The Effects of Synbiotic Supplementation on Body Mass Index, Metabolic and Inflammatory Biomarkers, and Appetite in Patients with Metabolic Syndrome: A Triple-Blind Randomized Controlled Trial

References

• Asemi Z, Samimi M, Tabassi Z, Naghibi Rad M, Rahimi Foroushani A, Khorammian H, Esmaillzadeh A. 2013. Effect of daily consumption of probiotic yoghurt on insulin resistance in pregnant women: a randomized controlled trial. Eur J Clin Nutr. 67:71–74. doi:10.1038/ejcn.2012.189. PMID: 23187955.
   PubMed Web of Science ®Google Scholar
• Baumann H, Gauldie J. 1994. The acute phase response. Immunology Today. 15:74–80. doi:10.1016/0167-5699(94)90137-6. PMID:7512342.
   PubMedGoogle Scholar
• Cani PD, Delzenne NM, Amar J, Burcelin R. 2008. Role of gut microflora in the development of obesity and insulin resistance following high-fat diet feeding. Pathol Biol. 56:305–309. doi:10.1016/j.patbio.2007.09.008. PMID:18178333.
   PubMed Web of Science ®Google Scholar
• Chang B, Park S, Jang Y, Ko SH, Joo NM, Kim SI, Kim CH, Chang DK. 2011. Effect of functional yogurt NY-YP901 in improving the trait of metabolic syndrome. Eur J Clin Nutr. 65:1250–1255. doi:10.1038/ejcn.2011.115.
   PubMed Web of Science ®Google Scholar
• De Preter V, Hamer H, Windey K, Verbeke K. 2011. The impact of pre- and/or probiotics on human colonic metabolism: does it affect human health? Mol Nutr Food Res. 55:46–57. doi:10.1002/mnfr.201000451. PMID:21207512.
   PubMed Web of Science ®Google Scholar
• Drisko J, Giles C, Bischoff B. 2003. Probiotics in health maintenance and disease prevention. Altern Med Rev. 8:143–155. PMID:12777160.
   PubMedGoogle Scholar
• Ejtahed H, Mohtadi Nia J, Homayouni Rad A, et al. 2011. The effects of probiotic and regular yogurt on blood glucose and insulin resistance in pateints with type 2 diabetes: clinical control randomaized trial. Int J Endocrinol Metab. 13:1–8.
   Google Scholar
• Ejtahed H, Mohtadi-Nia J, Homayouni-Rad A, Niafar M, Asghari-Jafarabadi M, Mofid V, Akbarian-Moghari A. 2011. Effect of probiotic yogurt containing Lactobacillus acidophilus and Bifidobacterium lactis on lipid profile in individuals with type 2 diabetes mellitus. J Dairy Sci. 94:3288–3294. doi:10.3168/jds.2010-4128. PMID:21700013.
   PubMed Web of Science ®Google Scholar
• Esteve E, Ricart W, Fernández-Real J. 2011. Gut microbiota interactions with obesity, insulin resistance and type 2 diabetes: did gut microbiote co-evolve with insulin resistance? Curr Opin Clin Nutr Metab Care. 14:483–490. doi:10.1097/MCO.0b013e328348c06d. PMID:21681087.
   PubMed Web of Science ®Google Scholar
• Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem Biol Interact. 18:499–502.
   Google Scholar
• Fukumori R, Mita T, Sugino T, Obitsu T, Taniguchi K. 2012. Plasma concentrations and effects of glucagon-like peptide-1 (7–36) amide in calves before and after weaning. Domest Anim Endocrinol. 43:299–306. doi:10.1016/j.domaniend.2012.05.003. PMID:22683323.
   PubMed Web of Science ®Google Scholar
• Fuller R. 1989. Probiotics in man and animals. J Appl Bacteriol. 66:365–78. doi:10.1111/j.1365-2672.1989.tb05105.x. PMID:2666378.
   PubMedGoogle Scholar
• Gao Z, Yin J, Zhang J, Ward RE, Martin RJ, Lefevre M, Cefalu WT, Ye J. 2009. Butyrate improves insulin sensitivity and increases energy expenditure in mice. Diabetes Care. 58:1509–1517. doi:10.2337/db08-1637.
