Screening of Weight-Loss Herbal Products for Synthetic Anti-Obesity Adulterants: A Target-Oriented Analysis by Liquid Chromatography–Tandem Mass Spectrometry

References

• Akkilagunta S, Premarajan K, Parameswaran S, Kar S. 2018. Association of non-allopathic drugs and dietary factors with chronic kidney disease: a matched case–control study in South India. J Family Med Prim Care. 7(6):1346. doi:10.4103/jfmpc.jfmpc_166_18.
   PubMedGoogle Scholar
• Balsevich G, Namendorf C, Gerlach T, Uhr M, Schmidt MV. 2014. The bio-distribution of the antidepressant clomipramine is modulated by chronic stress in mice: effects on behavior. Front Behav Neurosci. 8:445doi:10.3389/fnbeh.2014.00445.
   PubMed Web of Science ®Google Scholar
• Bogusz MJ, Hassan H, Al-Enazi E, Ibrahim Z, Al-Tufail M. 2006. Application of LC-ESI-MS-MS for detection of synthetic adulterants in herbal remedies. J Pharm Biomed Anal. 41(2):554–564. doi:10.1016/j.jpba.2005.12.015.
   PubMed Web of Science ®Google Scholar
• Frenzel C, Teschke R. 2016. Herbal Hepatotoxicity: Clinical Characteristics and Listing Compilation. IJMS 17(5):588. doi:10.3390/ijms17050588.
   Google Scholar
• Haneef J, Shaharyar M, Husain A, Rashid M, Mishra R, Siddique NA, Pal M. 2013. Analytical methods for the detection of undeclared synthetic drugs in traditional herbal medicines as adulterants: Traditional herbal medicines as adulterants. Drug Test Anal. 5(8):607–613. doi:10.1002/dta.1482.
   PubMed Web of Science ®Google Scholar
• ICH, Q2(R1) 2005. Validation of analytical procedures: text and methodology. Geneva, CH: Ifpma.
   Google Scholar
• Jacob P, Haller CA, Duan M, Yu L, Peng M, Benowitz NL. 2004. Determination of ephedra alkaloid and caffeine concentrations in dietary supplements and biological fluids. J Anal Toxicol. 28(3):152–159. doi:10.1093/jat/28.3.152.
   PubMed Web of Science ®Google Scholar
• Kang JG, Park C-Y. 2012. Anti-Obesity Drugs: A Review about Their Effects and Safety. Diabetes Metab J. 36(1):13–25. doi:10.4093/dmj.2012.36.1.13.
   PubMedGoogle Scholar
• Kiruthiga S. 2018. Homoeopathic Thyroidinum 3x–An Adjuvant in the Treatment of Hypothyroidism. Int J Complement Altern Med. 11:1–4.
   Google Scholar
• Le P, Wood B, Kumarasinghe SP. 2015. Cutaneous drug toxicity from 2,4-dinitrophenol (DNP): Case report and histological description. Australas J Dermatol. 56(4):307–309. doi:10.1111/ajd.12237.
   PubMed Web of Science ®Google Scholar
• Milman BL. 2011. Chemical identification and its quality assurance. Heidelberg (DE): Springer Science & Business Media.
   Google Scholar
• Müller LS, Moreira APL, Muratt DT, Viana C, de Carvalho LM. 2019. An ultra-high performance liquid chromatography–electrospray tandem mass spectrometric method for screening and simultaneous determination of anorexic, anxiolytic, antidepressant, diuretic, laxative and stimulant drugs in dietary supplements marketed for weight loss. J Chromatogr Sci. 57:528–540. doi:10.1093/chromsci/bmz025.
   PubMed Web of Science ®Google Scholar
• Niggemann B, Gruber C. 2003. Side-effects of complementary and alternative medicine. Allergy 58(8):707–716. doi:10.1034/j.1398-9995.2003.00219.x.
   PubMed Web of Science ®Google Scholar
• Noyes PD, Lema SC, Roberts SC, Cooper EM, Stapleton HM. 2014. Rapid method for the measurement of circulating thyroid hormones in low volumes of teleost fish plasma by LC-ESI/MS/MS. Anal Bioanal Chem. 406(3):715–726. doi:10.1007/s00216-013-7528-3.
   PubMed Web of Science ®Google Scholar
• Pagès G, Gerdova A, Williamson D, Gilard V, Martino R, Malet-Martino M. 2014. Evaluation of a Benchtop cryogen-free low-field 1H NMR spectrometer for the analysis of sexual enhancement and weight loss dietary supplements adulterated with pharmaceutical substances. Anal Chem.Chem86(23):11897–11904. doi:10.1021/ac503699u.
