833
Views
19
CrossRef citations to date
0
Altmetric
Articles

Randomized Study of the Effect of Vitamin D and Omega-3 Fatty Acids Cosupplementation as Adjuvant Chemotherapy on Inflammation and Nutritional Status in Colorectal Cancer Patients

, PhD, , PhD, , Fellowship in Oncology and Hematology, , PhD & , PhD

References

  • Aggarwal BB, Vijayalekshmi RV, Sung B. 2009. Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res. 15(2):425–30. doi:10.1158/1078-0432.CCR-08-0149.
  • Ahangar P, Sam MR, Nejati V, Habibian R. 2016. Treatment of undifferentiated colorectal cancer cells with fish-oil derived docosahexaenoic acid triggers caspase-3 activation and apoptosis. J Can Res Ther. 12:798–804. doi:10.4103/0973-1482.157326.
  • Aslan A, Triadafilopoulos G. 1992. Fish oil fatty acid supplementation in active ulcerative colitis: a double-blind, placebo-controlled, crossover study. Am J Gastroenterol. 87(4):432–7.
  • Akedo I, Ishikawa H, Nakamura T, Kimura K, Takeyama I, Suzuki T, Kameyama M, Sato S, Nakamura T, Matsuzawa Y, et al. 1998. Three cases with familial adenomatous polyposis diagnosed as having malignant lesions in the course of a long-term trial using docosahexanoic acid (DHA)-concentrated fish oil capsules. Jpn J Clin Oncol. 28(12):762–5.
  • Bao Y, Ng K, Wolpin BM, Michaud DS, Giovannucci E, Fuchs CS. 2010. Predicted vitamin D status and pancreatic cancer risk in two prospective cohort studies. Br J Cancer. 102(9):1422–7. doi:10.1038/sj.bjc.6605658.
  • Beck SA, Smith KL, Tisdale MJ. 1991. Anticachectic and antitumor effect of eicosapentaenoic acid and its effect on protein turnover. Cancer Res. 51(22):6089–93.
  • Belluzzi A, Boschi S, Brignola C, Munarini A, Cariani G, Miglio F. 2000. Polyunsaturated fatty acids and inflammatory bowel disease. Am J Clin Nutr. 71(1 Suppl):339S–42S. doi:10.1093/ajcn/71.1.339s.
  • Benson AL. 2007. Epidemiology, disease progression, and economic burden of colorectal cancer. J Manag Care Pharm. 13(6 suppl C):S5–S18. doi:10.18553/jmcp.2007.13.s6-c.5.
  • Berquin IM, Edward IJ, Chen YQ. 2008. Multi-targed therapy of cancer by omega-3 fatty acids. Cancer Lett. 269(2):363–77. doi:10.1016/j.canlet.2008.03.044.
  • Bolland MJ, Grey A, Gamble GD, Reid IR. 2011. Calcium and vitamin D supplements and health outcomes: a reanalysis of the Women’s Health Initiative (WHI) limited-access data set. Am J Clin Nutr. 94(4):1144–9. doi:10.3945/ajcn.111.015032.
  • Burns CP, Halabi S, Clamon G, Kaplan E, Hohl RJ, Atkins JN, Schwartz MA, Wagner BA, Paskett E. 2004. Phase II study of high-dose fish oil capsules for patients with cancer-related cachexia. Cancer. 101(2):370–8. doi:10.1002/cncr.20362.
  • Calder PC. 2007. Immunomodulation by omega-3 fatty acids. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 77(5-6):327–35. doi:10.1016/j.plefa.2007.10.015.
  • Cantorna MT, Munsick C, Bemiss C, Mahon BD. 2000. 1,25-Dihydroxycholecalciferol prevents and ameliorates symptoms of experimental murine inflammatory bowel disease. J Nutr. 130(11):2648–52. doi:10.1093/jn/130.11.2648.
  • Davis CD. 2008. Vitamin D and cancer: current dilemmas and future research needs. Am. J. Clin. Nutr. 88(2):565S–9S. doi:10.1093/ajcn/88.2.565S.