   Google Scholar
• Goldin B, Gorbach S. 2008. Clinical indications for probiotics: an overview. Clin Infect Dis. 46:S96–S100. doi:10.1086/523333. PMID:18181732.
   PubMed Web of Science ®Google Scholar
• Hatakka K, Mutanen M, Holma R, Saxelin M, Korpela R. 2008. Lactobacillus rhamnosus LC705 together with Propionibacterium freudenreichii ssp shermanii JS administered in capsules is ineffective in lowering serum lipids. J Am Coll Nutr. 27:441–447. doi:10.1080/07315724.2008.10719723. PMID:18978162.
   PubMed Web of Science ®Google Scholar
• Hotamisligil GS, Arner P, Caro JF, Atkinson RL, Spiegelman BM. 1995. Increased adipose tissue expression of tumor necrosis factor in human obesity and insulin resistance. J Clin Invest. 95:2409–2415. doi:10.1172/JCI117936. PMID:7738205.
   PubMed Web of Science ®Google Scholar
• Kelishadi R, Rabiee K, Khosravi A, et al. 2001. Association of physical activity pattern of adolescence in Isfahan. Shahrekord Univ Med Sci. 3:55–65.
   Google Scholar
• Kellow N, Coughlan M, Reid C. 2014. Metabolic benefits of dietary prebiotics in human subjects: a systematic review of randomised controlled trials. Br J Nutr. 13:1–15.
   Google Scholar
• Kondo S, Xiao J, Satoh T, Odamaki T, Takahashi S, Sugahara H, Yaeshima T, Iwatsuki K, Kamei A, Abe K. 2010. Antiobesity effects of Bifidobacterium breve strain B-3 supplementation in a mouse model with high-fat diet-induced obesity. Biosci Biotechnol Biochem. 74:1656–1661. doi:10.1271/bbb.100267. PMID:20699581.
   PubMed Web of Science ®Google Scholar
• Kumar M, Rakesh S, Nagpal R, Hemalatha R, Ramakrishna A, Sudarshan V, Ramagoni R, Shujauddin M, Verma V, Kumar A, et al. 2013. Probiotic Lactobacillus rhamnosus GG and Aloe vera gel improve lipid profiles in hypercholesterolemic rats. Nutrition. 29:574–579. doi:10.1016/j.nut.2012.09.006. PMID:23287067.
   PubMed Web of Science ®Google Scholar
• Lee S, Bose S, Seo J, Chung WS, Lim CY, Kim H. 2013. The effects of co-administration of probiotics with herbal medicine on obesity, metabolic endotoxemia and dysbiosis: A randomized double-blind controlled clinical trial. Clin Nutr. 13:329–324.
   Google Scholar
• Lesniewska V, Rowland I, Cani P, Neyrinck AM, Delzenne NM, Naughton PJ. 2006. Effect on components of the intestinal microflora and plasma neuropeptide levels of feeding Lactobacillus delbrueckii, Bifidobacterium lactis, and inulin to adult and elderly rats. Appl Environ Microbiol. 72:6533–6538. doi:10.1128/AEM.00915-06. PMID:17021202.
   PubMed Web of Science ®Google Scholar
• Ma X, Hua J, Li Z. 2008. Probiotics improve high fat diet-induced hepatic steatosis and insulin resistance by increasing hepatic NKT cells. J Hepatol. 49:821–830. doi:10.1016/j.jhep.2008.05.025. PMID:18674841.
   PubMed Web of Science ®Google Scholar
• Matsuzaki T, Yamazaki R, Hashimoto S, et al. 1997. Antidiabetic effects of an oral administration of Lactobacillus casei in a non-insulin-dependent diabetes mellitus (NIDDM) model using KK-A(y) mice. Endocrine J. 44:357–365. doi:10.1507/endocrj.44.357.
   PubMed Web of Science ®Google Scholar
• Mazloom Z, Yousefinejad A, Dabbaghmanesh M. 2013. Effect of probiotics on lipid profile, glycemic control, insulin action, oxidative stress, and inflammatory markers in patients with type 2 diabetes: a clinical trial. Iran J Med Sci. 38:38–43. PMID:23645956.
