387
Views
15
CrossRef citations to date
0
Altmetric
Reviews

The Efficacy of Vitamin D Supplementation against Nonalcoholic Fatty Liver Disease: A Meta-Analysis

, MDORCID Icon, , MScORCID Icon, , MScORCID Icon, , PhD & , PhDORCID Icon

References

  • Abramovitch S, Sharvit E, Weisman Y, Bentov A, Brazowski E, Cohenn G, Volovelsky O, Reif S. 2014. Vitamin D inhibits development of liver fibrosis in animal model but cannot ameliorate established cirrhosis. Am J Physiol Heart Circ Physiol. 308(2):G112–20. doi:10.1152/ajpgi.00132.2013.
  • Akbarian SA, Asgary S, Feizi A, Iraj B, Askari G. 2016. Comparative study on the effect of Plantago psyllium and Ocimum basilicum seeds on anthropometric measures in nonalcoholic fatty liver patients. Int J Prev Med. 7:114. doi:10.4103/2008-7802.191865.
  • Albano E, Mottaran E, Occhino G, Reale E, Vidali M. 2005. Review article: role of oxidative stress in the progression of non-alcoholic steatosis. Aliment Pharmacol Ther. 22(s2):71–73. doi:10.1111/j.1365-2036.2005.02601.x.
  • Arkan MC, Hevener AL, Greten FR, Maeda S, Li Z-W, Long J-M, Wynshaw-Boris A, Poli G, Olefsky J, Karin M. 2005. IKK-beta links inflammation to obesity-induced insulin resistance. Nat Med. 11(2):191–198. doi:10.1038/nm1185.
  • Barchetta I, Angelico F, Ben MD, Baroni MG, Pozzilli P, Morini S, Cavallo M-G. 2011. Strong association between non alcoholic fatty liver disease (NAFLD) and low 25(OH) vitamin D levels in an adult population with normal serum liver enzymes. BMC Med. 9(1):85. doi:10.1186/1741-7015-9-85.
  • Barchetta I, Carotti S, Labbadia G, Gentilucci UV, Muda AO, Angelico F, Silecchia G, Leonetti F, Fraioli A, Picardi A, et al. 2012. Liver vitamin D receptor, CYP2R1, and CYP27A1 expression: relationship with liver histology and vitamin D3 levels in patients with nonalcoholic steatohepatitis or hepatitis C virus. Hepatology. 56(6):2180–2187., doi:10.1002/hep.25930.
  • Barchetta I, Cimini F, Cavallo M. 2017. Vitamin D supplementation and non-alcoholic fatty liver disease: present and future. Nutrients. 9(9):1015.
  • Barchetta I, De Bernardinis M, Capoccia D, Baroni MG, Fontana M, Fraioli A, Morini S, Leonetti F, Cavallo MG. 2013. Hypovitaminosis D is independently associated with metabolic syndrome in obese patients. PLoS One. 8(7):e68689. doi:10.1371/journal.pone.0068689.
  • Barchetta I, Del Ben M, Angelico F, Di Martino M, Fraioli A, La Torre G, Saulle R, Perri L, Morini S, Tiberti C, et al. 2016. No effects of oral vitamin D supplementation on non-alcoholic fatty liver disease in patients with type 2 diabetes: a randomized, double-blind, placebo-controlled trial. BMC Med. 14:92.doi:10.1186/s12916-016-0638-y.
  • Bechmann LP, Hannivoort RA, Gerken G, Hotamisligil GS, Trauner M, Canbay A. 2012. The interaction of hepatic lipid and glucose metabolism in liver diseases. J Hepatol. 56(4):952–964. doi:10.1016/j.jhep.2011.08.025.
  • Borenstein M, Higgins JP. 2013. Meta-analysis and subgroups. Prev Sci. 14(2):134–143. doi:10.1007/s11121-013-0377-7.
  • Boucher BJ, Mannan N, Noonan K, Hales CN, Evans SJ. 1995. Glucose intolerance and impairment of insulin secretion in relation to vitamin D deficiency in east London Asians. Diabetologia. 38(10):1239–1245.
  • Chung M, Tang AM, Fu Z, Wang DD, Newberry SJ. 2016. Calcium intake and cardiovascular disease risk: an updated systematic review and meta-analysis. Ann Intern Med. 165(12):856–866. doi:10.7326/M16-1165.
  • Dabbaghmanesh MH, Danafar F, Eshraghian A, Omrani GR. 2018. Vitamin D supplementation for the treatment of non-alcoholic fatty liver disease: a randomized double blind placebo controlled trial. Diabetes Metab Syndr Obes. 12(4):513–517. doi:10.1016/j.dsx.2018.03.006.
  • Day CP. 2006. From fat to inflammation. Gastroenterology. 130(1):207–210. doi:10.1053/j.gastro.2005.11.017.
  • Del Ben M, Polimeni L, Baratta F, Pastori D, Angelico F. 2017. The role of nutraceuticals for the treatment of non-alcoholic fatty liver disease . Br J Clin Pharmacol. 83(1):88–95. doi:10.1111/bcp.12899.