  • Dommels YE, Haring MM, Keestra NG, Alink GM, van Bladeren PJ, van Ommen B. 2003. The role of cyclooxygenase in n‑6 and n‑3 polyunsaturated fatty acid mediated effects on cell proliferation, PGE[2] synthesis and cytotoxicity in human colorectal carcinoma cell lines. Carcinogenesis. 24(3):385–92. doi:10.1093/carcin/24.3.385.
  • Evans SR, Shchepotin EI, Young H, Rochon J, Uskokovic M, Shchepotin IB. 2000. 1,25- dihydroxyvitamin D3 synthetic analogs inhibit spontaneous metastases in a 1,2-dimethylhydrazine-induced colon carcinogenesis model. Int J Oncol. 16:1249–54.
  • Ferruci L, Cherubini A, Bandinelli S, Bartali B, Corsi A, Lauretani F, Andersen-Lacueva C, Senin V, Guralnik JM. 2006. Relationship of plasma polyunsaturated fatty acids to circulating inflammatory markers. J Clin Endocrinol Metab. 91(2):439–46. doi:10.1210/jc.2005-1303.
  • Falconer JS, Ross JA, Fearon KC, Hawkins RA, O'Riordain MG, Carter DC. 1994. Effect of eicosapentaenoic acid and other fatty acids on the growth in vitro of human pancreatic cancer cell lines. Br J Cancer. 69(5):826–32.
  • Fuchs MA, Yuan C, Sato K, Niedzwiecki D, Ye X, Saltz LB, Mayer RJ, Mowat RB, Whittom R, Hantel A, et al. 2017. Predicted vitamin D status and colon cancer recurrence and mortality in CALGB 89803 (Alliance). Ann Oncol. 28(6):1359–67. doi:10.1093/annonc/mdx109.
  • Germano G, Allavena P, Mantovani A. 2008. Cytokines as a key component of cancer-related inflammation. Cytokine. 43(3):374–9. doi:10.1016/j.cyto.2008.07.014.
  • Giuliano AR, Franceschi RT, Wood RJ. 1991. Characterization of the vitamin D receptor from the Caco-2 human colon carcinoma cell line: effect of cellular differentiation. Arch Biochem Biophys. 285(2):261–9. doi:10.1016/0003-9861(91)90358-P.
  • Gurlek A, Pittelkow MR, Kumar R. 2002. Modulation of growth factor/cytokine synthesis and signaling by 1alpha,25-dihydroxyvitamin D(3): implications in cell growth and differentiation. Endocr Rev. 23(6):763–86. doi:10.1210/er.2001-0044.
  • Hall MN, Chavarro JE, Lee IM, Willett WC, Ma JA. 2008. 22-year prospective study of fish, n-3 fatty acid intake, and colorectal cancer risk in men. Cancer. Epidemiol Biomarkers Prev. 17(5):1136–43. doi:10.1158/1055-9965.EPI-07-2803.
  • Hardman WE. 2002. Omega-3 fatty acids to augment cancer therapy. J Nutr. 132(11 Suppl):3508S–512S. doi:10.1093/jn/132.11.3508S.
  • Holick MF. 2006. Calcium plus vitamin D and the risk of colorectal cancer. N Engl J Med. 354(21):2287–8. doi:10.1056/NEJMc060753.
  • Hopkins MH, Owen J, Ahearn T, Fedirko V, Flanders WD, Jones DP, Bostick RM. 2011. Effects of supplemental vitamin D and calcium on biomarkers of inflammation in colorectal adenoma patients: a randomized, controlled clinical trial. Cancer Prev Res (Phila). 4(10):1645–54. doi:10.1158/1940-6207.CAPR-11-0105.
  • Kato T, Kolenic N, Pardini RS. 2007. Docosahexaenoic acid (DHA), a primary tumor suppressive omega-3 fatty acid, inhibits growth of colorectal cancer independent of p53 mutational status. Nutr Cancer. 58(2):178–87. doi:10.1080/01635580701328362.