   PubMedGoogle Scholar
• Musso G, Gambino R, Cassader M. 2010. Obesity, diabetes, and gut microbiota: the hygiene hypothesis expanded? Diabetes Care. 33:2277–2284. doi:10.2337/dc10-0556. PMID:20876708.
   PubMed Web of Science ®Google Scholar
• Nestel PJ, Connor WE, Reardon MF. 1984. Suppression by diets rich in fish oil of very low density lipoprotein productio in man. J Clin Invest. 74:82–89. doi:10.1172/JCI111422. PMID:6736254.
   PubMed Web of Science ®Google Scholar
• Nordgaard I, Mortensen PB, Langkilde AM. 1995. Small intestinal malabsorption and colonic fermentation of resistant starch and resistant peptides to short-chain fatty acids. Nutrition. 11:129–137. PMID:7544175.
   PubMed Web of Science ®Google Scholar
• Papanicolaou DA, Wilder RL, Manolagas SC, Chrousos GP. 1998. The pathophysiologic roles of interleukin-6 in human disease. Ann Intern Med. 128:127–137. doi:10.7326/0003-4819-128-2-199801150-00009. PMID:9441573.
   PubMed Web of Science ®Google Scholar
• Parnell J, Reimer R. 2012. Prebiotic fiber modulation of the gut microbiota improves risk factors for obesity and the metabolic syndrome. Gut Microbes. 3:29–34. doi:10.4161/gmic.19246. PMID:22555633.
   PubMed Web of Science ®Google Scholar
• Pataky Z, Bobbioni-Harsch E, Hadengue A, Carpentier A, Golay A. 2009. Gut microbiota, responsible for our body weight? Rev Med Suisse. 5:662–664. PMID:19462608.
   PubMedGoogle Scholar
• Pereira D, Gibson G. 2002. Effects of consumption of probiotics and prebiotics on serum lipid levels in humans. Biochem Mol Biol. 37:259–281.
   Google Scholar
• Puddu A, Sanguineti R, Montecucco F, Viviani GL. 2014. Evidence for the gut microbiota short-chain fatty acids as key pathophysiological molecules improving diabetes. Mediators Inflamm. 2014:162021. doi:10.1155/2014/162021. Epub 2014 Aug 17.
   PubMed Web of Science ®Google Scholar
• Purohit A, Ghilchik MW, Duncanet L, Wang DY, Singh A, Walker MM, Reed MJ. 1995. Aromatase activity and interleukin-6 production by normal and malignant breast tissues. J Clin Endocrinol Metab. 80:3052–3058. PMID:7559896.
   PubMed Web of Science ®Google Scholar
• Qin J, Li Z, Cai Y, Li S, Zhu J, Zhang F, Liang S, Zhang W, Guan Y, Shen D, et al. 2012. Ametagenome-wide association study of gut microbiota in type 2 diabetes. Nature. 490:55–60. doi:10.1038/nature11450. PMID:23023125.
   PubMed Web of Science ®Google Scholar
• Rabiei S, Shakerhosseini R, Saadat N. 2015. The effects of synbiotic therapy on anthropometric measures, body composition and blood pressure in patient with metabolic syndrome: a triple blind RCT. Med J Islam Repub Iran. 26:213.
   Google Scholar
• Rautava S, Isolauri E. 2003. Gut microbiota and the intestinal immune system in food allergy – targets for probiotic therapy. Food Allergy Intolerance. 4:5–31.
   Google Scholar
• Rajkumar H, Mahmood N, Kumar M, Variation SR, Challa HR, Myakala SP. 2014. Effect of probiotic (VSL#3) and omega-3 on lipid profile, insulin sensitivity, inflammatory markers, and gut colonization in overweight adults: a randomized, controlled trial. Mediators Inflamm. 2014:348959. doi:10.1155/2014/348959. Epub 2014 Mar 26.
   PubMed Web of Science ®Google Scholar
• Rohde LEP, Hennekens CH, Ridker PM. 1999. Survey of C-reactive protein and cardiovascular risk factors in apparently healthymen. Am J Cardiol. 84:1018–1022. doi:10.1016/S0002-9149(99)00491-9. PMID:10569656.
