(96)02051-5
  • Tiedge M, Lortz S, Drinkgern J, Lenzen S. Relation between antioxidant enzyme gene expression and antioxidative defense status of insulin-producing cells. Diabetes 1997; 46:1733-42; PMID:9356019; http://dx.doi.org/10.2337/diab.46.11.1733
  • Bottino R, Balamurugan AN, Bertera S, Pietropaolo M, Trucco M, Piganelli JD. Preservation of human islet cell functional mass by anti-oxidative action of a novel SOD mimic compound. Diabetes 2002; 51:2561-7; PMID:12145171; http://dx.doi.org/10.2337/diabetes.51.8.2561
  • Bottino R, Balamurugan AN, Tse H, Thirunavukkarasu C, Ge X, Profozich J, Milton M, Ziegenfuss A, Trucco M, Piganelli JD. Response of human islets to isolation stress and the effect of antioxidant treatment. Diabetes 2004; 53:2559-68; PMID:15448084; http://dx.doi.org/10.2337/diabetes.53.10.2559
  • Tse HM, Milton MJ, Piganelli JD. Mechanistic analysis of the immunomodulatory effects of a catalytic antioxidant on antigen-presenting cells: implication for their use in targeting oxidation-reduction reactions in innate immunity. Free Radic Biol Med 2004; 36:233-47; PMID:14744635; http://dx.doi.org/10.1016/j.freeradbiomed.2003.10.029
  • Jenkins MK, Khoruts A, Ingulli E, Mueller DL, McSorley SJ, Reinhardt RL, Itano A, Pape KA. In vivo activation of antigen-specific CD4 T cells. Annu Rev Immunol 2001; 19:23-45; PMID:11244029; http://dx.doi.org/10.1146/annurev.immunol.19.1.23
  • Yoshimura S, Bondeson J, Foxwell BM, Brennan FM, Feldmann M. Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines. Int Immunol 2001; 13:675-83; PMID:11312255; http://dx.doi.org/10.1093/intimm/13.5.675
  • Heimberg H, Heremans Y, Jobin C, Leemans R, Cardozo AK, Darville M, Eizirik DL. Inhibition of cytokine-induced NF-kappaB activation by adenovirus-mediated expression of a NF-kappaB super-repressor prevents beta-cell apoptosis. Diabetes 2001; 50:2219-24; PMID:11574401; http://dx.doi.org/10.2337/diabetes.50.10.2219
  • Sklavos MM, Bertera S, Tse HM, Bottino R, He J, Beilke JN, Coulombe MG, Gill RG, Crapo JD, Trucco M, et al. Redox modulation protects islets from transplant-related injury. Diabetes 2010; 59:1731-8; PMID:20413509; http://dx.doi.org/10.2337/db09-0588
  • Piganelli JD, Flores SC, Cruz C, Koepp J, Batinic-Haberle I, Crapo J, Day B, Kachadourian R, Young R, Bradley B, et al. A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. Diabetes 2002; 51:347-55; PMID:11812741; http://dx.doi.org/10.2337/diabetes.51.2.347
  • Batinic-Haberle I, Reboucas JS, Spasojevic I. Superoxide dismutase mimics: chemistry, pharmacology, and therapeutic potential. Antioxid Redox Signal 2010; 13:877-918; PMID:20095865; http://dx.doi.org/10.1089/ars.2009.2876
  • Delmastro MM, Piganelli JD. Oxidative stress and redox modulation potential in type 1 diabetes. Clin Dev Immunol 2011; 2011:593863; PMID:21647409; http://dx.doi.org/10.1155/2011/593863
  • Delmastro-Greenwood MM, Votyakova T, Goetzman E, Marre ML, Previte DM, Tovmasyan A, Batinic-Haberle I, Trucco MM, Piganelli JD. Mn porphyrin regulation of aerobic glycolysis: implications on the activation of diabetogenic immune cells. Antioxid Redox Signal 2013; 19:1902-15; PMID:23682840; http://dx.doi.org/10.1089/ars.2012.5167
  • Delmastro-Greenwood MM, Piganelli JD. Changing the energy of an immune response. Am J Clin Exp Immunol 2013; 2:30-54; PMID:23885324
  • Delmastro-Greenwood MM, Tse HM, Piganelli JD. Effects of metalloporphyrins on reducing inflammation and autoimmunity. Antioxid Redox Signal 2014; 20:2465-77; PMID:23472672; http://dx.doi.org/10.1089/ars.2013.5257
  • Pileggi A, Molano RD, Berney T, Cattan P, Vizzardelli C, Oliver R, Fraker C, Ricordi C, Pastori RL, Bach FH, et al. Heme oxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 2001; 50:1983-91; PMID:11522663; http://dx.doi.org/10.2337/diabetes.50.9.1983
  • Keymeulen B, Korbutt G, De Paepe M, Gorus F, Kloppel G, Pipeleers DG. Long-term metabolic control by rat islet grafts depends on the composition of the implant. Diabetes 1996; 45:1814-21; PMID:8922370; http://dx.doi.org/10.2337/diab.45.12.1814

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.