  • Kim S, Sandler DP, Galanko J, Martin C, Sandler RS. 2010. Intake of polyunsaturated fatty acids and distal large bowel cancer risk in whites and African Americans. Am J Epidemiol. 171(9):969–79. doi:10.1093/aje/kwq032.
  • Kobayashi M, Tsubono Y, Otani T, Hanaoka T, Sobue T, Tsugane S. 2004. Fish, long-chain n-3 polyunsaturated fatty acids, and risk of colorectal cancer in middle-aged Japanese: The JPHC study. Nutr Cancer. 49(1):32–40. doi:10.1207/s15327914nc4901_5.
  • Lai PBS, Ross JA, Fearon KCH, Anderson JD, Carter DC. 1996. Cell cycle arrest and induction of apoptosis in pancreatic cancer cells exposed to eicosapentaenoic acid in vitro. Br J Cancer. 74(9):1375–83.
  • Lappe JM, Travers-Gustafson D, Davies KM, Recker RR, Heaney RP. 2007. Vitamin D and calcium supplementation reduces cancer risk: results of a randomized trial. Am J Clin Nutr. 85(6):1586–91. doi:10.1093/ajcn/85.6.1586.
  • Li W, Wang QL, Liu X, Dong SH, Li HX, Li CY, Guo LS, Gao JM, Berger NA, Li L, et al. 2015. Combined use of vitamin D3 and metformin exhibits synergistic chemopreventive effects on colorectal neoplasia in rats and mice. Cancer Prev Res (Phila). 8(2):139–48. doi:10.1158/1940-6207.CAPR-14-0128.
  • Manson JE, Cook NR, Lee I-M, Christen W, Bassuk SS, Mora S, Gibson H, Gordon D, Copeland T, D’Agostino D, et al. 2019. Vitamin D supplements and prevention of cancer and cardiovascular disease. N Engl J Med. 380(1):33–44. doi:10.1056/NEJMoa1809944.
  • McDonnell SL, Baggerly CA, French CB, Baggerly LL, Garland CF, Gorham ED, Hollis BW, Trump DL, Lappe JM. 2018. Breast cancer risk markedly lower with serum 25-hydroxyvitamin D concentrations ≥60 vs <20 ng/ml (150 vs 50 nmol/L): pooled analysis of two randomized trials and a prospective cohort. PLoS One. 13(6):e0199265.
  • McDonnell SL, Baggerly C, French CB, Baggerly LL, Garland CF, Gorham ED, Lappe JM, Heaney RP. 2016. Serum 25-hydroxyvitamin D concentrations ≥40 ng/ml are associated with >65% lower cancer risk: pooled analysis of randomized trial and prospective cohort study. PLoS One. 11(4):e0152441.
  • Meeker S, Seamons A, Paik J, Treuting PM, Brabb T, Grady WM, Maggio-Price L. 2014. Increased dietary vitamin D suppresses MAPK signaling, colitis, and colon cancer. Cancer Res. 74(16):4398–408. doi:10.1158/0008-5472.CAN-13-2820.
  • Meggouh F, Lointier P, Saez S. 1991. Sex steroid and 1,25-dihydroxyvitamin D3 receptors in human colorectal adenocarcinoma and normal mucosa. Cancer Res. 51:1227–33.
  • Mohammadzadeh M, Faramarzi E, Mahdavi R, Nasirimotlagh B, Asghari Jafarabadi M. 2013. Effect of conjugated linoleic acid supplementation on inflammatory factors and matrix metalloproteinase enzymes in rectal cancer patients undergoing chemoradiotherapy. Integr Cancer Ther. 12(6):496–502. doi:10.1177/1534735413485417.
  • Morales-Oyarvide V, Meyerhardt JA, Ng K. 2016. Vitamin D and physical activity in patients with colorectal cancer: epidemiological evidence and therapeutic implications. Cancer J. 22(3):223–31. doi:10.1097/PPO.0000000000000197.