   PubMed Web of Science ®Google Scholar
• Sanchez M, Darimont C, Drapeau V, Emady-Azar S, Lepage M, Rezzonico E, Ngom-Bru C, Berger B, Philippe L, Ammon-Zuffrey C, et al. 2014. Effect of Lactobacillus rhamnosus CGMCC1.3724 supplementation on weight loss and maintenance in obese men and women. Br J Nutr. 111:1507–1519. doi:10.1017/S0007114513003875. PMID:24299712.
   PubMed Web of Science ®Google Scholar
• Shi H, Walker A. 2004. Bacterial colonization and the development of intestinal defences. Can J Gastroenterol. 18:493–500. doi:10.1155/2004/690421. PMID:15372112.
   PubMed Web of Science ®Google Scholar
• Simons LA, Amansec SG, Conway P. 2006. Effect of Lactobacillus fermentum on serum lipids in subjects with elevated serum cholesterol. Nutr Metab Cardiovasc Dis. 16:531–535. doi:10.1016/j.numecd.2005.10.009. PMID:17126768.
   PubMed Web of Science ®Google Scholar
• Tabuchi M, Ozaki M, Tamura A, Yamada N, Ishida T, Hosoda M, Hosono A. 2003. Antidiabetic effect of Lactobacillus GG in streptozotocin-induced diabetic rats. Biosci Biotechnol Biochem. 67:1421–1424. doi:10.1271/bbb.67.1421. PMID:12843677.
   PubMed Web of Science ®Google Scholar
• Tahri K, Grill J, Schneider F. 1996. Bifidobacteria strain behavior toward cholesterol: coprecipitation with bile salts and assimilation. Curr Microbiol. 33:187–193. doi:10.1007/s002849900098. PMID:8672088.
   PubMed Web of Science ®Google Scholar
• Teixeira T, Collado M, Ferreira C, Bressan J, Peluzio Mdo C. 2012. Potential mechanisms for the emerging link between obesity and increased intestinal permeability. Nutr Res. 32:637–647. doi:10.1016/j.nutres.2012.07.003. PMID:23084636.
   PubMed Web of Science ®Google Scholar
• Tilg H, Kaser A. 2011. Gut microbiome, obesity, and metabolic dysfunction. J Clin Invest. 121:2126–2132. doi:10.1172/JCI58109. PMID:21633181.
   PubMed Web of Science ®Google Scholar
• Tripolt N, Leber B, Blattl D, Eder M, Wonisch W, Scharnagl H, Stojakovic T, Obermayer-Pietsch B, Wascher TC, Pieber TR, et al. 2013. Short communication: Effect of supplementation with Lactobacillus casei Shirota on insulin sensitivity, β-cell function, and markers of endothelial function and inflammation in subjects with metabolic syndrome–a pilot study. J Dairy Sci. 96:89–95. doi:10.3168/jds.2012-5863. PMID:23164226.
   PubMed Web of Science ®Google Scholar
• Visser M, Bouter LM, McQuillan GM, Wener MH, Harris TB. 1999. Elevated C-reactive protein levels in overweight and obese adults. J Am Med Inform Assoc. 282:2131–2135. doi:10.1001/jama.282.22.2131.
   Web of Science ®Google Scholar
• Wang J, Tang H, Zhang C, Zhao Y, Derrien M, Rocher E, et al. 2015. Modulation of gut microbiota during probiotic-mediated attenuation of metabolic syndrome in high fat diet-fed mice. ISME J. 9(1):1–15. doi:10.1038/ismej.2014.99. Epub 2014 Jun 17.
   PubMed Web of Science ®Google Scholar
• Yadav H, Lee JH, Lloyd J, Walter P, Rane SG. 2013. Beneficial metabolic effects of a probiotic via butyrate-induced GLP-1 hormone secretion. J Biol Chem. 288:25088–25097. doi:10.1074/jbc.M113.452516. PMID:23836895.
   PubMed Web of Science ®Google Scholar
• Zarrati M, Salehi E, Nourijelyani K, Mofid V, Zadeh MJ, Najafi F, Ghaflati Z, Bidad K, Chamari M, Karimi M, et al. 2014. Effects of probiotic yogurt on fat distribution and gene expression of proinflammatory factors in peripheral blood mononuclear cells in overweight and obese people with or without weight-loss diet. J Am Coll Nutr. 31:1–9 [Epub ahead of print].
   Google Scholar