171
Views
0
CrossRef citations to date
0
Altmetric
Research Articles

Effect of Combined Grape Seed Extract and L-Citrulline Supplementation on Hemodynamic Responses to Exercise in Young Males

, , , ORCID Icon, , & show all

References

  • Ma T, Zhang Z, Chen Y, Su H, Deng X, Liu X, Fan Y. Delivery of nitric oxide in the cardiovascular system: implications for clinical diagnosis and therapy. IJMS. 2021;22(22):12166. doi:10.3390/ijms222212166.
  • Tejero J, Shiva S, Gladwin MT. Sources of vascular nitric oxide and reactive oxygen species and their regulation. Physiol Rev. 2019;99(1):311–79. doi:10.1152/physrev.00036.2017.
  • Farah C, Michel LYM, Balligand JL. Nitric oxide signalling in cardiovascular health and disease. Nat Rev Cardiol. 2018;15(5):292–316. doi:10.1038/nrcardio.2017.224.
  • Forstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012;33(7):829–37. 837a–837d. doi:10.1093/eurheartj/ehr304.
  • Ritchie RH, Drummond GR, Sobey CG, De Silva TM, Kemp-Harper BK. The opposing roles of NO and oxidative stress in cardiovascular disease. Pharmacol Res. 2017;116:57–69. doi:10.1016/j.phrs.2016.12.017.
  • Ahmad A, Dempsey SK, Daneva Z, Azam M, Li N, Li PL, Ritter JK. Role of nitric oxide in the cardiovascular and renal systems. IJMS. 2018;19(9):2605. doi:10.3390/ijms19092605.
  • Hord NG, Tang Y, Bryan NS. Food sources of nitrates and nitrites: the physiologic context for potential health benefits. Am J Clin Nutr. 2009;90(1):1–10. doi:10.3945/ajcn.2008.27131.
  • Bailey SJ, Blackwell JR, Lord T, Vanhatalo A, Winyard PG, Jones AM. l-Citrulline supplementation improves O2 uptake kinetics and high-intensity exercise performance in humans. J Appl Physiol (1985). 2015;119(4):385–95. doi:10.1152/japplphysiol.00192.2014.
  • Stanelle ST, McLaughlin KL, Crouse SF. One week of L-citrulline supplementation improves performance in trained cyclists. J Strength Cond Res. 2020;34(3):647–52. doi:10.1519/JSC.0000000000003418.
  • Roux-Mallouf TLE, Vallejo A, Pelen F, Halimaoui I, Doutreleau S, Verges S. Synergetic effect of NO precursor supplementation and exercise training. Med Sci Sports Exerc. 2020;52(11):2437–47. doi:10.1249/MSS.0000000000002387.
  • Lee JS, Stebbins CL, Jung E, Nho H, Kim JK, Chang MJ, Choi HM. Effects of chronic dietary nitrate supplementation on the hemodynamic response to dynamic exercise. Am J Physiol Regul Integr Comp Physiol. 2015;309(5):R459–466. doi:10.1152/ajpregu.00099.2015.
  • Barkhidarian B, Khorshidi M, Shab-Bidar S, Hashemi B. Effects of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis. Avicenna J Phytomed. 2019;9(1):10–20.
  • Gonzalez AM, Trexler ET. Effects of citrulline supplementation on exercise performance in humans: a review of the current literature. J Strength Cond Res. 2020;34(5):1480–95. doi:10.1519/JSC.0000000000003426.
  • Mirenayat MS, Moradi S, Mohammadi H, Rouhani MH. Effect of L-citrulline supplementation on blood pressure: a systematic review and meta-analysis of clinical trials. Curr Hypertens Rep. 2018;20(11):98. doi:10.1007/s11906-018-0898-3.
  • Morita M, Hayashi T, Ochiai M, Maeda M, Yamaguchi T, Ina K, Kuzuya M. Oral supplementation with a combination of L-citrulline and L-arginine rapidly increases plasma L-arginine concentration and enhances NO bioavailability. Biochem Biophys Res Commun. 2014;454(1):53–7. doi:10.1016/j.bbrc.2014.10.029.
  • Suzuki I, Sakuraba K, Horiike T, Kishi T, Yabe J, Suzuki T, Morita M, Nishimura A, Suzuki Y. A combination of oral L-citrulline and L-arginine improved 10-min full-power cycling test performance in male collegiate soccer players: a randomized crossover trial. Eur J Appl Physiol. 2019;119(5):1075–84. doi:10.1007/s00421-019-04097-7.
  • Suzuki T, Morita M, Hayashi T, Kamimura A. The effects on plasma L-arginine levels of combined oral L-citrulline and L-arginine supplementation in healthy males. Biosci Biotechnol Biochem. 2017;81(2):372–5. doi:10.1080/09168451.2016.1230007.
  • Chen K, Pittman RN, Popel AS. Nitric oxide in the vasculature: where does it come from and where does it go? A quantitative perspective. Antioxid Redox Signal. 2008;10(7):1185–98. doi:10.1089/ars.2007.1959.
  • Figueroa A, Wong A, Jaime SJ, Gonzales JU. Influence of L-citrulline and watermelon supplementation on vascular function and exercise performance. Curr Opin Clin Nutr Metab Care. 2017;20(1):92–8. doi:10.1097/MCO.0000000000000340.
  • Quiñones M, Guerrero L, Fernández-Vallinas S, Pons Z, Arola L, Aleixandre A, Muguerza B. Involvement of nitric oxide and prostacyclin in the antihypertensive effect of low-molecular-weight procyanidin rich grape seed extract in male spontaneously hypertensive rats. J Funct Foods. 2014;6:419–27. doi:10.1016/j.jff.2013.11.008.