  • Moses AW, Slater C, Preston T, Barber MD, Fearon KC. 2004. Reduced total energy expenditure and physical activity in cachexia patients with pancreatic cancer can be modulated by an energy and protein dense oral supplement enriched with n-3 fatty acids. Br J Cancer. 90(5):996–1002. doi:10.1038/sj.bjc.6601620.
  • Müller K, Odum N, Bendtzen K. 1993. 1,25- dihydroxyvitamin D3 selectively reduces interleukin-2 levels and proliferation of human T cell lines in vitro. Immunol Lett. 35(2):177–82.
  • Mumm JB, Oft M. 2008. Cytokine-based transformation of immune surveillance into tumorpromoting inflammation. Oncogene. 27(45):5913–9. doi:10.1038/onc.2008.275.
  • Murff HJ, Shrubsole MJ, Cai Q, Smalley WE, Dai Q, Milne GL, Ness RM, Zheng W. 2012. Dietary intake of PUFAs and colorectal polyp risk. Am J Clin Nutr. 95(3):703–12. doi:10.3945/ajcn.111.024000.
  • Narayanan BA, Narayanan NK, Simi B, Reddy BS. 2003. Modulation of inducible nitric oxide synthase and related proinflammatory genes by the omega‑3 fatty acid docosahexaenoic acid in human colon cancer cells. Cancer Res. 63:972–9.
  • Pan M-H, Lai C-S, Wu J-C, Ho C-T. 2011. Molecular mechanisms for chemoprevention of colorectal cancer by natural dietary compounds. Mol Nutr Food Res. 55(1):32–45. doi:10.1002/mnfr.201000412.
  • Read JA, Beale PJ, Volker DH, Smith N, Childs A, Clarke SJ. 2007. Nutritional intervention using an eicosapentaenoic acid (EPA)-containing supplement in patients with advanced colorectal cancer. Effecs on nutritional and inflammatory status: a phase II trial. Support Care Cancer. 15(3):301–7. doi:10.1007/s00520-006-0153-3.
  • Refaat B, El-Shemi AG, Kensara OA, Mohamed AM, Idris S, Ahmad J, Khojah A. 2015. Vitamin D3 enhances the tumouricidal effects of 5-fluorouracil through multipathway mechanisms in azoxymethane rat model of colon cancer. J Exp Clin Cancer Res. 34:71.
  • Ryz NR, Patterson SJ, Zhang Y, Ma C, Huang T, Bhinder G, Wu X, Chan J, Glesby A, Sham HP, et al. 2012. Active vitamin D(1,25-dihydroxyvitamin D3) increases host susceptibility to citrobacter rodentium by suppressing mucosal Th17 responses. Am J Physiol Gastrointest Liver Physiol. 303(12):G1299–311. doi:10.1152/ajpgi.00320.2012.
  • Saito T, Okamoto R, Haritunians T, O’Kelly J, Uskokovic M, Maehr H, Marczak S, Jankowski P, Badr R, Koeffler HP. 2008. Novel Gemini vitamin D(3) analogs have potent antitumor activity. J Steroid Biochem Mol Biol. 112(1-3):151–6. doi:10.1016/j.jsbmb.2008.09.012.
  • Salomon P, Kornbluth AA, Janowitz HD. 1990. Treatment of ulcerative colitis with fish oil n-3-omega-fatty acid: an open trial . J Clin Gastroenterol. 12(2):157–61.
  • Sharma G, Rani I, Bhatnagar A, Agnihotri N. 2016. Apoptosis-mediated chemoprevention by different ratios of fish oil in experimental colon carcinogenesis. Cancer Investig. 34(5):220–30. doi:10.1080/07357907.2016.1183023.
  • Silva JD, Trindade EB, Fabre ME, Menegotto VM, Gevaerd S, Buss ZD, Frode TS. 2012. Fish oil supplement alters markers of inflammatory and nutritional status in colorectal cancer patients. Nutr. Cancer. 64(2):267–73. doi:10.1080/01635581.2012.643133.
