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Articles

Hydro-Ethanolic Fruit Extract of Capsicum frutescens Reversed Triton-X-100–Induced Hyperlipidaemia in Rats

, BSc, MSc, PhD, , BSc, MSc, PhD & , BSc, MSc, PhDORCID Icon

References

  • Adeleye AO, Ajiboye TO, Iliasu GA, Abdussalam FA, Balogun A, Ojewuyi OB, Yakubu MT. 2014. Phenolic extract of Dialium guineense pulp enhances reactive oxygen species detoxification in Aflatoxin B1 Hepatocarcinogenesis. J Med Food. 17(8):875–885.
  • Adigun NS, Oladiji AT, Ajiboye TO. 2016. Antioxidant and anti-hyperlipidemic activity of hydroethanolic seed extract of Aframomum melegueta K. Schum in Triton X-100 induced hyperlipidemic rats. South African J Bot. 105:324–332.
  • Ajboye TO, Yakubu MT, Salau AK, Oladiji AT, Akanji MA, Okogun JI. 2010. Antioxidant and drug detoxification potential of aqueous extract of Annona senegalensis leaves in carbon tetrachloride-induced hepatocellular damage. Pharm Biol. 48(12):1361–1370.
  • Ajiboye TO, Salau AK, Yakubu MT, Oladiji AT, Akanji MA, Okogun JI. 2010. Acetaminophen perturbed redox homeostasis in Wistar rat liver: protective role of aqueous Pterocarpus osun leaf extract. Drug Chem Toxicol. 33(1):77–87.
  • Ajiboye TO, Abdussalam FA, Adeleye AO, Iliasu GA, Ariyo FA, Adediran ZA, Raji KO, Raji HO. 2013a. Bridelia ferruginea promotes reactive oxygen species Detoxification in N-Nitrosodiethylamine-Treated rats. J Diet Suppl. 10(3):210–228.
  • Ajiboye TO, Komolafe YO, Oloyede OB, Ogunbode SM, Adeoye MD, Abdulsalami IO, Nurudeen QO. 2013b. Polyphenolic extract of Sorghum bicolor grains enhances reactive oxygen species detoxification in N -nitrosodiethylamine-treated rats. Food Sci Hum Wellness. 2(1):39–47.
  • Ajiboye TO, Yakubu MT, Oladiji AT. 2014a. Lophirones B and C Extenuate AFB 1 -Mediated oxidative onslaught on cellular proteins, lipids, and DNA through Nrf-2 Expression. J Biochem Mol Toxicol. 0:1–10.
  • Ajiboye TO, Yakubu MT, Oladiji AT. 2014. Cytotoxic, antimutagenic, and antioxidant activities of methanolic extract and Chalcone Dimers (Lophirones B and C) derived from Lophira alata (Van Tiegh. Ex Keay) Stem Bark. J Evid Based Complementary Altern Med. 19(1):20–30.
  • Ajiboye TO. 2015. Standardized extract of Vitex doniana Sweet stalls protein oxidation, lipid peroxidation and DNA fragmention in acetaminophen- induced hepatotoxicity. J Ethnopharmacol. 164:273–282.
  • Ajiboye TO, Aliyu H, Tanimu MA, Muhammad RM, Ibitoye OB. 2016. Dioscoreophyllum cumminsii (Stapf) Diels leaves halt high-fructose induced metabolic syndrome: Hyperglycemia, insulin resistance, inflammation and oxidative stress. J Ethnopharmacol. 192:471–479.
  • Ajiboye TO, Hussaini AA, Nafiu BY, Ibitoye OB. 2017. Aqueous seed extract of Hunteria umbellata (K. Schum.) Hallier f. (Apocynaceae) palliates hyperglycemia, insulin resistance, dyslipidemia, inflammation and oxidative stress in high-fructose diet-induced metabolic syndrome in rats. J Ethnopharmacol. 198:184–193.
  • Ajiboye TO, Ahmad FM, Daisi AO, Yahaya AA, Ibitoye OB, Muritala HF, Sunmonu TO. 2017. Hepatoprotective potential of Phyllanthus muellarianus leaf extract: studies on hepatic, oxidative stress and inflammatory biomarkers. Pharm Biol. 55(1):1662–1670.
  • Barrita JLS, Sánchez M, del SS. 2013. Antioxidant role of ascorbic acid and his protective effects on chronic diseases. In: Oxidative Stress and Chronic Degenerative Diseases - A Role for Antioxidants. pp. 449–484.
  • Beers RF, Sizer IW. 1952. A spectrophotometric method for measuring the breakdown of hydrogen peroxide by catalase. J Biol Chem. 195(1):133–140.
  • Carr TP, Andresen CJ, Rudel LL. 1993. Enzymatic determination of triglyceride, free cholesterol, and total cholesterol in tissue lipid extracts. Clin Biochem. 26(1):39–42.