  • Del Ben M, Polimeni L, Baratta F, Pastori D, Loffredo L, Angelico F. 2014. Modern approach to the clinical management of non-alcoholic fatty liver disease. World J Gastroenterol. 20(26):8341–8350. doi:10.3748/wjg.v20.i26.8341.
  • Dinca M, Serban M-C, Sahebkar A, Mikhailidis DP, Toth PP, Martin SS, Blaha MJ, Blüher M, Gurban C, Penson P, et al. 2016. Does vitamin D supplementation alter plasma adipokines concentrations? A systematic review and meta-analysis of randomized controlled trials. Pharmacol Res. 107:360–371. doi:10.1016/j.phrs.2016.03.035.
  • Egger M, Smith GD, Schneider M, Minder C. 1997. Bias in meta-analysis detected by a simple, graphical test. BMJ. 315(7109):629–634. doi:10.1136/bmj.315.7109.629.
  • Eliades M, Spyrou E, Agrawal N, Lazo M, Brancati FL, Potter JJ, Koteish AA, Clark JM, Guallar E, Hernaez R. 2013. Meta-analysis: vitamin D and non-alcoholic fatty liver disease. Aliment Pharmacol Ther. 38(3):246–254. doi:10.1111/apt.12377.
  • Eliades M, Spyrou E. 2015. Vitamin D: a new player in non-alcoholic fatty liver disease? World J Gastroenterol. 21(6):1718–1727. doi:10.3748/wjg.v21.i6.1718.
  • Fan JG, Cao HX. 2013. Role of diet and nutritional management in non‐alcoholic fatty liver disease. J Gastroenterol Hepatol. 28(S4):81–87. doi:10.1111/jgh.12244.
  • Farrell GC, Larter CZ. 2006. Nonalcoholic fatty liver disease: from steatosis to cirrhosis. Hepatology. 43(2 Suppl 1):S99–S112.
  • Foroughi M, Maghsoudi Z, Ghiasvand R, Iraj B, Askari G. 2014. Effect of vitamin D supplementation on C-reactive protein in patients with nonalcoholic fatty liver. Int J Prev Med. 5(8):969–975.
  • Geier A, Eichinger M, Stirnimann G, Semela D, Tay F, Seifert B, Tschopp O, Bantel H, Jahn D, Marques Maggio E, et al. 2018. Treatment of non-alcoholic steatohepatitis patients with vitamin D: a double-blinded, randomized, placebo-controlled pilot study. Scand J Gastroenterol. 53(9):1114–1120. doi:10.1080/00365521.2018.1501091.
  • Hardy T, Oakley F, Anstee QM, Day CP. 2016. Nonalcoholic fatty liver disease: pathogenesis and disease spectrum. Annu Rev Pathol. 11:451–496. doi:10.1146/annurev-pathol-012615-044224.
  • Hernaez R, Lazo M, Bonekamp S, Kamel I, Brancati FL, Guallar E, Clark JM. 2011. Diagnostic accuracy and reliability of ultrasonography for the detection of fatty liver: a meta-analysis. Hepatology. 54(3):1082–1090. doi:10.1002/hep.24452.
  • Higgins JP, Green S. 2011. Cochrane handbook for systematic reviews of interventions. Vol. 4. Hoboken, NJ: John Wiley & Sons.
  • Hozo SP, Djulbegovic B, Hozo I. 2005. Estimating the mean and variance from the median, range, and the size of a sample. BMC Med Res Methodol. 5(1):13. doi:10.1186/1471-2288-5-13.
  • Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJM, Gavaghan DJ, McQuay HJ. 1996. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials. 17(1):1–12. doi:10.1016/0197-2456(95)00134-4.
  • Ju SY, Jeong HS, Kim DH. 2014. Blood vitamin D status and metabolic syndrome in the general adult population: a dose-response meta-analysis. J Clin Endocrinol Metab. 99(3):1053–1063. doi:10.1210/jc.2013-3577.
  • Kitson MT, Pham A, Gordon A, Kemp W, Roberts SK. 2016. High-dose vitamin D supplementation and liver histology in NASH. Gut. 65(4):717–718. doi:10.1136/gutjnl-2015-310417.
  • López-Velázquez JA, Silva-Vidal KV, Ponciano-Rodríguez G, Chávez-Tapia NC, Arrese M, Uribe M, Méndez-Sánchez N. 2014. The prevalence of nonalcoholic fatty liver disease in the Americas. Ann Hepatol. 13(2):166–178.
  • Lorvand-Amiri H, Agah S, Mousavi SN, Hosseini AF, Shidfar F. 2016. Regression of non-alcoholic fatty liver by vitamin D supplement: a double-blind randomized controlled clinical trial. Arch Iran Med. 19(9):631–638. doi:0161909/aim.006.
  • Maestro B, Campion J, Davila N, Calle C. 2000. Stimulation by 1,25-dihydroxyvitamin D3 of insulin receptor expression and insulin responsiveness for glucose transport in U-937 human promonocytic cells. Endocr J. 47(4):383–391.
  • Maestro B, Dávila N, Carranza MC, Calle C. 2003. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Mol Biol. 84(2–3):223–230.