  • Sheng H, Shao J, Washington MK, Dubois RN. 2001. Prostaglandin E2 increases growth and motility of colorectal carcinoma cells. J Biol Chem. 276(21):18075–81. doi:10.1074/jbc.M009689200.
  • Song M, Chan AT, Fuchs CS, Ogino S, Hu FB, Mozaffarian D, Ma J, Willett WC, Giovannucci EL, Wu K. 2014. Dietary intake of fish, ω-3 and ω-6 fatty acids and risk of colorectal cancer: a prospective study in U.S. men and women. Int J Cancer. 135(10):2413–23. doi:10.1002/ijc.28878.
  • Srivastava PK, Sharma VK, Kalonia DS, Grant DF. 2004. Polymorphisms in human soluble epoxide hydrolase: effects on enzyme activity, enzyme stability, and quaternary structure. Arch Biochem Biophys. 427(2):164–9. doi:10.1016/j.abb.2004.05.003.
  • Stern MC, Butler LM, Corral R, Joshi AD, Yuan JM, Koh WP, Yu MC. 2009. Polyunsaturated fatty acids, DNA repair single nucleotide polymorphisms and colorectal cancer in the Singapore Chinese health study. J Nutrigenet Nutrigenomics. 2(6):273–9. doi:10.1159/000308467.
  • Wactawski-Wende J, Kotchen JM, Anderson GL, Assaf AR, Brunner RL, O’Sullivan MJ, Margolis KL, Ockene JK, Phillips L, Pottern L, et al. 2006. Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 354(7):684–96. doi:10.1056/NEJMoa055222.
  • Wang W, Yang J, Nimiya Y, Lee KSS, Sanidad K, Qi W, Sukamtoh E, Park Y, Liu Z, Zhang G. 2017. ω-3 polyunsaturated fatty acids and their cytochrome P450-derived metabolites suppress colorectal tumor development in mice. J Nutr Biochem. 48:29–35. doi:10.1016/j.jnutbio.2017.06.006.
  • Wang W, Zhu J, Lyu F, Panigrahy D, Ferrara KW, Hammock B, Zhang G. 2014. ω-3 polyunsaturated fatty acids-derived lipid metabolites on angiogenesis, inflammation and cancer. Prostaglandins Other Lipid Mediat. 113-115:13–20. doi:10.1016/j.prostaglandins.2014.07.002.
  • Wietrzyk J, Milczarek M, Kutner A. 2007. The effect of combined treatment on head and neck human cancer cell lines with novel analogs of calcitriol and cytostatics. Oncol Res. 16(11):517–525. doi:10.3727/096504007783438330.
  • Wietrzyk J, Nevozhay D, Milczarek M, Filip B, Kutner A. 2008. Toxicity and antitumor activity of the vitamin D analogs PRI-1906 and PRI-1907 in combined treatment with cyclophosphamide in a mouse mammary cancer model. Cancer Chemother Pharmacol. 62(5):787–97. doi:10.1007/s00280-007-0666-6.
  • Woodworth HL, McCaskey SJ, Duriancik DM, Clinthorne JF, Langohr IM, Gardner EM, Fenton JI. 2010. Dietary fish oil alters T lymphocyte cell populations and exacerbates disease in a mouse model of inflammatory colitis. Cancer Res. 70(20):7960–9. doi:10.1158/0008-5472.CAN-10-1396.
  • Yang J, Zhu S, Lin G, Song C, He Z. 2017. Vitamin D enhances omega-3 polyunsaturated fatty acids-induced apoptosis in breast cancer cells. Cell Biol Int. 41(8):890–7. doi:10.1002/cbin.10806.
  • Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM, Hewison M. 2001. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab. 86(2):888–94. doi:10.1210/jcem.86.2.7220.
  • Zhao X, Feldman D. 1993. Regulation of vitamin D receptor abundance and responsiveness during differentiation of HT-29 human colon cancer cells. Endocrinology. 132(4):1808–14. doi:10.1210/endo.132.4.8384998.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.