  • Domitrović R, Jakovac H. 2010. Antifibrotic activity of anthocyanidin delphinidin in carbon tetrachloride-induced hepatotoxicity in mice. Toxicology. 272(1–3):1–10.
  • Duarte TL, Cooke MS, Jones GDD. 2009. Gene expression profiling reveals new protective roles for vitamin C in human skin cells. Free Radic Biol Med. 46(1):78–87.
  • Enyinnaya Ogbonnaya IM. 2014. Effect of crude ethanolic extract of Capsicum Frutescens fruit on Cisplatin-Induced renal insufficiency in rats. J Physiol Pharmacol Adv. 4:332–336.
  • Folch J, Lees M, Sloane Stanley GH. 1957. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 226:497–509.
  • Friedewald WT, Levy RI, Fredrickson DS. 1972. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:499–502.
  • Gundamaraju R, Hwi KK, Singla RK, Vemuri RC, Mulapalli SB. 2014. Antihyperlipidemic potential of Albizia amara (Roxb) Boiv. bark against Triton X-100 induced hyperlipidemic condition in rats. Phcog Res. 6(4):267–273.
  • Gupta UC, Jain GC. 2009. Study on hypolipidemic activity of Cassia fistula. Legume in rats. Asian J Exp Sci. 23(1):241–248.
  • Kang MJ, Lee EK, Lee SS. 2004. Effects of two P/S ratios with same peroxidizability index value and antioxidants supplementation on serum lipid concentration and hepatic enzyme activities of rats. Clin Chim Acta. 350(1–2):79–87.
  • Kaur A, Dhari J, Sharma OP, Gupta GD, Kharb V. 2012. In-vitro anti-oxidant and free radical scavenging activity of lycopene. Res J Pharm Biol Chem Sci. 3:1220–1228.
  • Kayamori F, Igarashi K. 1994. Effects of dietary Nasunin on the Serum cholesterol level in rats. Biosci Biotechnol Biochem. 58(3):570–571.
  • Kim JH, Lee HJ, Jeong SJ, Lee MH, Kim SH. 2012. Essential oil of pinus koraiensis leaves exerts antihyperlipidemic effects via up-regulation of low-density lipoprotein receptor and inhibition of acyl-coenzyme A: Cholesterol acyltransferase. Phytother Res. 26(9):1314–1319.
  • Laohavechvanich P, Kangsadalampai K, Tirawanchai N, Ketterman AJ. 2006. Effect of different Thai traditional processing of various hot chili peppers on urethane-induced somatic mutation and recombination in Drosophila melanogaster: Assessment of the role of glutathione transferase activity. Food Chem Toxicol. 44(8):1348–1354.
  • Levine GN, Keaney JF, Vita JA. 1995. Cholesterol reduction in cardiovascular disease—Clinical benefits and possible mechanisms. N Engl J Med. 332(8):512–521.
  • Levine RL, Garland D, Oliver CN, Amici A, Climent I, Lenz A-G, Ahn B-W, Shaltiel S, Stadtman ER. 1990. Determination of carbonyl content in oxidatively modified proteins. Methods Enzymol. 186:464–478.
  • Materska M, Perucka I. 2005. Antioxidant activity of the main phenolic compounds isolated from hot pepper fruit (Capsicum annuum L.). J Agric Food Chem. 53(5):1750–1756.
  • Mehta LK, Balaraman R, Amin AH, Bafna PA, Gulati OD. 2003. Effect of fruits of Moringa oleifera on the lipid profile of normal and hypercholesterolaemic rabbits. J Ethnopharmacol. 86(2–3):191–195.
  • Millan J, Pinto X, Munoz A, Zuniga M, Rubies-Prat J, Pallardo LF, Masana L, Mangas A, Hernandez-Mijares A, Gonzalez-Santos P, et al. 2009. Lipoprotein ratios: Physiological significance and clinical usefulness in cardiovascular prevention. Vasc Health Risk Manag. 5:757–765.
  • Modak B, Rojas M, Torres R, Rodilla J, Luebert F. 2007. Antioxidant activity of a new aromatic geranyl derivative of the resinous exudates from Heliotropium glutinosum Phil. Molecules. 12(5):1057–1063.
  • Oh P-S, Lee S-J, Lim K-T. 2006. Hypolipidemic and antioxidative effects of the plant glycoprotein (36 kDa) from Rhus verniciflua stokes fruit in Triton WR-1339-induced hyperlipidemic mice. Biosci Biotechnol Biochem. 70(2):447–456.
  • Oloyede HOB, Adaja MC, Ajiboye TO, Salawu MO. 2015. Anti-ulcerogenic activity of aqueous extract of Carica papaya seed on indomethacin-induced peptic ulcer in male albino rats. J Integr Med. 13(2):105–114.