  • Kim JK, Kim KA, Choi HM, Park SK, Stebbins CL. Grape seed extract supplementation attenuates the blood pressure response to exercise in prehypertensive men. J Med Food. 2018;21(5):445–53. doi:10.1089/jmf.2017.0133.
  • Lee DS, Kim J. Effects of grape seed extract supplementation on hemodynamic response and vascular endothelial function in postmenopausal women. Iran J Public Health. 2019;48(9):1735–7.
  • Odai T, Terauchi M, Kato K, Hirose A, Miyasaka N. Effects of grape seed proanthocyanidin extract on vascular endothelial function in participants with prehypertension: a randomized, double-blind, placebo-controlled study. Nutrients. 2019;11(12):2844. doi:10.3390/nu11122844.
  • Suzuki T, Morita M, Kobayashi Y, Kamimura A. Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: double-blind randomized placebo-controlled 2-way crossover study. J Int Soc Sports Nutr. 2016;13:6. doi:10.1186/s12970-016-0117-z.
  • Shrikhande A, Wang H, Kupina SA. 2011. Grape extract, dietary supplement thereof, and processes therefor. US Patent No, 8,075,929 B2
  • Bougault V, Lonsdorfer-Wolf E, Charloux A, Richard R, Geny B, Oswald-Mammosser M. Does thoracic bioimpedance accurately determine cardiac output in COPD patients during maximal or intermittent exercise? Chest. 2005;127(4):1122–31. doi: 10.1378/chest.127.4.1122
  • Charloux A, Lonsdorfer-Wolf E, Richard R, Lampert E, Oswald-Mammosser M, Mettauer B, Geny B, Lonsdorfer J. A new impedance cardiograph device for the non-invasive evaluation of cardiac output at rest and during exercise: comparison with the "direct" Fick method. Eur J Appl Physiol. 2000;82(4):313–20. doi:10.1007/s004210000226.
  • Dillon K, Shariffi B, Gillum T, Boyer W, Sullivan S, Kim JK. Effects of chronic dietary grape seed extract supplementation on aortic stiffness and hemodynamic responses in obese/overweight males during submaximal exercise. Eur J Sport Sci. 2021;20:1–8. doi:10.1080/17461391.2021.1923815.
  • Larsen FJ, Schiffer TA, Borniquel S, Sahlin K, Ekblom B, Lundberg JO, Weitzberg E. Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab. 2011;13(2):149–59. doi:10.1016/j.cmet.2011.01.004.
  • Tschakovsky ME, Joyner MJ. Nitric oxide and muscle blood flow in exercise. Appl Physiol Nutr Metab. 2008;33(1):151–61. doi:10.1139/H07-148.
  • Jones AM. Dietary nitrate supplementation and exercise performance. Sports Med. 2014;44(Suppl 1):S35–S45. doi:10.1007/s40279-014-0149-y.
  • Boorsma RK, Whitfield J, Spriet LL. Beetroot juice supplementation does not improve performance of elite 1500-m runners. Med Sci Sports Exerc. 2014;46(12):2326–34. doi:10.1249/MSS.0000000000000364.
  • Hickner RC, Tanner CJ, Evans CA, Clark PD, Haddock AMY, Fortune C, Geddis H, Waugh W, Mccammon M. L-citrulline reduces time to exhaustion and insulin response to a graded exercise test. Med Sci Sports Exerc. 2006;38(4):660–6. doi:10.1249/01.mss.0000210197.02576.da.
  • Figueroa A, Jaime SJ, Morita M, Gonzales JU, Moinard C. L-citrulline supports vascular and muscular benefits of exercise training in older adults. Exerc Sport Sci Rev. 2020;48(3):133–9. doi:10.1249/JES.0000000000000223.
  • Bailey SJ, Fulford J, Vanhatalo A, Winyard PG, Blackwell JR, DiMenna FJ, Wilkerson DP, Benjamin N, Jones AM. Dietary nitrate supplementation enhances muscle contractile efficiency during knee-extensor exercise in humans. J Appl Physiol (1985). 2010;109(1):135–48. doi:10.1152/japplphysiol.00046.2010.
  • Gonzales JU, Raymond A, Ashley J, Kim Y. Does l-citrulline supplementation improve exercise blood flow in older adults? Exp Physiol. 2017;102(12):1661–71. doi:10.1113/EP086587.
  • Matsumoto A, Hirata Y, Momomura S, Fujita H, Yao A, Sata M, Serizawa T. Increased nitric oxide production during exercise. Lancet. 1994;343(8901):849–50. doi:10.1016/S0140-6736(94)92047-8.

Reprints and Corporate Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

To request a reprint or corporate permissions for this article, please click on the relevant link below:

Academic Permissions

Please note: Selecting permissions does not provide access to the full text of the article, please see our help page How do I view content?

Obtain permissions instantly via Rightslink by clicking on the button below:

If you are unable to obtain permissions via Rightslink, please complete and submit this Permissions form. For more information, please visit our Permissions help page.