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Research Articles

Effects of Betaine Supplementation on Markers of Metabolic Flexibility, Body Composition, and Anaerobic Performance in Active College-Age Females

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References

  • Cho E, Zeisel SH, Jacques P, Selhub J, Dougherty L, Colditz GA, Willett WC. Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study. Am J Clin Nutr. 2006;83(4):905–11. doi:10.1093/ajcn/83.4.905.
  • Craig SA. Betaine in human nutrition. Am J Clin Nutr. 2004;80(3):539–49. doi:10.1093/ajcn/80.3.539.
  • Cholewa JM, Guimaraes-Ferreira L, Zanchi NE. Effects of betaine on performance and body composition: a review of recent findings and potential mechanisms. Amino Acids. 2014;46(8):1785–93. doi:10.1007/s00726-014-1748-5.
  • Eklund M, Bauer E, Wamatu J, Mosenthin R. Potential nutritional and physiological functions of betaine in livestock. Nutr Res Rev. 2005;18(1):31–48. doi:10.1079/NRR200493.
  • Barak AJ, Beckenhauer HC, Badakhsh S, Tuma DJ. The effect of betaine in reversing alcoholic steatosis. Alcoholism Clin Exp Res. 1997;21(6):1100–2. doi:10.1111/j.1530-0277.1997.tb04259.x.
  • Zhao G, He F, Wu C, Li P, Li N, Deng J, Zhu G, Ren W, Peng Y. Betaine in inflammation: mechanistic aspects and applications. Front Immunol. 2018;9:1070. doi:10.3389/fimmu.2018.01070.
  • Moylan JS, Reid MB. Oxidative stress, chronic disease, and muscle wasting. Muscle Nerve. 2007;35(4):411–29. doi:10.1002/mus.20743.
  • Lefort N, Glancy B, Bowen B, Willis WT, Bailowitz Z, De Filippis EA, Brophy C, Meyer C, Højlund K, Yi Z, et al. Increased reactive oxygen species production and lower abundance of complex I subunits and carnitine palmitoyltransferase 1B protein despite normal mitochondrial respiration in insulin-resistant human skeletal muscle. Diabetes. 2010;59(10):2444–52. doi:10.2337/db10-0174.
  • Patra R, Swarup D, Dwivedi S. Antioxidant effects of α tocopherol, ascorbic acid and L-methionine on lead induced oxidative stress to the liver, kidney and brain in rats. Toxicology. 2001;162(2):81–8. doi:10.1016/S0300-483X(01)00345-6.
  • Xing J, Kang L, Jiang Y. Effect of dietary betaine supplementation on lipogenesis gene expression and CpG methylation of lipoprotein lipase gene in broilers. Mol Biol Rep. 2011;38(3):1975–81. doi:10.1007/s11033-010-0319-4.
  • Li S, Wang H, Wang X, Wang Y, Feng J. Betaine affects muscle lipid metabolism via regulating the fatty acid uptake and oxidation in finishing pig. J Animal Sci Biotechnol. 2017;8(1):1–9. doi:10.1186/s40104-017-0200-6.
  • Zhang L, Qi Y, ALuo Z, Liu S, Zhang Z, Zhou L. Betaine increases mitochondrial content and improves hepatic lipid metabolism. Food Funct. 2019;10(1):216–23. doi:10.1039/c8fo02004c.
  • Costill DL, Hargreaves M. Carbohydrate nutrition and fatigue. Sports Medicine. 1992;13:86–92.
  • San-Millán I, Brooks GA. Assessment of metabolic flexibility by means of measuring blood lactate, fat, and carbohydrate oxidation responses to exercise in professional endurance athletes and less-fit individuals. Sports Med. 2018;48(2):467–79. doi:10.1007/s40279-017-0751-x.
  • McNulty KL, Elliott-Sale KJ, Dolan E, Swinton PA, Ansdell P, Goodall S, Thomas K, Hicks KM. The effects of menstrual cycle phase on exercise performance in eumenorrheic women: a systematic review and meta-analysis. Sports Med. 2020;:1–15.
  • Frandsen J, Pistoljevic N, Quesada JP, Amaro-Gahete FJ, Ritz C, Larsen S, Dela F, Helge JW. Menstrual cycle phase does not affect whole body peak fat oxidation rate during a graded exercise test. J Appl Physiol (1985)). 2020;128(3):681–7. doi:10.1152/japplphysiol.00774.2019.