   PubMed Web of Science ®Google Scholar
• Petróczi A, Ocampo JAV, Shah I, Jenkinson C, New R, James RA, Taylor G, Naughton DP. 2015. Russian roulette with unlicensed fat-burner drug 2,4-dinitrophenol (DNP): evidence from a multidisciplinary study of the internet, bodybuilding supplements and DNP users. Subst Abuse Treat Prev Policy.Policy10(1):39. doi:10.1186/s13011-015-0034-1.
   PubMedGoogle Scholar
• Poon WT, Ng SW, Lai CK, Chan YW, Mak WL. 2008. Factitious thyrotoxicosis and herbal dietary supplement for weight reduction. Clin Toxicol (Phila). 46(4):290–292. doi:10.1080/15563650701381179.
   PubMed Web of Science ®Google Scholar
• Pradeepa R, Anjana RM, Joshi SR, Bhansali A, Deepa M, Joshi PP, Dhandania VK, Madhu SV, Rao PV, Geetha L, et al. 2015. Prevalence of generalized & abdominal obesity in urban & rural India- the ICMR - INDIAB Study (Phase-I) [ICMR - INDIAB-3]. Indian J Med Res. 142:139–150. doi:10.4103/0971-5916.164234.
   PubMed Web of Science ®Google Scholar
• Rebiere H, Guinot P, Civade C, Bonnet P-A, Nicolas A. 2012. Detection of hazardous weight-loss substances in adulterated slimming formulations using ultra-high-pressure liquid chromatography with diode-array detection. Food Addit Contam Part Chem Anal Control Expo Risk Assess. 29(2):161–171. doi:10.1080/19440049.2011.638676.
   PubMed Web of Science ®Google Scholar
• Sarker MR. 2014. Adulteration of herbal medicines and dietary supplements with undeclared synthetic drugs: dangerous for human health. Int J Pharm Pharm Sci. 6(2):1–2.
   Google Scholar
• Savaliya AA, Prasad B, Raijada DK, Singh S. 2009. Detection and characterization of synthetic steroidal and non-steroidal anti-inflammatory drugs in Indian ayurvedic/herbal products using LC-MS/TOF. Drug Test Analysis.Anal1(8):372–381. doi:10.1002/dta.75.
   PubMed Web of Science ®Google Scholar
• Savaliya AA, Shah RP, Prasad B, Singh S. 2010. Screening of Indian aphrodisiac ayurvedic/herbal healthcare products for adulteration with sildenafil, tadalafil and/or vardenafil using LC/PDA and extracted ion LC-MS/TOF. J Pharm Biomed Anal. 52(3):406–409. doi:10.1016/j.jpba.2009.05.021.
   PubMed Web of Science ®Google Scholar
• Vaidya ADB, Devasagayam T. 2007. Current Status of Herbal Drugs in India: An Overview. J Clin Biochem Nutr. 41:1–11. doi:10.3164/jcbn.2007001.
   PubMed Web of Science ®Google Scholar
• Vasquez V, Plomley J, Furtado M, Deckers C, Keyhani A. 2018. Quantitation of fenfluramine and norfenfluramine in mouse cerebellum using a novel sle prototype. [cited 2019 oct 19] https://www.vinceandassociates.com/publications/scientificpublications?page=2.
   Google Scholar
• Wang J, Chen B, Yao S. 2008. Analysis of six synthetic adulterants in herbal weight-reducing dietary supplements by LC electrospray ionization-MS. Food Addit Contam Part Chem Anal Control Expo Risk Assess. 25(7):822–830. doi:10.1080/02652030801946553.
   PubMed Web of Science ®Google Scholar
• WHO 2018. World Health Organization. Obesity and overweight. [cited 2019 Oct 19]. https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
   Google Scholar
• Yan T, Fu Q, Wang J, Ma S. 2015. UPLC-MS/MS determination of ephedrine, methylephedrine, amygdalin and glycyrrhizic acid in Beagle plasma and its application to a pharmacokinetic study after oral administration of Ma Huang Tang. Drug Test Anal. 7(2):158–163. doi:10.1002/dta.1635.
   PubMed Web of Science ®Google Scholar
• Yen M, Ewald MB. 2012. Toxicity of weight loss agents. J Med Toxicol. 8(2):145–152. doi:10.1007/s13181-012-0213-7.
   PubMedGoogle Scholar
• Zeng Y, Xu Y, Kee C-L, Low M-Y, Ge X. 2016. Analysis of 40 weight loss compounds adulterated in health supplements by liquid chromatography quadrupole linear ion trap mass spectrometry. Drug Test Anal. 8(3/4):351–356. doi:10.1002/dta.1846.
   PubMed Web of Science ®Google Scholar