  • Mansour-Ghanaei F, Hadi A, Pourmasoumi M, Joukar F, Golpour S, Najafgholizadeh A. 2018. Green tea as a safe alternative approach for nonalcoholic fatty liver treatment: a systematic review and meta-analysis of clinical trials. Phytother Res. 32(10):1876–1884. doi:10.1002/ptr.6130.
  • Mansour-Ghanaei F, Pourmasoumi M, Hadi A, Joukar F. 2019. Efficacy of curcumin/turmeric on liver enzymes in patients with non-alcoholic fatty liver disease: a systematic review of randomized controlled trials. Integr Med Res. 8(1):57–61. doi:10.1016/j.imr.2018.07.004.
  • Moher D, Shamseer L, Clarke M, Ghersi D, Liberati A, Petticrew M, Shekelle P, Stewart LA. 2015. Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement. Syst Rev. 4(1):1. doi:10.1186/2046-4053-4-1.
  • Nadjarzadeh A, Jani N, Khoshnevisan M, Molajaafari A, Fallahzadeh H, Khabiri F, Shavakhi A. 2016. Effects of low caloric diet with and without vitamin D supplementation on anthropometric parameters in patients with non-alcoholic fatty liver. SSUJ. 14(6):410–422.
  • Nagpal J, Pande J, Bhartia A. 2009. A double‐blind, randomized, placebo‐controlled trial of the short‐term effect of vitamin D3 supplementation on insulin sensitivity in apparently healthy, middle‐aged, centrally obese men. Diabetic Med. 26(1):19–27. doi:10.1111/j.1464-5491.2008.02636.x.
  • National Heart Lung and Blood Institute (NHLBI). 2014. Quality assessment tool for before-after (pre-post) studies with no control group. National Heart Lung and Blood Institute. http://www.nhlbi.nih.gov/health-pro/guidelines/in-develop/cardiovascular-risk-reduction/tools/before-after.htm. Accessed September 13, 2015.
  • Papapostoli I, Lammert F, Stokes CS. 2016. Effect of short-term vitamin D correction on hepatic steatosis as quantified by controlled attenuation parameter (CAP). J Gastrointestin Liver Dis. 25(2):175–181. doi:10.15403/jgld.2014.1121.252.cap.
  • Sharifi N, Amani R, Hajiani E, Cheraghian B. 2014. Does vitamin D improve liver enzymes, oxidative stress, and inflammatory biomarkers in adults with non-alcoholic fatty liver disease? A randomized clinical trial. Endocrine. 47(1):70–80. doi:10.1007/s12020-014-0336-5.
  • Soleimani D, Paknahad Z, Askari G, Iraj B, Feizi A. 2016. Effect of garlic powder consumption on body composition in patients with nonalcoholic fatty liver disease: a randomized, double-blind, placebo-controlled trial. Adv Biomed Res. 5:2 doi:10.4103/2277-9175.174962.
  • Sterne J, Bradburn M. 2001. Meta-analysis in Stata In: Egger M, Smith G, Altman D, editors. Systematic reviews in health care. London: BMJ Publishing Group. p. 347–372.
  • Targher G, Bertolini L, Padovani R, Zenari L, Zoppini G, Falezza G. 2004. Relation of nonalcoholic hepatic steatosis to early carotid atherosclerosis in healthy men: role of visceral fat accumulation. Diabetes Care. 27(10):2498–2500. doi:10.2337/diacare.27.10.2498.
  • Targher G, Bertolini L, Scala L, Cigolini M, Zenari L, Falezza G, Arcaro G. 2007. Associations between serum 25-hydroxyvitamin D3 concentrations and liver histology in patients with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 17(7):517–524. doi: doi:10.1016/j.numecd.2006.04.002.
  • Targher G, Day CP, Bonora E. 2010. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med. 363(14):1341–1350. doi:10.1056/NEJMra0912063.
  • Vieth R, Chan PC, MacFarlane GD. 2001. Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 73(2):288–294. doi:10.1093/ajcn/73.2.288.
  • Villanova N, Moscatiello S, Ramilli S, Bugianesi E, Magalotti D, Vanni E, Zoli M, Marchesini G. 2005. Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease. Hepatology. 42(2):473–480. doi:10.1002/hep.20781.
  • Wang X, Li W, Zhang Y, Yang Y, Qin G. 2015. Association between vitamin D and non-alcoholic fatty liver disease/non-alcoholic steatohepatitis: results from a meta-analysis. Int J Clin Exp Med. 8(10):17221.
  • Wong RJ, Aguilar M, Cheung R, Perumpail RB, Harrison SA, Younossi ZM, Ahmed A. 2015. Nonalcoholic steatohepatitis is the second leading etiology of liver disease among adults awaiting liver transplantation in the United States. Gastroenterology. 148(3):547–555. doi:10.1053/j.gastro.2014.11.039.
  • Yeh MM, Brunt EM. 2007. Pathology of nonalcoholic fatty liver disease. Am J Clin Pathol. 128(5):837–847. doi:10.1309/RTPM1PY6YGBL2G2R.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.