  • Cholewa JM, Hudson A, Cicholski T, Cervenka A, Barreno K, Broom K, Barch M, Craig SA. The effects of chronic betaine supplementation on body composition and performance in collegiate females: a double-blind, randomized, placebo controlled trial. J Int Soc Sports Nutr. 2018;15(1): 11–37. doi:10.1186/s12970-018-0243-x.
  • Medicine ACoS Health-related physical fitness testing and interpretation. ACSM’Guidelines Exerc Testing Prescr. 2009;57(2):60–73.
  • Brožek J, Grande F, Anderson JT, Keys A. Densitometric analysis of body composition: revision of some quantitative assumptions. Ann N Y Acad Sci. 1963;110:113–40. doi:10.1111/j.1749-6632.1963.tb17079.x.
  • Panzak GL. Concurrent and construct validity of three alternative versions of the standard omni cycle scale of perceived exertion in young adult males. University of Pittsburgh, 2013.
  • Pryor JL, Craig SA, Swensen T. Effect of betaine supplementation on cycling sprint performance. J Int Soc Sports Nutr. 2012;9(1):1–7. doi:10.1186/1550-2783-9-12.
  • Brouwer E. On simple formulae for calculating the heat expenditure and the quantities of carbohydrate and fat oxidized in metabolism of men and animals, from gaseous exchange (Oxygen intake and carbonic acid output) and urine-N. Acta Physiol Pharmacol Neerl. 1957;6:795–802.
  • Apicella JM, Lee EC, Bailey BL, Saenz C, Anderson JM, Craig SA, Kraemer WJ, Volek JS, Maresh CM. Betaine supplementation enhances anabolic endocrine and Akt signaling in response to acute bouts of exercise. Eur J Appl Physiol. 2013;113(3):793–802. doi:10.1007/s00421-012-2492-8.
  • Armstrong LE, Casa DJ, Roti MW, Lee EC, Craig SA, Sutherland JW, Fiala KA, Maresh CM. Influence of betaine consumption on strenuous running and sprinting in a hot environment. The J Strength Condit Res. 2008;22(3):851–60. doi:10.1519/JSC.0b013e31816a6efb.
  • Cholewa JM, Wyszczelska-Rokiel M, Glowacki R, Jakubowski H, Matthews T, Wood R, Craig SA, Paolone V. Effects of betaine on body composition, performance, and homocysteine thiolactone. J Int Soc Sports Nutr. 2013;10(1):12–39. doi:10.1186/1550-2783-10-39.
  • Hoffman JR, Kang J, Ratamess NA, Rashti SL, Tranchina CP, Faigenbaum AD. Effect of betaine supplementation on power performance and fatigue. J Int Soc Sports Nutr. 2009;6(1):1–10. doi:10.1186/1550-2783-6-7.
  • Du J, Shen L, Tan Z, Zhang P, Zhao X, Xu Y, Yang Q, Ma J, Jiang A, Tang G. Betaine supplementation enhances lipid metabolism and improves insulin resistance in mice fed a high-fat diet. Nutrients. 2018;10:131. doi:10.3390/nu10020131.
  • Gao X, Zhang H, Guo X-f, Li K, Li S, Li D. Effect of betaine on reducing body fat—a systematic review and meta-analysis of randomized controlled trials. Nutrients. 2019;11:2480. doi:10.3390/nu11102480.
  • Hoffman JR, Ratamess NA, Kang J, Gonzalez AM, Beller NA, Craig SA. Effect of 15 days of betaine ingestion on concentric and eccentric force outputs during isokinetic exercise. J Strength Cond Res. 2011;25(8):2235–41. doi:10.1519/JSC.0b013e3182162530.
  • Stead LM, Brosnan JT, Brosnan ME, Vance DE, Jacobs RL. Is it time to reevaluate methyl balance in humans?Am J Clin Nutr. 2006;83(1):5–10. doi:10.1093/ajcn/83.1.5.
  • Ortiz ‐Costa S, Sorenson MM, and Sola ‐, Penna M. Betaine protects urea-induced denaturation of myosin subfragment-1. Febs J. 2008;275(13):3388–96. doi:10.1111/j.1742-4658.2008.06487.x.

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