  • Oloyede OB, Ajiboye TO, Abdussalam AF, Adeleye AO. 2014. Blighia sapida leaves halt elevated blood glucose, dyslipidemia and oxidative stress in alloxan-induced diabetic rats. J Ethnopharmacol. 157:309–319.
  • Abdel-Salam OME, Sleem AA, Hassan NS, Sharaf HA, Gy M. 2006. Capsaicin ameliorates hepatic injury caused by carbon Tetrachloride in the rat. J Pharmacol Toxicol. 1(2):147–156.
  • Onoja S, Ezeja M, Omeh Y, Emeh E. 2015. Phytochemical and hypolipidemic effects of methanolic extract of Aframomum melegueta Seed. EJMP. 5(4):377–383.
  • Prasad K. 1999. Reduction of serum cholesterol and hypercholesterolemic atherosclerosis in rabbits by secoisolariciresinol diglucoside isolated from flaxseed. Circulation. 99(10):1355–1362.
  • Prasad K, Kalra J. 1993. Oxygen free radicals and hypercholesterolemic atherosclerosis: effect of vitamin E. Am Heart J. 125(4):958–973.
  • Ravinayagam V, Jaganathan R, Panchanadham S, Palanivelu S. 2012. Potential Antioxidant Role of Tridham in Managing Oxidative Stress against Aflatoxin-B 1 -Induced Experimental Hepatocellular Carcinoma 2012.
  • Reilly CA, Aust SD. 2001. Measurement of lipid peroxidation. Curr Protoc Toxicol. Unit 2.4. Chapter 2, Chapter 2, Unit 2.4.
  • Roeschlau P, Bernt E, Gruber WA. 1974. Enzymatic Analysis of Total Cholesterol. Clinical Biochem. 12:226.
  • Ross R. 1993. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 362(6423):801–809.
  • Ruch RJ, Cheng SJ, Klaunig JE. 1989. Prevention of cytotoxicity and inhibition of intercellular communication by antioxidant catechins isolated from Chinese green tea. Carcinogenesis. 10(6):1003–1008.
  • Sambo N, Odeh SO, Ibu JO, Onyikwola O. 2002. The effects Of Capsicum Annuum and Capsicum Frutescens-induced gastric acid secretion in the rat is by H2 Receptor Stimulation. High Med Res J. 5:38–41.
  • Sheriff SA, Devaki T. 2012. Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats. Asian Pac J Trop Biomed. 2(12):975–980.
  • Sindhu ER, Preethi KC, Kuttan R. 2010. Antioxidant activity of carotenoid lutein in vitro and in vivo. Indian J Exp Biol. 48(8):843–848.
  • Smirnoff N, Cumbes QJ. 1989. Hydroxyl radical scavenging activity of compatible solutes. Phytochem. 28(4):1057–1060.
  • Sugamura K, Keaney JF. 2011. Reactive oxygen species in cardiovascular disease. Free Radic Biol Med. 51(5):978–992.
  • Sugiura M, Oikawa T, Hirano K, Maeda H, Yoshimura H, Sugiyama M, Kuratsu. 1977. A simple colorimetric method for determination of serum triglycerides with lipoprotein lipase and glycerol dehydrogenase. Clin Chim Acta. 81(2):125–130.
  • Sun T, Xu Z, Wu C-T, Janes M, Prinyawiwatkul W, No HK. 2007. Antioxidant activities of different colored sweet bell peppers (Capsicum annuum L.). J Food Sci. 72(2):S98–S102.
  • Takano F, Yamaguchi M, Takada S, Shoda S, Yahagi N, Takahashi T, Ohta T. 2007. Capsicum ethanol extracts and capsaicin enhance interleukin-2 and interferon-gamma production in cultured murine Peyer’s patch cells ex vivo. Life Sci. 80(17):1553–1563.
  • Tani Y, Fujioka T, Sumioka M, Furuichi Y, Hamada H, Watanabe T. 2004. Effects of capsinoid on serum and liver lipids in hyperlipidemic rats. J Nutr Sci Vitaminol. 50(5):351–355.
  • Toyin YM, Khadijat OF, Saoban SS, Olakunle AT, Abraham BF, Luqman QA. 2012. Antidiarrheal activity of aqueous leaf extract of Ceratotheca sesamoides in rats. Bangladesh J Pharmacol. 7(1):14–20.
  • Turkoglu A, Duru ME, Mercan N, Kivrak I, Gezer K. 2007. Antioxidant and antimicrobial activities of Laetiporus sulphureus (Bull.) Murrill. Food Chem. 101(1):267–273.
  • Wang H, Cao GH, Prior RL. 1997. Oxygen radical absorbing capacity of anthocyanins. J Agric Food Chem. 45(2):304–309.
  • WHO. 2015. Cardiovascular diseases (CVDs).

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